Histolin 4mg/120mg/50mg Syrup: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is nuhist expectorant used for?
This medicine is a combination syrup containing Chlorpheniramine Maleate (an antihistamine) and Ammonium Chloride (an expectorant). It is used to relieve cough, cold, and allergy symptoms such as sneezing, runny nose, and mucus congestion. It works by blocking histamine and thinning mucus. It may cause drowsiness, so avoid driving. Always follow your doctor's instructions.
- Generic Name: Chlorpheniramine Maleate (4mg) + Ammonium Chloride (120mg)
- Manufacturer: NuLife Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nuhist expectorant के बारे में (Hindi Summary)
उपयोग: यह दवा एलर्जी, सर्दी-खांसी और नाक बहने जैसी समस्याओं में राहत देती है। इसमें क्लोरफेनिरामाइन मेलिएट और अमोनियम क्लोराइड होते हैं। यह खांसी और जुकाम में म्यूकस को पतला करके बाहर निकालने में मदद करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, मुंह सूखना, चक्कर आना, जी मिचलाना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, सांस लेने में तकलीफ हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: दवा लेते समय गाड़ी न चलाएं। शराब न पिएं। डॉक्टर की सलाह के बिना खुराक न बढ़ाएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से परामर्श लें। बच्चों को डॉक्टर की सलाह के बिना न दें।
💊 nuhist expectorant Uses & Benefits
[{"condition":"Allergic rhinitis","description":"Relieves sneezing, runny nose, itching, and watery eyes associated with seasonal or perennial allergies.","evidence":"Well-established"},{"condition":"Common cold","description":"Provides symptomatic relief of cough, nasal congestion, and mucus production.","evidence":"Well-established"},{"condition":"Cough with mucus","description":"Helps loosen and thin mucus, making it easier to expel.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Pruritus","description":"Sometimes used off-label for itching due to allergic conditions.","evidence":"Limited"}]
Primary treatment for: Allergic rhinitis, common cold
Also treats: Cough with mucus, Pruritus
📋 Drug Information
| Generic Name(s) | Chlorpheniramine Maleate (4mg) + Ammonium Chloride (120mg) |
| Brand Name | nuhist expectorant |
| Manufacturer | NuLife Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C). Protect from light and moisture. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Chlorpheniramine Maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors, reducing allergic responses. Ammonium Chloride is an expectorant that irritates the gastric mucosa, reflexively increasing respiratory tract fluid secretion, which helps thin mucus and facilitate its removal.
Mechanism Steps
💡 How to Take nuhist expectorant
Strength: Each 5 mL contains Chlorpheniramine Maleate 4 mg and Ammonium Chloride 120 mg.
Dosage Information
| Adult Dosage | The usual adult dose is 5-10 mL (1-2 teaspoons) every 4-6 hours as needed, not to exceed 6 doses in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of chlorpheniramine, especially drowsiness and anticholinergic effects. Use with caution and consider lower doses. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult a doctor. |
| Maximum Daily Dose | Maximum daily dose for adults: 60 mL (12 teaspoons) in 24 hours. Do not exceed. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nuhist expectorant
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| Alcohol | Major | |
| CNS depressants | Major | |
| Anticholinergics | Moderate | |
| CYP2D6 inhibitors | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- MAO inhibitors
- CNS depressants (alcohol, opioids, sedatives)
⚡ Moderate Interactions
- Anticholinergics (e.g., atropine, tricyclic antidepressants)
- CYP2D6 inhibitors (e.g., fluoxetine, quinidine)
🍷 Alcohol Interaction
Alcohol increases the sedative effects of chlorpheniramine and should be avoided.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to chlorpheniramine, ammonium chloride, or any component of the formulation","Newborns and premature infants","Nursing mothers","Severe liver disease","Severe kidney disease","Patients with narrow-angle glaucoma","Patients with urinary retention","Patients with asthma (acute attack)"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery.","Avoid alcohol and other CNS depressants.","Use with caution in elderly patients due to increased risk of confusion, constipation, and urinary retention.","Use with caution in patients with glaucoma, prostatic hypertrophy, or urinary retention.","Do not use for persistent or chronic cough unless directed by a doctor.","Consult doctor if symptoms persist beyond 7 days or are accompanied by fever, rash, or persistent headache."]
🤱 Lactation Safety
Chlorpheniramine passes into breast milk and may cause drowsiness in the infant. Ammonium chloride may also pass into breast milk. Consult your doctor before use.
💊 Overdose Management
Overdose may cause severe drowsiness, seizures, respiratory depression, and anticholinergic effects. Seek immediate medical attention. Treatment is supportive and symptomatic. Gastric lavage may be considered if within 1-2 hours of ingestion. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Do not exceed the recommended dose. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause drowsiness. Avoid alcohol and other central nervous system depressants while taking this medicine. Consult your doctor before use if you are pregnant, planning to become pregnant, or breastfeeding. Do not use for persistent or chronic cough, or if you have a cough with excessive phlegm, unless directed by a doctor. Keep out of reach of children. Store in a cool, dry place, protected from light. Do not use if the seal is broken or the solution is discolored.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the anticholinergic and sedative effects of chlorpheniramine. Use with caution and consider lower doses. Monitor for confusion, constipation, and urinary retention.
🤰 Pregnancy Planning (TTC)
Consult your doctor before taking this medicine if you are planning to become pregnant. Chlorpheniramine is considered relatively safe in pregnancy but always consult a healthcare professional.
🏥 Post-Surgery Considerations
Consult your doctor before taking this medicine after surgery, as it may interact with other medications and affect recovery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may cause dry mouth and interact with anesthetics.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness. Avoid strenuous exercise or activities requiring alertness until you know how it affects you.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how it affects you. It may also cause dry mouth, which can be bothersome during work.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects. Do not stop abruptly if you have been taking it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use of chlorpheniramine may lead to tolerance, dependence, and increased risk of side effects. Ammonium chloride in high doses may cause metabolic acidosis. Regular monitoring of liver and kidney function may be required if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help relieve nasal congestion and mucus.
Evidence: Well-establishedHelps loosen mucus and soothe airways.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from light. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30-60 minutes after oral administration.
A: Consult your doctor before combining with other cold medicines to avoid overlapping ingredients and potential interactions.
A: Pediatric dosing is not established from available information. Consult a pediatrician.
🤔 Common Patient Concerns
🔄 Substitutes for nuhist expectorant
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure the common cold.
Fact: This medicine only relieves symptoms; it does not cure the underlying viral infection. - Myth: It is safe to take this medicine with alcohol.
Fact: Alcohol increases drowsiness and should be avoided. - Myth: This medicine is safe for everyone.
Fact: It is not safe for newborns, nursing mothers, and those with certain medical conditions.
🔄 Alternative Options
Generic Alternatives
- Chlorpheniramine + Ammonium Chloride syrup
Brand Alternatives
- Histolin
- Other brands containing Chlorpheniramine and Ammonium Chloride