ciprol eye ointment - Ciprofloxacin (NA) medicine

ciprol eye ointment

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🏭 Entod Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 22, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 22, 2026

What is ciprol eye ointment used for?

This medicine contains Ciprofloxacin (NA) and is used to treat OPHTHAL. Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, preventing DNA replication an. Always consult your doctor before use.

  • Generic Name: Ciprofloxacin
  • Manufacturer: Entod Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Category C
  • Prescription Required: Yes
💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 ciprol eye ointment Uses & Benefits

Bacterial conjunctivitis, keratitis, blepharitis, dacryocystitis, corneal ulcers.

Off-label uses: Prophylaxis in ophthalmic surgery; treatment of neonatal conjunctivitis.

📋 Drug Information

Generic Name(s)Ciprofloxacin
Brand NameArflox 0.3% Eye Drop
ManufacturerEntod Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassOPHTHAL
Action ClassQuinolones/ Fluroquinolones
Route of AdministrationOphthalmic (topical to the eye)
StorageStore at 15-30°C; protect from light; keep tightly closed.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMinimal systemic absorption after ophthalmic administration; peak plasma concentrations are low.
DistributionDistributes into ocular tissues; systemic distribution is negligible.
Protein Binding20-40%
MetabolismPartially metabolized in the liver; major metabolites are desethylene ciprofloxacin and sulfociprofloxacin.
Half-LifeSystemic half-life is 4 hours; ocular half-life is not well defined.
ExcretionPrimarily excreted unchanged in urine (systemic); ocular route results in minimal systemic excretion.
BioavailabilityNegligible systemic bioavailability after ophthalmic use.
Onset of ActionRapid; within 15-30 minutes after instillation.
Peak Plasma TimeNot applicable due to minimal systemic absorption.
Duration of ActionApproximately 6-8 hours after single dose; requires frequent dosing.

How It Works

Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, preventing DNA replication and transcription.

Mechanism Steps

1Ciprofloxacin enters bacterial cell through porin channels.
2Binds to DNA gyrase (topoisomerase II) and topoisomerase IV.
3Inhibits DNA supercoiling and replication.
4Leads to bacterial DNA fragmentation and cell death.

💡 How to Take ciprol eye ointment

Follow your doctor's prescription exactly.

⚠️ Side Effects of ciprol eye ointment

✅ Common Side Effects

Eye irritation
Burning
Stinging
Blurred vision
Taste perversion

🚨 Serious Side Effects

Corneal perforation
Anaphylaxis
Stevens-Johnson syndrome
Tendon rupture

⚠️ Rare Side Effects

Pseudomembranous colitis
Peripheral neuropathy
QT prolongation

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased bleeding risk
Theophylline Major Increased theophylline levels and toxicity
Tizanidine Major Increased sedation and hypotensive effects
Cyclosporine Moderate Increased nephrotoxicity risk
Methotrexate Moderate Increased methotrexate toxicity
Phenytoin Moderate Altered phenytoin levels
Caffeine Minor Reduced caffeine clearance
Diclofenac Minor Increased CNS stimulation risk
Metformin Minor Possible altered glucose control

🚨 Major Interactions

  • Warfarin
  • Theophylline
  • Tizanidine

⚡ Moderate Interactions

  • Cyclosporine
  • Methotrexate
  • Phenytoin

🍷 Alcohol Interaction

No known interaction with alcohol.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to ciprofloxacin or any quinolone; history of tendon disorders with quinolones.

🤱 Lactation Safety

Caution; limited data; avoid use unless clearly needed.

💊 Overdose Management

Flush eye with water; supportive care; unlikely to cause systemic toxicity.

⏰ Missed Dose

Apply as soon as remembered; if near next dose, skip missed dose and resume regular schedule.

🔄 Substitutes for ciprol eye ointment

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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