Rimarex 300mg Capsule - Moclobemide (300mg) medicine

Morex 300mg Tablet: Comprehensive Medicine Guide

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🏭 Sun Pharmaceutical Industries Ltd 📦 strip of 10 capsules 💊 Allopathy 📅 Updated: Sep 24, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for major depressive disorder.
Reviewed by
SaathiMed Expert Panel | Sep 24, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe headache with blurred vision or confusion
  • Chest pain, palpitations, or difficulty breathing
  • Agitation, hallucinations, fever, or muscle twitching
  • Yellowing of skin or eyes, dark urine, or severe abdominal pain
  • Rash, swelling of face or throat, or difficulty swallowing
  • Suicidal thoughts or self-harm urges
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is Rimarex 300mg Capsule used for?

This medicine is an antidepressant containing moclobemide 300 mg. It is used to treat major depressive disorder and works by increasing brain chemicals that improve mood. It is a prescription medicine and must be taken under medical supervision.

  • Generic Name: Moclobemide (300mg)
  • Manufacturer: Sun Pharmaceutical Industries Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 Rimarex 300mg Capsule के बारे में (Hindi Summary)

उपयोग: यह दवा मोक्लोबेमाइड 300 मिलीग्राम युक्त एक एंटीडिप्रेसेंट है। इसका उपयोग अवसाद (डिप्रेशन) और दीर्घकालिक उदासी के इलाज के लिए किया जाता है। यह मस्तिष्क में सेरोटोनिन, नॉरएपिनेफ्रिन और डोपामिन जैसे रसायनों के स्तर को बढ़ाकर मूड को बेहतर बनाने में मदद करती है। यह दवा केवल डॉक्टर के पर्चे पर मिलती है और इसे डॉक्टर की सलाह के अनुसार ही लेनी चाहिए।

साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में नींद न आना, चक्कर आना, सिरदर्द, मतली, मुँह सूखना और कब्ज शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको तेज सिरदर्द, धड़कन तेज होना, सीने में दर्द, सांस लेने में कठिनाई, या एलर्जी के लक्षण जैसे दाने या सूजन दिखें, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। दवा की खुराक खुद से न बदलें और न ही अचानक बंद करें। टायरामिन युक्त खाद्य पदार्थ जैसे पुरानी चीज़, प्रोसेस्ड मीट, और फर्मेंटेड सोया उत्पादों का अधिक सेवन न करें। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं, खासकर अन्य एंटीडिप्रेसेंट। गाड़ी चलाने या मशीन चलाने से बचें जब तक कि आपको पता न चल जाए कि यह दवा आप पर कैसे असर करती है। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 Rimarex 300mg Capsule Uses & Benefits

[{"condition":"Major depressive disorder","description":"This medicine is used to treat episodes of major depression, helping to improve mood, sleep, appetite, and energy levels.","evidence":"Well-established"},{"condition":"Dysthymia (persistent depressive disorder)","description":"It may be prescribed for chronic low-grade depression that lasts for at least two years in adults.","evidence":"Moderate"},{"condition":"Atypical depression","description":"Some clinicians use this medicine for depression with atypical features such as increased appetite and sleepiness.","evidence":"Limited"}]

Off-label uses: [{"condition":"Social anxiety disorder","description":"Occasionally prescribed off-label for social anxiety, but evidence is limited.","evidence":"Limited"},{"condition":"Panic disorder","description":"There is some evidence for use in panic disorder, but it is not a first-line treatment.","evidence":"Limited"}]

Primary treatment for: Major depressive disorder

Also treats: Dysthymia, Atypical depression

📋 Drug Information

Generic Name(s)Moclobemide (300mg)
Brand NameRimarex 300mg Capsule
ManufacturerSun Pharmaceutical Industries Ltd
Packaging / Formstrip of 10 capsules (Allopathy)
Therapeutic Class
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine in the morning to reduce the risk of insomnia.
2
Avoid tyramine-rich foods such as aged cheese, cured meats, and fermented soy products.
3
Do not stop this medicine abruptly; always taper under medical supervision.
4
Inform your doctor about all other medicines, especially other antidepressants and pain relievers.
5
Monitor for signs of serotonin syndrome such as agitation, confusion, rapid heart rate, and muscle twitching.
6
Report any unusual mood changes, especially suicidal thoughts, to your doctor immediately.
7
Use contraception if you are of childbearing age and discuss pregnancy plans with your doctor.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Persistent sadness
This medicine is commonly prescribed for depression.
Likely Use
Loss of interest
This medicine may help improve interest and pleasure in activities.
Likely Use
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is well absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability is approximately 55% to 70% due to first-pass metabolism. Food does not significantly affect the extent of absorption but may delay the time to peak concentration.
DistributionThis medicine is widely distributed throughout the body. It has a volume of distribution of approximately 1.2 to 1.5 L/kg. It crosses the blood-brain barrier to exert its effects in the central nervous system.
Protein BindingApproximately 50% of this medicine is bound to plasma proteins.
MetabolismThis medicine is extensively metabolized in the liver, primarily by cytochrome P450 enzymes, including CYP2C19 and CYP2D6. Its metabolites are largely inactive.
Half-LifeThe elimination half-life of this medicine is approximately 1 to 4 hours, with a mean of about 2 hours. In elderly patients, the half-life may be prolonged.
ExcretionThis medicine and its metabolites are primarily excreted in the urine. About 60% to 70% of a dose is excreted in urine, with less than 1% as unchanged drug.
BioavailabilityThe absolute bioavailability of this medicine is approximately 55% to 70%.
Onset of ActionThe onset of antidepressant effect typically takes 1 to 2 weeks, but full therapeutic benefits may take 4 to 6 weeks.
Peak Plasma TimePeak plasma concentrations are reached approximately 1 to 2 hours after oral administration.
Duration of ActionThe duration of action is approximately 8 to 12 hours, but the antidepressant effect is continuous with regular dosing.

How It Works

This medicine works by selectively and reversibly inhibiting the enzyme monoamine oxidase type A (MAO-A). This enzyme is responsible for breaking down neurotransmitters such as serotonin, norepinephrine, and dopamine. By blocking MAO-A, this medicine increases the levels of these neurotransmitters in the brain, which helps to elevate mood and reduce depressive symptoms. Because the inhibition is reversible, the enzyme activity can recover once the medicine is cleared, which reduces the risk of hypertensive crisis from dietary tyramine compared to irreversible MAO inhibitors.

Mechanism Steps

1
Reversible binding to MAO-A: This medicine binds reversibly to the active site of monoamine oxidase type A, temporarily blocking its activity.
2
Reduced neurotransmitter breakdown: With MAO-A inhibited, the breakdown of serotonin, norepinephrine, and dopamine is reduced, leading to higher levels of these neurotransmitters in the synaptic cleft.
3
Enhanced neurotransmission: Increased neurotransmitter availability enhances mood-regulating pathways in the brain, which helps alleviate depressive symptoms.
4
Reversibility and recovery: Because the inhibition is reversible, enzyme activity returns to normal once the medicine is eliminated, reducing the risk of tyramine-induced hypertension.

💡 How to Take Rimarex 300mg Capsule

Strength: Immediate-release tablet, 300 mg

1Take this medicine exactly as prescribed by your doctor.
2Swallow the tablet whole with a glass of water.
3You may take it with or without food, but taking it with food may reduce stomach upset.
4If you are taking it once daily, take it in the morning to avoid insomnia.
5If you are taking it twice daily, take it in the morning and early afternoon.
6Do not crush, chew, or break the tablet unless your doctor advises.
7Do not stop taking this medicine suddenly without consulting your doctor.

Dosage Information

Adult DosageThe usual starting dose of this medicine for adults is 300 mg per day, which may be taken as a single dose or divided into two doses. Depending on your response and tolerability, your doctor may adjust the dose. The maximum recommended daily dose is 600 mg. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine. Start with a lower dose and adjust gradually based on response and tolerability. Dose must be individualized by a qualified clinician.
Renal ImpairmentNo specific dose adjustment is provided in the available information. Use with caution in patients with severe renal impairment. Consult your doctor for individualized dosing.
Hepatic ImpairmentThis medicine is extensively metabolized in the liver. In patients with hepatic impairment, dose reduction may be necessary. Consult your doctor for individualized dosing.
Maximum Daily Dose600 mg per day

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and nausea.
Tyramine-rich foods
Avoid large amounts
May increase blood pressure.
Caffeine
Limit
May increase nervousness and insomnia.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of Rimarex 300mg Capsule

✅ Common Side Effects

Insomnia (Common (5-10%))
Take the medicine in the morning to reduce insomnia. If it persists, consult your doctor.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying positions. Avoid driving if dizzy.
Nausea (Common (5-10%))
Take with food to reduce nausea. If severe, contact your doctor.
Dry mouth (Common (5-10%))
Sip water frequently, chew sugar-free gum, or use saliva substitutes.
Headache (Common (5-10%))
Rest and stay hydrated. Consult doctor if headache is severe or persistent.

🚨 Serious Side Effects

Hypertensive crisis (Rare (<0.1%))
Seek immediate medical attention if you experience severe headache, blurred vision, chest pain, or shortness of breath.
Serotonin syndrome (Rare (<0.1%))
Go to the emergency room if you have agitation, hallucinations, rapid heart rate, fever, or muscle twitching.
Severe allergic reaction (Rare (<0.1%))
Call emergency services if you develop rash, swelling of face or throat, or difficulty breathing.
Liver enzyme elevation (Uncommon (0.1-1%))
Report yellowing of skin or eyes, dark urine, or abdominal pain to your doctor immediately.

⚠️ Rare Side Effects

Agranulocytosis
Seek medical attention if you develop fever, sore throat, or unusual infections.
Hepatitis
Report symptoms of liver inflammation such as jaundice, fatigue, and nausea.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
SSRIs Major
Sympathomimetics Major
Tramadol Major
Tricyclic antidepressants Moderate
CYP2C19 inhibitors Moderate
CYP2D6 inhibitors Moderate
Caffeine Minor
Alcohol Minor

🚨 Major Interactions

  • Other MAO inhibitors
  • SSRIs (e.g., fluoxetine, sertraline)
  • Sympathomimetics (e.g., pseudoephedrine)
  • Tramadol

⚡ Moderate Interactions

  • Tricyclic antidepressants
  • CYP2C19 inhibitors (e.g., omeprazole)
  • CYP2D6 inhibitors (e.g., paroxetine)

🍷 Alcohol Interaction

Alcohol may increase the sedative effects of this medicine and impair your ability to drive or operate machinery. It is best to avoid alcohol while taking this medicine. If you choose to drink, do so in moderation and never drink and drive.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to moclobemide or any component of the tablet","Acute confusional states","Severe liver impairment","Pheochromocytoma","Concurrent use with other MAO inhibitors or SSRIs"]

⚠️ Warnings & Precautions

["Antidepressants may increase the risk of suicidal thoughts and behaviors in children, adolescents, and young adults. Monitor closely.","Avoid tyramine-rich foods in large amounts.","Do not stop this medicine abruptly; taper under medical supervision.","Use with caution in patients with bipolar disorder, as it may trigger a manic episode.","May impair ability to drive or operate machinery. Avoid until you know how it affects you.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding."]

🤱 Lactation Safety

This medicine may pass into breast milk. Consult your doctor before breastfeeding. The benefits of breastfeeding should be weighed against the potential risks to the infant.

💊 Overdose Management

Overdose may cause severe drowsiness, dizziness, agitation, hypertension, and serotonin syndrome. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Contact a poison control center or emergency room right away.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it suddenly, as this can lead to withdrawal symptoms or worsening of depression. Avoid consuming large amounts of tyramine-rich foods such as aged cheese, cured meats, fermented soy products, and draft beer, although the risk is lower than with older monoamine oxidase inhibitors. Inform your doctor about all other medicines you are taking, especially other antidepressants, pain relievers, and cold remedies, because serious interactions can occur. Do not drive or operate heavy machinery until you know how this medicine affects you. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of reach of children and store it as directed on the label.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and drowsiness. Start with a lower dose and monitor closely. Regular follow-up is recommended.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established. Your doctor will weigh the benefits and risks.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with certain anesthetic agents. Your doctor may advise you to stop it temporarily before surgery.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine before any dental procedure. It may interact with certain local anesthetics or sedatives used during dental work.

💚 Lifestyle Tips for Better Results

🏃
Maintain a regular sleep schedule to support mood stability.
🥗
Engage in regular physical activity, such as walking or yoga, to boost mood.
😴
Eat a balanced diet rich in fruits, vegetables, and whole grains.
💧
Avoid alcohol and recreational drugs.
🧘
Practice stress-reduction techniques like meditation or deep breathing.
🌞
Stay connected with friends and family for emotional support.

🏋️ Exercise Considerations

Exercise is generally safe while taking this medicine. However, if you experience dizziness or lightheadedness, avoid strenuous activities until you feel better. Stay hydrated during exercise.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseeds.
Limit processed and high-sugar foods.
Stay well hydrated.
Avoid large amounts of tyramine-rich foods.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also affect your ability to concentrate. Discuss any work-related concerns with your doctor.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or need to stop for any reason, your doctor will guide you on how to taper the dose safely to avoid withdrawal symptoms.

📅 Long-Term Use Effects

Long-term use of this medicine is generally safe when monitored by a doctor. Regular follow-up is needed to assess mood, side effects, and any need for dose adjustment. Rarely, liver enzyme elevations may occur, so periodic liver function tests may be advised. Do not stop the medicine without medical guidance.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Psychotherapy

Cognitive behavioral therapy can be effective for depression and may complement medicine.

Evidence: Well-established
Lifestyle changes

Regular exercise, healthy diet, and stress management can help improve mood.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known. However, always inform your healthcare provider about all medicines you are taking before receiving any vaccine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, consult your doctor about adjusting the timing of your doses. Check local customs regulations regarding prescription medicines before you travel.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with major depressive disorder
She had been struggling with persistent sadness and loss of interest for months. Her doctor prescribed this medicine 300 mg daily. After about three weeks, she noticed her mood gradually improving and she was able to enjoy activities again. She experienced mild nausea initially, which subsided after taking the medicine with breakfast.
💡 Lesson: Consistent daily dosing and taking the medicine with food can improve tolerability and effectiveness.
👤 A 50-year-old man with dysthymia
He had chronic low-grade depression for years. His doctor started him on this medicine 300 mg daily. He initially felt dizzy when standing up quickly, so his doctor advised him to rise slowly. Over two months, his mood and energy levels improved significantly, and he was able to return to his hobbies.
💡 Lesson: Dose adjustment and lifestyle modifications can help manage side effects while achieving therapeutic benefits.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start to feel some improvement in 1 to 2 weeks, but full benefits may take 4 to 6 weeks.

Q: Can I stop taking this medicine when I feel better?

A: No, you should continue taking it for as long as your doctor advises to prevent relapse. Stopping suddenly can cause withdrawal symptoms.

Q: What should I avoid while taking this medicine?

A: Avoid large amounts of tyramine-rich foods, alcohol, and other antidepressants unless prescribed. Also avoid driving until you know how it affects you.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for Rimarex 300mg Capsule

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is addictive.
    Fact: This medicine is not considered addictive, but it should not be stopped abruptly without medical advice.
  • Myth: You can stop taking this medicine as soon as you feel better.
    Fact: You should continue taking this medicine for as long as your doctor advises, even if you feel better, to prevent relapse.
  • Myth: This medicine works immediately.
    Fact: It may take 1 to 2 weeks for initial effects and 4 to 6 weeks for full benefits.

🔄 Alternative Options

Generic Alternatives

  • Moclobemide 300 mg tablet

Brand Alternatives

  • Morex 300mg Tablet

📊 Comparison with Similar Medicines

[{"medicine":"This medicine (Moclobemide 300 mg)","class":"RIMA","main_use":"Major depressive disorder","common_side_effects":"Insomnia, dizziness, nausea"},{"medicine":"SSRIs (e.g., fluoxetine)","class":"SSRI","main_use":"Depression, anxiety","common_side_effects":"Sexual dysfunction, nausea, insomnia"},{"medicine":"Tricyclic antidepressants (e.g., amitriptyline)","class":"TCA","main_use":"Depression, neuropathic pain","common_side_effects":"Dry mouth, constipation, sedation"}]

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