adilin 40mg tablet sr - Isoxsuprine (40mg) medicine

Adilin 40mg Tablet SR: Uses, Side Effects, and Safety Information

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🏭 Lincoln Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
🤰 Pregnancy Category Not established from the available information. Isoxsuprine has been used historically as a tocolytic, but its safety in pregnancy is not well established. It should be used only if clearly needed and under medical supervision. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Limited
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe allergic reaction: swelling of face, lips, or throat, difficulty breathing.
  • Chest pain, irregular heartbeat, or palpitations.
  • Severe dizziness or fainting.
  • Unusual bleeding or bruising.
  • Severe abdominal pain or vomiting blood.
  • Yellowing of skin or eyes (jaundice).
  • Decreased urine output.

If experiencing severe symptoms, call emergency services immediately.

What is adilin 40mg tablet sr used for?

Adilin 40mg Tablet SR contains isoxsuprine, a vasodilator used to improve blood flow in conditions like peripheral vascular disease and Raynaud's phenomenon. It works by relaxing blood vessels. Take it exactly as prescribed, usually 2-3 times daily with food. Avoid alcohol and driving until you know how it affects you.

  • Generic Name: Isoxsuprine
  • Manufacturer: Lincoln Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 adilin 40mg tablet sr के बारे में (Hindi Summary)

उपयोग: यह दवा आइसोक्ससुप्रीन 40 मिलीग्राम का निरंतर-रिलीज़ टैबलेट है, जिसका उपयोग रक्त वाहिकाओं को फैलाकर रक्त प्रवाह में सुधार के लिए किया जाता है। यह मुख्य रूप से परिधीय संवहनी रोग, रेनॉड्स फेनोमेनन, और एक्रोसायनोसिस जैसी स्थितियों में उपयोग की जाती है। यह हाथों और पैरों में ठंडक, सुन्नता और दर्द को कम करने में मदद करती है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, चक्कर आना, सिरदर्द, और दिल की धड़कन तेज होना शामिल हैं। कुछ लोगों को चेहरे पर लालिमा, पसीना, या हल्के दाने भी हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर त्वचा पर लाल चकत्ते दिखाई दें, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं के बारे में बताएं। यदि आपको हृदय रोग, निम्न रक्तचाप, या रक्तस्राव विकार है, तो सावधानी बरतें। इस दवा को लेते समय शराब का सेवन न करें। गाड़ी चलाने या मशीनरी चलाने से बचें जब तक कि आपको पता न चल जाए कि यह दवा आपको कैसे प्रभावित करती है। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से परामर्श करें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 adilin 40mg tablet sr Uses & Benefits

[{"condition":"Peripheral vascular disease","description":"Helps improve blood flow to the limbs, reducing symptoms such as cold extremities, numbness, and pain.","evidence":"Limited"},{"condition":"Raynaud's phenomenon","description":"Relaxes blood vessels to reduce the frequency and severity of vasospastic attacks triggered by cold or stress.","evidence":"Limited"},{"condition":"Acrocyanosis","description":"Improves circulation to the extremities, reducing bluish discoloration of the hands and feet.","evidence":"Limited"},{"condition":"Cerebrovascular insufficiency","description":"May be used to improve blood flow to the brain, although evidence is not strong.","evidence":"Limited"},{"condition":"Preterm labor (tocolytic)","description":"Relaxes uterine smooth muscle to delay premature labor, but this use is largely historical and not first-line.","evidence":"Limited"}]

Off-label uses: [{"condition":"Erectile dysfunction","description":"Sometimes used off-label to improve penile blood flow, but not recommended due to lack of robust evidence.","evidence":"Insufficient"},{"condition":"Diabetic peripheral neuropathy","description":"May be prescribed off-label to improve nerve blood flow, but evidence is lacking.","evidence":"Insufficient"}]

Primary treatment for: Peripheral vascular disease

Also treats: Raynaud's phenomenon, Acrocyanosis, Cerebrovascular insufficiency

📋 Drug Information

Generic Name(s)Isoxsuprine
Brand NameAdilin 40mg Tablet SR
ManufacturerLincoln Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGYNAECOLOGICAL
Action ClassBeta 2 agonist - Uterus
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Shelf Life24 months from the date of manufacture, or as indicated on the packaging.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce the risk of stomach upset.
2
Swallow the sustained-release tablet whole; do not crush or chew it.
3
Avoid alcohol while taking this medicine as it can increase dizziness.
4
Do not drive or operate heavy machinery until you know how this medicine affects you.
5
Monitor your blood pressure regularly, especially if you have hypertension.
6
Report any unusual bleeding, bruising, or severe dizziness to your doctor immediately.
7
Do not stop taking this medicine abruptly without consulting your doctor.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Cold extremities
This medicine is commonly prescribed for this.
Likely Use
Numbness in fingers
This medicine may help improve circulation.
Likely Use
Fever
This medicine is not a fever reducer.
Not Primary
Headache
This medicine is not a primary headache treatment.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionIsoxsuprine is absorbed from the gastrointestinal tract after oral administration. The exact bioavailability is not well established from the available information. The sustained-release formulation is designed to release the drug slowly over an extended period, which may affect the rate and extent of absorption compared to immediate-release formulations.
DistributionThe distribution of isoxsuprine in the body is not well characterized. It is presumed to distribute widely into tissues, but specific data on volume of distribution and tissue penetration are not established from the available information.
Protein BindingNot established from the available information.
MetabolismThe metabolic pathway of isoxsuprine in humans is not fully established. It is likely metabolized in the liver, but specific enzymes and metabolites have not been well characterized.
Half-LifeNot established from the available information.
ExcretionThe route of excretion of isoxsuprine and its metabolites is not well established. It is likely excreted primarily in the urine, but specific data are lacking.
BioavailabilityNot established from the available information.
Onset of ActionThe onset of action for isoxsuprine is not precisely established. Some effects on blood flow may be noticed within 30 to 60 minutes after oral administration, but the full therapeutic effect may take longer.
Peak Plasma TimeNot established from the available information.
Duration of ActionThe duration of action of isoxsuprine is not well established. The sustained-release formulation is designed to provide prolonged effects, but specific duration data are lacking.

How It Works

Isoxsuprine is a synthetic derivative of epinephrine that acts primarily as a beta-2 adrenergic receptor agonist. It stimulates beta-2 receptors on vascular smooth muscle, leading to relaxation and vasodilation. This effect is more pronounced on the blood vessels supplying skeletal muscle and the brain. Additionally, isoxsuprine has some alpha-adrenergic blocking activity, which contributes to its vasodilatory effects. It also relaxes uterine smooth muscle, which is why it was historically used as a tocolytic agent. The vasodilation improves blood flow to ischemic tissues, which helps relieve symptoms of peripheral vascular disease and Raynaud's phenomenon. The exact mechanism by which it provides symptomatic relief in these conditions is not fully understood, but it is believed to involve a combination of increased blood flow and direct smooth muscle relaxation.

Mechanism Steps

1
Binding to beta-2 adrenergic receptors: Isoxsuprine binds to beta-2 adrenergic receptors located on the surface of vascular smooth muscle cells.
2
Activation of adenylate cyclase: This binding activates the enzyme adenylate cyclase, which increases the production of cyclic AMP (cAMP) inside the cell.
3
Reduction of intracellular calcium: Elevated cAMP levels lead to a decrease in intracellular calcium concentrations, which reduces the activity of myosin light-chain kinase.
4
Smooth muscle relaxation: The reduction in calcium and kinase activity causes the smooth muscle cells to relax, leading to vasodilation.
5
Increased blood flow: Vasodilation increases blood flow to the affected areas, relieving symptoms of ischemia and vasospasm.

💡 How to Take adilin 40mg tablet sr

Strength: Sustained-release tablet containing 40mg of isoxsuprine.

1Take the tablet whole with a full glass of water.
2Swallow it whole; do not crush, chew, or break the sustained-release tablet.
3Take it with food to reduce stomach upset.
4Take it at the same times each day to maintain consistent blood levels.
5If you miss a dose, follow the missed dose instructions.
6Do not take more than the prescribed dose.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one 40mg sustained-release tablet taken orally two to three times daily, or as directed by your physician. The dose may be adjusted based on your condition and response to treatment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. Take the tablet whole with a glass of water; do not crush or chew the sustained-release tablet.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of isoxsuprine, particularly dizziness and hypotension. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician.
Renal ImpairmentDose adjustment may be necessary in patients with renal impairment. Consult your doctor for individualized dosing.
Hepatic ImpairmentDose adjustment may be necessary in patients with hepatic impairment. Consult your doctor for individualized dosing.
Maximum Daily DoseThe maximum recommended daily dose is 120mg, but this may vary based on clinical judgment. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and improves absorption.
Grapefruit
Avoid
May increase drug levels by inhibiting metabolism.
Alcohol
Avoid
May increase dizziness and drowsiness.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of adilin 40mg tablet sr

✅ Common Side Effects

Nausea (Common (5-10%))
Take the medicine with food to reduce nausea. If it persists, consult your doctor.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how this medicine affects you. Lie down if you feel dizzy.
Headache (Common (5-10%))
Rest and stay hydrated. If headache is severe or persistent, consult your doctor.
Fast heartbeat (tachycardia) (Common (5-10%))
Report to your doctor if you notice a persistent fast heartbeat or palpitations.
Flushing (Common (5-10%))
This usually resolves on its own. If it bothers you, consult your doctor.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience swelling of the face, lips, or throat, difficulty breathing, or a severe rash.
Severe low blood pressure (hypotension) (Rare (<0.1%))
If you feel faint, have blurred vision, or collapse, lie down and seek emergency medical help.
Chest pain or irregular heartbeat (Rare (<0.1%))
Stop the medicine and seek immediate medical attention if you experience chest pain, shortness of breath, or palpitations.
Severe skin reactions (e.g., Stevens-Johnson syndrome) (Very rare (<0.01%))
Seek immediate medical attention if you develop a painful rash, blistering, or peeling skin.

⚠️ Rare Side Effects

Blood dyscrasias (e.g., thrombocytopenia)
Report any unusual bleeding or bruising to your doctor immediately.
Liver enzyme elevation
Your doctor may monitor liver function tests if you are on long-term therapy.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAOIs Major
Beta-blockers Major
Antihypertensives Moderate
Diuretics Moderate
Alcohol Minor

🚨 Major Interactions

  • Monoamine oxidase inhibitors (MAOIs)
  • Beta-blockers

⚡ Moderate Interactions

  • Antihypertensives
  • Diuretics

🍷 Alcohol Interaction

Alcohol may increase the risk of dizziness, drowsiness, and low blood pressure when taken with this medicine. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Recent myocardial infarction","Severe hypotension","Active bleeding disorders","Hypersensitivity to isoxsuprine or any component of the formulation","First trimester of pregnancy"]

⚠️ Warnings & Precautions

["Use with caution in patients with cardiovascular disease.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol while taking this medicine.","Use with caution in patients with renal or hepatic impairment.","Not recommended for use during the first trimester of pregnancy.","Consult your doctor before taking this medicine if you are breastfeeding.","Do not exceed the prescribed dose."]

🤱 Lactation Safety

It is not known whether isoxsuprine is excreted in human breast milk. Because many drugs are excreted in human milk, caution should be exercised when this medicine is administered to a breastfeeding woman. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose of isoxsuprine may cause severe hypotension, tachycardia, and cardiac arrhythmias. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic, including monitoring of vital signs and administration of intravenous fluids if necessary. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one.

Additional Safety Advice

General Safety

Before taking this medicine, inform your doctor if you have any heart problems, low blood pressure, or a history of bleeding disorders. Do not drive or operate heavy machinery until you know how this medicine affects you, as it can cause dizziness. Avoid drinking alcohol while taking this medicine, as it may increase dizziness and drowsiness. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Do not take this medicine if you have recently had a heart attack or if you have severe low blood pressure. Keep all your medical appointments and lab tests as scheduled by your doctor. Store this medicine at room temperature, away from moisture and direct sunlight. Do not share this medicine with anyone else, even if they have the same symptoms. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Never double the dose to make up for a missed one.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and low blood pressure. Use with caution and monitor closely. Dose adjustment may be necessary.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. It is not recommended during the first trimester. Your doctor will weigh the benefits and risks.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may affect blood pressure and heart rate during surgery. Your doctor may advise you to stop it temporarily.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine before any dental procedure. It may cause dizziness or low blood pressure during the procedure. Your dentist may take precautions.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce strain on your circulation.
🥗
Engage in regular low-impact exercise like walking or swimming.
😴
Avoid smoking, as it constricts blood vessels and worsens circulation.
💧
Keep your extremities warm in cold weather.
🧘
Manage stress through relaxation techniques like yoga or meditation.
🌞
Follow a balanced diet rich in fruits, vegetables, and whole grains.

🏋️ Exercise Considerations

While taking this medicine, you may experience dizziness or low blood pressure during exercise. Start with light activities and gradually increase intensity. Stay hydrated and avoid sudden changes in posture. If you feel dizzy or faint, stop exercising and rest.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseeds.
Reduce intake of processed and high-fat foods.
Stay well hydrated throughout the day.
Limit caffeine and alcohol consumption.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is advisable to inform your employer if your job involves operating heavy machinery.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your condition worsens, contact your doctor immediately. Your doctor will decide whether to adjust the dose or switch to another medicine.

📅 Long-Term Use Effects

Long-term use of this medicine may require periodic monitoring of blood pressure, heart rate, and liver function. Some patients may develop tolerance to its effects. It is important to have regular follow-ups with your doctor to assess the continued benefit and adjust the dose if needed. If you experience any new or worsening symptoms, report them to your doctor promptly.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can help improve circulation and reduce symptoms of peripheral vascular disease.

Evidence: Well-established
Lifestyle modifications

Quitting smoking, regular exercise, and a healthy diet can improve blood flow.

Evidence: Well-established
Biofeedback

May help manage Raynaud's phenomenon by teaching temperature control.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or exposure to extreme temperatures. Store it at room temperature, away from direct sunlight and moisture. If you are crossing time zones, adjust your dosing schedule gradually in consultation with your doctor. Check the customs regulations of your destination country regarding prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 55-year-old man with Raynaud's phenomenon
He experienced frequent episodes of cold, numb fingers triggered by cold weather. His doctor prescribed this medicine. After taking it regularly for a month, he noticed a significant reduction in the frequency and severity of attacks. He also made lifestyle changes like wearing gloves and avoiding cold exposure.
💡 Lesson: Consistent use of this medicine along with lifestyle modifications can effectively manage Raynaud's phenomenon.
👤 A 62-year-old woman with peripheral vascular disease
She had pain in her legs while walking and cold feet. She was started on this medicine. Within a few weeks, her walking distance improved, and her feet felt warmer. She experienced mild nausea initially, which subsided after taking the medicine with food.
💡 Lesson: Taking this medicine with food can minimize gastrointestinal side effects and improve tolerability.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Some effects may be noticed within 30-60 minutes, but full therapeutic benefits may take several days to weeks.

Q: Can I take this medicine with food?

A: Yes, taking it with food reduces stomach upset.

Q: What should I do if I miss a dose?

A: Take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular schedule.

Q: Is it safe during pregnancy?

A: Consult your doctor. It is not recommended during the first trimester.

Q: Can I stop taking this medicine suddenly?

A: Do not stop without consulting your doctor, as it may worsen your condition.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for adilin 40mg tablet sr

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Adilin 40mg Tablet SR can be taken without a prescription.
    Fact: This medicine is a prescription drug and should only be taken under medical supervision.
  • Myth: Adilin 40mg Tablet SR is a painkiller.
    Fact: It is not a painkiller; it improves blood flow and may relieve pain caused by poor circulation.
  • Myth: You can crush or chew the sustained-release tablet.
    Fact: The sustained-release tablet must be swallowed whole; crushing or chewing can cause rapid release and increase side effects.

🔄 Alternative Options

Generic Alternatives

  • Isoxsuprine 40mg sustained-release tablet

Brand Alternatives

  • Duvadilan 40mg Tablet SR
  • Isoxsuprine 40mg Tablet SR

📊 Comparison with Similar Medicines

[{"medicine":"Isoxsuprine","class":"Vasodilator","primary_use":"Peripheral vascular disease","route":"Oral"},{"medicine":"Nifedipine","class":"Calcium channel blocker","primary_use":"Raynaud's phenomenon, hypertension","route":"Oral"},{"medicine":"Pentoxifylline","class":"Hemorrh rheologic agent","primary_use":"Intermittent claudication","route":"Oral"}]

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