Brophyle-N Tablet: Comprehensive Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Chest pain or palpitations
- Severe allergic reaction (rash, swelling, itching)
- Blood in vomit or black stools
- Severe headache with vision changes
- Seizures or loss of consciousness
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is phill n 100mg/600mg tablet used for?
This medicine is a combination of Acebrophylline and Acetylcysteine used to treat chronic respiratory conditions like COPD and chronic bronchitis. It works by relaxing airway muscles and thinning mucus, making it easier to breathe and cough out mucus.
- Generic Name: Acebrophylline (100mg) + Acetylcysteine (600mg)
- Manufacturer: Synex Global Services Llp
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 phill n 100mg/600mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एसिब्रोफाइलिन और एसिटाइलसिस्टीन का संयोजन है, जिसका उपयोग क्रोनिक ऑब्सट्रक्टिव पल्मोनरी डिजीज (सीओपीडी), क्रोनिक ब्रोंकाइटिस और अस्थमा जैसी श्वसन संबंधी बीमारियों के इलाज में किया जाता है। यह श्वसन मार्ग की मांसपेशियों को आराम देकर सांस लेने में मदद करती है और बलगम को पतला करके बाहर निकालने में सहायता करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट में परेशानी, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, सांस लेने में कठिनाई, या दिल की धड़कन अनियमित होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे भोजन के बाद लें ताकि पेट में जलन न हो। शराब का सेवन न करें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। चक्कर आने पर वाहन न चलाएं। बच्चों की पहुंच से दूर रखें।
💊 phill n 100mg/600mg tablet Uses & Benefits
[{"condition":"Chronic obstructive pulmonary disease (COPD)","description":"Helps relieve bronchospasm and thin mucus, improving breathing and reducing cough.","evidence":"Well-established"},{"condition":"Chronic bronchitis","description":"Aids in clearing thick mucus from the airways, making cough more productive.","evidence":"Well-established"},{"condition":"Asthma","description":"Used as an adjunct to standard asthma therapy to help control symptoms and mucus plugging.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Cystic fibrosis","description":"Sometimes used to help thin mucus in cystic fibrosis patients, but not a standard treatment.","evidence":"Limited"},{"condition":"Post-operative atelectasis","description":"May be used to prevent or treat lung collapse after surgery by clearing secretions.","evidence":"Limited"}]
Primary treatment for: Chronic obstructive pulmonary disease (COPD)
Also treats: Chronic bronchitis, Asthma
📋 Drug Information
| Generic Name(s) | Acebrophylline (100mg) + Acetylcysteine (600mg) |
| Brand Name | phill n 100mg/600mg tablet |
| Manufacturer | Synex Global Services Llp |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Acebrophylline is a xanthine derivative that inhibits phosphodiesterase enzymes, leading to increased cyclic AMP levels in bronchial smooth muscle cells, which causes relaxation and bronchodilation. It also reduces inflammation and mucus production. Acetylcysteine is a mucolytic that breaks disulfide bonds in mucus glycoproteins, reducing mucus viscosity and elasticity, making it easier to cough out. Additionally, acetylcysteine acts as an antioxidant, scavenging free radicals and replenishing intracellular glutathione.
Mechanism Steps
💡 How to Take phill n 100mg/600mg tablet
Strength: Acebrophylline 100 mg + Acetylcysteine 600 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally once or twice daily, or as directed by your physician. The dose may be adjusted based on your condition and response to treatment. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Dose adjustment may be necessary based on renal and hepatic function. Consult your doctor. |
| Renal Impairment | Dose adjustment may be required in patients with renal impairment. Consult your doctor for appropriate dosing. |
| Hepatic Impairment | Dose adjustment may be required in patients with hepatic impairment. Consult your doctor for appropriate dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet twice daily, but this may vary based on your condition. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of phill n 100mg/600mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Nitroglycerin | Major | |
| Carbamazepine | Major | |
| Ciprofloxacin | Moderate | |
| Erythromycin | Moderate | |
| Phenytoin | Moderate | |
| Antacids | Minor | |
| Activated charcoal | Minor |
🚨 Major Interactions
- Warfarin
- Nitroglycerin
- Carbamazepine
⚡ Moderate Interactions
- Ciprofloxacin
- Erythromycin
- Phenytoin
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol may increase drowsiness, dizziness, and stomach irritation. It may also worsen liver function.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to acebrophylline, acetylcysteine, or any component of the tablet","Active peptic ulcer disease","Severe liver disease","Severe kidney disease","Uncontrolled seizures","Acute asthma attack (not for rescue therapy)"]
⚠️ Warnings & Precautions
["Do not use for acute bronchospasm; use a rescue inhaler instead.","Caution in patients with peptic ulcer history.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol consumption.","Inform your doctor if you have heart disease, thyroid disease, or diabetes.","Do not exceed prescribed dose.","Keep out of reach of children."]
🤱 Lactation Safety
It is not known whether acebrophylline and acetylcysteine pass into breast milk. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause nausea, vomiting, restlessness, tachycardia, and seizures. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Activated charcoal may be used if taken recently.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the tablet; swallow it whole with a glass of water. It is best taken after food to reduce stomach upset. Do not exceed the recommended dose. Avoid alcohol while taking this medicine as it may increase drowsiness and stomach irritation. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Also, tell your doctor about all other medicines you are taking, especially antibiotics, blood thinners, and seizure medicines. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and drowsiness. Dose adjustment may be needed based on kidney and liver function. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with certain anesthetic agents. Your doctor may advise temporary discontinuation before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth or increase bleeding risk if you are also on blood thinners. Your dentist may take precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you have severe breathlessness. Consult your doctor before starting any exercise program. Stop immediately if you experience chest pain, severe shortness of breath, or dizziness.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It should not affect your ability to work if you are not experiencing these side effects.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects, contact your doctor immediately. Your doctor will decide if and when to stop the medicine.
📅 Long-Term Use Effects
Long-term use may require periodic monitoring of liver and kidney function. It is generally well-tolerated, but regular follow-up with your doctor is advised to adjust the dose and monitor for any adverse effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps loosen mucus and ease breathing.
Evidence: Well-establishedTechniques to help clear mucus from airways.
Evidence: Well-establishedExercise and education program for chronic lung disease.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Ensure you are up to date with influenza and pneumococcal vaccines, as respiratory infections can worsen COPD and bronchitis. Consult your doctor about appropriate vaccination timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing times gradually as advised by your doctor. Keep enough supply for the entire trip. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Bronchodilation may begin within 30-60 minutes, but full benefits for mucus clearance may take several days of regular use.
A: Inform your doctor about all medicines you take, as interactions are possible, especially with blood thinners, antibiotics, and seizure medicines.
A: Consult your doctor. The safety of this medicine during pregnancy is not well established.
🤔 Common Patient Concerns
🔄 Substitutes for phill n 100mg/600mg tablet
View AllAlternative brands with exact same active ingredient:
-
nobro 100mg/600mg tabletIndiabulls pharmaceutical ltd ₹93.75 45.1% CHEAPER
-
stayhappi acebrophylline+acetylcysteine 100mg/600mg tabletSarvagunaushdhi Pvt Ltd ₹98.44 42.3% CHEAPER
-
placklin plus 100mg/600mg tabletPlacker Life Sciences ₹103.13 39.6% CHEAPER
-
acedril forte 100mg/600mg tabletIntra Labs India Pvt Ltd ₹131.25 23.1% CHEAPER
-
resebron plus 100mg/600mg tabletInvision Medi Sciences Pvt Ltd ₹131.83 22.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used as a rescue inhaler for sudden breathing attacks.
Fact: This medicine is not a rescue medication. It is for regular use to control chronic symptoms. For sudden attacks, use a prescribed rescue inhaler. - Myth: It is safe to double the dose if you miss one.
Fact: Never double dose. Follow the missed dose instructions or consult your doctor. - Myth: This medicine can cure asthma permanently.
Fact: It helps manage symptoms but does not cure asthma. Asthma requires long-term management.
🔄 Alternative Options
Generic Alternatives
- Acebrophylline + Acetylcysteine combination tablets from other manufacturers
Brand Alternatives
- Brophyle-N Tablet is the brand name. Generic versions may be available.