Azunate L 480 mg/80 mg Tablet: Complete Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction: swelling of face, lips, tongue, or throat, difficulty breathing.
- Irregular heartbeat, fainting, or severe dizziness.
- Yellowing of skin or eyes, dark urine, or severe abdominal pain.
- Painful skin rash with blisters or peeling.
- Persistent vomiting or inability to keep the medicine down.
- High fever that does not improve within 48 hours.
If experiencing severe symptoms, call emergency services immediately.
What is azunate l 480 mg/80 mg tablet used for?
This medicine is a combination antimalarial tablet containing artesunate 480 mg and lumefantrine 80 mg. It is used to treat uncomplicated Plasmodium falciparum malaria in adults. It works by killing malaria parasites in the blood. It must be taken with food for best absorption.
- Generic Name: Artesunate + Lumefantrine
- Manufacturer: Macleods Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 azunate l 480 mg/80 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मलेरिया के इलाज के लिए इस्तेमाल की जाती है, खासकर प्लास्मोडियम फाल्सीपेरम मलेरिया के लिए। यह आर्टेसुनेट और लुमेफैंट्रिन का संयोजन है जो मलेरिया परजीवी को मारता है। इसे भोजन के साथ लेना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में सिरदर्द, चक्कर आना, जी मिचलाना, उल्टी, पेट दर्द और भूख न लगना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, दिल की धड़कन में गड़बड़ी या लीवर की समस्या हो सकती है। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, भोजन या दूध के साथ। पूरा कोर्स पूरा करें, बीच में न छोड़ें। शराब न पिएं। दिल, लीवर या किडनी की बीमारी हो तो डॉक्टर को बताएं। दवा को ठंडी और सूखी जगह पर रखें।
💊 azunate l 480 mg/80 mg tablet Uses & Benefits
- [{"condition":"Uncomplicated Plasmodium falciparum malaria","description":"This medicine is used to treat acute, uncomplicated malaria caused by Plasmodium falciparum in adults.
- It rapidly reduces parasite load and resolves symptoms such as fever, chills, and body aches.","evidence":"Well-established"},{"condition":"Mixed malaria infections","description":"In areas where multiple malaria species coexist, this medicine may be used to treat mixed infections that include Plasmodium falciparum, although additional treatment for other species may be needed.","evidence":"Established"}]
Off-label uses: [{"condition":"Malaria in pregnancy (second and third trimester)","description":"This medicine may be used off-label in the second and third trimesters of pregnancy when other options are not suitable, but only under strict medical supervision.","evidence":"Limited"}]
Primary treatment for: Uncomplicated Plasmodium falciparum malaria
Also treats: Mixed malaria infections
📋 Drug Information
| Generic Name(s) | Artesunate + Lumefantrine |
| Brand Name | Azunate L 480 mg/80 mg Tablet |
| Manufacturer | Macleods Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI MALARIALS |
| Action Class | Antimalarial |
| Route of Administration | Oral |
| Storage | Store below 30°C in a dry place, protected from light. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | WHO recommends artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated Plasmodium falciparum malaria. This medicine is an ACT. |
| ICMR Guideline | ICMR guidelines recommend ACTs for uncomplicated P. falciparum malaria in India. This medicine is one such combination. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antimalarial agents with complementary mechanisms. Artesunate is a prodrug that is rapidly converted to dihydroartemisinin, which generates reactive oxygen species and alkylates parasite proteins, leading to rapid killing of blood-stage malaria parasites. Lumefantrine interferes with the parasite's ability to detoxify heme, causing toxic heme accumulation that kills the parasite. Together, they provide rapid symptom relief and prevent recrudescence.
Mechanism Steps
💡 How to Take azunate l 480 mg/80 mg tablet
Strength: Tablet containing artesunate 480 mg and lumefantrine 80 mg.
Dosage Information
| Adult Dosage | The usual adult dose is 4 tablets (each containing artesunate 480 mg and lumefantrine 80 mg) taken orally at 0, 8, 24, 36, 48, and 60 hours with food or milk. This provides a total of 24 tablets over 3 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients, but use with caution due to potential heart, liver, or kidney issues. Consult your doctor. |
| Renal Impairment | No dose adjustment is recommended for mild to moderate renal impairment. Use with caution in severe renal impairment. |
| Hepatic Impairment | No dose adjustment is recommended for mild to moderate hepatic impairment. Use with caution in severe hepatic impairment. |
| Maximum Daily Dose | The maximum daily dose is 4 tablets (artesunate 1920 mg + lumefantrine 320 mg) per day for 3 days. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of azunate l 480 mg/80 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampicin | Major | |
| Amiodarone | Major | |
| Warfarin | Moderate | |
| Hormonal contraceptives | Moderate | |
| Antacids | Moderate | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- CYP3A4 inducers (e.g., rifampicin, carbamazepine)
- QT-prolonging drugs (e.g., amiodarone, sotalol, moxifloxacin)
⚡ Moderate Interactions
- Hormonal contraceptives
- Warfarin
- Antacids
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol may increase the risk of heart rhythm problems and worsen side effects such as dizziness and nausea.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to artesunate, lumefantrine, or any component","Severe malaria (requires injectable therapy)","First trimester of pregnancy (unless no other option)","Known QT prolongation or family history of sudden death","Severe liver or kidney impairment"]
⚠️ Warnings & Precautions
["Take with food to ensure adequate absorption.","Avoid alcohol during treatment.","May cause dizziness; avoid driving if affected.","Inform your doctor if you have heart, liver, or kidney problems.","Do not use for malaria prevention.","Complete the full course as prescribed.","If vomiting occurs within 1 hour of dosing, consult your doctor."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Consult your doctor before breastfeeding. Breastfeeding may be continued if the infant is healthy and the mother is not severely ill.
💊 Overdose Management
Overdose may cause severe nausea, vomiting, dizziness, and heart rhythm disturbances. Seek immediate medical attention. Treatment is supportive and symptomatic. No specific antidote is available.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, with food or a fatty drink such as milk. Do not skip doses or stop early, even if you feel better. Avoid alcohol during treatment as it may increase the risk of heart rhythm problems. Inform your doctor if you have heart, liver, or kidney problems, or if you are taking other medicines, especially those that affect heart rhythm. Do not share this medicine with others. Store it in a cool, dry place away from direct sunlight and out of reach of children. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Use with caution in elderly due to potential heart, liver, or kidney issues. Monitor closely.
🤰 Pregnancy Planning (TTC)
Consult your doctor before planning pregnancy. Use effective contraception during treatment.
🏥 Post-Surgery Considerations
Consult your doctor before surgery. Inform the surgeon about this medicine.
🦷 Dental Procedures
Inform your dentist about this medicine. No specific precautions reported.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you feel dizzy or weak. Rest until you recover.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
May cause dizziness; avoid driving or operating machinery until you know how it affects you.
🛑 When to Stop This Medicine
Do not stop early. Complete the full course. If you experience severe side effects, consult your doctor before stopping.
📅 Long-Term Use Effects
Long-term effects are not well established as this medicine is typically used for a short 3-day course. No chronic toxicity has been reported with short-term use.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Artemether-lumefantrine or artesunate-amodiaquine can be alternatives.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions reported. Complete routine vaccinations as scheduled.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If traveling across time zones, adjust dosing times accordingly, but maintain the 8-hour intervals for the first day. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Fever usually subsides within 24-48 hours, but you must complete the full 3-day course.
A: No, it must be taken with food or milk to ensure proper absorption.
A: Consult your doctor. It is generally avoided in the first trimester.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken without food.
Fact: It must be taken with food, especially fatty food, to ensure proper absorption. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full 3-day course to prevent relapse and resistance. - Myth: This medicine can prevent malaria.
Fact: It is not for prevention; it is only for treatment of active malaria.
🔄 Alternative Options
Generic Alternatives
- Artesunate + Lumefantrine combination tablets from other manufacturers
Brand Alternatives
- Azunate L 480 mg/80 mg tablet