azunate l 480 mg/80 mg tablet
What is azunate l 480 mg/80 mg tablet used for?
Azunate L 480 mg/80 mg Tablet (Artesunate + Lumefantrine) is used to treat ANTI MALARIALS. It contains Artesunate (480mg) + Lumefantrine (80mg), which Artesunate produces free radicals that damage parasite proteins; Lumefantrine in. Always consult your doctor before use. Take as prescribed.
- Generic Name: Artesunate + Lumefantrine
- Manufacturer: Macleods Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ azunate l 480 mg/80 mg tablet Uses & Benefits
Uncomplicated Plasmodium falciparum malaria, chloroquine-resistant malaria.
Off-label uses: Severe malaria (IV artesunate preferred), mixed infections.
๐ Drug Information
| Generic Name(s) | Artesunate + Lumefantrine |
| Brand Name | Azunate L 480 mg/80 mg Tablet |
| Manufacturer | Macleods Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI MALARIALS |
| Action Class | Antimalarial |
| Route of Administration | Oral |
| Storage | Store at 25ยฐC (77ยฐF); excursions permitted to 15-30ยฐC (59-86ยฐF). Protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Artesunate produces free radicals that damage parasite proteins; Lumefantrine inhibits heme polymerization.
Mechanism Steps
๐ก How to Take azunate l 480 mg/80 mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of azunate l 480 mg/80 mg tablet
โ Common Side Effects
- Headache
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Cough
๐จ Serious Side Effects
- QT prolongation
- Severe allergic reaction
- Hemolytic anemia (artesunate)
- Hepatotoxicity
โ ๏ธ Rare Side Effects
- Seizures
- Acute renal failure
- Stevens-Johnson syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Rifampin | Major | Reduced lumefantrine levels |
| Ketoconazole | Major | Increased lumefantrine levels |
| Halofantrine | Major | Increased QT prolongation risk |
| Warfarin | Moderate | Increased INR |
| Oral contraceptives | Moderate | Reduced efficacy |
| Antacids | Minor | Reduced absorption |
๐จ Major Interactions
- CYP3A4 inducers (rifampin, carbamazepine)
- CYP3A4 inhibitors (ketoconazole, ritonavir)
- Antimalarials with QT prolongation (halofantrine)
โก Moderate Interactions
- Anticoagulants (warfarin)
- Oral contraceptives
- Antiepileptics
โน๏ธ Minor Interactions
- Antacids
- Cimetidine
๐ฝ๏ธ Food Interactions
Take with fatty food to enhance lumefantrine absorption.
๐ท Alcohol Interaction
Avoid alcohol due to potential hepatotoxicity.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, severe hepatic impairment, first trimester of pregnancy (unless no alternative).
๐ Monitoring Parameters
Parasite count, ECG (QT interval), liver function, renal function.
๐คฑ Lactation Safety
Excreted in milk; use with caution.
๐ Overdose Management
Symptomatic and supportive; monitor ECG and electrolytes.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose. Do not double.
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
This medicine was effective for me. I followed the doctor's advice.
Helpful and effective medicine as per my experience. Always consult a doctor.
Found this to be a helpful product. Good results.
Effective and reliable. Worked as expected.
Found this to be a helpful product. Good results.