D Cin O Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden severe pain, swelling, or inability to move a joint (possible tendon rupture).
- Numbness, tingling, or burning in hands or feet (peripheral neuropathy).
- Seizures or convulsions.
- Swelling of face, lips, tongue, or throat, or difficulty breathing (angioedema/anaphylaxis).
- Severe or bloody diarrhoea (possible C. difficile infection).
- Yellowing of skin or eyes, dark urine, or severe abdominal pain (liver injury).
- Irregular heartbeat, palpitations, or fainting (QT prolongation).
- Unusual bleeding or bruising, fever, or sore throat (blood dyscrasia).
If experiencing severe symptoms, call emergency services immediately.
What is ofrun oz syrup used for?
This medicine is a combination antibiotic containing ofloxacin and ornidazole. It is used to treat mixed bacterial and protozoal infections, including intra-abdominal infections, pelvic inflammatory disease, and amoebic liver abscess. It works by killing bacteria and protozoa through different mechanisms. It should be taken exactly as prescribed, and alcohol must be avoided.
- Generic Name: Ofloxacin (NA) + Ornidazole (NA)
- Manufacturer: Jarun Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ofrun oz syrup के बारे में (Hindi Summary)
उपयोग: यह दवा ऑफ़्लोक्सासिन और ओर्निडाज़ोल का संयोजन है, जिसका उपयोग विभिन्न जीवाणु और प्रोटोज़ोआ संक्रमणों के इलाज के लिए किया जाता है। यह पेट, आंत, श्रोणि और यकृत के संक्रमणों में प्रभावी है। यह दवा पेचिश, अमीबिक यकृत फोड़ा, और श्रोणि सूजन रोग के लिए दी जाती है। यह वायरल संक्रमण जैसे सर्दी-जुकाम के लिए प्रभावी नहीं है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, सिरदर्द, चक्कर आना और मुँह में धातु जैसा स्वाद शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ दिनों में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन टेंडन टूटना, तंत्रिका क्षति, दौरे, और गंभीर एलर्जी हो सकती है। अगर आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या असामान्य रक्तस्राव हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा का सेवन केवल डॉक्टर के पर्चे पर ही करें। वायरल संक्रमण के लिए इसका उपयोग न करें। उपचार के दौरान और आखिरी खुराक के 48 घंटे बाद तक शराब का सेवन बिल्कुल न करें, क्योंकि इससे गंभीर प्रतिक्रिया हो सकती है। अगर आपको गुर्दे या यकृत की बीमारी, मिर्गी, या टेंडन विकार का इतिहास है, तो डॉक्टर को बताएं। चक्कर आने पर वाहन न चलाएं। पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें।
💊 ofrun oz syrup Uses & Benefits
[{"condition":"Intra-abdominal infections","description":"Used for mixed aerobic and anaerobic bacterial infections of the abdomen, such as peritonitis and abscesses.","evidence":"Well-established"},{"condition":"Pelvic inflammatory disease","description":"Treats infections of the female reproductive organs caused by multiple bacteria, including anaerobes.","evidence":"Well-established"},{"condition":"Amoebic liver abscess","description":"Ornidazole component is effective against Entamoeba histolytica, and ofloxacin covers secondary bacterial infection.","evidence":"Well-established"},{"condition":"Complicated diarrhoea","description":"Used when diarrhoea is caused by mixed bacterial or protozoal infections, including amoebiasis.","evidence":"Moderate"},{"condition":"Bacterial vaginosis","description":"Ornidazole targets anaerobic bacteria, and ofloxacin covers a broad range of pathogens.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Dental infections","description":"Sometimes used for severe dental abscesses when anaerobic coverage is needed, but not a first-line choice.","evidence":"Limited"},{"condition":"Diabetic foot infections","description":"May be used in combination with other antibiotics for polymicrobial foot infections.","evidence":"Limited"}]
Primary treatment for: Mixed bacterial and protozoal infections
Also treats: Intra-abdominal infections, Pelvic inflammatory disease, Amoebic liver abscess, Complicated diarrhoea, Bacterial vaginosis
📋 Drug Information
| Generic Name(s) | Ofloxacin (NA) + Ornidazole (NA) |
| Brand Name | ofrun oz syrup |
| Manufacturer | Jarun Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. Guidelines for specific infections may recommend fluoroquinolone plus nitroimidazole combinations, but this specific product is not directly referenced. |
| ICMR Guideline | Not established from the available information. ICMR treatment guidelines for specific infections may include similar combinations, but this product is not specifically mentioned. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antibiotics with different mechanisms. Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication, repair, and transcription. This leads to double-strand breaks in bacterial DNA and rapid cell death. Ornidazole is a prodrug that enters anaerobic bacteria and protozoa, where its nitro group is reduced to reactive intermediates. These intermediates bind to DNA and cause strand breakage, inhibiting nucleic acid synthesis and leading to cell death. The combination provides broad coverage against aerobic gram-negative and anaerobic bacteria, as well as certain protozoa.
Mechanism Steps
💡 How to Take ofrun oz syrup
Strength: Not established from the available information. The product is a tablet containing ofloxacin and ornidazole in unspecified strengths.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally twice daily, approximately every 12 hours. The exact dose and duration depend on the type and severity of the infection, your kidney and liver function, and your overall health. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. Complete the full course as prescribed. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. Fluoroquinolones are generally not recommended for children under 18 years due to potential effects on cartilage development. |
| Elderly Dosage | Elderly patients may require dose adjustment based on renal function. Ofloxacin clearance decreases with age, so lower doses or longer intervals may be needed. Monitor for side effects such as tendon rupture, CNS effects, and renal impairment. |
| Renal Impairment | In patients with renal impairment, the dose of ofloxacin should be adjusted. For creatinine clearance 20-50 mL/min, the usual dose may be given once daily. For creatinine clearance less than 20 mL/min, the dose may need further reduction. Ornidazole does not require significant adjustment. Consult your doctor for personalized dosing. |
| Hepatic Impairment | In patients with severe hepatic impairment, ornidazole metabolism may be reduced. Dose adjustment may be necessary. Monitor liver function closely. Consult your doctor for personalized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is two tablets (ofloxacin 400 mg + ornidazole 1000 mg) per day, but this must be confirmed by your doctor. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ofrun oz syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Antacids | Major | |
| Iron supplements | Major | |
| Theophylline | Major | |
| NSAIDs | Major | |
| Corticosteroids | Major | |
| Cyclosporine | Moderate | |
| Oral hypoglycemics | Moderate | |
| Phenytoin | Moderate | |
| Caffeine | Minor |
🚨 Major Interactions
- Warfarin
- Antacids containing aluminium or magnesium
- Sucralfate
- Iron supplements
- Zinc supplements
- Theophylline
- NSAIDs
- Corticosteroids
⚡ Moderate Interactions
- Caffeine
- Cyclosporine
- Probenecid
- Oral hypoglycemics
- Phenytoin
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 48 hours after the last dose. Ornidazole can cause a disulfiram-like reaction with alcohol, leading to severe nausea, vomiting, flushing, headache, and palpitations. Alcohol may also worsen dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to ofloxacin, ornidazole, or any other fluoroquinolone or nitroimidazole","History of tendon disorders related to fluoroquinolone use","Myasthenia gravis","Epilepsy or seizure disorders (relative contraindication)","Pregnancy and breastfeeding (unless clearly needed)","Children under 18 years (fluoroquinolones not recommended)","Severe renal impairment (dose adjustment required)"]
⚠️ Warnings & Precautions
["Fluoroquinolones, including ofloxacin, can cause tendonitis and tendon rupture, especially in older adults, those with kidney disease, and those on corticosteroids.","Ofloxacin may worsen muscle weakness in patients with myasthenia gravis.","Peripheral neuropathy has been reported with fluoroquinolones; discontinue if symptoms occur.","Central nervous system effects including seizures, dizziness, and confusion may occur.","Avoid excessive sunlight and use sunscreen due to photosensitivity risk.","Ornidazole may cause a disulfiram-like reaction with alcohol; avoid alcohol during and for 48 hours after treatment.","Prolonged use may lead to superinfection with resistant organisms.","Use with caution in patients with hepatic impairment; monitor liver function.","May cause false-negative results in some diagnostic tests for syphilis.","Do not use for viral infections; it is ineffective and promotes resistance."]
🤱 Lactation Safety
Not established from the available information. Both ofloxacin and ornidazole are excreted in breast milk. Breastfeeding is not recommended while taking this medicine. Consult your doctor for alternative options.
💊 Overdose Management
Overdose may cause nausea, vomiting, dizziness, and seizures. There is no specific antidote. Treatment is supportive and symptomatic. Maintain adequate hydration and monitor vital signs. In case of accidental overdose, seek immediate medical attention or contact a poison control center.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine only when prescribed by a qualified doctor. Do not use it for viral infections or without a confirmed bacterial diagnosis. Avoid alcohol completely during treatment and for at least 48 hours after the last dose, as it can cause severe nausea, vomiting, flushing, and palpitations. Inform your doctor if you have kidney or liver disease, epilepsy, or a history of tendon disorders. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Complete the full course even if you feel better after a few days. Do not share this medicine with anyone else. Keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, kidney impairment, and central nervous system effects. Dose adjustment based on renal function is often necessary. Monitor closely for side effects.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. If you are trying to conceive, consult your doctor for alternative antibiotics. Use effective contraception while taking this medicine if you are of childbearing age.
🏥 Post-Surgery Considerations
This medicine may be used to treat or prevent post-surgical infections, especially after abdominal or pelvic surgery. It should be prescribed by the surgeon based on the type of surgery and infection risk.
🦷 Dental Procedures
This medicine is not routinely used for dental prophylaxis. It may be prescribed for severe dental infections with anaerobic coverage, but consult your dentist or doctor for appropriate antibiotic choice.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, as it may increase the risk of tendon injury. If you experience joint pain or swelling, stop exercising and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, drowsiness, or confusion. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take rest if you feel unwell. Inform your employer if you need to take sick leave.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance. If you experience serious side effects, contact your doctor immediately; they may advise you to stop.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of antibiotic resistance, superinfections, and rare side effects such as tendon damage, peripheral neuropathy, and liver or kidney problems. It should only be used for the prescribed duration. Regular monitoring of renal and hepatic function may be needed if used for prolonged periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May help prevent antibiotic-associated diarrhoea.
Evidence: ModerateImportant supportive care for diarrhoea and infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics may reduce the effectiveness of live bacterial vaccines such as typhoid vaccine. Complete the antibiotic course before receiving live vaccines, or consult your doctor for timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If traveling across time zones, adjust dosing times gradually to maintain even intervals. Check customs regulations for carrying prescription antibiotics. Always carry enough supply for the entire trip and a few extra days in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 2-3 days, but it is important to complete the full course as prescribed, which is usually 5-14 days depending on the infection.
A: Yes, taking it with food helps reduce stomach upset. However, avoid taking it with dairy products, antacids, or iron supplements within 2 hours.
A: If you remember within 6 hours, take the missed dose. If more than 6 hours have passed, skip it and continue with your regular schedule. Do not double dose.
A: No, alcohol must be strictly avoided during treatment and for 48 hours after the last dose to prevent a severe reaction.
A: No, you must complete the full course to ensure the infection is fully treated and to prevent resistance.
🤔 Common Patient Concerns
🔄 Substitutes for ofrun oz syrup
View AllAlternative brands with exact same active ingredient:
-
boldi sachetMedicross Pharmaceuticals ₹24.38 18.9% CHEAPER
-
ogit oz suspensionCoxswain Healthcare ₹28.57 5% CHEAPER
-
o ron o syrupNeuro Pharma GmbH ₹29.02 3.5% CHEAPER
-
oflong oz suspensionIntellect Lifescience ₹29.46 2% CHEAPER
-
bonflox injectionBestoChem Formulations India Ltd ₹29.91 0.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any infection.
Fact: This medicine only works for specific bacterial and protozoal infections. It is ineffective against viral infections like the common cold. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course to prevent recurrence and resistance, even if symptoms improve. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol can cause a severe reaction with ornidazole and should be strictly avoided. - Myth: This medicine is safe for children.
Fact: Fluoroquinolones are generally not recommended for children under 18 due to potential joint effects.
🔄 Alternative Options
Generic Alternatives
- Ofloxacin + Ornidazole tablet (generic)
Brand Alternatives
- Oflox OZ
- Ofloxacin Ornidazole
- O2
- Oflomac OZ
- Zanocin OZ