Aquaril TH 2mg/37.5mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is dree fact t 2mg/37.5mg injection used for?
This medicine is an injectable combination of Thiocolchicoside 2 mg and Diclofenac 37.5 mg used for rapid relief of acute painful muscle spasms and musculoskeletal pain. It is given intramuscularly by a healthcare professional for short-term use.
- Generic Name: Thiocolchicoside (2mg) + Diclofenac (37.5mg)
- Manufacturer: Synex Global Services Llp
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 dree fact t 2mg/37.5mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा थायोकोल्किकोसाइड 2 मिलीग्राम और डाइक्लोफेनाक 37.5 मिलीग्राम का इंजेक्शन है। यह मांसपेशियों में ऐंठन, तेज दर्द, सूजन और चोट के कारण होने वाले दर्द में राहत के लिए दी जाती है। यह इंजेक्शन डॉक्टर या नर्स द्वारा मांसपेशी में लगाया जाता है। यह अल्पकालिक उपयोग के लिए है और इसे स्वयं नहीं लगाना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन लगाने की जगह पर दर्द, लालिमा या सूजन, जी मिचलाना, उल्टी, पेट में जलन, दस्त, चक्कर आना, नींद आना और सिरदर्द शामिल हैं। गंभीर दुष्प्रभावों में पेट में तेज दर्द, काला मल, खून की उल्टी, सांस लेने में कठिनाई, चेहरे या गले में सूजन, पेशाब कम आना, आंखों या त्वचा का पीला पड़ना और सीने में दर्द शामिल हैं। ऐसे लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह इंजेक्शन केवल डॉक्टर या प्रशिक्षित नर्स द्वारा ही लगाया जाना चाहिए। इसे स्वयं न लगाएं। अपने डॉक्टर को अपनी सभी दवाओं और बीमारियों के बारे में बताएं। इस दवा के साथ शराब न पिएं क्योंकि इससे पेट में खून आने और लीवर की समस्या का खतरा बढ़ सकता है। गर्भवती महिलाओं को यह दवा नहीं लेनी चाहिए। अगर आपको चक्कर या नींद आ रही हो तो वाहन न चलाएं।
💊 dree fact t 2mg/37.5mg injection Uses & Benefits
[{"condition":"Acute musculoskeletal pain and muscle spasm","description":"Provides rapid relief of painful muscle spasms associated with strains, sprains, and sports injuries.","evidence":"Well-established"},{"condition":"Acute low back pain with muscle spasm","description":"Reduces pain and muscle tightness in the lower back when oral therapy is not feasible.","evidence":"Well-established"},{"condition":"Post-operative pain and spasm","description":"Used short-term after surgery to control pain and muscle spasm when injectable therapy is needed.","evidence":"Moderate"},{"condition":"Post-traumatic pain and inflammation" class="semantic-link" title="Medicines for swelling">swelling","description":"Helps reduce inflammation and pain after injuries such as fractures or soft tissue trauma.","evidence":"Moderate"},{"condition":"Cervical and thoracic muscle spasm","description":"Relieves neck and upper back muscle spasm causing pain and restricted movement.","evidence":"Limited"}]
Off-label uses: [{"condition":"Tension-type headache with muscle spasm","description":"Sometimes used off-label for short-term relief when muscle spasm contributes to headache.","evidence":"Limited"},{"condition":"Fibromyalgia flare with severe muscle spasm","description":"Occasionally used for short-term symptom relief in selected patients.","evidence":"Limited"}]
Primary treatment for: Acute musculoskeletal pain and muscle spasm
Also treats: Low back pain, Post-operative pain, Post-traumatic pain, Cervical muscle spasm
📋 Drug Information
| Generic Name(s) | Thiocolchicoside (2mg) + Diclofenac (37.5mg) |
| Brand Name | dree fact t 2mg/37.5mg injection |
| Manufacturer | Synex Global Services Llp |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Parenteral (intramuscular injection) |
| Storage | Store in a cool, dry place below 30°C, protected from light. Do not freeze. Keep out of reach of children. Once opened, use immediately and discard any unused portion. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise stated on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Thiocolchicoside is a semi-synthetic derivative of colchicine that acts primarily on spinal and supraspinal centers. It binds to GABA-A receptors and strychnine-sensitive glycine receptors, enhancing inhibitory neurotransmission and reducing excessive muscle tone. Diclofenac is a nonselective NSAID that reversibly inhibits cyclooxygenase-1 and cyclooxygenase-2 enzymes, decreasing the synthesis of prostaglandins, prostacyclin, and thromboxane. This reduces inflammation, pain, and fever. Together, the muscle relaxant and anti-inflammatory actions provide rapid relief of painful muscle spasm.
Mechanism Steps
💡 How to Take dree fact t 2mg/37.5mg injection
Strength: Each injection contains Thiocolchicoside 2 mg and Diclofenac 37.5 mg in an immediate-release parenteral formulation.
Dosage Information
| Adult Dosage | The usual adult dose is one intramuscular injection of this medicine (containing Thiocolchicoside 2 mg and Diclofenac 37.5 mg) given once or twice daily, depending on the severity of pain and muscle spasm. The exact dose and duration must be individualized by a qualified clinician based on the indication, age, weight, kidney function, liver function, and response to treatment. This medicine is intended for short-term use only. Do not self-administer. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients above 65 years may be more sensitive to the side effects of this medicine, especially kidney, heart, and gastrointestinal effects. The dose should be individualized by a clinician, and the lowest effective dose should be used for the shortest duration. Monitor kidney function and watch for bleeding. |
| Renal Impairment | This medicine should be used with caution in patients with kidney disease. Dose adjustment may be needed based on kidney function. It is contraindicated in severe kidney disease. Consult a doctor for individualized dosing. |
| Hepatic Impairment | This medicine should be used with caution in patients with liver disease. Dose adjustment may be needed based on liver function. It is contraindicated in severe liver disease. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is not established from the available information. The dose must be individualized by a qualified clinician based on the patient's condition and response to treatment. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of dree fact t 2mg/37.5mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Major | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Diuretics | Moderate | |
| Cyclosporine | Moderate | |
| Digoxin | Moderate |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Other NSAIDs including aspirin
- Methotrexate
- Lithium
- ACE inhibitors and angiotensin receptor blockers
⚡ Moderate Interactions
- Corticosteroids
- Selective serotonin reuptake inhibitors (SSRIs)
- Diuretics
- Cyclosporine
- Digoxin
🍷 Alcohol Interaction
Alcohol should be strictly avoided while receiving this medicine. Combining alcohol with diclofenac increases the risk of gastrointestinal bleeding, ulceration, and liver toxicity. It may also worsen dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to thiocolchicoside, diclofenac, or other NSAIDs","Active peptic ulcer or history of recurrent ulcers","Severe kidney disease or kidney failure","Severe liver disease or liver failure","Severe heart failure or recent heart attack","Third trimester of pregnancy","Children and adolescents under 18 years","History of asthma, urticaria, or allergic reaction after taking aspirin or other NSAIDs"]
⚠️ Warnings & Precautions
["This injection must be given only by a healthcare professional.","Do not use for prolonged periods without medical review.","Use with caution in the elderly due to increased risk of kidney, heart, and stomach problems.","Avoid in patients with dehydration or low blood volume.","Monitor for signs of bleeding, especially if on blood thinners.","Do not drive or operate machinery if you feel dizzy or drowsy.","Inform your doctor if you have diabetes, high blood pressure, or high cholesterol.","Avoid alcohol completely during treatment."]
🤱 Lactation Safety
Diclofenac passes into breast milk in small amounts. Thiocolchicoside excretion into breast milk is not established. This medicine is generally not recommended during breastfeeding unless the doctor decides the benefit outweighs the risk. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine may cause severe nausea, vomiting, stomach pain, bleeding, dizziness, drowsiness, and kidney or liver problems. There is no specific antidote. Treatment is supportive and symptomatic. If overdose is suspected, seek immediate medical attention. Do not try to vomit unless instructed by a doctor.
⏰ Missed Dose
This medicine is usually given as a single dose or a short course by a healthcare professional. If you miss a scheduled dose, contact your doctor or clinic as soon as possible. Do not attempt to self-administer a missed dose. Do not double the dose to catch up.
Additional Safety Advice
This injection must be given only by a doctor or trained nurse in a clinic or hospital setting. Do not self-administer. Inform your doctor about all medicines you take, especially blood thinners, other NSAIDs, steroids, blood pressure medicines, and antidepressants. Avoid alcohol while receiving this medicine because it increases the risk of stomach bleeding and liver problems. Do not use this medicine for more than the recommended short duration without medical review. If you have kidney disease, liver disease, heart failure, asthma, or a history of ulcers, tell your doctor before receiving this injection. Pregnant women should avoid this medicine, especially in the last three months. Do not drive or operate heavy machinery if you feel dizzy or drowsy after the injection.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients above 65 years are at higher risk of kidney, heart, and gastrointestinal side effects from this medicine. Use with caution, at the lowest effective dose for the shortest duration. Monitor kidney function, blood pressure, and signs of bleeding. Avoid in patients with severe kidney or heart disease.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor before using this medicine. Diclofenac and thiocolchicoside are not recommended during pregnancy, especially in the third trimester. Use effective contraception if you are of childbearing age and taking this medicine. Consult your doctor for safer alternatives.
🏥 Post-Surgery Considerations
This medicine may be used after surgery for short-term relief of pain and muscle spasm. It should be given only under medical supervision. Monitor for bleeding, kidney function, and interactions with other post-operative medicines such as anticoagulants. The dose and duration should be individualized by the surgeon or anesthesiologist.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine before any dental procedure. Diclofenac may increase bleeding risk during dental surgery, especially if you are also taking blood thinners. Your dentist may advise temporary discontinuation or additional precautions. Do not stop the medicine without consulting your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while receiving this medicine, especially if you have acute muscle spasm or pain. Gentle stretching and low-impact activities may be helpful once the acute phase subsides. Consult your doctor or physiotherapist before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is usually given in a clinic or hospital, so you may need to take time off work for the injection. Most people can resume light activities after the acute pain subsides, but heavy physical work should be avoided until cleared by a doctor.
🛑 When to Stop This Medicine
This medicine is intended for short-term use only. Stop using it when your doctor advises, usually when the acute pain and muscle spasm have resolved. Do not continue beyond the prescribed duration. If you experience serious side effects such as stomach bleeding, allergic reaction, or kidney problems, stop immediately and seek medical attention. Do not stop any prescribed treatment without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended. Prolonged use of diclofenac can increase the risk of gastrointestinal bleeding, ulcers, kidney injury, liver problems, and cardiovascular events such as heart attack and stroke. Thiocolchicoside may also cause liver enzyme changes. Regular monitoring of kidney and liver function is advised if extended use is necessary. Always use the lowest effective dose for the shortest duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and muscle spasm.
Evidence: Well-establishedMay help relieve muscle spasm and pain locally.
Evidence: ModerateAlternative when injectable therapy is not needed.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your doctor about this medicine. It is generally safe to receive vaccines while on this medicine, but your doctor will decide based on your overall condition.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
If you are prescribed this injection while traveling, carry it in its original packaging with the prescription copy. Store it in a cool, dry place below 30°C and protect it from light. Since it is an injectable medicine, it must be administered by a healthcare professional. Check local regulations for carrying injectable medicines across borders. Do not freeze the injection. If traveling by air, keep it in your carry-on luggage with proper documentation.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This injection usually starts relieving pain and muscle spasm within 15 to 30 minutes after administration.
A: It is given as an intramuscular injection by a doctor or nurse, usually into the buttock or another large muscle.
A: This medicine is generally avoided during pregnancy, especially in the third trimester. Consult your doctor for advice.
A: Common side effects include injection site pain, nausea, stomach discomfort, dizziness, and headache.
A: No, alcohol should be avoided as it increases the risk of stomach bleeding and liver problems.
🤔 Common Patient Concerns
🔄 Substitutes for dree fact t 2mg/37.5mg injection
View AllAlternative brands with exact same active ingredient:
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serofin-th injectionGlobus Remedies Ltd ₹34.00 27.7% CHEAPER
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Thioser D 2mg/37.5mg InjectionSerene Lifeworld Pvt Ltd ₹37.50 20.2% CHEAPER
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thioage-d injectionAllenge India ₹49.80 6% COSTLIER
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aquaril th 2mg/37.5mg injectionMerril Pharma Pvt Ltd ₹50.00 6.4% COSTLIER
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volrin th 2mg/37.5mg injectionWerke Healthcare ₹50.00 6.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This injection can be self-administered at home.
Fact: This medicine must be given only by a qualified healthcare professional in a clinical setting. - Myth: This medicine can be used for long-term pain relief.
Fact: It is intended for short-term use only. Long-term use increases the risk of serious side effects. - Myth: It is safe to take alcohol with this medicine.
Fact: Alcohol increases the risk of stomach bleeding and liver problems. It should be avoided. - Myth: This medicine is safe for children.
Fact: Pediatric dosing is not established. Consult a pediatrician.
🔄 Alternative Options
Generic Alternatives
- Thiocolchicoside + Diclofenac injection
Brand Alternatives
- Aquaril TH 2mg/37.5mg injection