Rf 3 Forte 255 Mg/150 Mg/750 Mg Tablet: Complete Guide To Uses, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of the skin or eyes (jaundice)
- Dark urine or pale stools
- Severe abdominal pain
- Persistent vomiting
- Tingling or numbness in hands or feet
- Vision changes or eye pain
- Seizures
- Severe skin rash with blisters or peeling
If experiencing severe symptoms, call emergency services immediately.
What is RF 3 Forte 255 mg/150 mg/750 mg Tablet used for?
This medicine is a combination of isoniazid and pyrazinamide, two antibiotics used together to treat active tuberculosis. It works by killing the bacteria that cause tuberculosis. It is taken orally, usually once daily, as part of a multi-drug regimen. It should be taken exactly as prescribed, and alcohol should be avoided due to the risk of liver damage.
- Generic Name: Isoniazid (255mg) + Pyrazinamide (150mg)
- Manufacturer: Sunij Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 RF 3 Forte 255 mg/150 mg/750 mg Tablet के बारे में (Hindi Summary)
उपयोग: यह दवा तपेदिक (टीबी) के इलाज के लिए इस्तेमाल की जाती है। इसमें आइसोनियाजिड और पायराजिनामाइड दो एंटीबायोटिक्स होते हैं जो टीबी के बैक्टीरिया को मारते हैं। यह दवा आमतौर पर अन्य टीबी दवाओं के साथ दी जाती है। इसे डॉक्टर के बताए अनुसार ही लें और बीच में न छोड़ें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में जी मिचलाना, उल्टी, भूख न लगना, जोड़ों में दर्द, और हाथ-पैरों में झनझनाहट शामिल हैं। कभी-कभी यह लिवर को नुकसान पहुंचा सकती है, इसलिए अगर आंखों या त्वचा में पीलापन, गहरे रंग का पेशाब, या पेट में तेज दर्द हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, बीच में न छोड़ें। शराब बिल्कुल न पिएं क्योंकि इससे लिवर को नुकसान हो सकता है। अगर आपको लिवर की बीमारी, गठिया, या मधुमेह है तो डॉक्टर को बताएं। डॉक्टर समय-समय पर लिवर की जांच करेंगे। विटामिन बी6 की गोलियां भी दी जा सकती हैं।
💊 RF 3 Forte 255 mg/150 mg/750 mg Tablet Uses & Benefits
[{"condition":"Active pulmonary tuberculosis","description":"Used in the intensive phase of treatment for drug-susceptible tuberculosis, typically for the first two months, in combination with rifampicin and ethambutol.","evidence":"Well-established"},{"condition":"Extrapulmonary tuberculosis","description":"Effective against tuberculosis affecting lymph nodes, bones, joints, and other organs, as part of a multi-drug regimen.","evidence":"Well-established"},{"condition":"Tuberculous meningitis","description":"Included in treatment regimens for tuberculosis of the central nervous system, often for a longer duration.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Latent tuberculosis infection","description":"Isoniazid alone is used for latent TB, but this combination is not standard for latent infection.","evidence":"Not established from the available information."}]
Primary treatment for: Tuberculosis
Also treats: Extrapulmonary tuberculosis, Tuberculous meningitis, Tuberculous lymphadenitis, Bone and joint tuberculosis
📋 Drug Information
| Generic Name(s) | Isoniazid (255mg) + Pyrazinamide (150mg) |
| Brand Name | RF 3 Forte 255 mg/150 mg/750 mg Tablet |
| Manufacturer | Sunij Pharma Pvt Ltd |
| Packaging / Form | strip of 10 tablets (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization recommends isoniazid and pyrazinamide as part of the standard regimen for drug-susceptible tuberculosis during the intensive phase. The fixed-dose combination is endorsed to improve adherence and reduce the risk of monotherapy. |
| ICMR Guideline | The Indian Council of Medical Research recommends weight-based dosing of isoniazid and pyrazinamide for the treatment of tuberculosis in India, following the Revised National Tuberculosis Control Program guidelines. Fixed-dose combinations are preferred to simplify treatment. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antitubercular drugs with distinct mechanisms. Isoniazid is a prodrug activated by the mycobacterial catalase-peroxidase enzyme KatG. The activated form inhibits InhA, an enoyl-acyl carrier protein reductase, blocking mycolic acid synthesis and disrupting the bacterial cell wall. Pyrazinamide is also a prodrug converted by mycobacterial pyrazinamidase to pyrazinoic acid, which disrupts membrane transport and energy production, especially in acidic environments. Together, they inhibit the growth of Mycobacterium tuberculosis and promote its elimination.
Mechanism Steps
💡 How to Take RF 3 Forte 255 mg/150 mg/750 mg Tablet
Strength: Each tablet contains isoniazid 255 mg and pyrazinamide 150 mg. The total strength is 255 mg + 150 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is based on body weight and is determined by the treating physician as part of a multi-drug regimen for tuberculosis. Typically, isoniazid is given as 5 mg/kg/day (maximum 300 mg/day) and pyrazinamide as 15-30 mg/kg/day (maximum 2 g/day) during the intensive phase. This fixed-dose combination is taken orally once daily, preferably on an empty stomach, but may be taken with food if gastrointestinal upset occurs. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more susceptible to side effects, especially peripheral neuropathy and liver toxicity. Dose should be individualized based on renal and hepatic function. Pyridoxine supplementation is often recommended. |
| Renal Impairment | Dose adjustment may be required in patients with severe renal impairment (creatinine clearance <30 mL/min). Isoniazid and pyrazinamide are removed by hemodialysis. Consult your doctor for specific dosing recommendations. |
| Hepatic Impairment | This medicine is contraindicated in patients with severe liver disease. In patients with mild to moderate hepatic impairment, dose reduction or alternative therapy may be necessary. Close monitoring of liver function is essential. |
| Maximum Daily Dose | The maximum daily dose of isoniazid is 300 mg, and the maximum daily dose of pyrazinamide is 2 g. However, the exact dose depends on the prescribed regimen. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of RF 3 Forte 255 mg/150 mg/750 mg Tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Rifampicin | Major | |
| Alcohol | Major | |
| Phenytoin | Major | |
| Carbamazepine | Major | |
| Warfarin | Major | |
| Acetaminophen | Moderate | |
| Ketoconazole | Moderate | |
| Theophylline | Moderate | |
| Benzodiazepines | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Rifampicin
- Alcohol
- Phenytoin
- Carbamazepine
- Warfarin
⚡ Moderate Interactions
- Acetaminophen
- Ketoconazole
- Theophylline
- Benzodiazepines
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine. Both isoniazid and pyrazinamide can cause liver damage, and alcohol significantly increases this risk. Alcohol also increases the risk of peripheral neuropathy and hyperuricemia. If you have alcohol use disorder, inform your doctor before starting treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to isoniazid or pyrazinamide","Severe liver disease (e.g., acute hepatitis, decompensated cirrhosis)","Acute gout","Previous isoniazid-induced hepatitis","Severe renal impairment (dose adjustment required)"]
⚠️ Warnings & Precautions
["Do not use this medicine for latent tuberculosis infection.","Avoid alcohol completely during treatment.","Use with caution in patients with diabetes, as isoniazid can affect blood sugar control.","Use with caution in patients with seizure disorders.","Use with caution in patients with gout or hyperuricemia.","Pyridoxine supplementation is recommended to prevent peripheral neuropathy.","Monitor liver function closely, especially in the first few months.","Do not stop treatment without consulting your doctor, as this can lead to drug resistance.","This medicine may cause dizziness; avoid driving or operating machinery until you know how it affects you.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding."]
🤱 Lactation Safety
Isoniazid and pyrazinamide are excreted in breast milk in small amounts. The American Academy of Pediatrics considers isoniazid compatible with breastfeeding. However, monitor the infant for jaundice, drowsiness, or poor feeding. Consult your doctor before breastfeeding while on this medicine.
💊 Overdose Management
Overdose of this medicine can cause severe liver toxicity, seizures, and metabolic acidosis. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and may include activated charcoal, management of seizures, and monitoring of liver and kidney function. There is no specific antidote for pyrazinamide; hemodialysis may be considered in severe cases.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your doctor for guidance.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, without skipping doses or stopping early, because incomplete treatment can lead to drug-resistant tuberculosis. Avoid alcohol completely while on this medicine, as it increases the risk of liver damage. Inform your doctor if you have a history of liver disease, gout, diabetes, or alcohol use. Your doctor will likely monitor your liver function tests before and during treatment. To prevent peripheral neuropathy, your doctor may prescribe pyridoxine (vitamin B6) supplements. Use effective contraception during treatment, as this medicine may harm an unborn baby. Do not share this medicine with anyone else, even if they have similar symptoms. Keep all follow-up appointments and laboratory tests.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of liver toxicity and peripheral neuropathy. Dose adjustment may be needed based on liver and kidney function. Pyridoxine supplementation is often recommended. Close monitoring is essential.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor. Tuberculosis treatment should not be delayed during pregnancy. This medicine is considered safe, but pyridoxine supplementation is recommended. Use effective contraception if you are taking other medications that may harm the fetus.
🏥 Post-Surgery Considerations
If you are undergoing surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents. Your doctor may advise you to continue or temporarily stop the medicine based on your condition.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may interact with certain antibiotics or anesthetics used in dental procedures. Maintain good oral hygiene to prevent infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel tired or weak. Avoid strenuous exercise until you feel better. Light activities like walking can be beneficial, but consult your doctor before starting any exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, which can affect your ability to drive or operate machinery. Avoid driving until you know how the medicine affects you. You may need to take time off work during the initial phase of treatment, especially if you have active tuberculosis and are contagious. Follow your doctor's advice regarding work and isolation.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping early can lead to treatment failure and drug-resistant tuberculosis. If you experience severe side effects, contact your doctor immediately; they may adjust your treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is not typically required, as it is usually taken for the intensive phase of tuberculosis treatment (2 months). However, if used for a longer duration, it can increase the risk of liver toxicity, peripheral neuropathy, and hyperuricemia. Regular monitoring of liver function and uric acid levels is necessary. Patients should be advised to report any unusual symptoms promptly.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A strategy recommended by the WHO to ensure adherence to tuberculosis treatment.
Evidence: Well-establishedAdequate nutrition can help improve outcomes in tuberculosis patients.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
The BCG vaccine is used to prevent severe forms of tuberculosis in children. It is not a treatment for active tuberculosis. If you are taking this medicine, you should not receive live vaccines without consulting your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, adjust the timing of your doses gradually, but do not skip doses. Check customs regulations for carrying prescription medicines. Carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within a few weeks, but it is essential to complete the full course of treatment as prescribed. The bacteria may still be present even if symptoms improve.
A: No, you must complete the full course of treatment. Stopping early can lead to relapse and drug-resistant tuberculosis.
A: Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine is generally considered safe during pregnancy when used to treat active tuberculosis. However, consult your doctor for personalized advice and monitoring.
🤔 Common Patient Concerns
🔄 Substitutes for RF 3 Forte 255 mg/150 mg/750 mg Tablet
View AllAlternative brands with exact same active ingredient:
-
Stanex 3 TabletStanford Biotech Pvt Ltd ₹41.72 25.5% COSTLIER
-
Tricox 255mg/150mg/750mg TabletThemis Medicare Ltd ₹51.13 53.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Tuberculosis treatment can be stopped once symptoms improve.
Fact: Treatment must be completed as prescribed to prevent relapse and drug resistance. - Myth: This medicine can be taken with alcohol.
Fact: Alcohol increases the risk of liver damage and should be avoided completely. - Myth: This medicine is safe to take without medical supervision.
Fact: This is a prescription medicine and must be taken under a doctor's supervision.
🔄 Alternative Options
Generic Alternatives
- Isoniazid and Pyrazinamide Combination Tablet
Brand Alternatives
- RF 3 Forte 255 mg/150 mg/750 mg Tablet