Flodot Oral Suspension: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain or cramping
- High fever with chills
- Signs of dehydration (dry mouth, decreased urine output, dizziness)
- Sudden pain or swelling in a joint or tendon
- Tingling, numbness, or burning in hands or feet
- Severe allergic reaction (swelling of face, lips, throat, difficulty breathing)
- Yellowing of skin or eyes
- Irregular heartbeat or palpitations
- Persistent diarrhoea after completing the course
If experiencing severe symptoms, call emergency services immediately.
What is ofzer dry syrup used for?
This medicine is a combination oral suspension containing racecadotril (an antidiarrheal) and ofloxacin (an antibiotic). It is used to treat acute bacterial diarrhoea. It works by reducing fluid secretion in the intestines and killing the bacteria causing the infection. It is available by prescription only and should be taken exactly as directed by a doctor.
- Generic Name: Racecadotril (15mg/5ml) + Ofloxacin (50mg/5ml)
- Manufacturer: Lifekyor Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ofzer dry syrup के बारे में (Hindi Summary)
उपयोग: यह दवा रेसीकैडोट्रिल और ऑफ्लोक्सासिन का संयोजन है, जिसका उपयोग तीव्र जीवाणुजनित दस्त के इलाज के लिए किया जाता है। रेसीकैडोट्रिल आंतों में पानी और इलेक्ट्रोलाइट्स के स्राव को कम करता है, जिससे दस्त कम होता है। ऑफ्लोक्सासिन एक एंटीबायोटिक है जो दस्त पैदा करने वाले बैक्टीरिया को मारता है। यह दवा केवल डॉक्टर के पर्चे पर मिलती है और डॉक्टर के निर्देशानुसार ही लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सिरदर्द और चक्कर आना शामिल हैं। ये आमतौर पर हल्के होते हैं और अपने आप ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें गंभीर एलर्जी प्रतिक्रिया, टेंडन टूटना, तंत्रिका क्षति और गंभीर त्वचा प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। बोतल को अच्छी तरह हिलाकर उपयोग करें। सही मापने वाले कप या चम्मच से ही दवा नापें। दूध, दही, या कैल्शियम युक्त खाद्य पदार्थों के साथ इस दवा को न लें, क्योंकि इससे ऑफ्लोक्सासिन का अवशोषण कम हो सकता है। दस्त के दौरान शरीर में पानी की कमी न होने दें, ओआरएस का सेवन करें। शराब का सेवन न करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। दवा का कोर्स पूरा करें, बीच में न छोड़ें।
💊 ofzer dry syrup Uses & Benefits
[{"condition":"Acute bacterial diarrhoea","description":"Used for the treatment of acute diarrhoea caused by bacteria susceptible to ofloxacin, with racecadotril reducing fluid loss.","evidence":"Well-established for ofloxacin; racecadotril is established as an antidiarrheal."},{"condition":"Traveler's diarrhoea","description":"May be prescribed for moderate to severe traveler's diarrhoea when bacterial cause is suspected.","evidence":"Ofloxacin is effective against common bacterial pathogens; racecadotril reduces symptoms."},{"condition":"Diarrhoea with dehydration risk","description":"Helps reduce stool output and prevent dehydration when used alongside oral rehydration therapy.","evidence":"Racecadotril has been shown to reduce stool volume; ofloxacin targets the infection."}]
Off-label uses: [{"condition":"Not established from the available information.","description":"Not established from the available information.","evidence":"Not established from the available information."}]
Primary treatment for: Acute bacterial diarrhoea
Also treats: Traveler's diarrhoea, Diarrhoea with dehydration
📋 Drug Information
| Generic Name(s) | Racecadotril (15mg/5ml) + Ofloxacin (50mg/5ml) |
| Brand Name | ofzer dry syrup |
| Manufacturer | Lifekyor Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store below 30°C in a dry place, protected from light. Do not freeze. Shake well before use. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. The World Health Organization does not routinely recommend antibiotics for all cases of acute diarrhoea. Antibiotics are recommended for specific cases such as cholera, dysentery, and severe traveler's diarrhoea. The use of racecadotril is not included in WHO essential medicines list for diarrhoea. |
| ICMR Guideline | Not established from the available information. The Indian Council of Medical Research may have guidelines for the management of diarrhoea, but specific recommendations for this combination are not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Racecadotril is a prodrug that is rapidly converted to thiorphan, which inhibits enkephalinase, the enzyme responsible for breaking down enkephalins. Enkephalins are natural opioids that reduce the secretion of water and electrolytes into the intestinal lumen. By inhibiting enkephalinase, racecadotril decreases intestinal hypersecretion without affecting intestinal motility. Ofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination. This leads to the death of susceptible bacteria. The combination targets both the infectious cause and the secretory symptoms of diarrhoea.
Mechanism Steps
💡 How to Take ofzer dry syrup
Strength: Each 5 ml of oral suspension contains Racecadotril 15 mg and Ofloxacin 50 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 ml (containing 30 mg racecadotril and 100 mg ofloxacin) taken orally twice daily for 3 to 5 days. However, the exact dose and duration depend on the severity of the infection, the patient's renal function, and clinical response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. Complete the full course even if you feel better. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine is generally not recommended for children under 18 years due to the risk of serious adverse effects from ofloxacin. |
| Elderly Dosage | Elderly patients (above 65 years) are at higher risk of tendon rupture, peripheral neuropathy, and renal impairment. Dose should be adjusted based on renal function. Use with caution and monitor closely for adverse effects. |
| Renal Impairment | Ofloxacin requires dose adjustment in patients with renal impairment. For creatinine clearance between 20-50 ml/min, the usual dose may be given once daily. For creatinine clearance below 20 ml/min, the dose may need further reduction. Racecadotril does not require dose adjustment. Consult a doctor for specific dosing. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. Use with caution and monitor liver function. Consult a doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is 20 ml (containing 60 mg racecadotril and 200 mg ofloxacin) in divided doses. Do not exceed this dose without medical supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ofzer dry syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Antacids | Major | |
| Warfarin | Major | |
| Theophylline | Major | |
| NSAIDs | Major | |
| Corticosteroids | Major | |
| Caffeine | Moderate | |
| Cyclosporine | Moderate | |
| Probenecid | Moderate | |
| Oral hypoglycemics | Moderate | |
| Didanosine | Minor |
🚨 Major Interactions
- Antacids, sucralfate, iron, zinc, or multivitamins containing these
- Warfarin
- Theophylline
- NSAIDs (e.g., ibuprofen, naproxen)
- Corticosteroids
⚡ Moderate Interactions
- Caffeine
- Cyclosporine
- Probenecid
- Oral hypoglycemics (e.g., glibenclamide)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can worsen dizziness, drowsiness, and stomach upset caused by ofloxacin. It can also increase the risk of seizures and other central nervous system effects. Additionally, alcohol can dehydrate you further, which is harmful when you have diarrhoea.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to ofloxacin, other quinolones, or racecadotril","History of tendon disorders associated with fluoroquinolone use","Myasthenia gravis (may worsen muscle weakness)","Severe renal impairment (requires dose adjustment, may be contraindicated)","Children under 18 years (unless specifically prescribed by a specialist)","Pregnancy and breastfeeding (unless clearly needed)","Patients with known QT interval prolongation or uncorrected hypokalemia"]
⚠️ Warnings & Precautions
["Fluoroquinolones, including ofloxacin, can cause disabling and potentially irreversible serious adverse reactions involving tendons, muscles, joints, nerves, and central nervous system. Reserve use for patients with no alternative treatment options.","Tendon inflammation and rupture can occur, especially in patients over 60, those taking corticosteroids, and transplant recipients. Stop at first sign of tendon pain.","Peripheral neuropathy may occur rapidly. Discontinue if symptoms develop.","Central nervous system effects including seizures, dizziness, and confusion have been reported. Use caution when driving or operating machinery.","May exacerbate muscle weakness in patients with myasthenia gravis. Avoid use.","Serious hypersensitivity reactions, including anaphylaxis, can occur. Discontinue immediately if allergic reaction suspected.","Clostridioides difficile-associated diarrhoea may occur. Evaluate if diarrhoea develops.","Avoid excessive sun exposure due to risk of photosensitivity.","Maintain adequate hydration to prevent crystalluria.","Do not use for viral infections; it will not work and may cause harm."]
🤱 Lactation Safety
Ofloxacin is excreted in breast milk and may cause serious adverse reactions in nursing infants. Racecadotril is also likely to be excreted in breast milk. This medicine is not recommended during breastfeeding unless clearly needed and prescribed by a doctor. If used, monitor the infant for diarrhoea, rash, or thrush.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, dizziness, and potentially seizures or QT prolongation. There is no specific antidote. Treatment should be symptomatic and supportive. Gastric lavage may be considered if ingestion is recent. Maintain adequate hydration and monitor cardiac rhythm. In case of overdose, seek immediate medical attention or contact a poison control center.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not self-medicate or share it with others. Shake the bottle well before each use to ensure the medicine is evenly mixed. Use a proper measuring cup or spoon to measure the dose accurately. Do not take this medicine with dairy products, antacids, or iron supplements as they can reduce the absorption of ofloxacin. Maintain good hydration by drinking plenty of fluids, especially oral rehydration solutions, to replace lost fluids and electrolytes. Avoid alcohol while taking this medicine as it can worsen dizziness and stomach upset. If you are pregnant, planning to become pregnant, or breastfeeding, inform your doctor before taking this medicine. Do not stop the medicine early even if you feel better, as this can lead to antibiotic resistance and recurrence of infection. Keep this medicine out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, peripheral neuropathy, and renal impairment. Dose adjustment may be needed based on renal function. Use with caution and monitor closely for adverse effects. Ensure adequate hydration.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy unless clearly needed. Ofloxacin may harm the developing fetus. Consult your doctor for alternative treatments if you are pregnant or planning to become pregnant.
🏥 Post-Surgery Considerations
Not established from the available information. If you have recently had surgery, inform your surgeon and anesthesiologist that you are taking this medicine. Ofloxacin may interact with certain anesthetic agents.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. Ofloxacin may increase the risk of bleeding and interact with certain medications used in dentistry. Maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while you have diarrhoea, as it can worsen dehydration. Rest is important for recovery. Once you feel better, gradually resume light activities. If you experience tendon pain, stop exercising and consult a doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness and drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. Take rest from work if you have severe diarrhoea or dehydration. Stay home to prevent spreading infection to others.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor immediately if you experience any serious side effects such as tendon pain, numbness or tingling, severe allergic reaction, or signs of liver problems. Do not stop the antibiotic early unless instructed by your doctor, as this can lead to resistance. Complete the full prescribed course.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended. Prolonged use of ofloxacin can lead to antibiotic resistance, superinfections, and an increased risk of tendon rupture, peripheral neuropathy, and CNS effects. Racecadotril is generally well-tolerated for short-term use. If diarrhoea persists beyond a few days, consult a doctor for further evaluation.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Essential for preventing and treating dehydration from diarrhoea.
Evidence: Well-establishedMay reduce duration and severity of diarrhoea, especially in children.
Evidence: Well-established for childrenMay help restore gut flora and reduce duration of diarrhoea.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. There are no known interactions between this medicine and vaccines. However, if you are due for a vaccine, inform your doctor that you are taking this medicine.
📦 Storage Guide
✅ DO
Store below 30°C in a dry place
❌ DON'T
Do not freeze
✅ DO
Keep in original container with cap tightly closed
❌ DON'T
Do not transfer to another container
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Shake well before each use
❌ DON'T
Do not use if the suspension has changed color or consistency
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription or a letter from your doctor, especially for international travel. Store the bottle in a cool, dry place away from direct sunlight. Do not leave it in a hot car. If crossing time zones, continue taking the medicine at the same intervals as prescribed; adjust timing gradually. Check customs regulations for carrying prescription medicines. Always pack it in your carry-on luggage to avoid loss.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Racecadotril starts reducing stool output within 1-2 hours. The antibiotic effect on the infection may take 24-48 hours to show noticeable improvement. Complete the full course as prescribed.
A: You can take it with a small meal if it upsets your stomach, but avoid dairy products as they can reduce the absorption of ofloxacin.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine is generally not recommended for children under 18 years due to the risk of serious side effects from ofloxacin. Consult a pediatrician.
A: No, avoid alcohol as it can worsen dizziness, drowsiness, and increase the risk of seizures.
A: Store below 30°C in a dry place, protected from light. Do not freeze. Shake well before use.
🤔 Common Patient Concerns
🔄 Substitutes for ofzer dry syrup
View AllAlternative brands with exact same active ingredient:
-
flodot oral suspensionEsquire Drug House ₹55.00 26.7% CHEAPER
-
raceril o oral suspensionSkymax Laboratories Pvt Ltd ₹65.00 13.3% CHEAPER
-
reequre-of oral suspensionBest Biotech ₹69.00 8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used for any type of diarrhoea.
Fact: This medicine contains an antibiotic and is only effective for bacterial diarrhoea. It is not effective for viral or parasitic diarrhoea and may cause harm if used inappropriately. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed to ensure the infection is fully treated and to prevent antibiotic resistance. - Myth: This medicine is safe for children.
Fact: This medicine is generally not recommended for children under 18 years due to the risk of serious side effects from ofloxacin. - Myth: You can take this medicine with milk to reduce stomach upset.
Fact: Milk and dairy products can reduce the absorption of ofloxacin. Take this medicine with water or a small meal that does not contain dairy.
🔄 Alternative Options
Generic Alternatives
- Racecadotril + Ofloxacin oral suspension
Brand Alternatives
- Flodot oral suspension