salpallin syrup - Salbutamol (NA) + Bromhexine (NA) medicine

Bronko Syrup: Comprehensive Medicine Guide

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🏭 Lincoln Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Established for individual components; combination evidence is limited.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Chest pain or palpitations
  • Severe dizziness or fainting
  • Difficulty breathing or worsening of breathing
  • Swelling of face, lips, or throat
  • Severe headache with visual changes
  • Blood in cough or vomit
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is salpallin syrup used for?

This medicine is a combination syrup containing salbutamol (a bronchodilator) and bromhexine (a mucolytic). It is used to relieve cough and breathing difficulty by opening airways and thinning mucus. It is taken orally as prescribed by a doctor.

  • Generic Name: Salbutamol (NA) + Bromhexine (NA)
  • Manufacturer: Lincoln Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 salpallin syrup के बारे में (Hindi Summary)

उपयोग: यह दवा सल्ब्यूटामोल और ब्रोमहेक्सिन का संयोजन है, जिसका उपयोग खांसी और सांस लेने में कठिनाई के इलाज के लिए किया जाता है। यह श्वसन मार्ग की मांसपेशियों को आराम देकर और बलगम को पतला करके काम करती है। यह ब्रोंकाइटिस, सीओपीडी और अस्थमा जैसी स्थितियों में राहत देती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में हाथ कांपना, सिरदर्द, घबराहट, मतली और हृदय गति बढ़ना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको सीने में दर्द, तेज़ धड़कन, या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक बढ़ाने से पहले डॉक्टर से सलाह लें। उपयोग से पहले बोतल को अच्छी तरह हिलाएं। सटीक खुराक के लिए मापने वाला कप या चम्मच उपयोग करें। यदि आपको चक्कर या कंपन महसूस हो तो वाहन चलाने से बचें। हृदय रोग, उच्च रक्तचाप, मधुमेह या थायरॉइड की समस्या हो तो डॉक्टर को बताएं।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 salpallin syrup Uses & Benefits

[{"condition":"Acute bronchitis","description":"Helps relieve cough and breathing difficulty by opening airways and thinning mucus.","evidence":"Well-established"},{"condition":"Chronic obstructive pulmonary disease (COPD)","description":"Used to relieve bronchospasm and facilitate mucus clearance in COPD patients.","evidence":"Well-established"},{"condition":"Asthma","description":"May be used as a bronchodilator in asthma, but not as a sole controller therapy.","evidence":"Established"},{"condition":"Productive cough with thick mucus","description":"Bromhexine helps liquefy mucus, making it easier to expectorate.","evidence":"Established"}]

Off-label uses: [{"condition":"Bronchiolitis in children","description":"Sometimes used off-label, but evidence is limited and not routinely recommended.","evidence":"Limited"}]

Primary treatment for: Respiratory conditions with cough and bronchospasm

Also treats: Acute bronchitis, Chronic obstructive pulmonary disease (COPD), Asthma

📋 Drug Information

Generic Name(s)Salbutamol (NA) + Bromhexine (NA)
Brand Namesalpallin syrup
ManufacturerLincoln Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Do not refrigerate. Keep the bottle tightly closed.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always shake the bottle well before measuring the dose.
2
Use a proper measuring cup or spoon; do not use a kitchen spoon.
3
Take the medicine with food if it causes stomach upset.
4
Avoid caffeine and alcohol while taking this medicine.
5
Do not exceed the prescribed dose, even if symptoms persist.
6
Consult your doctor if symptoms do not improve within 7 days.
7
Inform your doctor about all other medications you are taking.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Cough with mucus
This medicine is commonly prescribed for this.
Likely Use
✅
Breathing difficulty
Salbutamol helps open airways.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionSalbutamol is well absorbed from the gastrointestinal tract after oral administration. Bromhexine is also absorbed from the gastrointestinal tract. However, oral salbutamol undergoes significant first-pass metabolism, reducing its systemic bioavailability.
DistributionSalbutamol is widely distributed throughout the body, including the lungs. Bromhexine and its metabolites are also distributed to various tissues. Both drugs can cross the placenta and are excreted in breast milk.
Protein BindingSalbutamol is approximately 10% bound to plasma proteins. Bromhexine binding to plasma proteins is not well established from available information.
MetabolismSalbutamol is metabolized in the liver primarily by conjugation to inactive sulfate esters. Bromhexine is extensively metabolized in the liver, mainly by hydroxylation and conjugation.
Half-LifeThe elimination half-life of salbutamol is approximately 4 to 6 hours. The elimination half-life of bromhexine is approximately 1 to 2 hours for the parent drug, but its metabolites may have longer half-lives.
ExcretionSalbutamol and its metabolites are excreted primarily in the urine, with a smaller fraction in feces. Bromhexine metabolites are excreted mainly in the urine.
BioavailabilityOral salbutamol has a bioavailability of approximately 40% due to first-pass metabolism. The bioavailability of oral bromhexine is about 70-80%.
Onset of ActionBronchodilation from salbutamol typically begins within 15 to 30 minutes after oral administration. Bromhexine's mucolytic effect may take a few hours to become noticeable.
Peak Plasma TimePeak plasma concentrations of salbutamol are reached within 2 to 4 hours after oral administration. Bromhexine peak levels occur within 1 to 2 hours.
Duration of ActionThe bronchodilator effect of oral salbutamol lasts approximately 4 to 6 hours. The mucolytic effect of bromhexine lasts for several hours, depending on mucus production.

How It Works

This medicine combines two active ingredients with complementary actions. Salbutamol selectively stimulates beta-2 adrenergic receptors in the airways, leading to relaxation of bronchial smooth muscle and bronchodilation. Bromhexine increases the production of serous fluid in the respiratory tract and breaks down acidic mucopolysaccharide fibers in mucus, reducing its viscosity and making it easier to clear.

Mechanism Steps

1
Beta-2 receptor stimulation: Salbutamol binds to beta-2 adrenergic receptors on bronchial smooth muscle cells, activating intracellular cyclic AMP.
2
Bronchial smooth muscle relaxation: Increased cyclic AMP leads to relaxation of bronchial smooth muscle, resulting in bronchodilation and easier breathing.
3
Mucus viscosity reduction: Bromhexine breaks down acidic mucopolysaccharide fibers in mucus, reducing its thickness and stickiness.
4
Enhanced mucus clearance: Thinner mucus is more easily moved by cilia and coughed out, helping to clear the airways.

💡 How to Take salpallin syrup

Strength: Each 5 ml of syrup contains salbutamol 2 mg and bromhexine 4 mg (typical composition; actual strength may vary).

1Shake the bottle well before each use.
2Use the measuring cup or spoon provided to measure the correct dose.
3Take the medicine with or without food, but with food if it upsets your stomach.
4Swallow the syrup directly; do not mix with large amounts of liquid unless advised.
5Follow the prescribed schedule consistently.
6Do not exceed the recommended dose.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 10 ml (two teaspoons) taken three to four times a day, or as directed by your physician. The dose may vary depending on the severity of the condition and individual response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose without medical advice.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children.
Elderly DosageElderly patients may be more sensitive to the effects of salbutamol, especially cardiovascular effects. Use with caution and under medical supervision. Dose adjustment may be necessary based on renal and hepatic function.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be required based on the degree of impairment. Consult your doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be required. Consult your doctor.
Maximum Daily DoseThe maximum recommended daily dose is 40 ml (8 teaspoons) in divided doses, but this should not be exceeded without medical advice.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Caffeine
Limit
May increase nervousness and tremor.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of salpallin syrup

✅ Common Side Effects

Tremor (Common (5-10%))
Usually resolves with continued use. If bothersome, consult your doctor.
Headache (Common (5-10%))
Rest and stay hydrated. Consult doctor if persistent.
Nausea (Common (5-10%))
Take with food to reduce stomach upset.
Nervousness (Common (5-10%))
Usually temporary. Avoid caffeine if it worsens.
Increased heart rate (Uncommon (1-5%))
Monitor your pulse. If persistent or symptomatic, consult doctor.

🚨 Serious Side Effects

Palpitations (Rare (<0.1%))
Seek medical attention if you feel rapid or irregular heartbeat.
Chest pain (Rare (<0.1%))
Stop the medicine and seek immediate medical help.
Severe allergic reaction (anaphylaxis) (Very rare (<0.01%))
Call emergency services immediately if you experience swelling of face, lips, throat, or difficulty breathing.
Hypokalemia (Rare (<0.1%))
Report muscle weakness or cramps to your doctor.

⚠️ Rare Side Effects

Paradoxical bronchospasm
Stop the medicine and seek immediate medical attention if breathing worsens after taking it.
Urinary retention
Consult doctor if you have difficulty passing urine.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Propranolol Major
Furosemide Moderate
Digoxin Moderate
MAOIs Major
Tricyclic antidepressants Major
Corticosteroids Moderate
Thiazide diuretics Moderate
Ipratropium Minor
Caffeine Minor
Alcohol Moderate

🚨 Major Interactions

  • Non-selective beta-blockers (e.g., propranolol)
  • Monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants

⚡ Moderate Interactions

  • Diuretics (e.g., furosemide, thiazides)
  • Corticosteroids
  • Digoxin

🍷 Alcohol Interaction

Alcohol may increase the risk of dizziness, drowsiness, and cardiovascular side effects when taken with this medicine. It is advisable to avoid alcohol during treatment.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to salbutamol, bromhexine, or any component of the formulation","Severe cardiovascular disease or uncontrolled arrhythmias","Hyperthyroidism (relative contraindication)","Severe hepatic or renal impairment (use with caution)"]

⚠️ Warnings & Precautions

["Use with caution in patients with heart disease, hypertension, or diabetes.","May cause tremor and nervousness; avoid driving if affected.","Do not exceed the recommended dose.","Not recommended for children under 2 years without medical advice.","Consult doctor if symptoms persist beyond 7 days.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding."]

🤱 Lactation Safety

Salbutamol and bromhexine are excreted in breast milk in small amounts. It is generally considered safe during breastfeeding, but consult your doctor to weigh the benefits and risks.

💊 Overdose Management

Overdose may cause severe tremor, tachycardia, palpitations, and hypokalemia. Seek immediate medical attention. Treatment is supportive and symptomatic. Monitor cardiac and electrolyte status.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not increase the dose or frequency without medical advice. Shake the bottle well before each use. Use a proper measuring cup or spoon to ensure accurate dosing. Avoid driving or operating heavy machinery if you feel dizzy or shaky after taking this medicine. Inform your doctor if you have heart disease, high blood pressure, diabetes, thyroid problems, or liver or kidney disease. Do not use this medicine for a longer duration than recommended without consulting your doctor. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more susceptible to cardiovascular side effects such as tachycardia and palpitations. Use with caution and monitor heart rate and blood pressure regularly.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before using this medicine. It should be used during pregnancy only if clearly needed.

🏥 Post-Surgery Considerations

Consult your doctor before using this medicine after surgery, especially if you have heart or lung conditions. It may interact with anesthetic agents.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may cause dry mouth or interact with certain medications used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Avoid smoking and exposure to secondhand smoke.
🥗
Stay well hydrated to help thin mucus.
😴
Use a humidifier to keep airways moist.
💧
Practice deep breathing exercises.
🧘
Get adequate rest to support recovery.
🌞
Maintain good hand hygiene to prevent infections.

🏋️ Exercise Considerations

Avoid strenuous exercise if you experience tremor, dizziness, or increased heart rate after taking this medicine. Consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Include warm fluids like soups and herbal teas.
Avoid cold and sugary drinks that may worsen cough.
Eat a balanced diet rich in vitamins and minerals.
Limit caffeine intake.

💼 Impact on Daily Work & Life

This medicine may cause tremor or dizziness, which can affect driving or operating machinery. Avoid these activities until you know how the medicine affects you.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if symptoms worsen, if you experience severe side effects, or if you have taken it for the prescribed duration without improvement. Do not stop abruptly if you have been on long-term therapy without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine should be under medical supervision. Prolonged use of salbutamol may lead to tolerance and reduced effectiveness. Regular monitoring of respiratory function and cardiovascular status is advised. Do not use for longer than prescribed without consulting your doctor.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Can help loosen mucus and ease breathing.

Evidence: Traditional
Chest physiotherapy

Helps clear mucus from airways.

Evidence: Established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Ensure you are up to date with influenza and pneumococcal vaccinations if you have chronic respiratory disease. Consult your doctor for personalized advice.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from direct sunlight. If traveling across time zones, adjust dosing times gradually as advised by your doctor. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with acute bronchitis
He was prescribed this medicine for a productive cough and mild breathlessness. After taking it as directed for 5 days, his cough became more productive and breathing improved. He experienced mild hand tremor initially, which subsided after a few days.
💡 Lesson: Taking the medicine as prescribed and completing the course helps relieve symptoms. Mild side effects often diminish with continued use.
👤 A 60-year-old woman with COPD
She used this medicine as part of her COPD management. It helped her cough out mucus more easily and reduced breathlessness. She was advised to monitor her heart rate and report any palpitations.
💡 Lesson: This medicine can be beneficial in chronic respiratory conditions but requires monitoring for cardiovascular side effects, especially in older adults.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Bronchodilation typically begins within 15-30 minutes, and the mucolytic effect may take a few hours.

Q: Can I take it with other cough medicines?

A: Consult your doctor before combining with other cough medicines to avoid interactions.

Q: Is it safe for children?

A: Pediatric dosing is not established; consult a pediatrician.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my heart?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for salpallin syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure asthma permanently.
    Fact: This medicine provides symptomatic relief but does not cure asthma. It should be used as part of a comprehensive management plan.
  • Myth: It is safe to take extra doses if symptoms are severe.
    Fact: Taking more than the prescribed dose can lead to serious side effects. Always follow your doctor's instructions.

🔄 Alternative Options

Generic Alternatives

  • Salbutamol + Bromhexine syrup (generic)

Brand Alternatives

  • Bronko syrup

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Salbutamol + Bromhexine","key_feature":"Combination of bronchodilator and mucolytic"},{"medicine":"Salbutamol + Ambroxol","composition":"Salbutamol + Ambroxol","key_feature":"Ambroxol is a mucolytic with additional antioxidant properties"},{"medicine":"Terbutaline + Bromhexine","composition":"Terbutaline + Bromhexine","key_feature":"Terbutaline is a longer-acting bronchodilator"}]

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