Consium 100mg Injection (Carmustine): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fever above 38°C or chills
- Unusual bleeding or bruising
- Shortness of breath or dry cough
- Yellowing of skin or eyes
- Decreased urine output or swelling
- Severe headache with confusion or seizures
- Pain, redness, or swelling at the infusion site
If experiencing severe symptoms, call emergency services immediately.
What is carmuther 100 injection used for?
This medicine is a chemotherapy injection containing carmustine 100 mg. It is used to treat brain tumours, lymphomas, and multiple myeloma. It works by damaging cancer cell DNA. It is given into a vein by a healthcare professional and can cause low blood counts, nausea, and lung problems.
- Generic Name: Carmustine
- Manufacturer: Therdose Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 carmuther 100 injection के बारे में (Hindi Summary)
उपयोग: यह दवा कार्मस्टीन 100 मिलीग्राम इंजेक्शन है, जिसका उपयोग कैंसर के इलाज में किया जाता है। यह मुख्य रूप से मस्तिष्क के ट्यूमर जैसे ग्लियोब्लास्टोमा, ब्रेनस्टेम ग्लियोमा और मेडुलोब्लास्टोमा के लिए दी जाती है। इसके अलावा यह लिम्फोमा और मल्टीपल मायलोमा के कुछ मामलों में भी उपयोग की जाती है। यह दवा कैंसर कोशिकाओं के डीएनए को नुकसान पहुंचाकर उन्हें बढ़ने और फैलने से रोकती है। यह दवा केवल अस्पताल या कैंसर केंद्र में डॉक्टर या नर्स द्वारा नस में दी जाती है। मरीज को इसे घर पर स्वयं नहीं लगाना चाहिए। इलाज के दौरान खून की जांच, लीवर और किडनी की जांच नियमित रूप से करानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, भूख न लगना, थकान और बालों का झड़ना शामिल हैं। कई मरीजों में खून की कोशिकाएं कम हो जाती हैं, जिससे संक्रमण या खून बहने का खतरा बढ़ जाता है। गंभीर दुष्प्रभावों में फेफड़ों में सूजन या निशान, लीवर और किडनी की समस्या, और कभी-कभी दौरे पड़ना शामिल है। अगर आपको बुखार, सांस लेने में तकलीफ, असामान्य खून बहना या चोट लगने पर नील पड़ना दिखे, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा एक शक्तिशाली कीमोथेरेपी दवा है और इसे केवल अस्पताल या कैंसर केंद्र में प्रशिक्षित डॉक्टर या नर्स द्वारा ही दिया जाना चाहिए। इसे घर पर स्वयं न लगाएं। हर खुराक से पहले डॉक्टर आपके खून, लीवर, किडनी और फेफड़ों की जांच करेंगे। इलाज के दौरान संक्रमण से बचें, भीड़-भाड़ वाली जगहों पर जाने से बचें और साफ-सफाई का ध्यान रखें। नरम टूथब्रश और इलेक्ट्रिक रेजर का उपयोग करें। पर्याप्त पानी पिएं। इलाज के दौरान लाइव वैक्सीन न लगवाएं। पुरुष और महिला दोनों को इलाज के दौरान और उसके बाद कुछ महीनों तक गर्भनिरोधक उपाय करने चाहिए।
💊 carmuther 100 injection Uses & Benefits
[{"condition":"Glioblastoma multiforme and other high-grade gliomas","description":"Used as part of combination chemotherapy, often with radiation therapy, to treat malignant brain tumours in adults.","evidence":"Well-established"},{"condition":"Brainstem glioma and medulloblastoma","description":"Included in treatment regimens for certain paediatric and adult brain tumours, usually in specialised centres.","evidence":"Established"},{"condition":"Recurrent or refractory Hodgkin and non-Hodgkin lymphoma","description":"Used in combination regimens such as BEAM before autologous stem cell transplant.","evidence":"Well-established"},{"condition":"Multiple myeloma","description":"Part of some combination chemotherapy regimens for multiple myeloma, especially before stem cell transplant.","evidence":"Established"},{"condition":"Malignant melanoma and other solid tumours","description":"Occasionally used in regional chemotherapy or specialised protocols for advanced melanoma and certain gastrointestinal tumours.","evidence":"Limited"}]
Off-label uses: [{"condition":"Primary CNS lymphoma","description":"Sometimes included in high-dose chemotherapy regimens for primary central nervous system lymphoma.","evidence":"Limited"},{"condition":"Langerhans cell histiocytosis","description":"Rarely used in refractory cases as part of combination therapy.","evidence":"Limited"}]
Primary treatment for: Brain tumours (glioblastoma multiforme, brainstem glioma, medulloblastoma)
Also treats: Hodgkin lymphoma, Non-Hodgkin lymphoma, Multiple myeloma, Malignant melanoma
📋 Drug Information
| Generic Name(s) | Carmustine |
| Brand Name | Consium |
| Manufacturer | Therdose Pharma Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Alkylating agent |
| Route of Administration | Intravenous (into a vein) |
| Storage | Store this medicine in a refrigerator at 2°C to 8°C, protected from light. Do not freeze. Keep in the original carton until use. Once prepared for infusion, use as directed by the pharmacist, usually within a few hours. |
| Shelf Life | Refer to the expiry date on the vial. Do not use after the expiry date. Once reconstituted or diluted, follow the stability instructions provided by the hospital pharmacy. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Carmustine is a nitrosourea alkylating agent. It breaks down in the body to form reactive compounds that attach alkyl groups to DNA, creating cross-links between the two DNA strands. These cross-links prevent DNA from separating and copying itself, which blocks cancer cell division and leads to cell death. Because carmustine is highly fat-soluble, it crosses the blood-brain barrier well and is therefore useful for brain tumours. Its effects are not limited to a specific phase of the cell cycle, so it is called a cell-cycle non-specific agent.
Mechanism Steps
💡 How to Take carmuther 100 injection
Strength: Injection: 100 mg per vial
Dosage Information
| Adult Dosage | The dose of this medicine is determined by your oncologist based on your body size, type of cancer, previous treatments, and blood counts. A commonly used single-agent dose is 150 to 200 mg per square metre of body surface area given every six weeks, or 75 to 100 mg per square metre given on two consecutive days every six weeks. When used in combination with other chemotherapy drugs, the dose is usually lower. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and blood count recovery. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Older adults may be more sensitive to the side effects of this medicine, especially bone marrow suppression and lung toxicity. Doctors often start with lower doses and monitor blood counts, liver, kidney, and lung function more closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Carmustine is partly excreted by the kidneys. Patients with kidney problems may need lower doses and closer monitoring of kidney function. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | Carmustine is metabolised in the liver. Patients with liver problems may need lower doses and closer monitoring of liver function. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum dose depends on the treatment regimen and is determined by the oncologist. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of carmuther 100 injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Live vaccines | Major | |
| Cimetidine | Major | |
| Other chemotherapy agents | Major | |
| Phenytoin | Moderate | |
| Warfarin | Moderate | |
| Aminoglycosides | Moderate | |
| Amphotericin B | Moderate | |
| Paracetamol | Minor | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Live vaccines
- Other bone marrow suppressants (for example, other chemotherapy drugs, clozapine)
- Cimetidine
⚡ Moderate Interactions
- Phenytoin
- Warfarin
- Nephrotoxic drugs (for example, aminoglycosides, amphotericin B)
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine. It can worsen nausea and vomiting, increase the risk of liver problems, and may add to the depressant effect on bone marrow. If you drink alcohol regularly, discuss this with your doctor before treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to carmustine or any component of the formulation","Severe bone marrow suppression (low white cells, platelets, or red cells)","Active uncontrolled infection","Pregnancy or breastfeeding, unless clearly needed and advised by a specialist","Severe liver or kidney disease, unless the benefit outweighs the risk"]
⚠️ Warnings & Precautions
["This medicine must only be given by a qualified healthcare professional in a hospital or cancer centre.","Bone marrow suppression is common and can be severe; regular blood tests are essential.","Lung toxicity can occur months to years after treatment; report any breathing problems.","Avoid live vaccines during treatment.","Use effective contraception during treatment and for several months afterwards.","Do not handle this medicine if you are pregnant or breastfeeding.","Report any fever, unusual bleeding, or bruising immediately.","Avoid alcohol during treatment.","Tell your doctor about all other medicines, including herbal products."]
🤱 Lactation Safety
It is not known whether carmustine passes into breast milk. Because of the potential for serious side effects in a nursing infant, breastfeeding should be stopped during treatment and for a period afterwards as advised by the doctor.
💊 Overdose Management
There is no specific antidote for carmustine overdose. Overdose can cause severe bone marrow suppression, liver damage, and lung toxicity. Treatment is supportive and may include blood transfusions, antibiotics for infection, and close monitoring in a hospital. If an overdose is suspected, contact emergency medical services immediately.
⏰ Missed Dose
This medicine is given by a healthcare professional in a hospital or clinic. If you miss a scheduled appointment, contact your cancer centre as soon as possible to reschedule. Do not try to catch up on your own. Your doctor will decide the next dose based on your blood counts and overall condition.
Additional Safety Advice
This medicine is a powerful chemotherapy drug and must only be given by a qualified healthcare professional in a hospital or cancer centre. Do not attempt to handle or inject this medicine at home. Before each dose, your doctor will check your blood counts, liver function, kidney function, and lung function. Tell your doctor if you have an active infection, have had recent vaccinations, or are taking any other medicines, including over-the-counter products and herbal supplements. Avoid close contact with people who have colds or infections while your blood counts are low. Use a soft toothbrush and an electric razor to reduce bleeding risk. Drink plenty of fluids unless your doctor advises otherwise. Do not receive live vaccines during treatment. Both men and women should use effective contraception during treatment and for several months afterwards. If you miss a scheduled appointment, contact your cancer centre immediately to reschedule.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may be more sensitive to the side effects of this medicine, especially bone marrow suppression, lung toxicity, and liver or kidney problems. Doctors often use lower doses and monitor more closely. Regular blood tests and clinical reviews are essential.
🤰 Pregnancy Planning (TTC)
This medicine can harm an unborn baby. Women should avoid becoming pregnant during treatment and for at least six months afterwards. Men should avoid fathering a child during treatment and for at least three months afterwards. Discuss fertility preservation options with your doctor before starting treatment if you plan to have children in the future.
🏥 Post-Surgery Considerations
After surgery, this medicine may be used as part of adjuvant chemotherapy. Your doctor will decide the timing based on your recovery, wound healing, and blood counts. Report any signs of infection or poor wound healing before starting treatment.
🦷 Dental Procedures
Tell your dentist that you are receiving this medicine before any dental procedure. Because of low blood counts and increased bleeding risk, dental work may need to be delayed until your counts recover. Your dentist and oncologist should discuss the best timing.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Light exercise such as walking may help with fatigue, but avoid strenuous activity or contact sports while your blood counts are low. Stop exercising and rest if you feel dizzy, short of breath, or unusually tired. Always consult your doctor before starting any exercise programme during chemotherapy.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause tiredness, nausea, and low blood counts, which may affect your ability to work. Avoid driving or operating heavy machinery immediately after the infusion. Discuss your work schedule with your doctor and employer. Many patients need time off during treatment cycles and recovery.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your oncologist will decide when to stop based on your response to treatment, side effects, and blood test results. If you experience severe side effects, contact your doctor immediately; they may adjust or delay the next dose.
📅 Long-Term Use Effects
Long-term effects of this medicine can include persistent bone marrow suppression, lung scarring (pulmonary fibrosis), liver or kidney damage, and a small risk of developing a second cancer such as leukaemia. Regular follow-up with blood tests, liver and kidney function tests, and lung function tests is important. Report any new breathing problems, unusual tiredness, or bleeding to your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
An oral alkylating agent commonly used for glioblastoma, often with radiation therapy.
Evidence: Well-establishedAn oral nitrosourea used for brain tumours and lymphomas.
Evidence: EstablishedOften used together with or after chemotherapy for brain tumours.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine because the immune system is suppressed. Inactivated vaccines may be given, but their response may be reduced. Discuss all vaccinations with your oncologist before receiving them.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in the original carton to protect from light
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Follow hospital pharmacy instructions for prepared solutions
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
This medicine is given in a hospital or cancer centre, so you do not need to carry it while travelling. If you are travelling between treatment cycles, carry a copy of your prescription and a letter from your oncologist explaining your treatment. Keep all follow-up appointments and arrange blood tests at your destination if needed. Avoid travel to areas with high infection risk while your blood counts are low. Discuss travel plans with your doctor before booking.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The anti-cancer effect starts soon after the infusion, but tumour response is usually assessed after weeks or months with scans.
A: It is given slowly into a vein by a trained healthcare professional in a hospital or cancer centre.
A: Watch for fever, unusual bleeding or bruising, shortness of breath, and yellowing of the skin or eyes. Report these immediately.
A: Do not drive immediately after the infusion. Ask your doctor when it is safe to drive.
A: This medicine can harm an unborn baby. It should only be used during pregnancy if clearly needed and advised by a specialist.
🤔 Common Patient Concerns
🔄 Substitutes for carmuther 100 injection
View AllAlternative brands with exact same active ingredient:
-
nitsum 100mg injectionCelon Laboratories Ltd ₹3,900.00 8.3% CHEAPER
-
carustine 100mg injectionKhandelwal Laboratories Pvt Ltd ₹4,300.00 1.1% COSTLIER
-
carnumax 100 injectionGLS Pharma Ltd. ₹4,800.00 12.8% COSTLIER
-
consium 100mg injectionEmcure Pharmaceuticals Ltd ₹5,568.00 30.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken as a pill at home.
Fact: This medicine is an injection that must be given by a healthcare professional in a hospital or cancer centre. - Myth: This medicine only affects cancer cells and has no side effects.
Fact: It can affect normal cells too, causing low blood counts, nausea, hair loss, and other side effects. - Myth: You can stop this medicine whenever you feel better.
Fact: Treatment schedules are carefully planned by your oncologist. Do not stop or change treatment without medical advice. - Myth: This medicine is safe to use during pregnancy.
Fact: This medicine can harm an unborn baby and should only be used during pregnancy if clearly needed and advised by a specialist.
🔄 Alternative Options
Generic Alternatives
- Carmustine 100 mg injection
Brand Alternatives
- Consium 100mg injection