Aspigrel Loading 150 mg/75 mg Tablet: Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Sudden severe headache or confusion
- Swelling of face, lips, or throat
- Unusual fatigue or paleness
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is ptat a 150mg/75mg tablet used for?
This medicine is a dual antiplatelet tablet containing aspirin 150 mg and clopidogrel 75 mg. It is used to prevent blood clots in patients with acute coronary syndrome or after stent placement. It works by inhibiting platelet aggregation through two different mechanisms.
- Generic Name: Aspirin (150mg) + Clopidogrel (75mg)
- Manufacturer: Divine Savior Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ptat a 150mg/75mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एस्पिरिन 150 मिलीग्राम और क्लोपिडोग्रेल 75 मिलीग्राम का संयोजन है। इसका उपयोग तीव्र कोरोनरी सिंड्रोम, दिल के दौरे, और स्टेंट लगने के बाद रक्त के थक्के बनने से रोकने के लिए किया जाता है। यह प्लेटलेट्स को एक साथ चिपकने से रोकती है और रक्त प्रवाह को बनाए रखने में मदद करती है। यह दवा केवल डॉक्टर के परामर्श से ही लेनी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में अपच, मतली, पेट दर्द, दस्त और आसानी से चोट लगना शामिल हैं। गंभीर दुष्प्रभावों में पेट या आंतों में रक्तस्राव, मस्तिष्क में रक्तस्राव, और एलर्जी प्रतिक्रियाएं शामिल हैं। यदि आपको काला मल, खून की उल्टी, या असामान्य रक्तस्राव दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे चबाएं या तोड़ें नहीं। शराब का सेवन न करें क्योंकि इससे रक्तस्राव का खतरा बढ़ सकता है। अन्य दवाओं के साथ लेने से पहले डॉक्टर से सलाह लें। अचानक दवा बंद न करें, इससे दिल का दौरा या स्टेंट थ्रोम्बोसिस का खतरा बढ़ सकता है।
💊 ptat a 150mg/75mg tablet Uses & Benefits
[{"condition":"Acute coronary syndrome (ACS)","description":"Used as a loading dose in patients with unstable angina, non-ST-elevation myocardial infarction, or ST-elevation myocardial infarction to rapidly inhibit platelet aggregation and reduce ischemic events.","evidence":"Well-established"},{"condition":"Post-percutaneous coronary intervention (PCI) with stent placement","description":"Administered to prevent stent thrombosis and recurrent ischemic events after coronary stent implantation.","evidence":"Well-established"},{"condition":"Secondary prevention after myocardial infarction","description":"Used in combination to reduce the risk of recurrent cardiovascular events in patients who have had a myocardial infarction.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Peripheral arterial disease","description":"Sometimes prescribed off-label to reduce the risk of cardiovascular events in patients with peripheral arterial disease.","evidence":"Limited"},{"condition":"Cerebrovascular disease","description":"Occasionally used off-label for secondary prevention of stroke, though evidence is less robust than for coronary indications.","evidence":"Limited"}]
Primary treatment for: Acute coronary syndrome
Also treats: Post-myocardial infarction, Post-percutaneous coronary intervention, Unstable angina
📋 Drug Information
| Generic Name(s) | Aspirin (150mg) + Clopidogrel (75mg) |
| Brand Name | ptat a 150mg/75mg tablet |
| Manufacturer | Divine Savior Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antiplatelet agents with complementary mechanisms. Aspirin irreversibly acetylates cyclooxygenase-1 (COX-1) in platelets, preventing the conversion of arachidonic acid to prostaglandin H2, thereby reducing thromboxane A2 synthesis. Thromboxane A2 is a potent vasoconstrictor and platelet aggregator. Clopidogrel is a prodrug that requires hepatic activation by cytochrome P450 enzymes, primarily CYP2C19. Its active metabolite irreversibly binds to the P2Y12 ADP receptor on platelets, blocking ADP-mediated activation of the glycoprotein IIb/IIIa complex, which is necessary for platelet aggregation. The combination provides synergistic inhibition of platelet activation and aggregation.
Mechanism Steps
💡 How to Take ptat a 150mg/75mg tablet
Strength: Tablet containing aspirin 150 mg and clopidogrel 75 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet (aspirin 150 mg + clopidogrel 75 mg) taken orally once daily, or as a loading dose in acute coronary syndrome as directed by a cardiologist. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more susceptible to bleeding. Use with caution and monitor closely. Dose adjustment may be needed based on renal function. |
| Renal Impairment | Use with caution in renal impairment. Aspirin should be avoided in severe renal impairment. Clopidogrel dose adjustment not typically required, but monitor closely. |
| Hepatic Impairment | Contraindicated in severe hepatic impairment. Use with caution in mild to moderate impairment. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet (aspirin 150 mg + clopidogrel 75 mg). Do not exceed without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ptat a 150mg/75mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ibuprofen | Major | |
| Omeprazole | Moderate | |
| Heparin | Major | |
| Fluoxetine | Moderate | |
| Methotrexate | Moderate | |
| Ticagrelor | Major | |
| Alteplase | Major | |
| Corticosteroids | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- NSAIDs (e.g., ibuprofen, naproxen)
- Other antiplatelet agents (e.g., ticagrelor, prasugrel)
- Heparin
- Thrombolytic agents (e.g., alteplase)
⚡ Moderate Interactions
- Proton pump inhibitors (e.g., omeprazole)
- SSRIs (e.g., fluoxetine)
- Corticosteroids
- Methotrexate
🍷 Alcohol Interaction
Alcohol increases the risk of gastrointestinal bleeding and may enhance the antiplatelet effect. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active pathological bleeding (e.g., peptic ulcer, intracranial hemorrhage)","Hypersensitivity to aspirin or clopidogrel","Severe hepatic impairment","Active peptic ulcer disease","History of asthma induced by aspirin or NSAIDs"]
⚠️ Warnings & Precautions
["Increased risk of bleeding, especially with concomitant anticoagulants or NSAIDs.","Discontinue 5-7 days before surgery if possible, after consulting doctor.","Use with caution in patients with renal or hepatic impairment.","May cause thrombotic thrombocytopenic purpura (TTP); monitor for signs.","Avoid in patients with aspirin-sensitive asthma."]
🤱 Lactation Safety
Aspirin is excreted in breast milk; avoid in nursing mothers due to risk of Reye's syndrome. Clopidogrel: Unknown if excreted in breast milk; caution advised. Consult your doctor.
💊 Overdose Management
Overdose may cause severe bleeding, tinnitus, hyperventilation, and metabolic acidosis. Seek immediate medical attention. Treatment includes supportive care, activated charcoal if recent ingestion, and possibly platelet transfusion. There is no specific antidote for clopidogrel; aspirin overdose may be treated with sodium bicarbonate and hemodialysis.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not crush or chew the tablet unless instructed. Inform your doctor about all other medicines you are taking, especially blood thinners, NSAIDs, and proton pump inhibitors. Avoid alcohol consumption as it increases the risk of gastrointestinal bleeding. Report any unusual bleeding, bruising, or signs of infection immediately. Do not stop taking this medicine without consulting your doctor, as sudden discontinuation can increase the risk of heart attack or stent thrombosis. Keep this medicine out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of bleeding. Use with caution and monitor renal function and signs of bleeding regularly.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy, especially in the third trimester. If you are planning pregnancy, consult your doctor to discuss alternative treatments.
🏥 Post-Surgery Considerations
Discontinue this medicine 5-7 days before surgery if possible, after consulting your surgeon. It may increase the risk of bleeding during and after surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may increase bleeding during dental procedures. Your dentist may recommend stopping it temporarily.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid contact sports or activities that may cause injury or bleeding. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some patients. Avoid driving or operating heavy machinery until you know how it affects you. Inform your employer if your job involves risk of injury.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will determine the appropriate duration based on your condition, usually 6-12 months after stent placement or as recommended.
📅 Long-Term Use Effects
Long-term use of this medicine increases the risk of bleeding, including gastrointestinal and intracranial hemorrhage. Regular monitoring of hemoglobin, renal function, and signs of bleeding is recommended. Patients should be reviewed periodically to assess the need for continued therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Heart-healthy diet, exercise, and smoking cessation can complement medicine.
Evidence: Well-establishedAlternative combinations like aspirin plus ticagrelor may be used based on patient factors.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, inform your doctor before any vaccination, especially if you are on other medications.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. Store at room temperature and protect from moisture. If traveling across time zones, consult your doctor about adjusting the timing. Carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Aspirin starts working within 1 hour, and clopidogrel's antiplatelet effect begins within 2 hours after a loading dose.
A: Yes, taking it with food helps reduce stomach upset.
A: Take it as soon as you remember if less than 12 hours have passed. Otherwise, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, stopping suddenly can increase the risk of heart attack or stent thrombosis. Always consult your doctor before stopping.
🤔 Common Patient Concerns
🔄 Substitutes for ptat a 150mg/75mg tablet
View AllAlternative brands with exact same active ingredient:
-
aspigrel loading 150 mg/75 mg tabletShreya Life Sciences Pvt Ltd ₹2.81 92.9% CHEAPER
-
pilogrel a 150 mg/75 mg tabletPsychotropics India Ltd ₹15.23 61.3% CHEAPER
-
clopisa 150mg/75mg capsuleSkymax Laboratories Pvt Ltd ₹19.22 51.2% CHEAPER
-
myogrel ap 150mg tabletMacleods Pharmaceuticals Pvt Ltd ₹19.60 50.2% CHEAPER
-
davaindia aspirin+clopidogrel 150mg/75mg tabletDavaindia Generic Pharmacy ₹22.00 44.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any chest pain.
Fact: This medicine is specifically for acute coronary syndrome and should only be taken under medical supervision. - Myth: It is safe to stop this medicine once you feel better.
Fact: Stopping suddenly can increase the risk of heart attack or stent thrombosis. Always consult your doctor. - Myth: This medicine can be taken with any painkiller.
Fact: NSAIDs can interact and increase bleeding risk. Consult your doctor before taking any other medicine.
🔄 Alternative Options
Generic Alternatives
- Aspirin 150 mg + Clopidogrel 75 mg tablet (various manufacturers)
Brand Alternatives
- Aspigrel 150 mg/75 mg tablet
- Clopilet A 150 mg/75 mg tablet
- Deplatt A 150 mg/75 mg tablet
- Ecosprin AV 150 mg/75 mg tablet