Nise Spas 10 Mg/50 Mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Yellowing of skin or eyes
- Dark urine or decreased urine output
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Unusual bleeding or bruising
- Chest pain or difficulty breathing
If experiencing severe symptoms, call emergency services immediately.
What is nise spas ds 10 mg/50 mg tablet used for?
This medicine is a combination of dicyclomine (an antispasmodic) and nimesulide (an NSAID) used for short-term relief of abdominal cramps and pain associated with conditions like irritable bowel syndrome. It works by relaxing gut muscles and reducing inflammation. It should be taken with food and only as prescribed.
- Generic Name: Dicyclomine (10mg) + Nimesulide (50mg)
- Manufacturer: Dr Reddy's Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nise spas ds 10 mg/50 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डाइसाइक्लोमिन और नाइमेसुलाइड का संयोजन है, जिसका उपयोग पेट की ऐंठन और दर्द के इलाज के लिए किया जाता है। यह चिड़चिड़ा आंत्र सिंड्रोम (IBS), पित्ताशय की ऐंठन, और मांसपेशियों की ऐंठन से जुड़े दर्द में राहत देती है। यह दवा केवल अल्पकालिक उपयोग के लिए है और इसे डॉक्टर के परामर्श के बिना नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, चक्कर आना, नींद आना, जी मिचलाना, और पेट में असहजता शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, लीवर की क्षति, और गुर्दे की समस्या शामिल हो सकती है। यदि आपको काला मल, उल्टी में खून, या त्वचा का पीलापन दिखे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब न लें। यदि आपको नींद या चक्कर आते हैं तो वाहन न चलाएँ। गर्भवती या स्तनपान कराने वाली महिलाएँ बिना डॉक्टर की सलाह के इस दवा का सेवन न करें। 7 दिनों से अधिक इसका उपयोग न करें।
💊 nise spas ds 10 mg/50 mg tablet Uses & Benefits
[{"condition":"Irritable bowel syndrome (IBS) with cramps","description":"Provides relief from abdominal pain and spasm associated with IBS.","evidence":"Moderate"},{"condition":"Biliary colic","description":"Helps relieve pain and spasm in the biliary tract.","evidence":"Limited"},{"condition":"Musculoskeletal spasm with pain","description":"Used for short-term relief of painful muscle spasms.","evidence":"Limited"},{"condition":"Renal colic","description":"May be used for pain relief in kidney stones, but evidence is limited.","evidence":"Limited"}]
Off-label uses: [{"condition":"Menstrual cramps (dysmenorrhea)","description":"Sometimes prescribed off-label for painful periods, but not first-line.","evidence":"Limited"},{"condition":"Gastroenteritis with cramping","description":"May be used off-label for symptomatic relief of cramping in infectious diarrhea, but not routinely recommended.","evidence":"Limited"}]
Primary treatment for: Irritable bowel syndrome with cramps
Also treats: Biliary colic, Musculoskeletal spasm, Renal colic
📋 Drug Information
| Generic Name(s) | Dicyclomine (10mg) + Nimesulide (50mg) |
| Brand Name | nise spas ds 10 mg/50 mg tablet |
| Manufacturer | Dr Reddy's Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Dicyclomine is an antimuscarinic and antispasmodic agent that blocks acetylcholine at muscarinic receptors on smooth muscle, reducing gastrointestinal motility and spasm. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits cyclooxygenase-2 (COX-2), decreasing the production of prostaglandins, which are mediators of pain, inflammation, and fever. Together, they provide relief from both spasm and pain.
Mechanism Steps
💡 How to Take nise spas ds 10 mg/50 mg tablet
Strength: Tablet containing dicyclomine 10 mg and nimesulide 50 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally one to three times daily, depending on the severity of symptoms and the prescribing doctor's judgment. The maximum recommended duration is typically 7 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially anticholinergic effects and NSAID-related gastrointestinal and kidney risks. Use with caution and at the lowest effective dose. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose adjustment may be necessary. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose adjustment may be necessary. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is not established from the available information. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nise spas ds 10 mg/50 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Anticholinergics | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| Methotrexate | Moderate | |
| Antacids | Minor | |
| Alcohol | Major |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, aspirin)
- Corticosteroids
- Anticholinergic drugs (e.g., antihistamines, tricyclic antidepressants)
⚡ Moderate Interactions
- ACE inhibitors / ARBs
- Diuretics
- Lithium
- Methotrexate
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulcers, and liver damage, especially when combined with nimesulide. It may also worsen drowsiness and dizziness caused by dicyclomine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to dicyclomine, nimesulide, or any component of the formulation","Active peptic ulcer disease or history of recurrent ulcers","Severe liver impairment","Severe kidney impairment","History of NSAID-induced asthma, urticaria, or allergic reactions","Third trimester of pregnancy","Breastfeeding","Children under 12 years","Patients with myasthenia gravis","Patients with obstructive uropathy or gastrointestinal obstruction"]
⚠️ Warnings & Precautions
["Use with caution in elderly patients due to increased risk of side effects.","Avoid in patients with cardiovascular risk factors.","Do not use for more than 7 days without medical advice.","May cause drowsiness; avoid driving or operating machinery.","May cause dry mouth and constipation; maintain hydration.","Do not take with other NSAIDs or alcohol.","Consult doctor if symptoms persist or worsen."]
🤱 Lactation Safety
Not established from the available information. Dicyclomine and nimesulide may pass into breast milk. This medicine is not recommended during breastfeeding. Consult your doctor for alternative treatments.
💊 Overdose Management
Overdose may cause severe anticholinergic symptoms (e.g., dry mouth, blurred vision, tachycardia, urinary retention, confusion) and NSAID-related effects (e.g., nausea, vomiting, gastrointestinal bleeding, kidney impairment). Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs, electrolytes, and kidney function.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine, as it can increase the risk of gastrointestinal bleeding and liver problems. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Inform your doctor if you have a history of stomach ulcers, liver disease, kidney disease, asthma, or bleeding disorders. Do not take other pain relievers or NSAIDs without consulting your doctor. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before taking this medicine. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more susceptible to the side effects of this medicine, especially anticholinergic effects (confusion, dry mouth, constipation, urinary retention) and NSAID-related risks (gastrointestinal bleeding, kidney impairment). Use with caution and at the lowest effective dose. Regular monitoring of kidney and liver function is advised.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. If you are trying to conceive, consult your doctor for safer alternatives. Nimesulide may interfere with ovulation and is contraindicated in the third trimester.
🏥 Post-Surgery Considerations
Consult your doctor before taking this medicine after surgery, as it may increase the risk of bleeding and interfere with wound healing. It may also interact with other medications used post-operatively.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure, as it may increase the risk of bleeding. Your dentist may advise you to stop it temporarily.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you feel dizzy or drowsy. Listen to your body and rest if you experience abdominal pain or discomfort. Consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness and dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause dry mouth, so keep water handy. Inform your employer if your work requires alertness.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects such as blood in stool, yellowing of eyes, or severe abdominal pain. Do not stop abruptly if you have been on long-term therapy without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of serious side effects, including liver damage, kidney impairment, and gastrointestinal bleeding. If long-term use is necessary, regular monitoring of liver and kidney function is advised. Consult your doctor for alternative treatments if symptoms persist.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help relieve muscle spasms and improve mobility.
Evidence: Well-establishedA low-FODMAP diet can help manage IBS symptoms.
Evidence: ModerateYoga, meditation, and counseling can reduce stress-related cramps.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, continue your regular dosing schedule as prescribed. Check local customs regulations regarding prescription medicines. Do not leave it in a hot car or checked luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving cramps within 1-2 hours after taking it.
A: It is best taken with food or milk to reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: It can interact with several medicines, including blood thinners, other NSAIDs, and certain antidepressants. Always inform your doctor about all medicines you are taking.
🤔 Common Patient Concerns
🔄 Substitutes for nise spas ds 10 mg/50 mg tablet
View AllAlternative brands with exact same active ingredient:
-
nimad d 10mg/50mg oral dropsAdore Healthcare ₹18.75 44.6% CHEAPER
-
nise spas 10 mg/50 mg tabletDr Reddy's Laboratories Ltd ₹25.39 25% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any type of pain.
Fact: This medicine is specifically for cramping and pain associated with gastrointestinal or musculoskeletal spasm. It is not a general pain reliever. - Myth: It is safe to take this medicine for long periods.
Fact: This medicine should only be used short-term (usually up to 7 days) due to risks of liver and kidney damage. - Myth: This medicine is safe during pregnancy.
Fact: This medicine is not recommended during pregnancy, especially in the third trimester, due to potential risks to the fetus.
🔄 Alternative Options
Generic Alternatives
- Dicyclomine + Nimesulide combination (generic)
Brand Alternatives
- Nise Spas 10 mg/50 mg Tablet