Alphalan 50mg Injection: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fever, chills, or signs of infection
- Unusual bleeding or bruising
- Shortness of breath or difficulty breathing
- Severe abdominal pain or diarrhea
- Yellowing of skin or eyes
- Decreased urine output
- Severe allergic reaction (rash, swelling, difficulty breathing)
If experiencing severe symptoms, call emergency services immediately.
What is melphater 50mg injection used for?
This medicine is a chemotherapy drug used to treat multiple myeloma and certain other cancers. It works by damaging the DNA of cancer cells, preventing them from growing and dividing. It is given by injection under medical supervision.
- Generic Name: Melphalan (50mg)
- Manufacturer: Therdose Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 melphater 50mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा मेल्फलान 50 मिलीग्राम इंजेक्शन के रूप में एक कीमोथेरेपी दवा है, जिसका उपयोग मल्टीपल मायलोमा और कुछ अन्य कैंसर के इलाज के लिए किया जाता है। यह कैंसर कोशिकाओं के डीएनए को नुकसान पहुंचाकर उन्हें बढ़ने और विभाजित होने से रोकती है। यह दवा डॉक्टर की देखरेख में इंजेक्शन के माध्यम से दी जाती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, दस्त, भूख न लगना, मुंह के छाले, थकान और बालों का झड़ना शामिल हैं। गंभीर दुष्प्रभावों में अस्थि मज्जा का दमन, जिससे एनीमिया, संक्रमण का खतरा और रक्तस्राव की समस्या हो सकती है, शामिल हैं। यदि आपको कोई गंभीर लक्षण महसूस हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर की देखरेख में दी जानी चाहिए। नियमित रक्त परीक्षण आवश्यक हैं। संक्रमण वाले लोगों से संपर्क से बचें। इस दवा के दौरान जीवित टीके न लगवाएं। उपचार के दौरान और उसके बाद कुछ समय तक प्रभावी गर्भनिरोधक उपायों का उपयोग करें। पर्याप्त तरल पदार्थ पिएं। संक्रमण, असामान्य रक्तस्राव या चोट के किसी भी लक्षण की तुरंत रिपोर्ट करें।
💊 melphater 50mg injection Uses & Benefits
[{"condition":"Multiple myeloma","description":"Used as part of combination therapy to treat multiple myeloma, a cancer of plasma cells.","evidence":"Well-established"},{"condition":"Ovarian cancer","description":"Sometimes used in the treatment of ovarian cancer, especially in regional perfusion.","evidence":"Established"},{"condition":"Breast cancer","description":"May be used in certain cases of breast cancer, often in clinical trials or specific protocols.","evidence":"Limited"},{"condition":"Polycythemia vera","description":"Rarely used to treat polycythemia vera, a blood disorder.","evidence":"Limited"}]
Off-label uses: [{"condition":"Amyloidosis","description":"Sometimes used off-label to treat amyloidosis, a rare disease where abnormal proteins build up in organs.","evidence":"Limited"},{"condition":"Multiple sclerosis","description":"Investigated in some studies for multiple sclerosis but not standard.","evidence":"Experimental"}]
Primary treatment for: Multiple myeloma
Also treats: Ovarian cancer, Breast cancer, Polycythemia vera
📋 Drug Information
| Generic Name(s) | Melphalan (50mg) |
| Brand Name | melphater 50mg injection |
| Manufacturer | Therdose Pharma Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Alkylating agent |
| Route of Administration | Parenteral (intravenous infusion or regional perfusion) |
| Storage | Store refrigerated at 2°C to 8°C (36°F to 46°F). Protect from light. Do not freeze. Keep in original packaging. |
| Shelf Life | Refer to the product label for the expiration date. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Melphalan is an alkylating agent that works by attaching alkyl groups to DNA, causing cross-linking of DNA strands and preventing cell division. This leads to cell death, particularly in rapidly dividing cells such as cancer cells.
Mechanism Steps
💡 How to Take melphater 50mg injection
Strength: Injection: 50 mg lyophilized powder for reconstitution
Dosage Information
| Adult Dosage | The dose of this medicine is determined by a qualified clinician based on the specific condition being treated, the patient's body weight, and overall health. It is usually given as an intravenous infusion over 15-30 minutes. Common regimens include 16 mg/m² every 2 weeks or 0.25 mg/kg daily for 4 days every 4-6 weeks. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially bone marrow suppression. Dose adjustments may be necessary based on kidney function and overall health. Close monitoring is required. |
| Renal Impairment | Dose reduction may be necessary in patients with kidney impairment. Monitor kidney function closely. Consult a clinician for specific dosing. |
| Hepatic Impairment | Dose reduction may be necessary in patients with liver impairment. Monitor liver function closely. Consult a clinician for specific dosing. |
| Maximum Daily Dose | The maximum daily dose varies by indication and protocol. It should not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of melphater 50mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Live vaccines | Major | |
| Cyclosporine | Major | |
| Warfarin | Moderate | |
| Phenytoin | Moderate | |
| Cimetidine | Minor |
🚨 Major Interactions
- Live vaccines
- Cyclosporine
- Nalidixic acid
⚡ Moderate Interactions
- Warfarin
- Phenytoin
🍷 Alcohol Interaction
Alcohol may increase the risk of stomach irritation and liver problems. It is best to avoid alcohol while receiving this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to melphalan","Severe bone marrow suppression","Active infection","Pregnancy","Breastfeeding"]
⚠️ Warnings & Precautions
["Bone marrow suppression is common and may be severe. Monitor blood counts closely.","This medicine can cause secondary cancers. Long-term monitoring is required.","Avoid live vaccines during treatment.","Use effective contraception during and after treatment.","This medicine may impair fertility. Discuss fertility preservation options before treatment.","Administer with caution in patients with kidney or liver impairment."]
🤱 Lactation Safety
It is not known whether melphalan is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding should be discontinued during treatment.
💊 Overdose Management
Overdose can cause severe bone marrow suppression, gastrointestinal toxicity, and other serious effects. There is no specific antidote. Treatment is supportive, including blood transfusions, antibiotics, and growth factors. In case of overdose, seek immediate medical attention.
⏰ Missed Dose
This medicine is given by a healthcare professional in a clinical setting. If you miss an appointment for your dose, contact your doctor as soon as possible to reschedule. Do not attempt to self-administer.
Additional Safety Advice
This medicine must be given under the supervision of a qualified healthcare professional. Regular blood tests are necessary to monitor blood counts, liver function, and kidney function. Avoid contact with people who have infections. Do not receive live vaccines while on this medicine. Use effective contraception during treatment and for some time after, as this medicine can harm an unborn baby. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Drink plenty of fluids to help prevent kidney problems. Report any signs of infection, unusual bleeding, or bruising promptly.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to bone marrow suppression and other side effects. Dose adjustments and close monitoring are recommended.
🤰 Pregnancy Planning (TTC)
This medicine can harm an unborn baby. Use effective contraception during treatment and for at least 6 months after. Discuss pregnancy planning with your doctor before starting treatment.
🏥 Post-Surgery Considerations
This medicine may impair wound healing and increase infection risk. Inform your surgeon if you are on this medicine. Timing of surgery should be discussed with your oncologist.
🦷 Dental Procedures
Inform your dentist if you are on this medicine. It may increase the risk of bleeding and infection. Dental work should be coordinated with your oncologist.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Fatigue is common; adjust activity levels as needed. Avoid strenuous exercise if you feel tired or have low blood counts. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, making it difficult to work during treatment. Discuss with your employer about flexible arrangements. Avoid driving if you feel tired or dizzy.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Treatment duration is determined by your oncologist based on your response and side effects.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of secondary cancers, bone marrow suppression, and organ toxicity. Regular monitoring of blood counts, liver, and kidney function is required. Discuss any long-term concerns with your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the cancer type, other chemotherapy drugs may be used.
Evidence: Well-establishedFor multiple myeloma, targeted therapies may be used.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment. Inactivated vaccines may be given, but response may be reduced. Consult your doctor before any vaccination.
📦 Storage Guide
✅ DO
Store refrigerated at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original packaging
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store at room temperature for extended periods
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting, so travel is not applicable for self-administration. If you need to travel for treatment, carry your prescription and medical records. Ensure the clinic can store the medicine properly. Plan for adequate rest during travel. Consult your doctor before making travel plans.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The effects on cancer cells begin immediately, but it may take several weeks to see improvement in symptoms or blood tests.
A: It is given as an intravenous infusion by a healthcare professional.
A: Avoid live vaccines, contact with people who have infections, and alcohol. Use contraception.
🤔 Common Patient Concerns
🔄 Substitutes for melphater 50mg injection
View AllAlternative brands with exact same active ingredient:
-
alphalan 50mg injectionNatco Pharma Ltd ₹1,684.00 59.9% CHEAPER
-
alkacel 50 injectionCelon Laboratories Ltd ₹2,400.00 42.9% CHEAPER
-
melfalax 50mg injectionGLS Pharma Ltd. ₹2,500.00 40.5% CHEAPER
-
megval 50mg injectionEmcure Pharmaceuticals Ltd ₹2,597.00 38.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken at home.
Fact: This medicine must be given by a healthcare professional in a clinical setting. - Myth: This medicine has no serious side effects.
Fact: This medicine can cause severe bone marrow suppression and other serious side effects.
🔄 Alternative Options
Generic Alternatives
- Melphalan 50 mg injection
Brand Alternatives
- Alphalan 50mg injection