nelsid d 20 mg/100 mg tablet - Dicyclomine (20mg) + Nimesulide (100mg) medicine

Arsulide D 20 mg/100 mg Tablet: Complete Medicine Guide

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🏭 Ind Swift Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. However, NSAIDs like nimesulide are generally avoided during pregnancy, especially in the third trimester, due to risk of premature closure of ductus arteriosus and kidney problems in the fetus. Dicyclomine is not recommended in pregnancy unless clearly needed. Consult your doctor. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for short-term use in acute painful conditions.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bruising or bleeding

If experiencing severe symptoms, call emergency services immediately.

What is nelsid d 20 mg/100 mg tablet used for?

This medicine is a combination of dicyclomine (an antispasmodic) and nimesulide (an NSAID) used for short-term relief of acute abdominal cramps and musculoskeletal pain. It works by relaxing smooth muscles and reducing inflammation. It should be taken with food and not for prolonged periods.

  • Generic Name: Dicyclomine (20mg) + Nimesulide (100mg)
  • Manufacturer: Ind Swift Laboratories Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 nelsid d 20 mg/100 mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा डाइसाइक्लोमिन और नाइमसुलाइड का संयोजन है, जिसका उपयोग पेट की ऐंठन, मरोड़ और दर्द के इलाज के लिए किया जाता है। यह मांसपेशियों को आराम देती है और सूजन को कम करती है। यह अक्सर चिड़चिड़ा आंत्र सिंड्रोम (IBS), पेट दर्द, और मासिक धर्म के दर्द में राहत के लिए दी जाती है। इसे डॉक्टर की सलाह के अनुसार ही लें और खाने के साथ लें।

साइड इफेक्ट्स: आम दुष्प्रभावों में मुंह सूखना, चक्कर आना, नींद आना, जी मिचलाना, पेट दर्द, और दस्त शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, अल्सर, किडनी की समस्या, लीवर की समस्या, और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको काला मल, खून की उल्टी, तेज पेट दर्द, आंखों या त्वचा का पीलापन, या पेशाब कम आना जैसे लक्षण दिखें तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को खाने के साथ या दूध के साथ लें ताकि पेट में जलन न हो। शराब न पिएं क्योंकि इससे पेट में रक्तस्राव का खतरा बढ़ सकता है। यदि आपको चक्कर या नींद आती है तो वाहन न चलाएं। गर्भवती या स्तनपान कराने वाली महिलाएं बिना डॉक्टर की सलाह के इस दवा का सेवन न करें। बच्चों को यह दवा न दें। डॉक्टर द्वारा बताई गई अवधि से ज्यादा इसका इस्तेमाल न करें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 nelsid d 20 mg/100 mg tablet Uses & Benefits

[{"condition":"Acute abdominal cramps","description":"Relieves painful spasms of the gastrointestinal tract, often associated with irritable bowel syndrome or gastroenteritis.","evidence":"Well-established"},{"condition":"Irritable bowel syndrome (IBS)","description":"Helps reduce abdominal pain and cramping by relaxing smooth muscles and reducing inflammation.","evidence":"Moderate"},{"condition":"Musculoskeletal pain","description":"Provides short-term relief of pain and inflammation in conditions like muscle strains and sprains.","evidence":"Moderate"},{"condition":"Dysmenorrhea","description":"May help relieve menstrual cramps due to antispasmodic and anti-inflammatory effects.","evidence":"Limited"}]

Off-label uses: [{"condition":"Biliary colic","description":"Sometimes used off-label to relieve pain from gallbladder spasms.","evidence":"Limited"},{"condition":"Urinary tract spasms","description":"May be used off-label to reduce bladder spasms.","evidence":"Limited"}]

Primary treatment for: Acute abdominal cramps associated with smooth muscle spasm

Also treats: Irritable bowel syndrome, Musculoskeletal pain, Dysmenorrhea

📋 Drug Information

Generic Name(s)Dicyclomine (20mg) + Nimesulide (100mg)
Brand Namenelsid d 20 mg/100 mg tablet
ManufacturerInd Swift Laboratories Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine with food or milk to minimize stomach irritation.
2
Do not exceed the prescribed dose or duration; long-term use increases the risk of serious side effects.
3
Avoid alcohol and other NSAIDs while taking this medicine to prevent gastrointestinal bleeding.
4
If you experience dizziness or drowsiness, avoid driving or operating heavy machinery.
5
Inform your doctor if you have a history of kidney or liver disease, ulcers, or heart problems before taking this medicine.
6
Stay well hydrated throughout the day to help your kidneys flush out the medicine.
7
Do not use this medicine for more than 7 days without consulting your doctor.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Abdominal cramps
This medicine is commonly prescribed for this.
Likely Use
✅
Muscle spasms
This medicine helps relax smooth muscles.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
❌
Headache
This medicine is not typically used for headaches.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDicyclomine is well absorbed from the gastrointestinal tract. Nimesulide is rapidly and completely absorbed after oral administration. Food may slightly delay absorption but does not significantly affect the extent.
DistributionDicyclomine is widely distributed in body tissues. Nimesulide is highly protein-bound and distributes extensively into tissues, including synovial fluid.
Protein BindingDicyclomine: approximately 98% bound to plasma proteins. Nimesulide: approximately 99% bound to plasma proteins, primarily albumin.
MetabolismDicyclomine is metabolized in the liver via oxidation and conjugation. Nimesulide is extensively metabolized in the liver, primarily by CYP2C9, to several metabolites, including 4-hydroxynimesulide, which is pharmacologically active.
Half-LifeDicyclomine: approximately 1.8 hours. Nimesulide: approximately 3.5 to 4.5 hours.
ExcretionDicyclomine is excreted mainly in urine and feces. Nimesulide metabolites are excreted primarily in urine and to a lesser extent in feces.
BioavailabilityDicyclomine: approximately 50-60% due to first-pass metabolism. Nimesulide: approximately 90% after oral administration.
Onset of ActionDicyclomine: within 1-2 hours. Nimesulide: within 30-60 minutes.
Peak Plasma TimeDicyclomine: 1-2 hours. Nimesulide: 1.5-3 hours.
Duration of ActionDicyclomine: 4-6 hours. Nimesulide: 6-8 hours.

How It Works

This medicine combines two active ingredients. Dicyclomine blocks muscarinic acetylcholine receptors in the gastrointestinal tract, reducing smooth muscle contractions and spasms. Nimesulide selectively inhibits cyclooxygenase-2 (COX-2) enzyme, decreasing the production of prostaglandins, which are mediators of pain, inflammation, and fever. Together, they provide antispasmodic and anti-inflammatory effects.

Mechanism Steps

1
Dicyclomine blocks muscarinic receptors: Dicyclomine competitively inhibits acetylcholine at muscarinic receptors on smooth muscle cells, preventing muscle contraction and reducing spasms.
2
Nimesulide inhibits COX-2: Nimesulide selectively binds to and inhibits the COX-2 enzyme, blocking the conversion of arachidonic acid to prostaglandins.
3
Reduced prostaglandin synthesis: Lower prostaglandin levels decrease pain signaling, inflammation, and fever.
4
Combined effect: The antispasmodic action of dicyclomine and anti-inflammatory action of nimesulide work together to relieve pain and cramping.

💡 How to Take nelsid d 20 mg/100 mg tablet

Strength: Tablet containing Dicyclomine 20 mg and Nimesulide 100 mg.

1Take the tablet orally with a full glass of water.
2Take it with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Take at the same time each day to maintain consistent levels.
5Do not take more than the prescribed dose.
6If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally one to two times daily, or as directed by a physician. The dose may vary based on the condition being treated and the patient's response. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially anticholinergic effects and gastrointestinal bleeding. Use with caution and lower doses may be appropriate. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a doctor. Not recommended in severe renal impairment.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be necessary. Avoid in severe hepatic impairment.
Maximum Daily DoseThe maximum recommended daily dose is 2 tablets (Dicyclomine 40 mg + Nimesulide 200 mg). Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and gastrointestinal irritation.
Alcohol
Avoid
Increases risk of gastrointestinal bleeding and liver toxicity.
Grapefruit juice
Avoid
May increase drug levels by affecting liver enzymes.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of nelsid d 20 mg/100 mg tablet

✅ Common Side Effects

Dry mouth (Common (10-30%))
Sip water, chew sugar-free gum, or use saliva substitutes. Consult doctor if persistent.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you. Lie down if needed.
Drowsiness (Common (5-10%))
Avoid alcohol and activities requiring alertness. Usually resolves with continued use.
Nausea (Common (5-10%))
Take with food or milk. If persistent, consult doctor.
Stomach pain (Common (5-10%))
Take with food. Avoid spicy foods. Consult doctor if severe.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black, tarry stools, vomiting blood, or severe abdominal pain.
Peptic ulcer (Rare (<0.1%))
Report persistent stomach pain or heartburn to your doctor immediately.
Liver toxicity (Rare (<0.1%))
Seek medical help if you develop yellowing of skin or eyes, dark urine, or severe fatigue.
Kidney impairment (Rare (<0.1%))
Report decreased urine output, swelling, or fatigue to your doctor.
Severe allergic reaction (Rare (<0.1%))
Seek emergency care if you experience rash, itching, swelling of face/lips/throat, or difficulty breathing.

⚠️ Rare Side Effects

Blood disorders (e.g., agranulocytosis, thrombocytopenia)
Report unusual bruising, bleeding, or signs of infection to your doctor.
Pancreatitis
Seek immediate care for severe upper abdominal pain radiating to back.
Aseptic meningitis
Seek emergency care for severe headache, stiff neck, fever, and sensitivity to light.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Corticosteroids Major
Anticholinergics Major
ACE inhibitors/ARBs Moderate
Diuretics Moderate
Lithium Moderate
Methotrexate Moderate
Antacids Minor
Alcohol Major

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., ibuprofen, aspirin)
  • Corticosteroids
  • Anticholinergics (e.g., atropine, antihistamines)

⚡ Moderate Interactions

  • ACE inhibitors, ARBs
  • Diuretics
  • Lithium
  • Methotrexate

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulcers, and liver toxicity. It may also worsen dizziness and drowsiness.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to dicyclomine, nimesulide, or any component of the formulation","Active peptic ulcer or history of recurrent ulcers","Severe liver impairment","Severe kidney impairment","Inflammatory bowel disease (e.g., ulcerative colitis, Crohn's disease)","Severe heart failure","Children below 12 years of age","Pregnancy (especially third trimester)","Breastfeeding"]

⚠️ Warnings & Precautions

["Take with food to reduce stomach upset.","Avoid alcohol and other NSAIDs.","Do not drive or operate machinery if you experience dizziness or drowsiness.","Use with caution in elderly patients due to increased risk of side effects.","Inform your doctor if you have a history of kidney or liver disease, asthma, or heart problems.","Do not use for longer than prescribed without medical advice.","Stop and consult a doctor if you experience signs of gastrointestinal bleeding, liver problems, or allergic reactions."]

🤱 Lactation Safety

Not established from the available information. Dicyclomine may pass into breast milk and could cause anticholinergic effects in the infant. Nimesulide is not recommended during breastfeeding. Consult your doctor before use.

💊 Overdose Management

Overdose may cause severe abdominal pain, nausea, vomiting, drowsiness, dry mouth, blurred vision, and increased heart rate. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs and provide supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine with food or milk to reduce stomach upset. Do not exceed the recommended dose or duration. Avoid alcohol as it increases the risk of stomach bleeding. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Inform your doctor if you have a history of ulcers, kidney or liver disease, asthma, or heart problems. Do not take other NSAIDs or pain relievers without consulting your doctor. Stay well hydrated. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before taking this medicine. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more susceptible to the side effects of this medicine, especially anticholinergic effects (dry mouth, constipation, urinary retention) and gastrointestinal bleeding. Use with caution and lower doses may be appropriate. Regular monitoring of kidney and liver function is recommended.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended during pregnancy or when planning pregnancy. NSAIDs like nimesulide can affect ovulation and may increase the risk of miscarriage. Consult your doctor for alternative treatments if you are planning pregnancy.

🏥 Post-Surgery Considerations

This medicine may increase the risk of bleeding and interfere with wound healing after surgery. Consult your surgeon before taking this medicine post-surgery. Alternative pain management options may be recommended.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure, as it may increase the risk of bleeding. Your dentist may advise you to stop the medicine temporarily before surgery.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on your joints and muscles.
🥗
Regular low-impact exercise like swimming or walking can help improve muscle strength and reduce cramps.
😴
Practice good posture to prevent musculoskeletal pain.
💧
Include anti-inflammatory foods in your diet, such as fruits, vegetables, and omega-3 rich fish.
🧘
Get adequate sleep to help your body recover.
🌞
Manage stress through relaxation techniques like deep breathing or meditation.

🏋️ Exercise Considerations

Avoid strenuous exercise or heavy lifting while taking this medicine, especially if you experience dizziness or drowsiness. Gentle stretching and low-impact activities are generally safe. Consult your doctor before starting any new exercise routine.

🥗 Diet Recommendations

Include omega-3 rich foods like salmon, flaxseeds, and walnuts.
Reduce intake of processed and spicy foods that can irritate the stomach.
Stay well hydrated by drinking plenty of water.
Eat small, frequent meals to ease digestion.
Avoid alcohol and caffeine as they can worsen stomach irritation.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is advisable to take rest if you experience abdominal cramps or muscle pain. Inform your employer if your work involves operating heavy machinery.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor immediately if you experience any serious side effects such as blood in stool, severe abdominal pain, yellowing of skin or eyes, decreased urine output, or allergic reactions. Do not stop taking this medicine without consulting your doctor if you are on a prescribed course.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended due to the risk of serious side effects such as gastrointestinal bleeding, ulcers, kidney impairment, and liver toxicity. If you need to take it for more than 7 days, your doctor should monitor your liver and kidney function regularly. Always consult your doctor before extending the duration of treatment.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain and muscle spasms.

Evidence: Well-established
Heat or cold therapy

Applying heat or cold packs can help relieve muscle spasms and pain.

Evidence: Moderate
Dietary modifications

Avoiding trigger foods can help manage IBS symptoms.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Not established from the available information. There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while taking this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, adjust dosing times gradually as advised by your doctor. Check local customs regulations regarding prescription medicines. Always carry enough supply for your trip.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with irritable bowel syndrome (IBS)
She experienced frequent abdominal cramps and bloating. Her doctor prescribed this medicine for short-term relief. She took it with food twice daily for 5 days and noticed significant reduction in cramping. She also made dietary changes and practiced stress management. She was advised not to take it long-term.
💡 Lesson: This medicine can provide effective short-term relief for IBS-related cramps when taken as prescribed and with food. Lifestyle modifications are also important.
👤 A 50-year-old man with acute muscle strain
He injured his back while lifting heavy objects and had severe muscle spasms. He was prescribed this medicine for 3 days. He took it with meals and avoided alcohol. His pain and spasms improved within 2 days. He was advised to rest and apply ice packs.
💡 Lesson: This medicine can help relieve acute musculoskeletal pain and spasms, but it should be used for a short duration along with rest and physical therapy.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain and cramps within 1-2 hours after taking it.

Q: Can I take this medicine on an empty stomach?

A: It is best to take this medicine with food or milk to reduce the risk of stomach upset and ulcers.

Q: Is it safe to take this medicine with other painkillers?

A: Do not take other NSAIDs or painkillers without consulting your doctor, as it may increase the risk of side effects.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for nelsid d 20 mg/100 mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken long-term for chronic pain.
    Fact: This medicine is for short-term use only. Long-term use increases the risk of serious side effects like gastrointestinal bleeding and liver toxicity.
  • Myth: It is safe to take this medicine without food.
    Fact: Taking this medicine without food increases the risk of stomach upset and ulcers. Always take it with food or milk.
  • Myth: This medicine is safe during pregnancy.
    Fact: This medicine is not recommended during pregnancy, especially in the third trimester, due to potential harm to the fetus.

🔄 Alternative Options

Generic Alternatives

  • Dicyclomine + Nimesulide combination tablets from other manufacturers

Brand Alternatives

  • Arsulide D 20 mg/100 mg Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Dicyclomine + Nimesulide","composition":"Dicyclomine 20 mg + Nimesulide 100 mg","uses":"Abdominal cramps, musculoskeletal pain","notes":"Combination provides antispasmodic and anti-inflammatory effects."},{"medicine":"Dicyclomine + Paracetamol","composition":"Dicyclomine 20 mg + Paracetamol 500 mg","uses":"Abdominal cramps, pain, fever","notes":"Paracetamol is safer for liver but less anti-inflammatory."},{"medicine":"Dicyclomine alone","composition":"Dicyclomine 20 mg","uses":"Abdominal cramps","notes":"No anti-inflammatory effect."}]

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