Nobel Spas RF 10mg/ml / 25mg/ml Injection: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
- Severe dizziness or fainting
If experiencing severe symptoms, call emergency services immediately.
What is nobel spas rf 10mg/ml/25mg/ml injection used for?
This medicine is an injectable combination of dicyclomine and diclofenac used for rapid relief of severe pain associated with smooth muscle spasm, such as renal colic, biliary colic, and severe menstrual cramps. It works by relaxing smooth muscle and reducing inflammation. It is given by a healthcare professional and is not for self-administration.
- Generic Name: Dicyclomine (10mg/ml) + Diclofenac (25mg/ml)
- Manufacturer: Mankind Pharma Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nobel spas rf 10mg/ml/25mg/ml injection के बारे में (Hindi Summary)
उपयोग: यह दवा डाइसाइक्लोमिन और डाइक्लोफेनाक का संयोजन है, जो इंजेक्शन के रूप में दी जाती है। यह पेट, आंत, पित्त नली और गुर्दे की नली की मांसपेशियों में ऐंठन और सूजन के कारण होने वाले तेज दर्द के इलाज के लिए उपयोग की जाती है। इसका उपयोग गुर्दे की पथरी के दर्द, पित्त की पथरी के दर्द, मासिक धर्म के गंभीर दर्द, और ऑपरेशन के बाद के दर्द में किया जाता है। यह दवा केवल डॉक्टर की देखरेख में अस्पताल या क्लिनिक में ही दी जानी चाहिए। इसे स्वयं न लगवाएं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुंह सूखना, धुंधली दृष्टि, चक्कर आना, नींद आना, जी मिचलाना, उल्टी, पेट में असहजता, कब्ज, और इंजेक्शन लगाने की जगह पर दर्द या लालिमा शामिल हैं। गंभीर दुष्प्रभावों में पेट या आंतों में रक्तस्राव, गुर्दे की समस्या, लीवर की समस्या, गंभीर एलर्जी, और दिल का दौरा या स्ट्रोक का खतरा शामिल है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा ही दी जानी चाहिए। इसे स्वयं न लगवाएं। अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं के बारे में बताएं, विशेष रूप से पेट के अल्सर, गुर्दे या लीवर की बीमारी, दिल की विफलता, अस्थमा, ग्लूकोमा, और पेशाब रोकने की समस्या के बारे में। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं। इस दवा के साथ शराब न लें। जब तक आपको पता न चले कि यह दवा आपको कैसे प्रभावित करती है, तब तक वाहन न चलाएं। यदि आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं, या स्तनपान करा रही हैं, तो डॉक्टर को बताएं।
💊 nobel spas rf 10mg/ml/25mg/ml injection Uses & Benefits
[{"condition":"Renal colic","description":"Provides rapid relief of severe flank pain caused by kidney stones by reducing both inflammation and ureteral spasm.","evidence":"Well-established"},{"condition":"Biliary colic","description":"Relieves pain and spasm associated with gallbladder stones or biliary dyskinesia.","evidence":"Well-established"},{"condition":"Severe menstrual cramps (dysmenorrhea)","description":"Reduces prostaglandin-driven uterine contractions and associated pain when oral therapy is not adequate.","evidence":"Well-established"},{"condition":"Post-operative pain with spasm","description":"Used for short-term management of moderate to severe pain after surgery when smooth muscle spasm contributes to discomfort.","evidence":"Moderate"},{"condition":"Acute musculoskeletal pain with spasm","description":"May be used for severe muscle spasm and pain following injury when injectable therapy is required.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Irritable bowel syndrome severe exacerbation","description":"Sometimes used off-label for short-term relief of severe abdominal cramping in irritable bowel syndrome when oral antispasmodics are insufficient.","evidence":"Limited"},{"condition":"Acute pancreatitis pain","description":"Occasionally used off-label for pain and spasm in acute pancreatitis, though evidence is limited and other treatments are preferred.","evidence":"Limited"}]
Primary treatment for: Acute pain with smooth muscle spasm
Also treats: Renal colic, Biliary colic, Dysmenorrhea, Post-operative pain, Musculoskeletal spasm
📋 Drug Information
| Generic Name(s) | Dicyclomine (10mg/ml) + Diclofenac (25mg/ml) |
| Brand Name | nobel spas rf 10mg/ml/25mg/ml injection |
| Manufacturer | Mankind Pharma Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Parenteral (intramuscular or intravenous injection) |
| Storage | Store in a cool, dry place at room temperature (15-30°C). Protect from light. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Dicyclomine is a synthetic antispasmodic that blocks muscarinic acetylcholine receptors on smooth muscle, reducing calcium influx and preventing excessive contraction. This relaxes the smooth muscle of the gastrointestinal, biliary, and genitourinary tracts, relieving spasm and cramping. Diclofenac is a nonsteroidal anti-inflammatory drug that reversibly inhibits cyclo-oxygenase-1 and cyclo-oxygenase-2 enzymes, decreasing the synthesis of prostaglandins, prostacyclin, and thromboxane. This reduces pain, inflammation, and fever. Together, the antispasmodic and anti-inflammatory effects provide rapid relief of pain associated with smooth muscle spasm and inflammation.
Mechanism Steps
💡 How to Take nobel spas rf 10mg/ml/25mg/ml injection
Strength: Each millilitre contains dicyclomine hydrochloride 10 mg and diclofenac sodium 25 mg. Available in 2 ml ampoules or vials.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 2 ml (containing dicyclomine 20 mg and diclofenac 50 mg) given by deep intramuscular injection, repeated every 6 to 8 hours if needed, up to a maximum of 4 ml (dicyclomine 40 mg and diclofenac 100 mg) in 24 hours. For intravenous use, the dose may be given slowly over 1 to 2 minutes. The exact dose and frequency must be individualized by a qualified clinician based on the indication, severity of pain, age, weight, renal and hepatic function, and response to treatment. This medicine is not for long-term use. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the anticholinergic effects of dicyclomine and the gastrointestinal and renal toxicity of diclofenac. Use the lowest effective dose for the shortest duration. Monitor closely for confusion, urinary retention, and gastrointestinal bleeding. |
| Renal Impairment | Use with caution in patients with renal impairment. Diclofenac can worsen kidney function. Dose reduction or avoidance may be necessary. Consult a clinician for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dicyclomine and diclofenac are metabolized in the liver. Dose reduction may be required. Monitor liver function. |
| Maximum Daily Dose | The maximum recommended daily dose is 4 ml (dicyclomine 40 mg and diclofenac 100 mg) in 24 hours, but this must be individualized by a clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nobel spas rf 10mg/ml/25mg/ml injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Major | |
| Other NSAIDs | Major | |
| Anticholinergics | Moderate | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Lithium | Moderate | |
| Metoclopramide | Moderate | |
| Digoxin | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (including aspirin)
- Methotrexate
- ACE inhibitors and angiotensin receptor blockers
- Potassium-sparing diuretics
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., atropine, antihistamines, tricyclic antidepressants)
- Metoclopramide
- Corticosteroids
- Selective serotonin reuptake inhibitors (SSRIs)
- Lithium
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine because it increases the risk of gastrointestinal bleeding, ulceration, and liver toxicity. Alcohol may also worsen dizziness and drowsiness caused by dicyclomine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active peptic ulcer disease or history of gastrointestinal bleeding","Severe heart failure","Severe kidney impairment","Severe liver impairment","Known hypersensitivity to dicyclomine, diclofenac, or other NSAIDs","Third trimester of pregnancy","Coronary artery bypass graft surgery (peri-operative period)","Myasthenia gravis","Paralytic ileus","Glaucoma (narrow-angle)","Urinary retention"]
⚠️ Warnings & Precautions
["Use with caution in elderly patients due to increased risk of anticholinergic effects and NSAID toxicity.","Avoid in patients with a history of asthma triggered by NSAIDs.","Monitor for signs of gastrointestinal bleeding, especially with concomitant use of corticosteroids or anticoagulants.","Use with caution in patients with cardiovascular risk factors.","Do not use for more than the recommended duration without medical review.","May cause drowsiness or blurred vision; avoid driving or operating machinery until effects are known.","Use with caution in patients with hepatic or renal impairment.","May worsen symptoms of benign prostatic hyperplasia or urinary retention."]
🤱 Lactation Safety
Dicyclomine may pass into breast milk and could cause anticholinergic effects in the infant. Diclofenac passes into breast milk in small amounts. This medicine should be used during breastfeeding only if clearly needed and under medical supervision.
💊 Overdose Management
Overdose of this medicine may cause severe anticholinergic symptoms (dry mouth, flushing, tachycardia, urinary retention, confusion, hallucinations) and NSAID toxicity (nausea, vomiting, gastrointestinal bleeding, kidney failure, seizures). Treatment is supportive and symptomatic. There is no specific antidote. If overdose is suspected, seek immediate medical attention. Gastric lavage may be considered if ingestion was recent and oral, but this is an injectable product. Monitor vital signs, kidney and liver function, and provide supportive care.
⏰ Missed Dose
This medicine is usually given as a single dose or as a short course in a healthcare setting. If you miss a scheduled dose, contact your healthcare provider for instructions. Do not attempt to self-administer an extra dose.
Additional Safety Advice
This medicine must be administered only by a qualified healthcare professional. Do not self-administer or use it without a prescription. Inform your doctor about all your medical conditions, especially stomach ulcers, kidney or liver disease, heart failure, asthma, glaucoma, urinary retention, and any allergies. Tell your doctor about all other medicines you take, including blood thinners, blood pressure medicines, antidepressants, and other pain relievers. Avoid alcohol while receiving this medicine because it increases the risk of stomach bleeding and liver problems. Do not drive or operate machinery until you know how this medicine affects you, as it can cause dizziness or blurred vision. If you are pregnant, planning pregnancy, or breastfeeding, inform your doctor before receiving this medicine. Do not use this medicine for more than the recommended duration without medical review. Report any black stools, vomiting blood, severe abdominal pain, reduced urine output, yellowing of eyes or skin, or unusual swelling immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of anticholinergic effects (confusion, urinary retention, constipation) and NSAID-related gastrointestinal and renal toxicity. Use the lowest effective dose for the shortest duration and monitor closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. Diclofenac should be avoided in the third trimester. Dicyclomine should be used only if clearly needed.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain with spasm, but it should not be used for peri-operative pain in coronary artery bypass graft surgery. Inform your surgeon and anesthesiologist about all medicines you are taking.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may increase bleeding risk during dental procedures. Your dentist may recommend stopping it temporarily or taking precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while receiving this medicine, especially if you have pain or spasm. Gentle stretching and walking may be beneficial, but consult your doctor before starting any exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause dizziness, drowsiness, and blurred vision, which may affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause dry mouth and constipation, which can be uncomfortable but manageable.
🛑 When to Stop This Medicine
This medicine is for short-term use only. Stop using it and consult your doctor if your symptoms improve or if you experience any serious side effects. Do not stop or change the dose without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended. Prolonged use of diclofenac can increase the risk of gastrointestinal bleeding, kidney impairment, liver toxicity, and cardiovascular events. Dicyclomine can cause persistent anticholinergic effects. Regular monitoring of kidney and liver function is advised if used for more than a few days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Oral medications can be used once acute symptoms subside.
Evidence: Well-establishedCan help manage chronic musculoskeletal pain and spasm.
Evidence: Well-establishedLocal heat application can relax tense muscles.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions known with this medicine. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use if solution is discolored or contains particles
✈️ Traveling with This Medicine
This medicine is an injectable prescription product and is typically administered in a healthcare setting. If you are traveling and need to carry it, keep it in its original packaging with the prescription label. Carry a copy of your prescription and a letter from your doctor explaining the medical need. Store it at room temperature (15-30°C) and protect it from light. Do not freeze. Check with the airline and customs about regulations for carrying injectable medicines. If you need a dose during travel, arrange for administration at a local clinic or hospital.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 15 to 30 minutes after injection.
A: It is given as an intramuscular or intravenous injection by a healthcare professional.
A: No, this medicine must be administered in a healthcare setting under medical supervision.
A: Common side effects include dry mouth, dizziness, nausea, and injection site pain.
A: It should be avoided in the third trimester. Consult your doctor if you are pregnant or planning pregnancy.
🤔 Common Patient Concerns
🔄 Substitutes for nobel spas rf 10mg/ml/25mg/ml injection
View AllAlternative brands with exact same active ingredient:
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dp-spas 10mg/ml/25mg/ml injectionSpeciality Meditech Pvt Ltd ₹8.20 56% CHEAPER
-
superspas rf injectionSeagull Pharmaceutical Pvt Ltd ₹19.90 6.8% COSTLIER
-
spasmo-proxyvon forte injectionWockhardt Ltd ₹27.00 44.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken at home like an oral painkiller.
Fact: This medicine is an injectable prescription medicine and must be administered by a healthcare professional in a clinical setting. - Myth: This medicine is safe for long-term use.
Fact: This medicine is intended for short-term use only. Prolonged use increases the risk of serious side effects. - Myth: This medicine can be used for any type of pain.
Fact: This medicine is specifically for pain associated with smooth muscle spasm and inflammation. It is not appropriate for all types of pain.
🔄 Alternative Options
Generic Alternatives
- Dicyclomine 10 mg/ml + Diclofenac 25 mg/ml injection (generic)
Brand Alternatives
- Nobel Spas RF 10mg/ml / 25mg/ml Injection