clopisa 150mg/75mg capsule - Aspirin (150mg) + Clopidogrel (75mg) medicine

Clopitab-A 150 Capsule: Complete Medicine Guide

No reviews yet
🏭 Skymax Laboratories Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 23, 2026
⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Well-established for cardiovascular indications.
Reviewed by
SaathiMed Expert Panel | Oct 23, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or black, tarry stools
  • Vomiting blood or material that looks like coffee grounds
  • Severe abdominal pain or stomach cramps
  • Sudden severe headache, confusion, or weakness
  • Unexplained bruising or bleeding that does not stop
  • Swelling of face, lips, or throat, or difficulty breathing
  • Yellowing of skin or eyes, or dark urine

If experiencing severe symptoms, call emergency services immediately.

What is clopisa 150mg/75mg capsule used for?

This medicine is a combination of aspirin and clopidogrel used to prevent heart attacks and strokes in high-risk patients. It works by inhibiting platelet aggregation.

  • Generic Name: Aspirin + Clopidogrel
  • Manufacturer: Skymax Laboratories Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 clopisa 150mg/75mg capsule के बारे में (Hindi Summary)

उपयोग: यह दवा एस्पिरिन और क्लोपिडोग्रेल का संयोजन है, जिसका उपयोग दिल के दौरे और स्ट्रोक को रोकने के लिए किया जाता है। यह उन रोगियों के लिए निर्धारित की जाती है जिन्हें पहले से हृदय रोग, स्टेंट लगाना, या स्ट्रोक हुआ है। यह रक्त के थक्के बनने से रोकती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में अपच, पेट दर्द, मतली, और आसानी से चोट लगना या खून बहना शामिल हैं। गंभीर दुष्प्रभावों में पेट या आंतों में रक्तस्राव, मस्तिष्क में रक्तस्राव, और गंभीर एलर्जी प्रतिक्रिया शामिल हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे अचानक बंद न करें, खासकर स्टेंट लगाने के बाद। किसी भी सर्जरी या दंत चिकित्सा से पहले अपने डॉक्टर को इस दवा के बारे में बताएं। शराब का सेवन न करें। चोट लगने से बचें। यदि आपको काला मल, खून की उल्टी, या असामान्य चोट दिखे तो तुरंत डॉक्टर से मिलें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 clopisa 150mg/75mg capsule Uses & Benefits

[{"condition":"Acute coronary syndrome","description":"Used to prevent further heart attacks and complications in patients who have had a heart attack or unstable angina.","evidence":"Well-established"},{"condition":"Post-stent placement","description":"Prescribed after coronary artery stent insertion to prevent stent thrombosis and restenosis.","evidence":"Well-established"},{"condition":"Peripheral arterial disease","description":"Helps reduce the risk of heart attack, stroke, and limb ischemia in patients with narrowed peripheral arteries.","evidence":"Well-established"},{"condition":"Secondary stroke prevention","description":"Used to prevent recurrent strokes in patients who have already had a transient ischemic attack or ischemic stroke.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Primary prevention in high-risk individuals","description":"Sometimes considered for patients with multiple risk factors but no prior cardiovascular event, though benefits must be weighed against bleeding risk.","evidence":"Limited"}]

Primary treatment for: Cardiovascular disease prevention

Also treats: Acute coronary syndrome, Peripheral arterial disease, Stroke prevention

📋 Drug Information

Generic Name(s)Aspirin + Clopidogrel
Brand NameAspidol Tablet
ManufacturerSkymax Laboratories Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassBLOOD RELATED
Action ClassAntiplatelet Agent
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time every day to maintain consistent antiplatelet effect.
2
Always take it with food to reduce the risk of stomach upset and bleeding.
3
Inform your doctor immediately if you notice any unusual bleeding or bruising.
4
Do not stop this medicine without consulting your doctor, especially if you have a stent.
5
Avoid alcohol and NSAIDs while taking this medicine to prevent bleeding complications.
6
Keep all your medical appointments for regular monitoring of blood counts and organ function.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chest pain or history of heart attack
This medicine is commonly prescribed for secondary prevention.
Likely Use
✅
History of stroke or TIA
Used to prevent recurrent strokes.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAspirin is rapidly absorbed from the stomach and upper intestine. Clopidogrel is well absorbed, with peak plasma levels occurring about 1 hour after ingestion. Food does not significantly affect the absorption of either component.
DistributionBoth drugs are distributed widely in the body. Aspirin is partially bound to plasma proteins, while clopidogrel and its active metabolite are highly bound to plasma proteins (approximately 98%).
Protein BindingAspirin: 80-90%; Clopidogrel: approximately 98% (active metabolite).
MetabolismAspirin is hydrolyzed to salicylic acid, which is further metabolized in the liver by conjugation with glycine and glucuronic acid. Clopidogrel is extensively metabolized in the liver, primarily by CYP2C19 and CYP3A4, to its active thiol metabolite.
Half-LifeAspirin: 15-20 minutes for aspirin itself; salicylate: 2-3 hours at low doses, longer at high doses. Clopidogrel: active metabolite half-life is about 30 minutes, but the antiplatelet effect lasts for the platelet lifespan (7-10 days).
ExcretionAspirin metabolites are excreted primarily in urine. Clopidogrel metabolites are excreted in urine (about 50%) and feces (about 46%).
BioavailabilityAspirin: approximately 50-75% (due to first-pass metabolism). Clopidogrel: approximately 50% for the parent drug, but the active metabolite has variable bioavailability.
Onset of ActionAntiplatelet effect of aspirin begins within 1 hour; clopidogrel's effect starts within 2 hours after a loading dose, but with chronic dosing, steady-state inhibition occurs after 3-7 days.
Peak Plasma TimeAspirin: 1-2 hours; Clopidogrel: about 1 hour for parent drug, 30-60 minutes for active metabolite.
Duration of ActionThe antiplatelet effect lasts for the lifespan of the platelet (7-10 days) due to irreversible inhibition.

How It Works

This medicine combines two antiplatelet agents with complementary mechanisms. Aspirin irreversibly inhibits cyclooxygenase-1 (COX-1) in platelets, blocking the conversion of arachidonic acid to thromboxane A2, a potent platelet aggregator and vasoconstrictor. Clopidogrel is a prodrug that is metabolized in the liver to an active metabolite, which irreversibly binds to the P2Y12 receptor on platelets, blocking ADP-mediated platelet activation and aggregation. Together, they provide potent and sustained inhibition of platelet function.

Mechanism Steps

1
Aspirin inhibits COX-1: Aspirin irreversibly acetylates COX-1 in platelets, preventing the formation of thromboxane A2.
2
Reduced thromboxane A2: Lower thromboxane A2 levels decrease platelet activation and aggregation.
3
Clopidogrel activation: Clopidogrel is converted by liver enzymes (CYP2C19) into an active metabolite.
4
P2Y12 receptor blockade: The active metabolite irreversibly binds to P2Y12 receptors on platelets, blocking ADP-induced activation.
5
Synergistic antiplatelet effect: The two mechanisms together produce stronger inhibition of platelet aggregation than either drug alone.

💡 How to Take clopisa 150mg/75mg capsule

Strength: Capsule containing aspirin 150 mg and clopidogrel 75 mg.

1Take the capsule whole with a glass of water.
2Swallow it whole; do not crush or chew.
3Take it at the same time each day.
4You can take it with or without food, but taking it with food may reduce stomach upset.
5If you miss a dose, follow the missed dose instructions.
6Do not stop taking this medicine without consulting your doctor.

Dosage Information

Adult DosageThe usual adult dose is one capsule (aspirin 150 mg + clopidogrel 75 mg) taken orally once daily, with or without food. However, the dose and duration must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and bleeding risk. Do not self-adjust the dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the bleeding effects. Dose should be individualized by a clinician, and renal function should be monitored.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be needed based on creatinine clearance. Consult a doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be needed. Consult a doctor.
Maximum Daily DoseThe maximum recommended daily dose is one capsule (aspirin 150 mg + clopidogrel 75 mg). Do not exceed this dose unless directed by a doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and risk of gastrointestinal bleeding.
Grapefruit
Avoid
May increase clopidogrel levels and risk of side effects.
Alcohol
Avoid
Increases risk of gastrointestinal bleeding.

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours have passed since the missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with your regular schedule.
📌 More than 12 hours have passed since the missed dose
→ Skip the missed dose.
💡 Do not double the dose to catch up.

⚠️ Side Effects of clopisa 150mg/75mg capsule

✅ Common Side Effects

Indigestion (Common (5-10%))
Take with food or antacids. Consult doctor if persistent.
Nausea (Common (5-10%))
Take with meals. Usually resolves on its own.
Easy bruising (Common (5-10%))
Avoid activities that may cause injury. Report unusual bruising to doctor.
Prolonged bleeding from cuts (Common (5-10%))
Apply pressure to stop bleeding. Seek help if bleeding persists.

🚨 Serious Side Effects

Gastrointestinal bleeding (Uncommon (0.1-1%))
Seek immediate medical attention if you notice black stools, vomiting blood, or severe abdominal pain.
Intracranial hemorrhage (Rare (<0.1%))
Go to the emergency room if you experience sudden severe headache, confusion, or weakness.
Severe allergic reaction (Rare (<0.1%))
Call emergency services if you have swelling of face, lips, or throat, or difficulty breathing.

⚠️ Rare Side Effects

Thrombotic thrombocytopenic purpura (TTP)
Seek immediate medical attention if you have fever, confusion, or purple spots on skin.
Severe liver injury
Report yellowing of skin or eyes, dark urine, or severe fatigue to your doctor immediately.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Ibuprofen Major
Omeprazole Major
SSRIs Major
Heparin Moderate
Thrombolytics Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • NSAIDs (e.g., ibuprofen, naproxen)
  • SSRIs
  • Omeprazole

⚡ Moderate Interactions

  • Heparin
  • Thrombolytics

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine because it increases the risk of gastrointestinal bleeding and may reduce the effectiveness of clopidogrel.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Active bleeding or bleeding disorders","Severe liver disease","Allergy to aspirin or clopidogrel","Children and adolescents with viral infections (risk of Reye's syndrome)","Recent gastrointestinal bleeding"]

⚠️ Warnings & Precautions

["Increased risk of bleeding, especially gastrointestinal.","Do not stop suddenly, especially after stent placement.","Avoid alcohol.","Inform surgeons and dentists before procedures.","Use with caution in elderly and those with kidney disease."]

🤱 Lactation Safety

Not established from the available information. Consult your doctor before breastfeeding.

💊 Overdose Management

Overdose can cause severe bleeding, ringing in the ears, rapid breathing, and confusion. Seek emergency medical attention immediately. Treatment is supportive and may include activated charcoal, gastric lavage, and blood transfusion if needed.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Additional Safety Advice

General Safety

Always take this medicine exactly as prescribed by your doctor. Do not stop taking it suddenly, especially if you have a stent, as this can lead to a heart attack or blood clot. Inform all your healthcare providers, including dentists and surgeons, that you are taking this medicine before any procedure. Avoid activities that increase the risk of injury or bleeding. Do not take other pain relievers or blood thinners without consulting your doctor, as this can increase bleeding risk. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Never double the dose. Store this medicine at room temperature, away from moisture and direct sunlight. Keep it out of reach of children. If you notice any signs of bleeding, such as black stools, blood in urine, or unusual bruising, seek medical attention immediately.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of bleeding and may require dose adjustments. Regular monitoring of renal function and blood counts is recommended.

🤰 Pregnancy Planning (TTC)

Consult your doctor if you are planning pregnancy or are pregnant. This medicine may not be safe during pregnancy, especially in the third trimester.

🏥 Post-Surgery Considerations

Inform your surgeon that you are taking this medicine before any surgery. It may need to be stopped temporarily to reduce bleeding risk, but only under medical supervision.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine before any dental procedure. You may need to stop it temporarily to prevent excessive bleeding, but only after consulting your doctor.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce cardiovascular risk.
🥗
Engage in regular low-impact exercise like walking or swimming.
😴
Avoid smoking and limit alcohol consumption.
💧
Eat a heart-healthy diet rich in fruits, vegetables, and whole grains.
🧘
Manage stress through relaxation techniques.
🌞
Get adequate sleep.

🏋️ Exercise Considerations

Avoid contact sports or activities that increase the risk of injury or bleeding. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseeds.
Reduce intake of processed and high-fat foods.
Stay well hydrated.
Limit salt and sugar intake.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or fatigue in some people. Avoid driving or operating heavy machinery until you know how it affects you. It should not interfere with most desk jobs, but caution is advised for high-risk activities.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. It is usually continued long-term, sometimes for life, depending on the underlying condition. Your doctor may consider stopping if the bleeding risk outweighs the benefits.

📅 Long-Term Use Effects

Long-term use of this medicine increases the risk of bleeding, including gastrointestinal and intracranial bleeding. Regular monitoring of blood counts, renal function, and liver function is recommended. It may also increase the risk of stomach ulcers. Patients should be reviewed periodically to assess the ongoing need for the medicine.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Aspirin alone

May be sufficient for some patients with lower cardiovascular risk.

Evidence: Well-established
Clopidogrel alone

Used when aspirin is not tolerated or contraindicated.

Evidence: Well-established
Ticagrelor

A more potent antiplatelet agent used in acute coronary syndrome.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are established. However, inform your doctor before any vaccination, especially if you are on other medications.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, continue taking your dose at the same local time as usual, but consult your doctor if unsure. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 58-year-old man with a history of heart attack
He was prescribed this medicine after undergoing angioplasty with stent placement. He took it regularly as directed. After six months, he noticed he bruised more easily but had no major bleeding. His doctor monitored his blood counts regularly. He emphasized the importance of not missing doses.
💡 Lesson: Consistent adherence to this medicine is crucial to prevent stent thrombosis and recurrent heart attacks.
👤 A 65-year-old woman with peripheral arterial disease
She started this medicine to reduce her risk of stroke and heart attack. She experienced mild indigestion initially, which improved when she took it with meals. She was advised to avoid alcohol and to report any unusual bleeding. She has been stable on the medicine for two years.
💡 Lesson: Taking the medicine with food and avoiding alcohol can improve tolerability and safety.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: The antiplatelet effect starts within hours, but full benefit in preventing cardiovascular events develops over days to weeks of consistent use.

Q: Can I stop taking this medicine if I feel better?

A: No, you should not stop without consulting your doctor. Stopping suddenly can increase the risk of heart attack or stroke, especially if you have a stent.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for clopisa 150mg/75mg capsule

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken for any type of pain.
    Fact: This medicine is not a painkiller; it is an antiplatelet agent used for cardiovascular protection.
  • Myth: It is safe to stop this medicine once you feel better.
    Fact: Stopping suddenly can increase the risk of heart attack or stroke, especially after stent placement.

🔄 Alternative Options

Generic Alternatives

  • Aspirin + Clopidogrel generic capsules

Brand Alternatives

  • Clopitab-A 150
  • Deplatt-A 150
  • Clopilet-A 150

📊 Comparison with Similar Medicines

[{"medicine":"Aspirin alone","difference":"Less potent antiplatelet effect; often used for primary prevention."},{"medicine":"Clopidogrel alone","difference":"Used when aspirin is not tolerated; less GI bleeding risk."},{"medicine":"Ticagrelor","difference":"More potent P2Y12 inhibitor; different side effect profile."}]

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory