Mucokef 250 mg/4 mg Capsule: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat, or difficulty breathing.
- Severe, watery, or bloody diarrhoea, even weeks after finishing the antibiotic.
- A painful rash with blisters or peeling skin, or sores in the mouth, eyes, or genitals.
- Yellowing of the eyes or skin, dark urine, or severe abdominal pain.
- Unusual bruising or bleeding, or signs of infection such as fever or sore throat.
- Decreased urine output, swelling in the legs, or blood in the urine.
- Seizures or severe headache with visual changes.
If experiencing severe symptoms, call emergency services immediately.
What is Resporidex 250 mg/4 mg Capsule used for?
This medicine is a combination of cefalexin, an antibiotic, and bromhexine, a mucolytic. It is used to treat bacterial respiratory infections with thick mucus. It works by killing bacteria and thinning mucus to help you cough it out. Always complete the full course as prescribed.
- Generic Name: Cefalexin (250mg) + Bromhexine (4mg)
- Manufacturer: Sun Pharmaceutical Industries Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Resporidex 250 mg/4 mg Capsule के बारे में (Hindi Summary)
उपयोग: यह दवा सेफालेक्सिन और ब्रोमहेक्सिन का संयोजन है। इसका उपयोग बैक्टीरियल श्वसन संक्रमण के इलाज के लिए किया जाता है, जिसमें गाढ़ा बलगम होता है। सेफालेक्सिन बैक्टीरिया को मारता है और ब्रोमहेक्सिन बलगम को पतला करके खांसी के माध्यम से बाहर निकालने में मदद करता है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, और भूख में कमी शामिल हैं। कुछ लोगों को त्वचा पर चकत्ते, खुजली, या सिरदर्द हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी की प्रतिक्रिया, सांस लेने में कठिनाई, या गंभीर दस्त हो सकते हैं। यदि आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें। दवा को भोजन के साथ या बिना भोजन के ले सकते हैं, लेकिन भोजन के साथ लेने से पेट की परेशानी कम हो सकती है। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। शराब का सेवन न करें। यदि आपको दाने, खुजली, या सांस लेने में कठिनाई हो तो दवा बंद करें और तुरंत डॉक्टर से मिलें।
💊 Resporidex 250 mg/4 mg Capsule Uses & Benefits
[{"condition":"Bacterial respiratory tract infections with thick mucus","description":"Used to treat infections such as acute bronchitis, exacerbations of chronic bronchitis, and pneumonia caused by susceptible bacteria, while bromhexine helps clear thick secretions.","evidence":"Well-established for the antibiotic component; mucolytic benefit is supportive."},{"condition":"Bacterial sinusitis","description":"May be prescribed when sinusitis is confirmed or strongly suspected to be bacterial, and when thick nasal or sinus secretions are present.","evidence":"Established for cefalexin; bromhexine used for symptomatic relief of mucus."},{"condition":"Bacterial pharyngitis or tonsillitis","description":"Cefalexin is active against many common bacteria causing sore throat, and bromhexine may help if there is associated thick post-nasal drip or mucus.","evidence":"Established for cefalexin; bromhexine effect is adjunctive."},{"condition":"Acute otitis media","description":"Cefalexin can be used for middle ear infections caused by susceptible organisms, though it is not the first choice for all cases.","evidence":"Established for cefalexin; bromhexine has no direct role in ear infection."},{"condition":"Skin and soft tissue infections","description":"Cefalexin is effective against many staphylococcal and streptococcal skin infections, but bromhexine does not contribute to this use.","evidence":"Established for cefalexin; combination use is not standard for skin infections."}]
Off-label uses: [{"condition":"Acne vulgaris","description":"Cefalexin is sometimes used off-label for inflammatory acne, but this combination with bromhexine is not standard for acne.","evidence":"Limited"},{"condition":"Prophylaxis of recurrent urinary tract infections","description":"Cefalexin may be used off-label for prevention in some patients, but bromhexine has no role here.","evidence":"Limited"}]
Primary treatment for: Bacterial respiratory tract infections with thick mucus
Also treats: Bacterial sinusitis, Bacterial pharyngitis, Acute otitis media, Skin and soft tissue infections
📋 Drug Information
| Generic Name(s) | Cefalexin (250mg) + Bromhexine (4mg) |
| Brand Name | Resporidex 250 mg/4 mg Capsule |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Packaging / Form | strip of 8 capsules (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Keep the capsules in their original container, tightly closed, and protect them from light and moisture. Do not store in the bathroom. Keep out of reach of children and pets. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture, but check the expiry date printed on the pack. Do not use the medicine after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Cefalexin is a first-generation cephalosporin antibiotic that binds to penicillin-binding proteins on the bacterial cell wall, inhibiting the final step of peptidoglycan cross-linking. This weakens the bacterial cell wall and leads to bacterial cell death, especially in actively dividing organisms. Bromhexine is a mucolytic agent that reduces the viscosity of mucus by breaking down acidic mucopolysaccharide fibres and stimulating serous bronchial secretion. This makes thick secretions thinner and easier to cough out, helping to clear the airways. The combination does not treat viral infections and should only be used when a bacterial infection is suspected or confirmed.
Mechanism Steps
💡 How to Take Resporidex 250 mg/4 mg Capsule
Strength: Capsule containing cefalexin 250 mg and bromhexine 4 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one capsule taken two to four times a day, depending on the severity of the infection and your kidney function. The exact dose and duration must be individualized by a qualified clinician based on the indication, your age, weight, renal and hepatic function, and clinical response. Do not self-adjust the dose. Always complete the full course prescribed by your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced kidney function, which can affect the elimination of cefalexin. Your doctor may adjust the dose based on your kidney function. Regular monitoring of kidney function is advised. Take the medicine exactly as prescribed and report any side effects promptly. |
| Renal Impairment | In patients with kidney impairment, the dose of cefalexin must be adjusted. For mild impairment, the usual dose may be given, but for moderate to severe impairment, the dose or frequency may need to be reduced. Your doctor will determine the appropriate dose based on your creatinine clearance. Bromhexine does not require dose adjustment in kidney disease, but caution is advised. |
| Hepatic Impairment | No specific dose adjustment is established for cefalexin in liver disease, but caution is advised in severe liver impairment. Bromhexine is metabolized in the liver, so its dose may need to be reduced in severe liver disease. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose of cefalexin is generally 4 grams per day for adults, but the exact maximum for this combination depends on the prescribed regimen. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Resporidex 250 mg/4 mg Capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aminoglycosides | Major | |
| Loop diuretics | Major | |
| Probenecid | Moderate | |
| Methotrexate | Moderate | |
| Oral contraceptives | Moderate | |
| Cholestyramine | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Warfarin
- Aminoglycosides (e.g., gentamicin)
- Loop diuretics (e.g., furosemide)
- Probenecid
⚡ Moderate Interactions
- Methotrexate
- Oral contraceptives
- Cholestyramine
🍷 Alcohol Interaction
It is advisable to avoid alcohol while taking this medicine. Alcohol can increase the risk of stomach upset, nausea, and dizziness. It may also put extra strain on the liver, especially since bromhexine is metabolized in the liver. If you drink alcohol regularly, discuss this with your doctor before starting this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to cefalexin, other cephalosporins, or any component of this medicine.","Previous severe allergic reaction to penicillins or other beta-lactam antibiotics.","Use in patients with a history of severe kidney disease without dose adjustment.","Not recommended during the first trimester of pregnancy.","Should not be used for viral infections such as the common cold or influenza."]
⚠️ Warnings & Precautions
["Before starting this medicine, tell your doctor if you are allergic to penicillin or cephalosporin antibiotics.","Inform your doctor if you have kidney or liver disease, as dose adjustments may be needed.","If you develop a rash, itching, or swelling, stop the medicine and seek medical help immediately.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","Do not use this medicine to treat viral infections; it will not help and may cause harm.","If you are pregnant or breastfeeding, consult your doctor before using this medicine.","Avoid alcohol while taking this medicine to reduce the risk of stomach upset and liver strain.","Complete the full course as prescribed, even if you feel better, to prevent recurrence and resistance."]
🤱 Lactation Safety
Cefalexin is excreted in small amounts in breast milk and is generally considered compatible with breastfeeding. Bromhexine may also pass into breast milk, but the amount and effects on the nursing infant are not well established. Consult your doctor before using this medicine while breastfeeding. If you notice any changes in your baby, such as diarrhoea or thrush, contact your doctor.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, stomach pain, and diarrhoea. In severe cases, it may lead to kidney problems or seizures, especially in patients with kidney disease. If you suspect an overdose, contact your doctor or a poison control centre immediately. Treatment is supportive and may include activated charcoal if the overdose is recent, and measures to maintain hydration and kidney function. There is no specific antidote for cefalexin or bromhexine.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure what to do, contact your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop the course early, even if you feel better, because incomplete treatment can allow the infection to return and may promote antibiotic resistance. Swallow the capsule whole with a full glass of water. You may take it with or without food, but taking it with a meal can reduce stomach upset. If you have kidney problems, your doctor may need to adjust the dose. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not share this medicine with anyone else, even if they have similar symptoms. Avoid alcohol while taking this medicine because it can worsen stomach irritation and may affect how your body handles the antibiotic. If you develop a rash, itching, or any breathing difficulty, stop the medicine and seek medical help immediately. Keep all follow-up appointments so your doctor can check your progress and monitor for any side effects.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can affect the elimination of cefalexin. Your doctor may adjust the dose based on your kidney function. Regular monitoring of kidney function is advised. Elderly patients may also be more susceptible to side effects such as dizziness and confusion. Take the medicine exactly as prescribed and report any unusual symptoms promptly.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss this medicine with your doctor before starting. Cefalexin is generally considered safe during pregnancy, but bromhexine is not recommended in the first trimester. Your doctor may choose an alternative antibiotic if needed. Do not start or stop any medicine without consulting your doctor.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon and anesthesiologist that you are taking this medicine. Antibiotics can interact with certain anaesthetics and may affect surgical outcomes. Your doctor may advise you to stop the medicine before surgery or adjust the dose. Follow your healthcare team's instructions carefully.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. Antibiotics can affect the balance of bacteria in the mouth and may interact with other medications used during dental work. Your dentist may recommend postponing non-urgent procedures until you complete the course. Maintain good oral hygiene to prevent dental infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel tired or dizzy. Avoid strenuous exercise until you feel better. Light activities like walking are fine if you feel up to it. If you experience shortness of breath, chest pain, or severe fatigue, stop exercising and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, drowsiness, or fatigue in some people. Avoid driving or operating heavy machinery until you know how it affects you. If your work involves close contact with others, take precautions to prevent spreading the infection. Stay home if you have a fever or feel unwell. Most people can continue light work, but listen to your body and rest when needed.
🛑 When to Stop This Medicine
Stop taking this medicine only after completing the full course prescribed by your doctor. Do not stop early, even if you feel better, as this can lead to relapse and antibiotic resistance. If you experience a serious side effect such as a severe allergic reaction, severe diarrhoea, or a painful rash, stop the medicine and seek immediate medical attention. Always consult your doctor before stopping the medicine for any other reason.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended unless prescribed for a specific chronic infection. Prolonged use of antibiotics can lead to antibiotic resistance, overgrowth of non-susceptible organisms, and rare blood or liver abnormalities. If you need to take it for more than 10 days, your doctor may monitor your kidney and liver function, as well as your blood counts. Always follow your doctor's instructions and do not self-medicate for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps loosen thick mucus and relieve chest congestion naturally.
Evidence: SupportiveCan help clear nasal passages and reduce congestion in sinusitis.
Evidence: ModerateTechniques to help clear airway secretions, especially in chronic lung disease.
Evidence: Well-established for certain conditionsCan soothe sore throat and help suppress cough.
Evidence: Limited but widely used💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with most vaccines. However, if you are scheduled to receive a live vaccine, inform your doctor, as antibiotics generally do not affect vaccine efficacy but the underlying infection may be a reason to postpone vaccination until you recover. Follow your doctor's advice regarding timing of vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not refrigerate unless specified.
✅ DO
Keep in the original container, tightly closed.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom cabinet.
✅ DO
Keep out of reach of children and pets.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with the prescription label clearly visible. Bring a copy of your prescription or a letter from your doctor, especially for international travel. Store it in a cool, dry place away from direct sunlight. If you are crossing time zones, adjust your dosing schedule gradually to maintain even intervals, but consult your doctor or pharmacist for specific advice. Keep enough supply for your entire trip and carry it in your hand luggage if flying. Check the customs regulations of your destination country regarding prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start to feel some improvement within 24 to 48 hours, but it may take 3 to 5 days for noticeable relief. Complete the full course as prescribed.
A: Yes, you can take it with or without food. Taking it with a meal can help reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Cefalexin is generally considered safe during pregnancy, but bromhexine is not recommended in the first trimester. Consult your doctor before use.
A: It is best to avoid alcohol as it can increase stomach upset and liver strain.
A: Seek immediate medical help if you experience swelling of the face or throat, difficulty breathing, severe diarrhoea, or a painful rash with blisters.
🤔 Common Patient Concerns
🔄 Substitutes for Resporidex 250 mg/4 mg Capsule
View AllAlternative brands with exact same active ingredient:
-
mucokef 250 mg/4 mg capsuleEli Lilly and Company India Pvt Ltd ₹27.65 45.2% CHEAPER
-
brocif tabletZephyr Medicare Pvt Ltd ₹60.94 20.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure the common cold.
Fact: This medicine contains an antibiotic and is not effective against viral infections like the common cold. It should only be used for bacterial infections. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full course prescribed by your doctor, even if you feel better, to prevent the infection from returning and to reduce antibiotic resistance. - Myth: This medicine is safe to take without a prescription.
Fact: This medicine contains an antibiotic and requires a prescription. Self-medication can lead to incorrect use, side effects, and antibiotic resistance. - Myth: Taking this medicine with alcohol is safe.
Fact: Alcohol can increase stomach upset and liver strain. It is best to avoid alcohol while taking this medicine.
🔄 Alternative Options
Generic Alternatives
- Cefalexin + Bromhexine
Brand Alternatives
- Mucokef 250 mg/4 mg capsule