Bryxta 100 Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe abdominal pain, fever, or vomiting (possible gastrointestinal perforation)
- Blood in vomit, stool, or urine (severe bleeding)
- Chest pain, shortness of breath, or swelling in legs (blood clots)
- Severe headache with blurred vision or confusion (hypertensive crisis or PRES)
- Eye pain, redness, or vision loss after intravitreal injection (endophthalmitis)
- Sudden weakness or difficulty speaking (stroke)
- Yellowing of skin or eyes (liver problems)
If experiencing severe symptoms, call emergency services immediately.
What is krabeva 100mg injection used for?
This medicine is a prescription injection containing bevacizumab, used to treat various cancers and certain eye conditions by blocking the growth of new blood vessels. It is given by a healthcare professional and requires regular monitoring.
- Generic Name: Bevacizumab (100mg)
- Manufacturer: Biocon
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 krabeva 100mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा बेवासीज़ुमैब नामक सक्रिय तत्व वाला एक प्रिस्क्रिप्शन इंजेक्शन है, जिसका उपयोग कई प्रकार के कैंसर जैसे कोलोरेक्टल कैंसर, फेफड़ों के कैंसर, ग्लियोब्लास्टोमा, गुर्दे के कैंसर, गर्भाशय ग्रीवा के कैंसर और डिम्बग्रंथि के कैंसर के इलाज में किया जाता है। यह आंखों की कुछ स्थितियों जैसे उम्र से संबंधित धब्बेदार अध:पतन, डायबिटिक मैकुलर एडिमा और रेटिनल वेन ऑक्लूजन के बाद मैकुलर एडिमा के इलाज में भी उपयोग किया जाता है। यह दवा नई रक्त वाहिकाओं के विकास को रोककर काम करती है, जिससे ट्यूमर को पोषण मिलना बंद हो जाता है और आंखों में असामान्य वाहिकाओं का विकास कम होता है। यह दवा केवल एक योग्य स्वास्थ्य सेवा पेशेवर द्वारा अस्पताल या क्लिनिक में ही दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में उच्च रक्तचाप, थकान, सिरदर्द, नाक से खून आना, दस्त, मतली, भूख में कमी, मुंह के छाले और स्वाद में बदलाव शामिल हैं। कुछ रोगियों में पेशाब में प्रोटीन बढ़ सकता है। गंभीर दुष्प्रभावों में गंभीर रक्तस्राव, रक्त के थक्के, आंतों में छेद, घाव भरने में देरी, गंभीर उच्च रक्तचाप और मस्तिष्क की एक दुर्लभ स्थिति शामिल हो सकती है। आंखों में इंजेक्शन के मामले में आंखों में दर्द, लालिमा, धब्बे और दुर्लभ मामलों में आंखों में संक्रमण हो सकता है। किसी भी असामान्य लक्षण को तुरंत अपने डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल एक योग्य स्वास्थ्य सेवा पेशेवर द्वारा अस्पताल या क्लिनिक में ही दी जानी चाहिए। इसे स्वयं लेने का प्रयास न करें। अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों के बारे में बताएं, विशेष रूप से यदि आपको उच्च रक्तचाप, रक्तस्राव विकार, हाल की सर्जरी या रक्त के थक्के की समस्या है। इस दवा के दौरान गर्भवती होने से बचें, क्योंकि यह अजन्मे बच्चे को नुकसान पहुंचा सकती है। उपचार के दौरान और अंतिम खुराक के कम से कम छह महीने बाद तक प्रभावी गर्भनिरोधक का उपयोग करें। इस दवा के दौरान स्तनपान न करें। यदि आपको असामान्य रक्तस्राव, गंभीर सिरदर्द, दृष्टि में बदलाव या पेट दर्द हो तो अपने डॉक्टर को बताएं।
💊 krabeva 100mg injection Uses & Benefits
[{"condition":"Metastatic colorectal cancer","description":"Used in combination with chemotherapy for first-line and subsequent treatment of metastatic colorectal cancer.","evidence":"Well-established"},{"condition":"Non-small cell lung cancer","description":"Used in combination with platinum-based chemotherapy for advanced non-squamous non-small cell lung cancer.","evidence":"Well-established"},{"condition":"Glioblastoma","description":"Used as a single agent or in combination for recurrent glioblastoma.","evidence":"Established"},{"condition":"Renal cell carcinoma","description":"Used in combination with interferon alfa for metastatic renal cell carcinoma.","evidence":"Established"},{"condition":"Cervical cancer","description":"Used in combination with chemotherapy for persistent, recurrent, or metastatic cervical cancer.","evidence":"Established"},{"condition":"Ovarian cancer","description":"Used in combination with chemotherapy for platinum-resistant recurrent ovarian cancer.","evidence":"Established"},{"condition":"Wet age-related macular degeneration","description":"Used as an intravitreal injection to treat neovascular age-related macular degeneration.","evidence":"Well-established (off-label in some countries)"},{"condition":"Diabetic macular edema","description":"Used as an intravitreal injection to treat diabetic macular edema.","evidence":"Established (off-label in some countries)"},{"condition":"Macular edema following retinal vein occlusion","description":"Used as an intravitreal injection to treat macular edema secondary to retinal vein occlusion.","evidence":"Established (off-label in some countries)"}]
Off-label uses: [{"condition":"Hereditary hemorrhagic telangiectasia","description":"Sometimes used to reduce epistaxis and bleeding in patients with hereditary hemorrhagic telangiectasia.","evidence":"Limited"},{"condition":"Neurofibromatosis type 2","description":"Has been studied for progressive vestibular schwannomas in neurofibromatosis type 2.","evidence":"Limited"},{"condition":"Malignant pleural mesothelioma","description":"Used off-label in some regimens for malignant pleural mesothelioma.","evidence":"Limited"}]
Primary treatment for: Metastatic colorectal cancer
Also treats: Non-small cell lung cancer, Glioblastoma, Renal cell carcinoma, Cervical cancer, Ovarian cancer, Wet age-related macular degeneration, Diabetic macular edema, Macular edema following retinal vein occlusion
📋 Drug Information
| Generic Name(s) | Bevacizumab (100mg) |
| Brand Name | krabeva 100mg injection |
| Manufacturer | Biocon |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Vascular endothelial growth factor (VEGF) inhibitor |
| Route of Administration | Parenteral (intravenous infusion or intravitreal injection) |
| Storage | Store vials in a refrigerator at 2°C to 8°C. Do not freeze. Keep vials in the original carton to protect from light. Do not shake. |
| Shelf Life | Refer to the product label for the exact shelf life. Typically 24 months from the date of manufacture when stored properly. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a recombinant humanized monoclonal antibody that binds to vascular endothelial growth factor (VEGF) and prevents its interaction with VEGF receptors (VEGFR-1 and VEGFR-2) on the surface of endothelial cells. By blocking this interaction, it inhibits the signalling pathways that promote endothelial cell proliferation, survival, migration, and new blood vessel formation. This leads to reduced angiogenesis, which is important for tumour growth and metastasis. In the eye, it reduces vascular permeability and abnormal blood vessel growth, helping to resolve macular edema and prevent vision loss.
Mechanism Steps
💡 How to Take krabeva 100mg injection
Strength: 100 mg concentrate for solution for infusion
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the specific condition being treated, the patient's weight, and other factors. For cancer indications, it is usually given as an intravenous infusion every 2 to 3 weeks. For eye conditions, it is given as an intravitreal injection, typically every 4 to 6 weeks. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-administer. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients based on age alone. However, elderly patients may be more susceptible to certain side effects such as hypertension and thromboembolic events. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No dose adjustment is required for renal impairment. However, patients with renal impairment should be monitored for proteinuria and worsening renal function. |
| Hepatic Impairment | No dose adjustment is required for hepatic impairment. However, patients with hepatic impairment should be monitored for liver function. |
| Maximum Daily Dose | Not applicable as this medicine is not given daily. The maximum dose is determined by the treating clinician based on the indication. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of krabeva 100mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Heparin | Major | |
| Aspirin | Major | |
| Clopidogrel | Major | |
| Ibuprofen | Major | |
| Naproxen | Major | |
| Sunitinib | Major | |
| Sorafenib | Major | |
| Doxorubicin | Moderate | |
| Cisplatin | Moderate |
🚨 Major Interactions
- Anticoagulants (e.g., warfarin, heparin)
- Antiplatelet agents (e.g., aspirin, clopidogrel)
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Other VEGF inhibitors (e.g., sunitinib, sorafenib)
⚡ Moderate Interactions
- Anthracyclines (e.g., doxorubicin)
- Platinum-based chemotherapy (e.g., cisplatin)
- Taxanes (e.g., paclitaxel)
🍷 Alcohol Interaction
Alcohol may increase the risk of liver problems and bleeding. It is advisable to avoid alcohol while receiving this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Recent surgery (within 28 days)","Active bleeding","Severe uncontrolled hypertension","History of arterial thromboembolic events","Hypersensitivity to bevacizumab or any component of the formulation","Pregnancy"]
⚠️ Warnings & Precautions
["Gastrointestinal perforation: Discontinue if it occurs.","Surgery and wound healing: Discontinue at least 28 days before elective surgery.","Hemorrhage: Monitor for bleeding.","Hypertension: Monitor and treat.","Proteinuria: Monitor urine protein.","Arterial thromboembolic events: Discontinue if severe.","Venous thromboembolic events: Monitor.","Heart failure: Monitor for signs.","Posterior reversible encephalopathy syndrome: Discontinue if occurs.","Ovarian failure: May impair fertility."]
🤱 Lactation Safety
It is not known whether this medicine is present in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants, women should discontinue nursing during treatment and for at least 6 months after the last dose.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of overdose, treatment should be symptomatic and supportive. Monitor vital signs and provide appropriate care.
⏰ Missed Dose
If you miss an appointment for your dose, contact your healthcare provider as soon as possible to reschedule. Do not attempt to self-administer. The dosing schedule is important for effectiveness.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a hospital or clinic setting. Do not attempt to self-administer. Inform your doctor about all your medical conditions, especially if you have high blood pressure, bleeding disorders, recent surgery, or a history of blood clots. Your blood pressure, urine protein, and blood counts will be monitored regularly. Avoid becoming pregnant while receiving this medicine, as it can harm the unborn baby. Use effective contraception during treatment and for at least six months after the last dose. Do not breastfeed while on this medicine. Tell your doctor if you experience any unusual bleeding, severe headache, vision changes, or abdominal pain. Keep all appointments for monitoring and follow-up.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects such as hypertension and thromboembolic events. Close monitoring is recommended. No specific dose adjustment is required based on age alone.
🤰 Pregnancy Planning (TTC)
This medicine can harm the unborn baby. Women of childbearing potential should use effective contraception during treatment and for at least 6 months after the last dose. If you are planning to become pregnant, discuss with your doctor before stopping contraception.
🏥 Post-Surgery Considerations
This medicine should be discontinued at least 28 days before elective surgery due to the risk of wound healing complications and bleeding. It should not be restarted until the surgical wound is fully healed.
🦷 Dental Procedures
Inform your dentist that you are receiving this medicine. Dental procedures that cause bleeding may need to be postponed or managed with caution. Consult your doctor before any dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise may need to be modified based on your condition and side effects. Avoid strenuous activities that could increase the risk of bleeding or injury. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, or vision changes, which can affect your ability to drive or operate machinery. Avoid driving if you feel unwell. Discuss with your doctor about work modifications if needed.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. It should be discontinued if serious side effects occur, such as gastrointestinal perforation, severe bleeding, or hypertensive crisis. Your doctor will decide if and when to stop treatment based on your response and side effects.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of hypertension, proteinuria, and thromboembolic events. Regular monitoring of blood pressure, urine protein, and blood counts is required. Ovarian failure may occur in women, affecting fertility. Patients should be reviewed regularly to assess the benefit-risk balance of continued treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Ranibizumab or aflibercept may be used for eye conditions.
Evidence: Well-establishedFor some cancers, chemotherapy without bevacizumab may be an option.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep vials in the original carton to protect from light
❌ DON'T
Do not shake the vial
✅ DO
Keep out of reach of children
❌ DON'T
Do not use if the solution is discolored or contains particles
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. It must be stored in a refrigerator at 2°C to 8°C; use a cooler bag with ice packs during travel. Inform airport security about the medication and any necessary medical documentation. Plan your travel around your dosing schedule to avoid missing doses. Consult your doctor before traveling to ensure it is safe and to get advice on managing time zone changes.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The onset of action varies. For cancer, effects may take weeks to become apparent. For eye conditions, improvement in vision may be noticed within weeks after injection.
A: No, this medicine must be administered by a healthcare professional in a hospital or clinic setting.
A: Avoid alcohol, live vaccines, and activities that increase bleeding risk. Inform your doctor about all medications you are taking.
🤔 Common Patient Concerns
🔄 Substitutes for krabeva 100mg injection
View AllAlternative brands with exact same active ingredient:
-
versavo 100 solution for infusionDr Reddy's Laboratories Ltd ₹7,686.00 52.6% CHEAPER
-
bevatas 100 injectionIntas Pharmaceuticals Ltd ₹9,500.00 41.4% CHEAPER
-
advamab 100mg injectionAlkem Laboratories Ltd ₹11,802.00 27.2% CHEAPER
-
vegfxta solution for infusionFresenius Kabi India Pvt Ltd ₹13,026.09 19.7% CHEAPER
-
abevmy 100mg injectionMylan Pharmaceuticals Pvt Ltd ₹13,451.00 17% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be self-administered at home.
Fact: This medicine must only be given by a healthcare professional in a clinical setting. - Myth: This medicine is a cure for cancer.
Fact: This medicine helps control cancer but is not a cure. It is used in combination with other treatments. - Myth: This medicine has no serious side effects.
Fact: This medicine can cause serious side effects such as bleeding, blood clots, and gastrointestinal perforation.
🔄 Alternative Options
Generic Alternatives
- Bevacizumab
Brand Alternatives
- Avastin
- Mvasi
- Zirabev