ampine mpl tablet
What is ampine mpl tablet used for?
Amtas-M 50 Tablet PR (Amlodipine + Metoprolol Succinate) is used to treat CARDIAC. It contains Amlodipine (5mg) + Metoprolol Succinate (50mg), which Amlodipine inhibits calcium influx across cell membranes, causing vasodilation; . Always consult your doctor before use. Take as prescribed.
- Generic Name: Amlodipine + Metoprolol Succinate
- Manufacturer: Sunij Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ ampine mpl tablet Uses & Benefits
Hypertension, stable angina, chronic heart failure (metoprolol).
Off-label uses: Migraine prophylaxis (metoprolol), Raynaud's phenomenon (amlodipine).
๐ Drug Information
| Generic Name(s) | Amlodipine + Metoprolol Succinate |
| Brand Name | Amtas-M 50 Tablet PR |
| Manufacturer | Sunij Pharma Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Antihypertensive combination (Calcium channel blocker + Beta-blocker) |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC, protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Amlodipine inhibits calcium influx across cell membranes, causing vasodilation; Metoprolol selectively blocks beta-1 adrenergic receptors, reducing heart rate and contractility.
Mechanism Steps
๐ก How to Take ampine mpl tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of ampine mpl tablet
โ Common Side Effects
- Edema
- Dizziness
- Fatigue
- Headache
- Nausea
- Bradycardia
๐จ Serious Side Effects
- Heart block
- Severe hypotension
- Bronchospasm
- Hepatotoxicity
โ ๏ธ Rare Side Effects
- Leukopenia
- Thrombocytopenia
- Stevens-Johnson syndrome
- Pulmonary fibrosis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | Increased amlodipine levels, risk of toxicity |
| Fluoxetine | Major | Increased metoprolol levels, bradycardia |
| NSAIDs | Moderate | Reduced antihypertensive effect |
| Digoxin | Moderate | Increased risk of bradycardia |
| Grapefruit juice | Minor | Increased amlodipine absorption |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP2D6 inhibitors (e.g., fluoxetine)
- Beta-blockers (additive bradycardia)
- Calcium channel blockers (additive hypotension)
โก Moderate Interactions
- NSAIDs
- Digoxin
- Clonidine
- Cimetidine
โน๏ธ Minor Interactions
- Grapefruit juice (amlodipine)
- Antacids
- Rifampin
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase amlodipine levels; avoid high-fat meals with metoprolol.
๐ท Alcohol Interaction
May enhance hypotensive effects; avoid excessive alcohol.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, cardiogenic shock, severe bradycardia, heart block, sick sinus syndrome, uncontrolled heart failure, severe hypotension.
๐ Monitoring Parameters
Blood pressure, heart rate, ECG, renal function, liver enzymes.
๐คฑ Lactation Safety
Excreted in breast milk; use with caution.
๐ Overdose Management
Supportive care; atropine for bradycardia, vasopressors for hypotension, calcium gluconate for amlodipine overdose.
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double.
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Found this to be a helpful product. Good results.
Helpful and effective medicine as per my experience. Always consult a doctor.
Good quality medicine. Satisfied with the outcome.
This medicine was effective for me. I followed the doctor's advice.
Found this to be a helpful product. Good results.