Rez-Q 300 Tablet (Quinine 300mg): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
- Fainting or palpitations
- Confusion or seizures
If experiencing severe symptoms, call emergency services immediately.
What is quin o quin 300mg tablet used for?
This medicine contains quinine, an antimalarial drug used to treat uncomplicated malaria. It works by killing the malaria parasite in the blood. It is usually taken every 8 hours for 7 days. Common side effects include nausea, headache, and ringing in the ears. It should only be used under medical supervision.
- Generic Name: Quinine (300mg)
- Manufacturer: Leo Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 quin o quin 300mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्विनाइन (300 मिलीग्राम) युक्त एक एंटीमलेरियल टैबलेट है, जिसका उपयोग मलेरिया के इलाज के लिए किया जाता है। यह मलेरिया परजीवी को मारकर काम करती है। यह आमतौर पर डॉक्टर के पर्चे पर ही ली जाती है। इसका उपयोग मलेरिया के बुखार, ठंड लगना और मांसपेशियों में दर्द जैसे लक्षणों को कम करने में मदद करता है। यह दवा पैरों में ऐंठन के लिए नहीं लेनी चाहिए क्योंकि इससे गंभीर दुष्प्रभाव हो सकते हैं। इसे भोजन के साथ लें ताकि पेट खराब न हो। पूरा कोर्स पूरा करें, बीच में न छोड़ें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, सिरदर्द, कान में घंटी बजना, चक्कर आना और पेट दर्द शामिल हैं। ये आमतौर पर हल्के होते हैं और दवा बंद करने पर ठीक हो जाते हैं। कभी-कभी गंभीर दुष्प्रभाव जैसे खून की कमी, हृदय की धड़कन में गड़बड़ी, और ब्लड शुगर कम होना भी हो सकता है। अगर आपको असामान्य खून बहना, चक्कर आना, बेहोशी, या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को केवल डॉक्टर की सलाह पर ही लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। शराब का सेवन बिल्कुल न करें क्योंकि इससे दुष्प्रभाव बढ़ सकते हैं। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं, खासकर खून पतला करने वाली दवाएं। अगर आपको कान में आवाज आना, धुंधला दिखना, या दिल की धड़कन तेज होना महसूस हो, तो तुरंत डॉक्टर को बताएं। बिना डॉक्टर की सलाह के दवा बंद न करें।
💊 quin o quin 300mg tablet Uses & Benefits
[{"condition":"Uncomplicated malaria","description":"Used for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum and other susceptible species, often in combination with other antimalarials.","evidence":"Well-established"},{"condition":"Severe malaria","description":"May be used as an alternative when artesunate is not available, but it is not the preferred treatment.","evidence":"Established"},{"condition":"Nocturnal leg cramps","description":"Sometimes prescribed for the prevention of nocturnal leg cramps, although this use is not recommended due to potential serious side effects.","evidence":"Limited"}]
Off-label uses: [{"condition":"Myotonia congenita","description":"Quinine has been used off-label to reduce muscle stiffness in myotonia congenita, but safer alternatives exist.","evidence":"Limited"}]
Primary treatment for: Malaria
Also treats: Nocturnal leg cramps (not recommended), Myotonia congenita (off-label)
📋 Drug Information
| Generic Name(s) | Quinine (300mg) |
| Brand Name | quin o quin 300mg tablet |
| Manufacturer | Leo Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI MALARIALS |
| Action Class | Antimalarial- others |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. |
| Shelf Life | Typically 24 months from the date of manufacture. Check the expiry date on the packaging. |
| WHO Guideline | The World Health Organization recommends artemisinin-based combination therapies (ACTs) as first-line treatment for uncomplicated falciparum malaria. Quinine is recommended as a second-line or alternative treatment when ACTs are not available or contraindicated. For severe malaria, intravenous artesunate is the preferred treatment; quinine is an alternative if artesunate is unavailable. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) guidelines for malaria treatment in India recommend ACTs for uncomplicated falciparum malaria and chloroquine for vivax malaria. Quinine may be used as an alternative in specific situations, such as in pregnant women during the first trimester or when ACTs are not available. Always follow national guidelines and consult a healthcare professional. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Quinine accumulates in the food vacuole of the malaria parasite, where it inhibits the polymerization of toxic heme into inert hemozoin. This leads to the accumulation of free heme, which is toxic to the parasite and causes its death. Additionally, quinine may interfere with the parasite's ability to transport and utilize nutrients, further contributing to its antimalarial effect. In humans, quinine also affects skeletal muscle by increasing the refractory period, which may explain its effect on leg cramps, but this mechanism is not fully understood.
Mechanism Steps
💡 How to Take quin o quin 300mg tablet
Strength: Each tablet contains 300 mg of quinine (as quinine sulfate).
Dosage Information
| Adult Dosage | The usual adult dose for uncomplicated malaria is 600 mg of quinine base (equivalent to 648 mg of quinine sulfate) every 8 hours for 7 days, often combined with doxycycline or clindamycin. For severe malaria, a loading dose of 20 mg/kg of quinine dihydrochloride is given intravenously over 4 hours, followed by 10 mg/kg every 8 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and concomitant medications. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing. |
| Elderly Dosage | Elderly patients may have reduced renal and hepatic function, requiring dose adjustment. Start with a lower dose and monitor closely for side effects. Consult a clinician for individualized dosing. |
| Renal Impairment | In patients with severe renal impairment (creatinine clearance <10 mL/min), the dose should be reduced or the dosing interval extended. Monitor plasma levels if possible. Consult a nephrologist for guidance. |
| Hepatic Impairment | In patients with hepatic impairment, quinine metabolism may be reduced, leading to increased plasma levels. Dose reduction may be necessary. Monitor liver function and clinical response. |
| Maximum Daily Dose | The maximum daily dose is not firmly established and depends on the indication. For malaria, up to 1800 mg of quinine base per day may be used, but doses above this increase the risk of toxicity. Always follow the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of quin o quin 300mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Amiodarone | Major | |
| Mefloquine | Major | |
| Artemether/lumefantrine | Major | |
| Antacids | Moderate | |
| Cimetidine | Moderate | |
| Rifampicin | Moderate | |
| Digoxin | Moderate | |
| Grapefruit juice | Moderate | |
| Alcohol | Moderate |
🚨 Major Interactions
- Warfarin
- Artemether/lumefantrine
- Amiodarone
- Mefloquine
⚡ Moderate Interactions
- Antacids (aluminum/magnesium hydroxide)
- Cimetidine
- Rifampicin
- Digoxin
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Both alcohol and quinine can affect the heart and central nervous system, and alcohol may worsen side effects such as dizziness, nausea, and low blood sugar. Additionally, alcohol can increase the risk of liver toxicity.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to quinine or any component of the formulation","History of blackwater fever","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["Quinine can cause hypoglycemia; monitor blood glucose closely, especially in patients with malaria.","May cause cinchonism; dose reduction may be necessary.","Avoid in patients with known QT prolongation or those taking other QT-prolonging drugs.","Use with caution in patients with atrial fibrillation or other cardiac conditions.","May exacerbate porphyria; avoid in patients with porphyria.","Can cause hemolysis in patients with G6PD deficiency; use with caution.","Do not use for nocturnal leg cramps due to risk of serious side effects.","May impair ability to drive or operate machinery; avoid until you know how it affects you."]
🤱 Lactation Safety
Quinine is excreted in breast milk in small amounts. It is generally considered compatible with breastfeeding, but monitoring for infant side effects such as irritability or feeding difficulties is advised. Consult your doctor before use.
💊 Overdose Management
Overdose of quinine can be life-threatening. Symptoms include severe cinchonism, cardiac arrhythmias, hypotension, seizures, and coma. Immediate medical attention is required. Treatment is supportive and may include activated charcoal if within 1-2 hours of ingestion, intravenous fluids, sodium bicarbonate for cardiac toxicity, and management of seizures. Hemodialysis or hemoperfusion may be considered in severe cases. Contact a poison control center immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
This medicine should only be taken under the supervision of a qualified healthcare professional. Do not self-medicate or share this medicine with others. Take the tablet exactly as prescribed, usually with food to reduce stomach upset. Do not crush or chew the tablet unless instructed; swallow it whole with a glass of water. Avoid alcohol while taking this medicine, as it can increase the risk of side effects and may worsen liver toxicity. Inform your doctor about all other medications you are taking, especially blood thinners, antacids, and drugs that affect heart rhythm. If you experience symptoms like ringing in the ears, vision changes, severe nausea, or palpitations, contact your doctor immediately. Do not stop taking this medicine without consulting your doctor, even if you feel better, to prevent recurrence of malaria. Keep this medicine out of reach of children and store it in its original container away from direct sunlight and moisture.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney and liver function, which can affect how this medicine is processed in the body. They may be more susceptible to side effects such as dizziness, hearing changes, and cardiac arrhythmias. Dose adjustment and close monitoring are recommended. Consult a doctor for individualized dosing.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before taking this medicine. Quinine is not recommended for routine use during pregnancy unless you have malaria. If you are pregnant and have malaria, your doctor will weigh the benefits and risks. Use effective contraception while taking this medicine if you are of childbearing age and not planning pregnancy.
🏥 Post-Surgery Considerations
If you have recently had surgery, inform your surgeon and anesthesiologist that you are taking this medicine. Quinine can affect heart rhythm and blood sugar, which may interact with surgical medications. Your doctor may recommend monitoring during the perioperative period.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. Quinine can cause dry mouth and may interact with local anesthetics or sedatives. Your dentist may take precautions to monitor your heart rhythm and blood sugar during the procedure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel dizzy or weak. Avoid strenuous exercise until you have fully recovered from malaria. Light activities like walking are fine if you feel up to it, but listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, blurred vision, or ringing in the ears, which can affect your ability to drive or operate machinery. Avoid driving or operating heavy machinery until you know how this medicine affects you. You may need to take time off work to rest and recover from malaria. Discuss with your employer if you need flexible hours during treatment.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. You should complete the full prescribed course even if you feel better. If you experience severe side effects such as chest pain, severe dizziness, or signs of an allergic reaction, stop the medicine and seek immediate medical attention. Your doctor may adjust the dose or switch to a different medicine if needed.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended unless specifically prescribed for a chronic condition. Prolonged use can increase the risk of cinchonism, blood disorders, and cardiac toxicity. Regular monitoring of blood counts, liver and kidney function, and ECG may be required. If you need to take this medicine for more than a few weeks, your doctor will monitor you closely for adverse effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
ACTs are the first-line treatment for uncomplicated falciparum malaria and are generally better tolerated than quinine.
Evidence: Well-establishedUsed for chloroquine-sensitive malaria, especially Plasmodium vivax.
Evidence: Well-establishedHydration, rest, and antipyretics can help manage symptoms while the antimalarial takes effect.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are planning to receive a vaccine, inform your doctor that you are taking this medicine. Live vaccines should be avoided during acute illness, including malaria.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store it at room temperature and protect it from direct sunlight and moisture. If crossing time zones, continue taking the medicine at the prescribed intervals; you may need to adjust the timing gradually. Check the customs regulations of your destination country regarding prescription medications. Always carry enough supply for your entire trip and a few extra days in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts reducing fever and other symptoms within 24 to 48 hours after starting treatment. However, you must complete the full course as prescribed to ensure the parasite is completely eliminated.
A: Yes, taking this medicine with food or milk is recommended to reduce stomach upset and nausea.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor for individualized advice.
A: No, alcohol should be avoided while taking this medicine as it can increase the risk of side effects and may worsen liver toxicity.
🤔 Common Patient Concerns
🔄 Substitutes for quin o quin 300mg tablet
View AllAlternative brands with exact same active ingredient:
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quinine dihydrochloride 300mg injectionMerck Ltd ₹9.27 85% CHEAPER
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Falciquin 300mg InjectionTheta Lab Pvt Ltd ₹10.76 82.6% CHEAPER
-
quinolod 300mg injectionWockhardt Ltd ₹14.37 76.8% CHEAPER
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quininga 300mg injectionInga Laboratories Pvt Ltd ₹14.56 76.5% CHEAPER
-
winmal q 300mg injectionGlobal Medisciences Ltd ₹14.80 76.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used to treat leg cramps safely.
Fact: This medicine is not approved for leg cramps due to the risk of serious side effects such as blood disorders and heart rhythm problems. Safer alternatives exist. - Myth: Once you feel better, you can stop taking this medicine.
Fact: You must complete the full course as prescribed to ensure the parasite is completely eliminated and to prevent recurrence or resistance. - Myth: This medicine is safe to take without a prescription.
Fact: This medicine is a prescription drug and should only be taken under medical supervision due to its potential for serious side effects and interactions.
🔄 Alternative Options
Generic Alternatives
- Quinine sulfate 300 mg tablet
Brand Alternatives
- Rez-Q 300 Tablet