Meftal 500 Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual weight gain or swelling
If experiencing severe symptoms, call emergency services immediately.
What is mefrin 500mg tablet used for?
This medicine is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve mild to moderate pain, inflammation, and fever. It works by blocking COX enzymes and is typically taken 2-3 times daily with food. It is not suitable for everyone and should be used under medical supervision.
- Generic Name: Mefenamic Acid (500mg)
- Manufacturer: Rhine Biogenics Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 mefrin 500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेफेनामिक एसिड 500 मिलीग्राम की एक ओरल टैबलेट है, जिसका उपयोग हल्के से मध्यम दर्द, सूजन और बुखार को कम करने के लिए किया जाता है। यह मासिक धर्म के दर्द, गठिया, मांसपेशियों की चोट और दांत के दर्द में राहत देती है। यह दवा प्रोस्टाग्लैंडिन नामक रसायनों को कम करके काम करती है जो दर्द और सूजन का कारण बनते हैं। इसे डॉक्टर की सलाह के बिना न लें और खाने के साथ लें ताकि पेट में जलन न हो।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सिरदर्द, चक्कर आना और दस्त शामिल हैं। गंभीर दुष्प्रभावों में पेट या आंतों में रक्तस्राव, अल्सर, गुर्दे की समस्या, यकृत की क्षति और गंभीर एलर्जी प्रतिक्रिया शामिल हैं। यदि आपको काला या खूनी मल, खून की उल्टी, तेज पेट दर्द, पेशाब में कमी, आंखों या त्वचा का पीलापन, या चेहरे, होंठ या गले में सूजन दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खाने के साथ लें ताकि पेट में जलन न हो। शराब न पिएं क्योंकि इससे पेट में रक्तस्राव का खतरा बढ़ सकता है। अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको गुर्दे, यकृत या हृदय की समस्या है, तो डॉक्टर को बताएं। बच्चों की पहुंच से दूर रखें।
💊 mefrin 500mg tablet Uses & Benefits
[{"condition":"Primary dysmenorrhea","description":"Relieves menstrual cramps and pelvic pain by reducing prostaglandin production.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"Reduces joint pain and inflammation, improving mobility.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Helps control pain and swelling in inflamed joints.","evidence":"Well-established"},{"condition":"Soft tissue injuries","description":"Used for sprains, strains, and sports injuries to reduce pain and swelling.","evidence":"Well-established"},{"condition":"Postoperative pain","description":"Provides short-term relief after minor surgical procedures.","evidence":"Well-established"},{"condition":"Fever","description":"Reduces fever by acting on the hypothalamus.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks.","evidence":"Limited"},{"condition":"Menorrhagia","description":"May reduce heavy menstrual bleeding in some patients.","evidence":"Limited"}]
Primary treatment for: Pain and inflammation
Also treats: Primary dysmenorrhea, Osteoarthritis, Rheumatoid arthritis, Soft tissue injuries, Postoperative pain, Fever
📋 Drug Information
| Generic Name(s) | Mefenamic Acid (500mg) |
| Brand Name | mefrin 500mg tablet |
| Manufacturer | Rhine Biogenics Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID's- Non-Selective COX 1&2 Inhibitors (fenamates) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by reversibly inhibiting the cyclooxygenase (COX) enzymes, COX-1 and COX-2, which are responsible for converting arachidonic acid into prostaglandins and thromboxanes. By blocking these enzymes, it reduces the production of prostaglandins that cause pain, inflammation, and fever. It also inhibits platelet aggregation by affecting thromboxane A2 production. The analgesic, anti-inflammatory, and antipyretic effects are primarily due to decreased prostaglandin synthesis in peripheral tissues and the central nervous system.
Mechanism Steps
💡 How to Take mefrin 500mg tablet
Strength: Tablet, 500 mg
Dosage Information
| Adult Dosage | The usual adult dose is 250 mg to 500 mg taken three times daily with food, but the exact dose and duration depend on the condition being treated, your age, weight, kidney and liver function, and other medications you take. For menstrual cramps, a common regimen is 500 mg initially, then 250 mg every 6 hours as needed. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are at higher risk of side effects, especially gastrointestinal bleeding and kidney problems. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose reduction may be necessary. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose reduction may be necessary. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is 1500 mg, but this should not be exceeded. Follow your doctor's prescription. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of mefrin 500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Lithium | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| SSRIs | Moderate | |
| Beta-blockers | Moderate |
🚨 Major Interactions
- Warfarin
- Aspirin
- Other NSAIDs
- Corticosteroids
- Lithium
- Methotrexate
⚡ Moderate Interactions
- ACE inhibitors
- Diuretics
- SSRIs
- Beta-blockers
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine because it can increase the risk of stomach bleeding, ulcers, and liver problems. Alcohol may also worsen dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Allergy to mefenamic acid or other NSAIDs","Active peptic ulcer or history of recurrent ulcers","Severe kidney disease","Severe liver disease","Heart failure","History of aspirin-sensitive asthma","Third trimester of pregnancy","Coronary artery bypass graft (CABG) surgery"]
⚠️ Warnings & Precautions
["Take with food to reduce stomach upset.","Avoid alcohol.","Do not use for longer than prescribed.","May increase risk of heart attack or stroke.","May cause kidney problems.","May cause liver damage.","May increase bleeding risk.","Do not use with other NSAIDs.","Inform your doctor if you are pregnant or breastfeeding.","Keep out of reach of children."]
🤱 Lactation Safety
This medicine is excreted in breast milk in small amounts. Consult your doctor before use while breastfeeding. Short-term use is generally considered acceptable, but monitor the infant for diarrhea or rash.
💊 Overdose Management
Overdose may cause nausea, vomiting, stomach pain, drowsiness, and in severe cases, seizures, kidney failure, or coma. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Activated charcoal may be used if taken recently. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not take more than the recommended dose or use it for longer than advised. Take it with food or milk to reduce stomach upset. Avoid alcohol because it can increase the risk of stomach bleeding. Do not take other NSAIDs or pain relievers without consulting your doctor. If you have kidney, liver, or heart problems, your doctor may need to adjust your dose or monitor you closely. Do not use this medicine if you are allergic to mefenamic acid or other NSAIDs. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Keep this medicine out of reach of children. Store it at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly. Avoid if possible in those with kidney or heart disease.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. It may affect ovulation and is not recommended during the third trimester. Use effective contraception if you are taking this medicine and do not wish to become pregnant.
🏥 Post-Surgery Considerations
This medicine may increase the risk of bleeding after surgery. Inform your surgeon if you are taking it. It may need to be stopped before surgery as advised by your doctor.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk. Your dentist may advise you to stop it temporarily.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may cause injury while taking this medicine, as it can mask pain and increase the risk of bleeding. Consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food. Most people can continue their daily activities with caution.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe stomach pain, black or bloody stools, vomiting blood, signs of an allergic reaction, decreased urine output, or yellowing of the skin or eyes. Do not stop suddenly if you have been taking it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal bleeding, ulcers, kidney impairment, liver damage, and cardiovascular events such as heart attack and stroke. Regular monitoring of kidney and liver function, blood counts, and blood pressure is advised. Use the lowest effective dose for the shortest duration. Consult your doctor if you need to take it for more than a few days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedLocal application of heat or cold can help relieve pain and inflammation.
Evidence: Well-establishedMay help with certain types of pain, but evidence is mixed.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are established. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture and heat. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines. Keep enough supply for your trip and carry it in your hand luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it.
A: It is best taken with food or milk to reduce stomach upset.
A: It is generally recommended for short-term use. Do not take it for more than 7 days without consulting your doctor.
A: Avoid during the third trimester. Consult your doctor before use if you are pregnant or planning pregnancy.
A: No, alcohol increases the risk of stomach bleeding and should be avoided.
🤔 Common Patient Concerns
🔄 Substitutes for mefrin 500mg tablet
View AllAlternative brands with exact same active ingredient:
-
mefalth 500mg tabletOrchid Chemicals & Pharmaceuticals Ltd ₹18.27 11.4% CHEAPER
-
osra 500mg tabletBennet Pharmaceuticals Limited ₹20.00 3.1% CHEAPER
-
almefkem 500mg tabletAlkem Laboratories Ltd ₹22.46 8.9% COSTLIER
-
mefanex 500mg tabletLividus Pharmaceuticals Pvt Ltd ₹22.97 11.3% COSTLIER
-
mefalgin 500mg tabletAnthus Pharmaceuticals Pvt Ltd ₹23.67 14.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe to take for any pain without a prescription.
Fact: This medicine is a prescription NSAID and should only be taken under medical supervision. It can cause serious side effects. - Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food or milk to reduce stomach upset and risk of ulcers. - Myth: This medicine is safe to take with other pain relievers.
Fact: Combining with other NSAIDs increases the risk of bleeding and kidney problems. Consult your doctor.
🔄 Alternative Options
Generic Alternatives
- Mefenamic acid 500 mg tablet
Brand Alternatives
- Meftal 500 tablet
- Mefkind 500 tablet
- Mefanorm 500 tablet
- Mefenamic acid 500 mg tablet