Drotel Mf Tablet: Comprehensive Guide To Uses, Dosage, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is nocolic dm tablet used for?
This medicine is a combination of drotaverine and mefenamic acid used to relieve painful menstrual cramps and abdominal spasms. It works by relaxing smooth muscles and reducing inflammation. Take it with food as prescribed by your doctor.
- Generic Name: Drotaverine (NA) + Mefenamic Acid (NA)
- Manufacturer: Rusi Remedies P Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nocolic dm tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ड्रोटावेरिन और मेफेनामिक एसिड का संयोजन है, जिसका उपयोग मासिक धर्म के दर्द, पेट की ऐंठन, और अन्य स्पास्मोडिक दर्द के इलाज के लिए किया जाता है। यह मांसपेशियों को आराम देकर और सूजन को कम करके काम करती है। इसे डॉक्टर के निर्देशानुसार भोजन के साथ लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, अल्सर, गुर्दे की समस्या और एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको काला मल, उल्टी में खून, या गंभीर पेट दर्द हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे भोजन या दूध के साथ लें ताकि पेट की जलन कम हो। इस दवा के साथ शराब न लें। यदि आपको चक्कर आते हैं तो वाहन न चलाएं। गुर्दे या लीवर की बीमारी, अल्सर, या खून से संबंधित विकार होने पर डॉक्टर को बताएं। 7 दिनों से अधिक इसका उपयोग बिना डॉक्टर की सलाह के न करें।
💊 nocolic dm tablet Uses & Benefits
[{"condition":"Primary dysmenorrhea","description":"Relieves menstrual cramps and associated pain by relaxing uterine smooth muscle and reducing prostaglandin-induced inflammation.","evidence":"Well-established"},{"condition":"Abdominal spasms","description":"Used to relieve spasms of the gastrointestinal tract, biliary tract, and urinary tract.","evidence":"Moderate"},{"condition":"Renal colic","description":"Helps relieve pain from kidney stones by relaxing smooth muscle in the urinary tract.","evidence":"Moderate"},{"condition":"Biliary colic","description":"Used for pain relief in gallbladder spasms.","evidence":"Limited"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine relief due to anti-inflammatory and antispasmodic effects.","evidence":"Limited"},{"condition":"Post-operative pain","description":"Occasionally used for post-operative smooth muscle spasm pain.","evidence":"Limited"}]
Primary treatment for: Dysmenorrhea
Also treats: Abdominal spasms, Renal colic, Biliary colic
📋 Drug Information
| Generic Name(s) | Drotaverine (NA) + Mefenamic Acid (NA) |
| Brand Name | nocolic dm tablet |
| Manufacturer | Rusi Remedies P Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Drotaverine is a selective phosphodiesterase-4 inhibitor that increases cyclic adenosine monophosphate (cAMP) levels in smooth muscle cells, leading to relaxation. It also inhibits calcium influx through voltage-gated calcium channels. Mefenamic acid is an NSAID that reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. The combination provides both antispasmodic and analgesic-anti-inflammatory effects.
Mechanism Steps
💡 How to Take nocolic dm tablet
Strength: Drotaverine 80 mg + Mefenamic acid 250 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally 2 to 3 times daily, preferably with food. The exact dose and duration must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Use with caution and lower doses may be appropriate. Consult a doctor for individualized dosing. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult a doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is 3 tablets in divided doses. Do not exceed without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nocolic dm tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Ibuprofen | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| SSRIs | Moderate | |
| Corticosteroids | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., aspirin, ibuprofen)
- Corticosteroids
- Methotrexate
- Lithium
⚡ Moderate Interactions
- ACE inhibitors
- Diuretics
- Beta-blockers
- SSRIs
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulcers, and liver toxicity. It may also enhance drowsiness and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to drotaverine, mefenamic acid, or any component","Active peptic ulcer or history of recurrent ulcers","Severe renal impairment","Severe hepatic impairment","Third trimester of pregnancy","Children under 12 years","Patients with aspirin-sensitive asthma"]
⚠️ Warnings & Precautions
["Take with food to reduce gastrointestinal irritation.","Avoid alcohol consumption.","Do not drive or operate machinery if you experience dizziness or drowsiness.","Use with caution in elderly patients due to increased risk of side effects.","Do not use for prolonged periods without medical supervision.","Inform your doctor if you have a history of kidney or liver disease, asthma, or bleeding disorders.","May increase risk of cardiovascular events; use with caution in patients with heart disease."]
🤱 Lactation Safety
Mefenamic acid is excreted in breast milk. Limited data on drotaverine. Consult your doctor before use during breastfeeding.
💊 Overdose Management
Overdose may cause severe nausea, vomiting, abdominal pain, drowsiness, and gastrointestinal bleeding. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs and electrolytes.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of gastrointestinal bleeding. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, asthma, or bleeding disorders. Do not use this medicine for more than 7 days without medical advice. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal, renal, and cardiovascular side effects. Use with caution and lower doses may be appropriate.
🤰 Pregnancy Planning (TTC)
Consult your doctor before planning pregnancy. This medicine should be avoided during pregnancy, especially in the third trimester.
🏥 Post-Surgery Considerations
Consult your doctor before using this medicine after surgery, as it may increase bleeding risk.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may increase bleeding risk during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you experience dizziness or drowsiness. Listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness, affecting your ability to drive or operate machinery. Avoid these activities until you know how it affects you.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects, allergic reactions, or if your symptoms do not improve within 7 days.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, ulcers, kidney problems, and cardiovascular events. Regular monitoring of renal and hepatic function is advised. Use the lowest effective dose for the shortest duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Applying a heating pad to the lower abdomen can help relieve menstrual cramps.
Evidence: Well-establishedCan complement medicine for chronic pain.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. Consult your doctor for individualized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 1-2 hours after taking it.
A: It is best taken with food or milk to reduce stomach upset.
A: Consult your doctor. It is generally avoided in the third trimester.
🤔 Common Patient Concerns
🔄 Substitutes for nocolic dm tablet
View AllAlternative brands with exact same active ingredient:
-
euvarin m tabletEuphoric Pharmaceuticals Pvt Ltd ₹45.03 23.7% CHEAPER
-
vegaspas dn tabletVega Laboratories Pvt Ltd ₹51.25 13.1% CHEAPER
-
drotel mf tabletLife Sciences Inc ₹54.50 7.6% CHEAPER
-
clomin dm tabletAbaris Healthcare ₹65.80 11.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any type of pain.
Fact: This medicine is specifically for spasmodic pain and menstrual cramps. It is not a general pain reliever for all conditions. - Myth: It is safe to take this medicine for long periods without a doctor's supervision.
Fact: Prolonged use can cause serious side effects like gastrointestinal bleeding and kidney problems. Use only as prescribed. - Myth: This medicine is safe during pregnancy.
Fact: It should be avoided in the third trimester and used only if clearly needed under medical supervision.
🔄 Alternative Options
Generic Alternatives
- Drotaverine + Mefenamic Acid tablet
Brand Alternatives
- Drotel MF Tablet