advacan 0.25mg tablet - Everolimus (0.25mg) medicine

Advacan 0.25mg Tablet (Everolimus): Comprehensive Medicine Guide

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🏭 Biocon 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 18, 2026
⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: High
Reviewed by
SaathiMed Expert Panel | Oct 18, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Fever, chills, or signs of infection
  • New or worsening cough, shortness of breath, or chest pain
  • Severe mouth sores preventing eating or drinking
  • Decreased urine output or swelling in legs
  • Unusual bleeding or bruising
  • Yellowing of skin or eyes
  • Severe abdominal pain
  • Rash with blistering or peeling skin

If experiencing severe symptoms, call emergency services immediately.

What is advacan 0.25mg tablet used for?

This medicine contains everolimus, an mTOR inhibitor used to treat certain cancers and prevent organ transplant rejection. It works by blocking a protein that helps cells grow and divide. It is taken orally as a tablet, usually once daily, and requires regular monitoring for side effects.

  • Generic Name: Everolimus
  • Manufacturer: Biocon
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 advacan 0.25mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा एवरोलिमस 0.25 मिलीग्राम टैबलेट के रूप में उपलब्ध है और मुख्य रूप से कैंसर के इलाज और अंग प्रत्यारोपण में अस्वीकृति को रोकने के लिए उपयोग की जाती है। यह स्तन कैंसर, अग्नाशय के न्यूरोएंडोक्राइन ट्यूमर, गैस्ट्रोइंटेस्टाइनल न्यूरोएंडोक्राइन ट्यूमर और गुर्दे के कैंसर में प्रभावी है। यह दवा कोशिकाओं के विकास को धीमा करने और प्रतिरक्षा प्रणाली को दबाने का काम करती है। इसे डॉक्टर की सलाह के अनुसार ही लें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह के छाले, दाने, थकान, दस्त, जी मिचलाना, भूख में कमी और स्वाद में बदलाव शामिल हैं। गंभीर दुष्प्रभावों में गंभीर संक्रमण, फेफड़ों में सूजन, गुर्दे की समस्या और रक्त शर्करा या कोलेस्ट्रॉल का बढ़ना शामिल हो सकता है। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। टैबलेट को चबाएं या तोड़ें नहीं। हर दिन एक ही समय पर लें। अंगूर और अंगूर के रस से बचें। अन्य दवाओं, सप्लीमेंट्स और हर्बल उत्पादों के बारे में डॉक्टर को बताएं। गर्भावस्था के दौरान इस दवा का उपयोग न करें। स्तनपान न कराएं। नियमित रक्त परीक्षण कराएं। संक्रमण, असामान्य रक्तस्राव या सांस लेने में कठिनाई होने पर तुरंत डॉक्टर से संपर्क करें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 advacan 0.25mg tablet Uses & Benefits

[{"condition":"Hormone receptor-positive, HER2-negative advanced breast cancer","description":"Used in combination with exemestane for postmenopausal women with advanced breast cancer after failure of treatment with letrozole or anastrozole.","evidence":"Well-established"},{"condition":"Pancreatic neuroendocrine tumors (pNET)","description":"Used for progressive, well-differentiated, non-functional neuroendocrine tumors of pancreatic origin that are unresectable, locally advanced, or metastatic.","evidence":"Well-established"},{"condition":"Gastrointestinal neuroendocrine tumors (GI-NET)","description":"Used for progressive, well-differentiated, non-functional neuroendocrine tumors of gastrointestinal or lung origin that are unresectable, locally advanced, or metastatic.","evidence":"Well-established"},{"condition":"Renal cell carcinoma (RCC)","description":"Used for advanced renal cell carcinoma after failure of treatment with sunitinib or sorafenib.","evidence":"Well-established"},{"condition":"Organ transplant rejection prophylaxis","description":"Used in combination with other immunosuppressants to prevent rejection of kidney or liver transplants, though the 0.25 mg strength is not typically used for this indication.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Tuberous sclerosis complex (TSC)-associated tumors","description":"Everolimus is approved for some TSC-associated tumors, but other uses may be off-label.","evidence":"Limited"},{"condition":"Lymphangioleiomyomatosis (LAM)","description":"Everolimus is approved for LAM in some regions; off-label use may occur in others.","evidence":"Limited"}]

Primary treatment for: Hormone receptor-positive, HER2-negative advanced breast cancer

Also treats: Pancreatic neuroendocrine tumors, Gastrointestinal neuroendocrine tumors, Renal cell carcinoma, Organ transplant rejection

📋 Drug Information

Generic Name(s)Everolimus
Brand NameAfinitan
ManufacturerBiocon
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI NEOPLASTICS
Action ClassImmunosuppressant- mTOR inhibitors
Route of AdministrationOral
StorageStore at room temperature between 20°C and 25°C (68°F to 77°F). Keep in the original container, tightly closed, away from light and moisture. Do not freeze.
Shelf LifeThe shelf life is typically 24 months from the date of manufacture. Check the expiry date on the pack.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day to maintain consistent blood levels.
2
Avoid grapefruit and grapefruit juice, as they can increase drug levels and toxicity.
3
Use effective contraception during treatment and for at least 8 weeks after stopping.
4
Report any new or worsening cough, shortness of breath, or fever immediately.
5
Monitor your blood sugar and cholesterol levels regularly as advised.
6
Do not receive live vaccines while on this medicine.
7
Inform your dentist about this medicine before any dental procedure.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Advanced breast cancer
This medicine is approved for this condition.
Likely Use
✅
Pancreatic neuroendocrine tumor
This medicine is approved for this condition.
Likely Use
✅
Organ transplant rejection
This medicine is used for prophylaxis.
Likely Use
❌
Common cold
This medicine is not used for viral infections.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionEverolimus is rapidly absorbed after oral administration, with peak concentrations achieved in about 1 to 2 hours. Food can affect absorption; high-fat meals may reduce peak levels and increase time to peak. The absolute bioavailability is not well established but is estimated to be around 30%.
DistributionEverolimus is highly bound to plasma proteins and distributes widely into tissues. The volume of distribution is not well characterized but is large.
Protein BindingApproximately 74% bound to plasma proteins, primarily albumin.
MetabolismEverolimus is extensively metabolized in the liver, primarily by CYP3A4 and to a lesser extent by CYP2C8. It is a substrate of P-glycoprotein.
Half-LifeThe elimination half-life of everolimus is approximately 30 hours.
ExcretionEverolimus is primarily excreted in feces (about 80%) and urine (about 5%) as metabolites.
BioavailabilityThe absolute bioavailability of everolimus is not established from the available information, but it is estimated to be around 30%.
Onset of ActionThe onset of action for everolimus varies depending on the indication. For immunosuppression, effects are seen within days to weeks. For antitumor effects, it may take several weeks.
Peak Plasma TimePeak plasma concentrations are reached approximately 1 to 2 hours after oral administration.
Duration of ActionThe duration of action is not well established, but given the half-life of about 30 hours, effects persist for several days.

How It Works

This medicine works by selectively inhibiting the mammalian target of rapamycin (mTOR), a serine-threonine kinase that regulates cell growth, proliferation, and survival. Everolimus binds to the intracellular protein FKBP-12, forming a complex that inhibits mTOR complex 1 (mTORC1). This inhibition leads to reduced protein synthesis and cell cycle arrest in the G1 phase, thereby slowing tumor growth and proliferation. In transplant settings, this medicine suppresses T-cell activation and proliferation, reducing the immune response against the transplanted organ.

Mechanism Steps

1
Binding to FKBP-12: Everolimus binds to the immunophilin FKBP-12 inside cells.
2
Formation of everolimus-FKBP-12 complex: This complex interacts with mTOR, specifically mTORC1.
3
Inhibition of mTORC1: The complex inhibits the kinase activity of mTORC1, blocking downstream signaling.
4
Reduced protein synthesis: Inhibition of mTORC1 leads to decreased phosphorylation of S6K1 and 4E-BP1, reducing protein synthesis.
5
Cell cycle arrest: This results in cell cycle arrest at the G1 phase, inhibiting cell proliferation.
6
Immunosuppression and antitumor effects: In transplant settings, T-cell proliferation is suppressed; in cancer, tumor growth is inhibited.

💡 How to Take advacan 0.25mg tablet

Strength: Everolimus 0.25 mg immediate-release tablet

1Take this medicine exactly as prescribed by your doctor.
2Swallow the tablet whole with a glass of water.
3Do not crush, chew, or split the tablet unless instructed by your doctor.
4Take at the same time each day, with or without food, but be consistent.
5Avoid grapefruit and grapefruit juice while taking this medicine.
6If you miss a dose, follow the missed dose instructions.
7Do not stop taking this medicine without consulting your doctor.

Dosage Information

Adult DosageThe usual adult dose of this medicine depends on the condition being treated. For advanced breast cancer, the recommended dose is 10 mg once daily in combination with exemestane. For neuroendocrine tumors, the recommended dose is 10 mg once daily. For renal cell carcinoma, the recommended dose is 10 mg once daily. For transplant patients, the dose is individualized based on therapeutic drug monitoring. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dose adjustment is recommended for elderly patients based on age alone. However, elderly patients may be more susceptible to side effects and should be monitored closely.
Renal ImpairmentNo dose adjustment is required for patients with renal impairment. However, everolimus should be used with caution in patients with severe renal impairment.
Hepatic ImpairmentFor patients with mild hepatic impairment (Child-Pugh A), the dose should be reduced to 7.5 mg once daily. For moderate hepatic impairment (Child-Pugh B), the dose should be reduced to 5 mg once daily. For severe hepatic impairment (Child-Pugh C), the dose should be reduced to 2.5 mg once daily. Use with caution and monitor closely.
Maximum Daily DoseThe maximum recommended daily dose is 10 mg once daily for oncology indications. For transplant patients, the dose is individualized.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With or without food
Be consistent
Food can affect absorption; consistency helps maintain stable levels.
Grapefruit
Avoid
Increases drug levels and risk of toxicity.
High-fat meals
Avoid taking with high-fat meals
Reduces peak levels and increases time to peak.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of advacan 0.25mg tablet

✅ Common Side Effects

Mouth sores (stomatitis) (Very common (>10%))
Use alcohol-free mouthwash, avoid spicy foods, and consult your doctor for topical treatments.
Rash (Very common (>10%))
Keep skin moisturized, avoid harsh soaps, and report to your doctor if severe.
Fatigue (Very common (>10%))
Get adequate rest, pace activities, and inform your doctor if it interferes with daily life.
Diarrhea (Very common (>10%))
Stay hydrated, avoid high-fiber foods during episodes, and use anti-diarrheal medicines only if approved by your doctor.
Nausea (Very common (>10%))
Take with food, eat small frequent meals, and ask your doctor about anti-nausea medicines.
Decreased appetite (Common (1-10%))
Eat small, frequent meals and consult a dietitian if weight loss occurs.
Altered taste (Common (1-10%))
Try different seasonings, and usually resolves over time.

🚨 Serious Side Effects

Severe infections (e.g., pneumonia, sepsis) (Common (1-10%))
Seek immediate medical attention if you have fever, chills, cough, or difficulty breathing.
Lung inflammation (pneumonitis) (Uncommon (0.1-1%))
Report new or worsening cough, shortness of breath, or chest pain immediately.
Kidney failure (Uncommon (0.1-1%))
Regular blood tests are needed; report decreased urine output or swelling.
Severe allergic reactions (anaphylaxis) (Rare (<0.1%))
Seek emergency help if you experience rash, hives, swelling of face or throat, or difficulty breathing.
Heart failure (Uncommon (0.1-1%))
Report shortness of breath, swelling in legs, or rapid weight gain.
Bleeding (Uncommon (0.1-1%))
Report unusual bruising or bleeding to your doctor immediately.

⚠️ Rare Side Effects

Pancreatitis
Seek medical attention for severe abdominal pain radiating to the back.
Hepatitis
Report yellowing of skin or eyes, dark urine, or abdominal pain.
Progressive multifocal leukoencephalopathy (PML)
Report neurological symptoms such as confusion, weakness, or vision changes.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Rifampin Major
Clarithromycin Major
Carbamazepine Major
St. John's wort Major
Erythromycin Moderate
Verapamil Moderate
Phenobarbital Moderate
Cyclosporine Moderate
Live vaccines Major

🚨 Major Interactions

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine, St. John's wort)
  • Live vaccines

⚡ Moderate Interactions

  • Moderate CYP3A4 inhibitors (e.g., erythromycin, verapamil)
  • Moderate CYP3A4 inducers (e.g., efavirenz, phenobarbital)
  • P-glycoprotein inhibitors (e.g., cyclosporine)

🍷 Alcohol Interaction

Alcohol may increase the risk of liver problems and worsen side effects such as nausea and fatigue. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to everolimus or any component of the formulation","Severe hepatic impairment","Active infections requiring systemic treatment","Live vaccines during treatment","Pregnancy and breastfeeding"]

⚠️ Warnings & Precautions

["This medicine can cause serious infections; monitor for signs and symptoms.","May cause lung inflammation (pneumonitis); report new respiratory symptoms.","Can cause severe allergic reactions; seek immediate help if symptoms occur.","May impair wound healing; caution after surgery.","Can increase blood sugar and cholesterol; monitor levels.","May cause kidney damage; regular monitoring required.","Avoid live vaccines during treatment.","Use effective contraception during and after treatment.","Do not breastfeed while taking this medicine.","Avoid grapefruit and grapefruit juice.","Inform your doctor of all other medicines you are taking."]

🤱 Lactation Safety

It is not known whether everolimus is excreted in human milk. Because of the potential for serious adverse reactions in breastfed infants, women should not breastfeed during treatment and for at least 2 weeks after the last dose.

💊 Overdose Management

There is no specific antidote for everolimus overdose. Treatment should be symptomatic and supportive. In case of suspected overdose, contact a poison control center or emergency room immediately. General supportive measures include monitoring of vital signs and appropriate clinical observation.

⏰ Missed Dose

If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.

Additional Safety Advice

General Safety

This medicine must be taken exactly as prescribed by your doctor. Do not crush, chew, or split the tablet unless your doctor instructs you to do so. Take this medicine at the same time each day, with or without food, but be consistent. Avoid grapefruit and grapefruit juice, as they can increase the levels of this medicine in your body and lead to more side effects. Inform your doctor about all other medicines, supplements, and herbal products you are taking, as many interactions can occur. Use effective contraception during treatment and for a period after stopping, as this medicine can harm an unborn baby. Do not breastfeed while taking this medicine. Regular blood tests to monitor blood counts, kidney function, liver function, and blood sugar levels are essential. Report any signs of infection, unusual bleeding, or breathing difficulties immediately.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more susceptible to side effects such as infections, fatigue, and kidney problems. Close monitoring is recommended. No specific dose adjustment is required based on age alone.

🤰 Pregnancy Planning (TTC)

This medicine can cause fetal harm. Women of childbearing potential should use effective contraception during treatment and for at least 8 weeks after the last dose. Men should also use contraception. If you are planning pregnancy, consult your doctor before stopping the medicine.

🏥 Post-Surgery Considerations

This medicine may impair wound healing. Inform your surgeon that you are taking this medicine before any surgery. Your doctor may advise temporary interruption.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine before any dental procedure. This medicine may increase the risk of bleeding and infection. Your dentist may recommend antibiotics or other precautions.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy diet rich in fruits and vegetables.
🥗
Stay physically active as tolerated to improve overall well-being.
😴
Avoid smoking and limit alcohol consumption.
💧
Practice good hygiene to reduce infection risk.
🧘
Get adequate rest and manage stress.
🌞
Stay up to date with vaccinations (except live vaccines).

🏋️ Exercise Considerations

Moderate exercise is generally safe, but avoid strenuous activities if you have fatigue, anemia, or heart problems. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Eat small, frequent meals if you have nausea or mouth sores.
Avoid spicy, acidic, or rough-textured foods if you have mouth sores.
Stay well hydrated.
Limit high-fat and high-sugar foods to manage cholesterol and blood sugar.
Include protein-rich foods to support healing.

💼 Impact on Daily Work & Life

This medicine may cause fatigue, dizziness, or vision changes, which can affect your ability to drive or operate machinery. Avoid driving if you feel unwell. Discuss with your doctor about work modifications if needed.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects, your doctor may adjust the dose or temporarily interrupt treatment. Stopping suddenly can worsen your condition.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to chronic immunosuppression, increasing the risk of infections and certain cancers. Regular monitoring of blood counts, kidney and liver function, and lipid levels is essential. Patients should be monitored for signs of lung toxicity and heart failure. Dose adjustments may be needed based on tolerability and efficacy.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Clinical trials

Enroll in clinical trials for new therapies.

Evidence: Varies
Palliative care

Focus on symptom management and quality of life.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Live vaccines should be avoided during treatment with this medicine due to the risk of infection. Inactivated vaccines may be less effective. Consult your doctor before receiving any vaccine.

📦 Storage Guide

✅ DO

Store at room temperature (20-25°C)

❌ DON'T

Do not refrigerate or freeze

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight and moisture

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid temperature extremes. If traveling across time zones, consult your doctor about adjusting the dosing schedule. Ensure you have enough supply for your entire trip. Check customs regulations for controlled substances in your destination country.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 58-year-old woman with advanced breast cancer
She was started on this medicine along with exemestane. After 4 weeks, she noticed mouth sores and fatigue. Her doctor reduced the dose temporarily and gave her a mouthwash. She learned to avoid spicy foods and use a soft toothbrush. Her cancer stabilized after 3 months.
💡 Lesson: Early reporting of side effects allows timely management and helps maintain treatment adherence.
👤 A 45-year-old man with pancreatic neuroendocrine tumor
He was prescribed this medicine after his tumor progressed on other treatments. He experienced diarrhea and rash initially, which were managed with dose adjustment and supportive care. He remained on treatment for over a year with stable disease.
💡 Lesson: Dose adjustments and supportive care can help patients continue treatment and achieve long-term benefit.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: The onset of action varies. For cancer, it may take several weeks to months to see benefits. For transplant, immunosuppressive effects occur within days.

Q: Can I take this medicine with food?

A: Yes, you can take it with or without food, but be consistent. Avoid high-fat meals and grapefruit.

Q: What should I do if I miss a dose?

A: Take it as soon as you remember if less than half the dosing interval has passed. Otherwise, skip it and continue with your regular schedule. Do not double dose.

Q: Is this medicine safe during pregnancy?

A: No, this medicine can harm an unborn baby. Use effective contraception during treatment and for at least 8 weeks after stopping.

Q: Can I drink alcohol while taking this medicine?

A: It is advisable to avoid alcohol as it may increase the risk of liver problems and worsen side effects.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe to take during pregnancy?
  • Can I breastfeed while on this medicine?

🔄 Substitutes for advacan 0.25mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Everolimus is a chemotherapy drug.
    Fact: Everolimus is a targeted therapy (mTOR inhibitor), not traditional chemotherapy. It specifically targets cancer cells with less effect on normal cells.
  • Myth: You can stop taking everolimus if you feel better.
    Fact: Everolimus should be taken exactly as prescribed. Stopping suddenly can worsen your condition. Always consult your doctor before stopping.
  • Myth: Everolimus has no serious side effects.
    Fact: Everolimus can cause serious side effects, including infections, lung inflammation, and kidney problems. Regular monitoring is essential.

🔄 Alternative Options

Generic Alternatives

  • Everolimus 0.25 mg tablet (generic)

Brand Alternatives

  • Afinitor 0.25mg tablet
  • Certican 0.25mg tablet
  • Zortress 0.25mg tablet

📊 Comparison with Similar Medicines

[{"medicine":"Everolimus","class":"mTOR inhibitor","primary_use":"Advanced breast cancer, NET, RCC, transplant","route":"Oral","half_life":"~30 hours"},{"medicine":"Sirolimus","class":"mTOR inhibitor","primary_use":"Transplant rejection prophylaxis","route":"Oral","half_life":"~62 hours"},{"medicine":"Temsirolimus","class":"mTOR inhibitor","primary_use":"Renal cell carcinoma","route":"Intravenous","half_life":"~17 hours"}]

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