AD 150mg/100mg Suspension: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Seizures or convulsions
- Severe allergic reaction (swelling of face, lips, throat, difficulty breathing)
- Bloody diarrhea or severe abdominal pain
- Visual disturbances (blurred vision, color changes)
- Numbness or tingling in hands or feet
- Unusual bruising or bleeding
- Yellowing of skin or eyes (jaundice)
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is mexigyl suspension used for?
This medicine is a prescription oral suspension containing nalidixic acid and metronidazole, used for specific bacterial and protozoal infections. It works by killing susceptible microorganisms. It must be taken exactly as prescribed, and alcohol must be avoided.
- Generic Name: Nalidixic Acid (150mg) + Metronidazole (100mg)
- Manufacturer: Medicaman Biotech Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 mexigyl suspension के बारे में (Hindi Summary)
उपयोग: यह दवा नालिडिक्सिक एसिड और मेट्रोनिडाजोल का संयोजन है, जिसका उपयोग कुछ विशिष्ट जीवाणु और प्रोटोज़ोआ संक्रमणों के इलाज के लिए किया जाता है। यह आमतौर पर पेट और मूत्र मार्ग के संक्रमणों में दी जाती है, लेकिन यह हर तरह के संक्रमण के लिए प्रभावी नहीं है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट में असहजता, सिरदर्द, चक्कर आना और मुँह में धातु जैसा स्वाद शामिल हैं। कुछ मामलों में दौरे, हाथ-पैरों में झुनझुनी, दृष्टि में बदलाव, और त्वचा पर रैश जैसी गंभीर समस्याएँ भी हो सकती हैं। अगर कोई भी असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। बोतल को अच्छी तरह हिलाकर ही मापें। शराब का सेवन बिल्कुल न करें, क्योंकि इससे गंभीर प्रतिक्रिया हो सकती है। धूप में जाने से बचें और सनस्क्रीन का उपयोग करें। अगर आपको दौरे, लीवर या किडनी की समस्या है, तो डॉक्टर को बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं बिना डॉक्टर की सलाह के इसका सेवन न करें।
💊 mexigyl suspension Uses & Benefits
[{"condition":"Gastrointestinal infections caused by susceptible anaerobic bacteria","description":"This medicine may be used to treat certain gut infections where both nalidixic acid and metronidazole are expected to be effective, though nalidixic acid has limited modern utility.","evidence":"Limited"},{"condition":"Urinary tract infections caused by susceptible Gram-negative bacteria","description":"Nalidixic acid component has historically been used for uncomplicated urinary tract infections, but resistance is common and safer alternatives are preferred.","evidence":"Limited"},{"condition":"Protozoal infections such as giardiasis or amoebiasis (when combined with metronidazole)","description":"Metronidazole is effective against certain protozoa, and the combination may be prescribed in specific mixed infections, but this is not a standard first-line approach.","evidence":"Limited"}]
Off-label uses: []
Primary treatment for: Mixed bacterial and protozoal infections of the gastrointestinal or urinary tract (specific indications determined by clinician)
Also treats: Giardiasis, Amoebiasis, Urinary tract infections
📋 Drug Information
| Generic Name(s) | Nalidixic Acid (150mg) + Metronidazole (100mg) |
| Brand Name | mexigyl suspension |
| Manufacturer | Medicaman Biotech Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, protected from light. Do not freeze. Shake well before use. Keep the bottle tightly closed. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the label. |
| WHO Guideline | Not established from the available information. This combination is not a standard first-line therapy in current WHO guidelines for common infections. |
| ICMR Guideline | Not established from the available information. ICMR guidelines do not routinely recommend this combination due to limited efficacy and safety concerns. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antimicrobial agents with distinct mechanisms. Nalidixic acid inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair, leading to bacterial cell death. Metronidazole enters anaerobic organisms and protozoa, where its nitro group is reduced to reactive intermediates that damage DNA and disrupt helical structure, causing cell death. The combination targets both aerobic Gram-negative bacteria (nalidixic acid) and anaerobic bacteria/protozoa (metronidazole), though nalidixic acid's spectrum is limited and resistance is widespread.
Mechanism Steps
💡 How to Take mexigyl suspension
Strength: Each 5 mL of suspension contains nalidixic acid 150 mg and metronidazole 100 mg.
Dosage Information
| Adult Dosage | The adult dosage of this medicine must be individualized by a qualified clinician based on the specific indication, severity of infection, age, weight, renal and hepatic function. Typically, nalidixic acid is dosed at 500 mg to 1 g every 6 hours, and metronidazole at 250-500 mg every 8 hours, but this fixed-dose suspension contains lower amounts per 5 mL. Therefore, the exact volume and frequency must be determined by your doctor. Do not self-adjust the dose. Complete the full course as prescribed. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine may not be appropriate for children due to the risk of serious side effects, including seizures and tendon problems. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness, seizures, and blood disorders. Dose adjustment may be necessary based on renal and hepatic function. Consult your doctor. |
| Renal Impairment | In patients with renal impairment, dose reduction may be required, especially for nalidixic acid, which is excreted renally. Monitor renal function and adjust dose as prescribed by your doctor. |
| Hepatic Impairment | In patients with hepatic impairment, metronidazole metabolism may be reduced, increasing the risk of toxicity. Dose adjustment may be necessary. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose must be determined by a qualified clinician based on the individual patient's condition and response. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of mexigyl suspension
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Phenytoin | Major | |
| Lithium | Major | |
| Cimetidine | Moderate | |
| Antacids | Moderate | |
| Oral contraceptives | Moderate |
🚨 Major Interactions
- Warfarin
- Alcohol
- Phenytoin
- Lithium
⚡ Moderate Interactions
- Cimetidine
- Antacids containing magnesium or aluminum
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 48 hours after the last dose. Metronidazole can cause a disulfiram-like reaction characterized by severe nausea, vomiting, flushing, headache, and rapid heartbeat. This reaction can be dangerous and requires immediate medical attention if it occurs.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nalidixic acid, metronidazole, or other quinolones/nitroimidazoles","History of seizures or convulsive disorders","Severe hepatic impairment","Severe renal impairment","Pregnancy (especially first trimester) unless clearly needed","Breastfeeding","Use of alcohol or disulfiram within the past 2 weeks"]
⚠️ Warnings & Precautions
["May cause seizures, especially in patients with a history of epilepsy or those taking certain medications.","Can cause peripheral neuropathy; report numbness or tingling.","May cause photosensitivity; avoid prolonged sun exposure and use sunscreen.","Can cause visual disturbances; avoid driving if affected.","May cause blood disorders; monitor if symptoms occur.","Avoid alcohol completely during and for 48 hours after treatment.","Use with caution in elderly patients and those with liver or kidney disease.","Do not use for viral infections; it is ineffective.","Complete the full course as prescribed to prevent resistance."]
🤱 Lactation Safety
Metronidazole is excreted in breast milk and may affect the nursing infant. Nalidixic acid is also excreted in breast milk. Breastfeeding is generally not recommended while taking this medicine. Consult your doctor for guidance.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, dizziness, and potentially seizures. There is no specific antidote. Treatment is supportive and symptomatic. If overdose is suspected, seek immediate medical attention. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs and neurological status.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, using a proper measuring device to ensure the correct dose. Shake the bottle well before each use because it is a suspension. Do not skip doses or stop the course early, even if you feel better, as this can lead to incomplete treatment and bacterial resistance. Avoid alcohol completely while taking this medicine and for at least 48 hours after the last dose, because it can cause a severe reaction. Limit sun exposure and use sunscreen, as this medicine can make your skin more sensitive to sunlight. Inform your doctor if you have a history of seizures, liver or kidney problems, or blood disorders. Do not drive or operate heavy machinery if you feel dizzy or have vision changes. Keep this medicine out of reach of children and store it as directed on the label. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to side effects such as dizziness, seizures, and blood disorders. They may also have reduced kidney and liver function, requiring dose adjustments. Close monitoring is advised. Consult your doctor for appropriate dosing.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy, especially in the first trimester, unless clearly needed. If you are planning pregnancy, consult your doctor before taking this medicine. Effective contraception should be used during treatment. Discuss alternative treatments with your doctor.
🏥 Post-Surgery Considerations
If you have recently undergone surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with other medications used during surgery. Your doctor will decide whether to continue or temporarily stop the medicine.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may interact with other medications or affect healing. Your dentist may recommend postponing elective procedures until you complete the course.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, especially if you experience dizziness, fatigue, or muscle weakness. Nalidixic acid can rarely cause tendon problems, so stop exercising and consult your doctor if you feel sudden joint pain or swelling.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, headache, or visual disturbances, which can affect your ability to drive or operate machinery. Avoid driving or operating heavy machinery until you know how this medicine affects you. If your work involves operating machinery or requires high alertness, inform your employer and take necessary precautions. Most people can continue their normal daily activities with caution.
🛑 When to Stop This Medicine
Stop taking this medicine and contact your doctor immediately if you experience seizures, severe allergic reactions, visual disturbances, numbness or tingling in hands or feet, unusual bruising or bleeding, or yellowing of skin or eyes. Do not stop the medicine without consulting your doctor, as completing the full course is important to prevent recurrence and resistance.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of serious side effects such as peripheral neuropathy, seizures, and blood disorders. Prolonged use may also lead to bacterial resistance. Regular monitoring of liver and kidney function may be required if extended therapy is necessary. Always consult your doctor before using this medicine for more than the prescribed duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A more precise approach using specific antibiotics for the identified pathogen, which may be safer and more effective.
Evidence: Well-establishedCan help restore gut flora during and after antibiotic treatment, but should be taken at least 2 hours apart from the antibiotic.
Evidence: ModerateEssential for managing diarrhea and preventing dehydration, regardless of the cause.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. There are no known interactions between this medicine and vaccines. However, if you are scheduled for a vaccine, inform your doctor that you are taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container with cap tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and heat
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Shake well before each use
❌ DON'T
Do not use if the suspension has changed color or consistency
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case of customs checks. Store it at room temperature and protect it from extreme heat or cold. If crossing time zones, adjust dosing times gradually as advised by your doctor. Always pack it in your carry-on luggage to avoid loss. Do not expose to direct sunlight.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but you must complete the full course as prescribed. If symptoms persist or worsen, contact your doctor.
A: Yes, taking it with food can help reduce stomach upset. However, try to take it consistently with or without food.
A: If you remember within a short time, take it. If it is almost time for your next dose, skip the missed dose and continue your regular schedule. Do not double dose.
A: No, alcohol must be completely avoided during treatment and for at least 48 hours after the last dose, as it can cause a severe reaction.
A: No, you must complete the full course as prescribed to prevent the infection from returning and to reduce the risk of resistance.
🤔 Common Patient Concerns
🔄 Substitutes for mexigyl suspension
View AllAlternative brands with exact same active ingredient:
-
ad 150mg/100mg suspensionVeritaz Healthcare Ltd ₹10.22 20.5% CHEAPER
-
matrix mn suspensionMacleods Pharmaceuticals Pvt Ltd ₹11.10 13.6% CHEAPER
-
betadix syrupAgron Remedies Pvt Ltd ₹12.00 6.6% CHEAPER
-
bactomet 150mg/100mg suspensionWin-Medicare Pvt Ltd ₹22.72 76.8% COSTLIER
-
gramoneg m 150 mg/100 mg suspensionSun Pharmaceutical Industries Ltd ₹22.86 77.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any stomach infection.
Fact: It is only effective against specific susceptible bacteria and protozoa. It does not work for viral infections or all types of diarrhea. - Myth: I can stop taking this medicine once I feel better.
Fact: You must complete the full course as prescribed to prevent recurrence and resistance, even if symptoms improve. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol can cause a severe disulfiram-like reaction with metronidazole. It must be avoided completely during and for 48 hours after treatment.
🔄 Alternative Options
Generic Alternatives
- Nalidixic acid + metronidazole suspension (generic equivalents may be available)