Alither Forte Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Chest pain, palpitations, or fainting
- Difficulty breathing or swelling of the face, lips, or throat
- Yellowing of the eyes or skin, or dark urine
- Severe or persistent vomiting
- Confusion, seizures, or reduced consciousness
- Unusual bleeding or bruising
- High fever that does not improve after starting treatment
If experiencing severe symptoms, call emergency services immediately.
What is Numinate Tablet used for?
This medicine is an oral antimalarial combination of Arteether 80 mg and Lumefantrine 480 mg used to treat uncomplicated Plasmodium falciparum malaria in adults. It works by rapidly killing malaria parasites in the blood and preventing them from returning. It must be taken with food and only under a doctor's prescription.
- Generic Name: Arteether (80mg) + Lumefantrine (480mg)
- Manufacturer: Numera Life Sciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Numinate Tablet के बारे में (Hindi Summary)
उपयोग: यह दवा आर्टीथर 80 मिलीग्राम और ल्यूमेफैंट्रिन 480 मिलीग्राम का मिश्रण है, जिसका उपयोग वयस्कों में अनकॉम्प्लिकेटेड प्लास्मोडियम फाल्सीपेरम मलेरिया के इलाज के लिए किया जाता है। यह मलेरिया के परजीवियों को खून में तेजी से मारती है और दोबारा बीमारी लौटने से रोकने में मदद करती है। यह दवा सिर्फ डॉक्टर की सलाह और पर्चे के बाद ही लेनी चाहिए। इसे खाने के साथ या दूध के साथ लेना बहुत जरूरी है, क्योंकि इससे दवा का असर बेहतर होता है। बुखार कम होने पर भी पूरा कोर्स पूरा करना जरूरी है।
साइड इफेक्ट्स: इस दवा को लेने पर आमतौर पर सिरदर्द, चक्कर आना, जी मिचलाना, उल्टी, पेट में हल्का दर्द, भूख कम लगना और नींद में गड़बड़ी जैसी हल्की समस्याएं हो सकती हैं। कुछ लोगों को धड़कन तेज महसूस हो सकती है या हल्का दाना निकल सकता है। गंभीर दुष्प्रभाव कम होते हैं, लेकिन अगर सीने में दर्द, बेहोशी, सांस लेने में तकलीफ, चेहरे या गले में सूजन, या आंखों-त्वचा का पीला पड़ना दिखे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें और पूरा कोर्स पूरा करें, भले ही आप पहले कुछ दिनों में बेहतर महसूस करने लगें। गोली को पानी के साथ निगलें और खाने या दूध के साथ लें ताकि पेट की तकलीफ कम हो और दवा अच्छे से अवशोषित हो। इस दवा के साथ शराब न लें। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं, खासकर दिल की धड़कन, अवसाद, फंगल और एंटीबायोटिक दवाओं के बारे में। यह दवा किसी और के साथ साझा न करें।
💊 Numinate Tablet Uses & Benefits
[{"condition":"Uncomplicated Plasmodium falciparum malaria","description":"This medicine is used to treat acute uncomplicated malaria caused by Plasmodium falciparum in adults, with the goal of rapidly clearing parasites and preventing recurrence.","evidence":"Well-established"},{"condition":"Mixed malaria infection with Plasmodium falciparum","description":"May be used when a mixed infection is confirmed and Plasmodium falciparum is the dominant or dangerous species, as determined by a clinician.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Malaria in special populations","description":"Use in pregnancy, young children, or patients with significant liver or kidney disease may occur only under specialist guidance and is not a standard approved use of this exact fixed-dose tablet.","evidence":"Limited"}]
Primary treatment for: Uncomplicated Plasmodium falciparum malaria
Also treats: Mixed malaria infection with Plasmodium falciparum
📋 Drug Information
| Generic Name(s) | Arteether (80mg) + Lumefantrine (480mg) |
| Brand Name | Numinate Tablet |
| Manufacturer | Numera Life Sciences |
| Packaging / Form | strip of 6 tablets (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and moisture. Keep it in the original packaging and out of the reach of children. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture, but the exact expiry date is printed on the pack. Do not use the medicine after the expiry date. |
| WHO Guideline | Artemisinin-based combination therapies are recommended by the World Health Organization for the treatment of uncomplicated Plasmodium falciparum malaria. The specific combination of arteether and lumefantrine should be used according to national malaria treatment guidelines and confirmed local policy. |
| ICMR Guideline | Indian malaria treatment guidelines recommend artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria, with the exact regimen determined by national and state program guidance. Clinicians should refer to the latest ICMR and National Vector Borne Disease Control Programme recommendations. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antimalarial agents with complementary mechanisms. Arteether is converted in the body to dihydroartemisinin, which generates reactive oxygen species and damages parasite proteins and membranes, leading to rapid death of blood-stage malaria parasites. Lumefantrine interferes with the parasite's ability to detoxify heme, causing toxic heme accumulation that kills the parasite. Together, the fast-acting arteether reduces the parasite load quickly, while lumefantrine provides a longer-lasting effect that clears residual parasites and reduces the chance of relapse.
Mechanism Steps
💡 How to Take Numinate Tablet
Strength: Immediate-release tablet containing Arteether 80 mg and Lumefantrine 480 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is determined by the treating clinician based on the confirmed diagnosis of uncomplicated Plasmodium falciparum malaria, body weight, and local treatment guidelines. It is typically given as a short course over a few days, and the tablet must be taken with food or a milky drink to improve absorption. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-medicate or adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this exact fixed-dose tablet. Consult a pediatrician for appropriate weight-based antimalarial treatment. |
| Elderly Dosage | Elderly patients may be more sensitive to the cardiac and neurological side effects of this medicine. A clinician should assess heart health, liver and kidney function, and other medicines before prescribing, and monitoring may need to be more frequent. |
| Renal Impairment | Dose adjustment guidance for patients with kidney disease is not established from the available information. A qualified clinician should assess kidney function and decide whether this medicine is appropriate. |
| Hepatic Impairment | This medicine should be used with caution in patients with liver disease because lumefantrine is metabolized by the liver. A qualified clinician should assess liver function and may recommend monitoring or an alternative treatment. |
| Maximum Daily Dose | The maximum daily dose is determined by the prescribed regimen and must not be exceeded. Do not take more than the dose prescribed by your clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Numinate Tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Amiodarone | Major | |
| Ketoconazole | Major | |
| Rifampicin | Major | |
| Erythromycin | Moderate | |
| Ciprofloxacin | Moderate | |
| Warfarin | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor | |
| Carbamazepine | Major | |
| Ritonavir | Major |
🚨 Major Interactions
- QT-prolonging drugs such as amiodarone, sotalol, or certain antipsychotics
- Strong CYP3A4 inhibitors such as ketoconazole or ritonavir
- Strong CYP3A4 inducers such as rifampicin or carbamazepine
⚡ Moderate Interactions
- Halofantrine or other antimalarials
- Macrolide antibiotics such as erythromycin or clarithromycin
- Fluoroquinolone antibiotics
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. It can worsen dizziness, nausea, and drowsiness, and it may increase the risk of liver-related side effects. Alcohol can also dehydrate you, which is particularly harmful during a malaria infection.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to arteether, lumefantrine, or any component of this medicine","Severe or complicated malaria requiring injectable therapy","First trimester of pregnancy unless no safer option is available and a specialist approves","Known congenital or acquired QT prolongation","Concurrent use of medicines that strongly prolong the QT interval","Severe liver disease with impaired function"]
⚠️ Warnings & Precautions
["Take this medicine with food or a milky drink to ensure adequate absorption.","Complete the full course even if you feel better after a few doses.","Avoid alcohol during treatment.","Tell your doctor about all other medicines, especially heart rhythm drugs and antibiotics.","Do not use this medicine for malaria prevention.","Seek urgent care for palpitations, fainting, or difficulty breathing.","Use with caution in patients with liver or kidney disease.","Do not share this medicine with others."]
🤱 Lactation Safety
It is not known whether arteether and lumefantrine pass into breast milk in amounts that could harm a nursing infant. Breastfeeding mothers should consult a doctor before using this medicine, and the decision should balance the need for malaria treatment against the potential risk to the infant.
💊 Overdose Management
Overdose with this medicine may cause severe nausea, vomiting, dizziness, and heart rhythm disturbances. If an overdose is suspected, seek emergency medical care immediately. Treatment is supportive and may include monitoring of heart rhythm, blood pressure, and electrolytes. Do not try to induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, provided that more than half the dosing interval has not passed. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you vomit within one hour of taking a dose, contact your doctor because the dose may need to be repeated.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor and complete the full course even if you start feeling better after the first few doses. Swallow the tablet whole with water and take it with food or a milky drink to improve absorption and reduce stomach upset. Do not crush, chew, or split the tablet unless your doctor specifically instructs you to do so. Avoid alcohol while taking this medicine because it can worsen dizziness and liver-related side effects. Inform your doctor about all other medicines you take, especially heart rhythm medicines, antidepressants, antifungals, and antibiotics, because some can interact dangerously with this medicine. Do not share this medicine with anyone else, even if they have similar symptoms. Keep all follow-up appointments and blood tests so your doctor can confirm that the infection has cleared.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may be more prone to dizziness, falls, and heart rhythm changes while taking this medicine. A doctor should review heart health, kidney and liver function, and all other medicines before prescribing. Monitoring may need to be more frequent in this age group.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss malaria prevention and treatment with your doctor before conception. This medicine is not recommended in the first trimester unless clearly necessary. Use effective mosquito protection and follow your doctor's advice on safe antimalarial options if you are pregnant or trying to conceive.
🏥 Post-Surgery Considerations
If you have recently had surgery, tell your surgeon and anesthesiologist that you are taking this medicine. It can affect heart rhythm and may interact with anesthetic drugs. Your medical team should review all medicines and monitor you closely during the perioperative period.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. There are no specific contraindications for dental work, but the dentist should know about your medicines and any history of heart rhythm problems. Maintain good oral hygiene and stay hydrated.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while you are recovering from malaria and while taking this medicine, especially if you feel dizzy, weak, or have a fever. Light activity may be resumed as you feel better, but check with your doctor before returning to intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause dizziness, headache, and tiredness, which may affect your ability to drive or operate machinery. Avoid driving or hazardous tasks until you know how the medicine affects you. Most people can return to normal activities as fever and weakness improve, but take rest as needed.
🛑 When to Stop This Medicine
Do not stop this medicine early unless your doctor tells you to. Complete the full prescribed course even if you feel better. If you develop serious side effects such as chest pain, fainting, difficulty breathing, or yellowing of the eyes or skin, stop the medicine and seek emergency medical care immediately.
📅 Long-Term Use Effects
This medicine is usually given as a short course, so long-term effects are not expected when it is used correctly. Rarely, liver enzyme changes or heart rhythm effects may occur during treatment. Follow-up testing may be needed to confirm that the malaria infection has cleared. Do not repeat or prolong the course without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Alternatives such as artemether-lumefantrine or artesunate-amodiaquine may be used depending on local guidelines and availability.
Evidence: Well-establishedUsing insecticide-treated nets and indoor residual spraying helps prevent malaria and complements treatment.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known vaccine interactions specific to this medicine. However, if you are due for any vaccine, inform your doctor that you are taking an antimalarial, and follow national immunization guidance. Malaria itself can temporarily affect immune responses, so timing of vaccination should be discussed with a clinician.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless specifically instructed
✅ DO
Keep in the original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of the reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
If you are traveling while taking this medicine, carry it in its original packaging with a copy of your prescription. Keep it in a cool, dry place away from direct sunlight and moisture. If you cross time zones, ask your doctor how to adjust the dosing schedule so that doses are not missed. Declare the medicine to customs if required and check the destination country's rules for carrying prescription medicines. Do not pack it in checked luggage where it may be exposed to extreme temperatures.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Fever and symptoms often begin to improve within 24 to 48 hours, but you must complete the full prescribed course to clear all parasites and prevent recurrence.
A: No. This medicine should be taken with food or a milky drink because food greatly improves absorption of lumefantrine and the chance of cure.
A: If less than half the dosing interval has passed, take the missed dose as soon as you remember. If more than half has passed, skip it and continue your regular schedule. Do not double dose.
A: It is best to avoid alcohol because it can worsen dizziness, nausea, and liver-related side effects.
A: It is not recommended in the first trimester unless a specialist decides it is necessary. In later pregnancy, it may be used under medical supervision. Always consult your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for Numinate Tablet
View AllAlternative brands with exact same active ingredient:
-
intamether l 80mg/480mg tabletIntas Pharmaceuticals Ltd ₹51.21 61.3% CHEAPER
-
lumaria tabletTroikaa Pharmaceuticals Ltd ₹73.98 44% CHEAPER
-
baxmether 80mg/480mg tabletBaxton Pharmacia ₹123.75 6.4% CHEAPER
-
methicap-l 80mg/480mg tabletBiomax Biotechnics Pvt Ltd ₹126.09 4.6% CHEAPER
-
alither forte tabletAllenge India ₹126.94 4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken on an empty stomach.
Fact: This medicine should be taken with food or milk because food greatly improves absorption of lumefantrine and the chance of cure. - Myth: You can stop this medicine once the fever goes away.
Fact: You must complete the full prescribed course to clear all parasites and prevent recurrence. - Myth: This medicine can prevent malaria.
Fact: This medicine is for treatment, not prevention. It does not prevent malaria infection. - Myth: This medicine is safe to share with family members who have fever.
Fact: This medicine is prescription-only and should never be shared. Fever can have many causes and requires proper diagnosis.
🔄 Alternative Options
Generic Alternatives
- Arteether and Lumefantrine fixed-dose combination
Brand Alternatives
- Alither Forte Tablet