Advacan 0.25mg Tablet (Everolimus): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fever, chills, or signs of infection
- New or worsening cough, shortness of breath, or chest pain
- Severe mouth sores preventing eating or drinking
- Decreased urine output or swelling in legs
- Unusual bleeding or bruising
- Yellowing of skin or eyes
- Severe abdominal pain
- Rash with blistering or peeling skin
If experiencing severe symptoms, call emergency services immediately.
What is advacan 0.25mg tablet used for?
This medicine contains everolimus, an mTOR inhibitor used to treat certain cancers and prevent organ transplant rejection. It works by blocking a protein that helps cells grow and divide. It is taken orally as a tablet, usually once daily, and requires regular monitoring for side effects.
- Generic Name: Everolimus
- Manufacturer: Biocon
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 advacan 0.25mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एवरोलिमस 0.25 मिलीग्राम टैबलेट के रूप में उपलब्ध है और मुख्य रूप से कैंसर के इलाज और अंग प्रत्यारोपण में अस्वीकृति को रोकने के लिए उपयोग की जाती है। यह स्तन कैंसर, अग्नाशय के न्यूरोएंडोक्राइन ट्यूमर, गैस्ट्रोइंटेस्टाइनल न्यूरोएंडोक्राइन ट्यूमर और गुर्दे के कैंसर में प्रभावी है। यह दवा कोशिकाओं के विकास को धीमा करने और प्रतिरक्षा प्रणाली को दबाने का काम करती है। इसे डॉक्टर की सलाह के अनुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह के छाले, दाने, थकान, दस्त, जी मिचलाना, भूख में कमी और स्वाद में बदलाव शामिल हैं। गंभीर दुष्प्रभावों में गंभीर संक्रमण, फेफड़ों में सूजन, गुर्दे की समस्या और रक्त शर्करा या कोलेस्ट्रॉल का बढ़ना शामिल हो सकता है। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। टैबलेट को चबाएं या तोड़ें नहीं। हर दिन एक ही समय पर लें। अंगूर और अंगूर के रस से बचें। अन्य दवाओं, सप्लीमेंट्स और हर्बल उत्पादों के बारे में डॉक्टर को बताएं। गर्भावस्था के दौरान इस दवा का उपयोग न करें। स्तनपान न कराएं। नियमित रक्त परीक्षण कराएं। संक्रमण, असामान्य रक्तस्राव या सांस लेने में कठिनाई होने पर तुरंत डॉक्टर से संपर्क करें।
💊 advacan 0.25mg tablet Uses & Benefits
[{"condition":"Hormone receptor-positive, HER2-negative advanced breast cancer","description":"Used in combination with exemestane for postmenopausal women with advanced breast cancer after failure of treatment with letrozole or anastrozole.","evidence":"Well-established"},{"condition":"Pancreatic neuroendocrine tumors (pNET)","description":"Used for progressive, well-differentiated, non-functional neuroendocrine tumors of pancreatic origin that are unresectable, locally advanced, or metastatic.","evidence":"Well-established"},{"condition":"Gastrointestinal neuroendocrine tumors (GI-NET)","description":"Used for progressive, well-differentiated, non-functional neuroendocrine tumors of gastrointestinal or lung origin that are unresectable, locally advanced, or metastatic.","evidence":"Well-established"},{"condition":"Renal cell carcinoma (RCC)","description":"Used for advanced renal cell carcinoma after failure of treatment with sunitinib or sorafenib.","evidence":"Well-established"},{"condition":"Organ transplant rejection prophylaxis","description":"Used in combination with other immunosuppressants to prevent rejection of kidney or liver transplants, though the 0.25 mg strength is not typically used for this indication.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Tuberous sclerosis complex (TSC)-associated tumors","description":"Everolimus is approved for some TSC-associated tumors, but other uses may be off-label.","evidence":"Limited"},{"condition":"Lymphangioleiomyomatosis (LAM)","description":"Everolimus is approved for LAM in some regions; off-label use may occur in others.","evidence":"Limited"}]
Primary treatment for: Hormone receptor-positive, HER2-negative advanced breast cancer
Also treats: Pancreatic neuroendocrine tumors, Gastrointestinal neuroendocrine tumors, Renal cell carcinoma, Organ transplant rejection
📋 Drug Information
| Generic Name(s) | Everolimus |
| Brand Name | Afinitan |
| Manufacturer | Biocon |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Immunosuppressant- mTOR inhibitors |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F to 77°F). Keep in the original container, tightly closed, away from light and moisture. Do not freeze. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture. Check the expiry date on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by selectively inhibiting the mammalian target of rapamycin (mTOR), a serine-threonine kinase that regulates cell growth, proliferation, and survival. Everolimus binds to the intracellular protein FKBP-12, forming a complex that inhibits mTOR complex 1 (mTORC1). This inhibition leads to reduced protein synthesis and cell cycle arrest in the G1 phase, thereby slowing tumor growth and proliferation. In transplant settings, this medicine suppresses T-cell activation and proliferation, reducing the immune response against the transplanted organ.
Mechanism Steps
💡 How to Take advacan 0.25mg tablet
Strength: Everolimus 0.25 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose of this medicine depends on the condition being treated. For advanced breast cancer, the recommended dose is 10 mg once daily in combination with exemestane. For neuroendocrine tumors, the recommended dose is 10 mg once daily. For renal cell carcinoma, the recommended dose is 10 mg once daily. For transplant patients, the dose is individualized based on therapeutic drug monitoring. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients based on age alone. However, elderly patients may be more susceptible to side effects and should be monitored closely. |
| Renal Impairment | No dose adjustment is required for patients with renal impairment. However, everolimus should be used with caution in patients with severe renal impairment. |
| Hepatic Impairment | For patients with mild hepatic impairment (Child-Pugh A), the dose should be reduced to 7.5 mg once daily. For moderate hepatic impairment (Child-Pugh B), the dose should be reduced to 5 mg once daily. For severe hepatic impairment (Child-Pugh C), the dose should be reduced to 2.5 mg once daily. Use with caution and monitor closely. |
| Maximum Daily Dose | The maximum recommended daily dose is 10 mg once daily for oncology indications. For transplant patients, the dose is individualized. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of advacan 0.25mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampin | Major | |
| Clarithromycin | Major | |
| Carbamazepine | Major | |
| St. John's wort | Major | |
| Erythromycin | Moderate | |
| Verapamil | Moderate | |
| Phenobarbital | Moderate | |
| Cyclosporine | Moderate | |
| Live vaccines | Major |
🚨 Major Interactions
- Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- Strong CYP3A4 inducers (e.g., rifampin, carbamazepine, St. John's wort)
- Live vaccines
⚡ Moderate Interactions
- Moderate CYP3A4 inhibitors (e.g., erythromycin, verapamil)
- Moderate CYP3A4 inducers (e.g., efavirenz, phenobarbital)
- P-glycoprotein inhibitors (e.g., cyclosporine)
🍷 Alcohol Interaction
Alcohol may increase the risk of liver problems and worsen side effects such as nausea and fatigue. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to everolimus or any component of the formulation","Severe hepatic impairment","Active infections requiring systemic treatment","Live vaccines during treatment","Pregnancy and breastfeeding"]
⚠️ Warnings & Precautions
["This medicine can cause serious infections; monitor for signs and symptoms.","May cause lung inflammation (pneumonitis); report new respiratory symptoms.","Can cause severe allergic reactions; seek immediate help if symptoms occur.","May impair wound healing; caution after surgery.","Can increase blood sugar and cholesterol; monitor levels.","May cause kidney damage; regular monitoring required.","Avoid live vaccines during treatment.","Use effective contraception during and after treatment.","Do not breastfeed while taking this medicine.","Avoid grapefruit and grapefruit juice.","Inform your doctor of all other medicines you are taking."]
🤱 Lactation Safety
It is not known whether everolimus is excreted in human milk. Because of the potential for serious adverse reactions in breastfed infants, women should not breastfeed during treatment and for at least 2 weeks after the last dose.
💊 Overdose Management
There is no specific antidote for everolimus overdose. Treatment should be symptomatic and supportive. In case of suspected overdose, contact a poison control center or emergency room immediately. General supportive measures include monitoring of vital signs and appropriate clinical observation.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
This medicine must be taken exactly as prescribed by your doctor. Do not crush, chew, or split the tablet unless your doctor instructs you to do so. Take this medicine at the same time each day, with or without food, but be consistent. Avoid grapefruit and grapefruit juice, as they can increase the levels of this medicine in your body and lead to more side effects. Inform your doctor about all other medicines, supplements, and herbal products you are taking, as many interactions can occur. Use effective contraception during treatment and for a period after stopping, as this medicine can harm an unborn baby. Do not breastfeed while taking this medicine. Regular blood tests to monitor blood counts, kidney function, liver function, and blood sugar levels are essential. Report any signs of infection, unusual bleeding, or breathing difficulties immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects such as infections, fatigue, and kidney problems. Close monitoring is recommended. No specific dose adjustment is required based on age alone.
🤰 Pregnancy Planning (TTC)
This medicine can cause fetal harm. Women of childbearing potential should use effective contraception during treatment and for at least 8 weeks after the last dose. Men should also use contraception. If you are planning pregnancy, consult your doctor before stopping the medicine.
🏥 Post-Surgery Considerations
This medicine may impair wound healing. Inform your surgeon that you are taking this medicine before any surgery. Your doctor may advise temporary interruption.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. This medicine may increase the risk of bleeding and infection. Your dentist may recommend antibiotics or other precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid strenuous activities if you have fatigue, anemia, or heart problems. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, or vision changes, which can affect your ability to drive or operate machinery. Avoid driving if you feel unwell. Discuss with your doctor about work modifications if needed.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects, your doctor may adjust the dose or temporarily interrupt treatment. Stopping suddenly can worsen your condition.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to chronic immunosuppression, increasing the risk of infections and certain cancers. Regular monitoring of blood counts, kidney and liver function, and lipid levels is essential. Patients should be monitored for signs of lung toxicity and heart failure. Dose adjustments may be needed based on tolerability and efficacy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Enroll in clinical trials for new therapies.
Evidence: VariesFocus on symptom management and quality of life.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine due to the risk of infection. Inactivated vaccines may be less effective. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid temperature extremes. If traveling across time zones, consult your doctor about adjusting the dosing schedule. Ensure you have enough supply for your entire trip. Check customs regulations for controlled substances in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The onset of action varies. For cancer, it may take several weeks to months to see benefits. For transplant, immunosuppressive effects occur within days.
A: Yes, you can take it with or without food, but be consistent. Avoid high-fat meals and grapefruit.
A: Take it as soon as you remember if less than half the dosing interval has passed. Otherwise, skip it and continue with your regular schedule. Do not double dose.
A: No, this medicine can harm an unborn baby. Use effective contraception during treatment and for at least 8 weeks after stopping.
A: It is advisable to avoid alcohol as it may increase the risk of liver problems and worsen side effects.
🤔 Common Patient Concerns
🔄 Substitutes for advacan 0.25mg tablet
View AllAlternative brands with exact same active ingredient:
-
lanolimus 0.25mg tabletMylan Pharmaceuticals Pvt Ltd ₹406.00 23.5% CHEAPER
-
everomus 0.25mg tabletZydus Cadila ₹666.78 25.6% COSTLIER
-
evergraf 0.25mg tabletPanacea Biotec Ltd ₹700.59 31.9% COSTLIER
-
certican 0.25mg tabletNovartis India Ltd ₹978.00 84.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Everolimus is a chemotherapy drug.
Fact: Everolimus is a targeted therapy (mTOR inhibitor), not traditional chemotherapy. It specifically targets cancer cells with less effect on normal cells. - Myth: You can stop taking everolimus if you feel better.
Fact: Everolimus should be taken exactly as prescribed. Stopping suddenly can worsen your condition. Always consult your doctor before stopping. - Myth: Everolimus has no serious side effects.
Fact: Everolimus can cause serious side effects, including infections, lung inflammation, and kidney problems. Regular monitoring is essential.
🔄 Alternative Options
Generic Alternatives
- Everolimus 0.25 mg tablet (generic)
Brand Alternatives
- Afinitor 0.25mg tablet
- Certican 0.25mg tablet
- Zortress 0.25mg tablet