mefcil spas 20 mg/500 mg tablet - Dicyclomine (20mg) + Mefenamic Acid (500mg) medicine

Dimic 20mg/500mg Tablet: Complete Medicine Guide

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🏭 Psycormedies 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 25, 2026
⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Use only if clearly needed and prescribed by a doctor. Avoid in the third trimester due to risk of premature closure of ductus arteriosus. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Oct 25, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is mefcil spas 20 mg/500 mg tablet used for?

This medicine is a combination of dicyclomine (20 mg) and mefenamic acid (500 mg) used to relieve abdominal cramps and pain associated with irritable bowel syndrome, menstrual cramps, and gastrointestinal spasms. It works by relaxing smooth muscles and reducing inflammation.

  • Generic Name: Dicyclomine (20mg) + Mefenamic Acid (500mg)
  • Manufacturer: Psycormedies
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 mefcil spas 20 mg/500 mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा डाइसाइक्लोमिन 20 मिलीग्राम और मेफेनामिक एसिड 500 मिलीग्राम का संयोजन है। इसका उपयोग पेट की ऐंठन, दर्द, और सूजन को कम करने के लिए किया जाता है। यह चिड़चिड़ा आंत्र सिंड्रोम (IBS), मासिक धर्म के दर्द, और पेट की मांसपेशियों की ऐंठन में राहत देती है। यह दवा मांसपेशियों को आराम देकर और सूजन को कम करके काम करती है। इसे डॉक्टर की सलाह के बिना न लें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुंह सूखना, चक्कर आना, नींद आना, जी मिचलाना, उल्टी, पेट दर्द, कब्ज और दस्त शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, अल्सर, गुर्दे की समस्या, गंभीर एलर्जी और रक्त विकार शामिल हो सकते हैं। यदि आपको काला या खूनी मल, खून की उल्टी, तेज पेट दर्द, सांस लेने में कठिनाई, या चेहरे पर सूजन हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। इसे भोजन या दूध के साथ लें ताकि पेट की जलन कम हो। इस दवा के साथ शराब न पिएं। यदि आपको चक्कर या नींद आती है तो वाहन न चलाएं। यदि आपको पेट के अल्सर, गुर्दे या यकृत की बीमारी, दमा, या रक्तस्राव विकार है तो डॉक्टर को बताएं। 7 दिनों से अधिक इस दवा का उपयोग बिना डॉक्टर की सलाह के न करें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 mefcil spas 20 mg/500 mg tablet Uses & Benefits

[{"condition":"Irritable bowel syndrome (IBS)","description":"Helps relieve abdominal cramps and pain associated with IBS by reducing smooth muscle spasms and inflammation.","evidence":"Well-established"},{"condition":"Primary dysmenorrhea","description":"Reduces menstrual cramps and pelvic pain by inhibiting prostaglandin production and relaxing uterine muscles.","evidence":"Well-established"},{"condition":"Gastrointestinal spasms","description":"Provides relief from spasmodic pain in the stomach and intestines due to various causes.","evidence":"Well-established"},{"condition":"Biliary colic","description":"May be used to relieve pain from gallbladder spasms, though definitive evidence is limited.","evidence":"Limited"}]

Off-label uses: [{"condition":"Urinary tract spasms","description":"Sometimes prescribed off-label to relieve bladder spasms, but evidence is limited.","evidence":"Limited"}]

Primary treatment for: Irritable bowel syndrome

Also treats: Primary dysmenorrhea, Gastrointestinal spasms, Biliary colic

📋 Drug Information

Generic Name(s)Dicyclomine (20mg) + Mefenamic Acid (500mg)
Brand Namemefcil spas 20 mg/500 mg tablet
ManufacturerPsycormedies
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Do not exceed the prescribed dose or duration of treatment.
3
Avoid alcohol while taking this medicine to prevent gastrointestinal bleeding.
4
Do not drive or operate heavy machinery if you feel dizzy or drowsy.
5
Consult your doctor if symptoms persist beyond 7 days.
6
Report any unusual bleeding, bruising, or severe abdominal pain immediately.
7
Stay well hydrated throughout the day to support kidney function.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Abdominal cramps
This medicine is commonly prescribed for this.
Likely Use
✅
Menstrual cramps
This medicine is effective for primary dysmenorrhea.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
❌
Headache
This medicine is not indicated for headache.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDicyclomine is well absorbed from the gastrointestinal tract after oral administration. Mefenamic acid is also absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 2 to 4 hours.
DistributionDicyclomine is distributed widely in the body, including the central nervous system. Mefenamic acid is highly bound to plasma proteins and distributes into synovial fluid and other tissues.
Protein BindingDicyclomine is approximately 80% bound to plasma proteins. Mefenamic acid is more than 90% bound to plasma proteins, primarily albumin.
MetabolismDicyclomine is extensively metabolized in the liver, primarily by oxidation and conjugation. Mefenamic acid is metabolized in the liver by cytochrome P450 enzymes, including CYP2C9, to inactive metabolites.
Half-LifeThe elimination half-life of dicyclomine is approximately 1.8 hours. The elimination half-life of mefenamic acid is approximately 2 to 4 hours.
ExcretionDicyclomine and its metabolites are excreted primarily in the urine and feces. Mefenamic acid metabolites are excreted mainly in the urine.
BioavailabilityThe oral bioavailability of dicyclomine is approximately 50% to 60%. The oral bioavailability of mefenamic acid is approximately 80% to 90%.
Onset of ActionThe onset of action for dicyclomine is within 1 to 2 hours. Mefenamic acid begins to relieve pain within 1 to 2 hours after oral administration.
Peak Plasma TimePeak plasma concentrations of dicyclomine are reached within 1 to 2 hours. Peak plasma concentrations of mefenamic acid are reached within 2 to 4 hours.
Duration of ActionThe duration of action for dicyclomine is approximately 4 to 6 hours. The analgesic effect of mefenamic acid lasts approximately 4 to 6 hours.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Dicyclomine is an anticholinergic and antispasmodic agent that blocks muscarinic acetylcholine receptors in the gastrointestinal tract, reducing smooth muscle contractions and spasms. Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), decreasing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Together, they provide relief from both spasmodic and inflammatory components of abdominal pain.

Mechanism Steps

1
Dicyclomine blocks muscarinic receptors: Dicyclomine competitively inhibits acetylcholine at muscarinic receptors on gastrointestinal smooth muscle, decreasing muscle contractions and spasms.
2
Mefenamic acid inhibits cyclooxygenase: Mefenamic acid reversibly inhibits COX-1 and COX-2 enzymes, reducing the conversion of arachidonic acid to prostaglandins.
3
Reduced prostaglandin synthesis: Lower prostaglandin levels decrease inflammation, pain, and uterine contractions.
4
Combined relief of spasms and pain: The antispasmodic effect of dicyclomine and the anti-inflammatory effect of mefenamic acid work together to alleviate abdominal cramps and pain.

💡 How to Take mefcil spas 20 mg/500 mg tablet

Strength: Tablet containing dicyclomine 20 mg and mefenamic acid 500 mg.

1Take this medicine orally with a full glass of water.
2Take it with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Follow the prescribed schedule exactly.
5Do not take more than the recommended dose.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally two to three times daily, preferably with food. The exact dose and duration depend on the condition being treated and the patient's response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the anticholinergic effects of dicyclomine and the gastrointestinal and renal effects of mefenamic acid. Use with caution and consider lower doses. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a doctor for individualized dosing.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult a doctor for individualized dosing.
Maximum Daily DoseThe maximum recommended daily dose is 3 tablets (dicyclomine 60 mg + mefenamic acid 1500 mg). Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and gastrointestinal irritation.
Alcohol
Avoid
Increases risk of gastrointestinal bleeding and drowsiness.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of mefcil spas 20 mg/500 mg tablet

✅ Common Side Effects

Dry mouth (Common (5-10%))
Sip water or chew sugarless gum. Consult doctor if persistent.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how this medicine affects you.
Drowsiness (Common (5-10%))
Avoid alcohol and activities requiring alertness. Consult doctor if severe.
Nausea (Common (5-10%))
Take with food or milk to reduce stomach upset.
Constipation (Common (5-10%))
Increase fiber and fluid intake. Consult doctor if persistent.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black or bloody stools, vomiting blood, or severe abdominal pain.
Peptic ulcer (Rare (<0.1%))
Report persistent stomach pain or heartburn to your doctor immediately.
Kidney impairment (Rare (<0.1%))
Seek medical attention if you experience decreased urine output, swelling, or fatigue.
Severe allergic reaction (Rare (<0.1%))
Seek emergency help if you develop rash, itching, swelling of face or throat, or difficulty breathing.
Blood disorders (Rare (<0.1%))
Report unusual bleeding, bruising, or signs of infection to your doctor.

⚠️ Rare Side Effects

Agranulocytosis
Seek immediate medical attention if you develop fever, sore throat, or mouth ulcers.
Aplastic anemia
Report unusual fatigue, pallor, or shortness of breath to your doctor.
Hepatitis
Seek medical attention if you notice yellowing of skin or eyes, dark urine, or abdominal pain.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Anticholinergics Major
Lithium Moderate
Methotrexate Moderate
ACE inhibitors Moderate
ARBs Moderate
Diuretics Moderate
Antacids Minor
Corticosteroids Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., aspirin, ibuprofen)
  • Anticholinergic drugs (e.g., atropine, antihistamines)

⚡ Moderate Interactions

  • Lithium
  • Methotrexate
  • ACE inhibitors and ARBs
  • Diuretics

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol can increase the risk of gastrointestinal bleeding and may enhance drowsiness and dizziness caused by dicyclomine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to dicyclomine, mefenamic acid, or any component of the formulation","Active peptic ulcer disease or history of recurrent ulcers","Severe renal impairment","Severe hepatic impairment","Asthma triggered by NSAIDs","Third trimester of pregnancy","Children below 12 years of age","Patients with myasthenia gravis","Patients with obstructive uropathy","Patients with paralytic ileus"]

⚠️ Warnings & Precautions

["Use with caution in elderly patients due to increased risk of anticholinergic effects and NSAID-related complications.","Avoid in patients with cardiovascular risk factors due to increased risk of thrombotic events.","Do not use for more than 7 days without medical advice.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol consumption while taking this medicine.","Inform your doctor if you have a history of kidney or liver disease, asthma, or bleeding disorders.","May increase the risk of gastrointestinal bleeding, especially with concurrent use of other NSAIDs or corticosteroids."]

🤱 Lactation Safety

Dicyclomine may pass into breast milk and could cause anticholinergic effects in the infant. Mefenamic acid also passes into breast milk. Consult your doctor before breastfeeding while taking this medicine.

💊 Overdose Management

Overdose may cause severe anticholinergic symptoms (e.g., dry mouth, blurred vision, tachycardia, urinary retention, confusion) and NSAID-related effects (e.g., nausea, vomiting, gastrointestinal bleeding). Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of gastrointestinal bleeding and drowsiness. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, asthma, or bleeding disorders. Do not use this medicine for more than 7 days without consulting your doctor. Keep out of reach of children. Store at room temperature away from moisture and heat.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the anticholinergic effects of dicyclomine and the gastrointestinal and renal effects of mefenamic acid. Use with caution and consider lower doses. Regular monitoring of kidney and liver function is advised.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. It is generally avoided during pregnancy, especially in the third trimester, due to potential risks to the fetus.

🏥 Post-Surgery Considerations

Consult your doctor before taking this medicine after surgery, as it may interact with other medications or affect healing. NSAIDs can increase bleeding risk.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk. Your dentist may advise temporarily stopping it.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on your digestive system.
🥗
Eat a balanced diet rich in fiber to prevent constipation.
😴
Stay hydrated by drinking plenty of water.
💧
Avoid trigger foods that worsen your abdominal cramps.
🧘
Practice stress-reducing techniques like yoga or meditation.
🌞
Get adequate sleep to support overall health.

🏋️ Exercise Considerations

Avoid strenuous exercise if you feel dizzy or drowsy. Mild to moderate exercise like walking may help with digestion and overall well-being.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseeds.
Reduce intake of processed and spicy foods.
Eat small, frequent meals to ease digestion.
Stay well hydrated.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness or dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause dry mouth, so keep water handy.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if you experience severe side effects such as gastrointestinal bleeding, allergic reactions, or if your symptoms do not improve within 7 days. Do not stop abruptly if you have been on long-term therapy without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of gastrointestinal bleeding, ulcers, kidney impairment, and liver toxicity. Regular monitoring of renal and hepatic function is recommended. It should only be used for short-term relief unless otherwise directed by a doctor.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain.

Evidence: Well-established
Dietary modifications

A low-FODMAP diet may help manage IBS symptoms.

Evidence: Well-established
Heat therapy

Applying a heating pad to the abdomen can help relieve cramps.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known. However, consult your doctor before receiving any vaccine while taking this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from moisture and direct sunlight. If crossing time zones, adjust your dosing schedule gradually under medical advice. Check local customs regulations regarding prescription medicines before traveling internationally.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 32-year-old woman with severe menstrual cramps
She was prescribed this medicine for primary dysmenorrhea. She took one tablet twice daily with food during her periods. Within a few hours, her cramps reduced significantly. She experienced mild dry mouth but it was manageable. She was advised not to take it for more than 3 days without consulting her doctor.
💡 Lesson: Taking this medicine with food reduces stomach upset and consistent dosing provides effective relief from menstrual cramps.
👤 A 45-year-old man with irritable bowel syndrome
He had frequent abdominal cramps and bloating. His doctor prescribed this medicine for short-term relief. He took it three times daily with meals. His symptoms improved within two days. He was advised to avoid alcohol and to follow a low-FODMAP diet. He was monitored for kidney function due to his age.
💡 Lesson: This medicine can effectively relieve IBS-related cramps when taken as prescribed, but lifestyle modifications and monitoring are important.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 1 to 2 hours after taking it.

Q: Can I take it on an empty stomach?

A: It is best taken with food or milk to reduce stomach upset.

Q: Is it safe during pregnancy?

A: Consult your doctor. It is generally avoided in the third trimester.

Q: Can I take it with other painkillers?

A: Do not take with other NSAIDs without consulting your doctor due to increased risk of side effects.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for mefcil spas 20 mg/500 mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken for any type of stomach pain.
    Fact: This medicine is specifically for spasmodic and inflammatory abdominal pain. It is not effective for all types of stomach pain and should only be used as prescribed.
  • Myth: It is safe to take this medicine for a long time without doctor supervision.
    Fact: Long-term use of this medicine can increase the risk of kidney, liver, and gastrointestinal problems. It should only be used for short periods under medical supervision.

🔄 Alternative Options

Generic Alternatives

  • Dicyclomine + Mefenamic Acid tablet

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Dicyclomine 20 mg + Mefenamic Acid 500 mg","primary_use":"Abdominal cramps and pain","route":"Oral"},{"medicine":"Dicyclomine + Paracetamol","composition":"Dicyclomine 20 mg + Paracetamol 500 mg","primary_use":"Abdominal cramps and pain","route":"Oral"},{"medicine":"Mefenamic Acid alone","composition":"Mefenamic Acid 500 mg","primary_use":"Pain and inflammation","route":"Oral"}]

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