advamab 100mg injection - Bevacizumab (100mg) medicine

advamab 100mg injection

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Bevacizumab (100mg)
🏭 Alkem Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

What is advamab 100mg injection used for?

This medicine contains Bevacizumab (100mg) and is used to treat ANTI NEOPLASTICS. Bevacizumab binds to vascular endothelial growth factor (VEGF), preventing its interaction with VEGF. Always consult your doctor before use.

  • Generic Name: Bevacizumab
  • Manufacturer: Alkem Laboratories Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 advamab 100mg injection Uses & Benefits

Metastatic colorectal cancer, non-small cell lung cancer, glioblastoma, renal cell carcinoma, ovarian cancer, cervical cancer.

Off-label uses: Age-related macular degeneration (intravitreal), diabetic retinopathy, other solid tumors.

📋 Drug Information

Generic Name(s)Bevacizumab
Brand NameAvastin
ManufacturerAlkem Laboratories Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI NEOPLASTICS
Action ClassVascular endothelial growth factor (VEGF) inhibitor
Route of AdministrationIntravenous infusion
StorageStore at 2-8°C (36-46°F). Do not freeze. Protect from light.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionSlow absorption after subcutaneous administration; intravenous administration results in complete bioavailability.
DistributionDistributes primarily in plasma and extracellular fluid; limited penetration into certain tissues.
Protein BindingNo significant protein binding (monoclonal antibody).
MetabolismMetabolized by proteolytic degradation into small peptides and amino acids.
Half-LifeApproximately 20 days (range 11-50 days).
ExcretionNot excreted renally; eliminated via intracellular catabolism.
Bioavailability100% (intravenous).
Onset of ActionWithin days to weeks.
Peak Plasma TimeAt end of intravenous infusion.
Duration of ActionSeveral weeks.

How It Works

Bevacizumab binds to vascular endothelial growth factor (VEGF), preventing its interaction with VEGF receptors on endothelial cells, thereby inhibiting angiogenesis.

Mechanism Steps

1Bevacizumab binds to circulating VEGF-A.
2Prevents VEGF-A from interacting with VEGFR-1 and VEGFR-2 on endothelial cells.
3Inhibits VEGF receptor dimerization and activation.
4Blocks downstream signaling pathways (e.g., PI3K/Akt, MAPK).
5Reduces endothelial cell proliferation, migration, and survival.
6Decreases tumor angiogenesis and vascular permeability.
7Leads to inhibition of tumor growth and metastasis.

💡 How to Take advamab 100mg injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of advamab 100mg injection

✅ Common Side Effects

Hypertension
Fatigue
Diarrhea
Nausea
Headache
Proteinuria
Epistaxis

🚨 Serious Side Effects

Gastrointestinal perforation
Hemorrhage
Arterial thromboembolism
Wound dehiscence
Congestive heart failure
Reversible posterior leukoencephalopathy syndrome

⚠️ Rare Side Effects

Osteonecrosis of the jaw
Nephrotic syndrome
Pulmonary hypertension
Ovarian failure

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Sunitinib Major Increased risk of microangiopathic hemolytic anemia
Anthracyclines Major Increased cardiotoxicity risk
Alkylating agents Major Increased risk of neutropenia and infections
Anticoagulants Moderate Increased bleeding risk
Antiplatelet agents Moderate Increased bleeding risk
NSAIDs Moderate Increased bleeding risk
ACE inhibitors Minor Increased risk of proteinuria
Diuretics Minor Increased risk of electrolyte imbalance

🚨 Major Interactions

  • Sunitinib
  • Anthracyclines
  • Alkylating agents

⚡ Moderate Interactions

  • Anticoagulants
  • Antiplatelet agents
  • NSAIDs

🍷 Alcohol Interaction

No known interaction.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to bevacizumab or any excipients; untreated CNS metastases; recent surgery or wound healing complications; severe bleeding disorders.

🤱 Lactation Safety

Not recommended; excreted in human milk? Unknown, but potential for harm.

💊 Overdose Management

No specific antidote; manage symptoms and monitor for adverse effects.

⏰ Missed Dose

Administer as soon as possible; do not double dose.

🔄 Substitutes for advamab 100mg injection

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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