advacan 0.25mg tablet - Uses, Price, Side Effects & Substitutes
What is advacan 0.25mg tablet used for?
Afinitan (Everolimus) is used to treat ANTI NEOPLASTICS. It contains Everolimus (0.25mg), which Inhibits mTOR kinase, a key regulator of cell growth, proliferation, and angioge. Always consult your doctor before use. Take as prescribed.
- Generic Name: Everolimus
- Manufacturer: Biocon
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ advacan 0.25mg tablet Uses & Benefits
Advanced renal cell carcinoma, advanced breast cancer (hormone receptor-positive, HER2-negative), pancreatic neuroendocrine tumors, subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis, renal angiomyolipoma with tuberous sclerosis.
Off-label uses: Graft-versus-host disease, lymphangioleiomyomatosis, tuberous sclerosis complex (non-SEGA manifestations).
๐ Drug Information
| Generic Name(s) | Everolimus |
| Brand Name | Afinitan |
| Manufacturer | Biocon |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Immunosuppressant- mTOR inhibitors |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits mTOR kinase, a key regulator of cell growth, proliferation, and angiogenesis.
Mechanism Steps
๐ก How to Take advacan 0.25mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of advacan 0.25mg tablet
โ Common Side Effects
- Stomatitis
- Rash
- Fatigue
- Diarrhea
- Nausea
- Edema
- Hyperglycemia
- Hyperlipidemia
- Infections
๐จ Serious Side Effects
- Non-infectious pneumonitis
- Renal failure
- Bowel perforation
- Hemorrhage
- Severe infections
- Angioedema
โ ๏ธ Rare Side Effects
- Interstitial lung disease
- Pericardial effusion
- Thrombotic microangiopathy
- Hepatic artery thrombosis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | Increased everolimus exposure (AUC increased 15-fold) |
| Rifampin | Major | Decreased everolimus exposure (AUC reduced 63%) |
| Cyclosporine | Major | Increased everolimus exposure; monitor levels |
| Grapefruit juice | Minor | Modest increase in everolimus exposure |
๐จ Major Interactions
- Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, voriconazole, clarithromycin)
- Strong CYP3A4 inducers (e.g., rifampin, rifabutin, phenytoin, carbamazepine)
- P-glycoprotein inhibitors (e.g., cyclosporine)
โก Moderate Interactions
- Moderate CYP3A4 inhibitors (e.g., fluconazole, diltiazem, verapamil)
- Moderate CYP3A4 inducers (e.g., dexamethasone, efavirenz)
โน๏ธ Minor Interactions
- Grapefruit juice
- St. John's Wort
๐ฝ๏ธ Food Interactions
High-fat meal reduces absorption; take consistently with or without food.
๐ท Alcohol Interaction
No specific interaction reported; avoid excessive alcohol due to potential hepatotoxicity.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to everolimus or sirolimus; severe hepatic impairment (Child-Pugh C).
๐ Monitoring Parameters
Complete blood count, liver function tests, renal function, blood glucose, lipid profile, everolimus trough levels (if needed).
๐คฑ Lactation Safety
Not recommended; excreted in animal milk; unknown in humans.
๐ Overdose Management
No specific antidote; supportive care; monitor for adverse effects.
โฐ Missed Dose
If missed, skip dose and take next at regular time; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for advacan 0.25mg tablet
View AllAlternative brands with exact same active ingredient (Everolimus (0.25mg)):
-
lanolimus 0.25mg tabletMylan Pharmaceuticals Pvt Ltd โน406.00 23.5% CHEAPER
-
everomus 0.25mg tabletZydus Cadila โน666.78 25.6% COSTLIER
-
evergraf 0.25mg tabletPanacea Biotec Ltd โน700.59 31.9% COSTLIER
-
certican 0.25mg tabletNovartis India Ltd โน978.00 84.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.