Kombiglyze XR 5mg/1000mg Tablet: Complete Information
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Rapid breathing, muscle pain, or extreme tiredness (possible lactic acidosis)
- Severe abdominal pain radiating to the back (possible pancreatitis)
- Swelling of face, lips, tongue, or throat (possible angioedema)
- Signs of hypoglycemia: shakiness, sweating, confusion, rapid heartbeat
- Yellowing of skin or eyes, dark urine (possible liver problem)
- Decreased urine output or swelling in legs (possible kidney problem)
- Persistent nausea, vomiting, or severe diarrhea
If experiencing severe symptoms, call emergency services immediately.
What is kombiglyze xr 5mg/1000mg tablet used for?
This medicine is a combination of saxagliptin and metformin used to treat type 2 diabetes. It helps control blood sugar by increasing insulin release and reducing glucose production in the liver.
- Generic Name: Saxagliptin (5mg) + Metformin (1000mg)
- Manufacturer: AstraZeneca
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 kombiglyze xr 5mg/1000mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा टाइप 2 डायबिटीज के इलाज के लिए इस्तेमाल की जाती है। यह शरीर में इंसुलिन की मात्रा बढ़ाने और लीवर में ग्लूकोज बनने को कम करने में मदद करती है। यह दवा खून में शुगर के स्तर को नियंत्रित करने में सहायक है। इसे डॉक्टर की सलाह के अनुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, जुकाम, दस्त, मतली और पेट में असहजता शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन लैक्टिक एसिडोसिस, पैन्क्रियाटाइटिस और हाइपोग्लाइसीमिया हो सकते हैं। अगर आपको सांस लेने में तकलीफ, मांसपेशियों में दर्द, या पेट में तेज दर्द हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ निगलें, चबाएं नहीं। शराब का सेवन न करें क्योंकि इससे लैक्टिक एसिडोसिस का खतरा बढ़ सकता है। अपने गुर्दे की कार्यप्रणाली की नियमित जांच कराते रहें। बिना डॉक्टर की सलाह के दवा बंद न करें।
💊 kombiglyze xr 5mg/1000mg tablet Uses & Benefits
[{"condition":"Type 2 diabetes mellitus","description":"Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.","evidence":"Well-established"}]
Off-label uses: []
Primary treatment for: Type 2 diabetes mellitus
📋 Drug Information
| Generic Name(s) | Saxagliptin (5mg) + Metformin (1000mg) |
| Brand Name | kombiglyze xr 5mg/1000mg tablet |
| Manufacturer | AstraZeneca |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F to 77°F). Keep in the original container, tightly closed. Protect from moisture and light. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antidiabetic agents with complementary mechanisms. Saxagliptin is a selective DPP-4 inhibitor that prolongs the activity of incretin hormones (GLP-1 and GIP), leading to increased insulin secretion and decreased glucagon release in a glucose-dependent manner. Metformin decreases hepatic glucose production, reduces intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
Mechanism Steps
💡 How to Take kombiglyze xr 5mg/1000mg tablet
Strength: Extended-release tablet containing saxagliptin 5 mg and metformin hydrochloride 1000 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken once daily with a meal. The dose may be adjusted by your doctor based on your blood sugar levels and kidney function. Do not exceed the maximum recommended dose of saxagliptin 5 mg and metformin 2000 mg per day. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Renal function should be assessed before and during treatment. Dose adjustment may be necessary based on renal function. |
| Renal Impairment | Assess renal function before initiation and periodically. For patients with eGFR 45-59 mL/min/1.73 m2, continue with caution. For eGFR 30-44 mL/min/1.73 m2, do not initiate; if already on treatment, consider dose reduction. For eGFR <30 mL/min/1.73 m2, contraindicated. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Avoid in severe hepatic impairment. |
| Maximum Daily Dose | Saxagliptin 5 mg and metformin 2000 mg per day. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of kombiglyze xr 5mg/1000mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Cationic drugs | Major | |
| Carbonic anhydrase inhibitors | Major | |
| CYP3A4 inhibitors | Moderate | |
| CYP3A4 inducers | Moderate | |
| Insulin/sulfonylureas | Major | |
| Alcohol | Moderate | |
| Diuretics | Moderate | |
| NSAIDs | Moderate | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin)
- Carbonic anhydrase inhibitors (e.g., acetazolamide, dichlorphenamide, topiramate)
- CYP3A4/5 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- CYP3A4/5 inducers (e.g., rifampin, carbamazepine, phenytoin)
- Insulin or insulin secretagogues (e.g., sulfonylureas)
⚡ Moderate Interactions
- Alcohol
- Diuretics
- NSAIDs
🍷 Alcohol Interaction
Alcohol should be avoided or limited while taking this medicine because it can increase the risk of lactic acidosis and hypoglycemia. Excessive alcohol intake may also worsen diabetes control.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Lactic acidosis: Rare but serious; risk increases with renal impairment, sepsis, dehydration, excessive alcohol use, and hepatic disease.","Pancreatitis: Acute pancreatitis has been reported; monitor for signs and discontinue if suspected.","Heart failure: Saxagliptin may increase risk of hospitalization for heart failure; monitor and consider discontinuation if symptoms develop.","Hypoglycemia: Risk increases when used with insulin or sulfonylureas; dose adjustment may be needed.","Renal function: Assess before initiation and periodically; dose adjustment required for mild to moderate renal impairment.","Vitamin B12 deficiency: Metformin may reduce B12 levels; monitor periodically.","Surgery: Discontinue before elective surgery and restart after renal function is stable.","Alcohol: Avoid excessive intake due to risk of lactic acidosis."]
🤱 Lactation Safety
Not established from the available information. Consult your doctor before breastfeeding.
💊 Overdose Management
In case of overdose, seek immediate medical attention. Symptoms may include severe hypoglycemia, lactic acidosis, or pancreatitis. Treatment is supportive and symptomatic. Hemodialysis may be considered for metformin overdose.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Swallow the tablet whole with a meal to reduce stomach upset and improve absorption. Do not crush, chew, or split the tablet. Do not exceed the recommended dose. Inform your doctor if you have kidney or liver problems, heart failure, or a history of pancreatitis. Avoid excessive alcohol consumption while taking this medicine, as it increases the risk of lactic acidosis. Your doctor may check your kidney function and vitamin B12 levels periodically. If you experience symptoms such as rapid breathing, severe nausea, or unusual muscle pain, seek immediate medical attention. Do not stop taking this medicine without consulting your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially regarding renal function and hypoglycemia. Renal function should be assessed before and during treatment. Dose adjustment may be necessary based on kidney function.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established. Your doctor may switch you to a different treatment approach.
🏥 Post-Surgery Considerations
Discontinue this medicine before elective surgery and restart only after your kidney function is stable and your doctor approves. This is important to reduce the risk of lactic acidosis.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. No specific precautions are usually needed, but maintain good oral hygiene and monitor blood sugar before dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is encouraged as part of diabetes management, but monitor your blood sugar before and after exercise, especially if you take insulin or sulfonylureas. Carry a fast-acting carbohydrate source in case of hypoglycemia. Stay hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or hypoglycemia in some patients, which can affect your ability to drive or operate machinery. Avoid driving if you feel dizzy or experience symptoms of low blood sugar. Inform your employer about your condition if your work involves operating heavy machinery.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as lactic acidosis, pancreatitis, or severe allergic reactions, seek immediate medical attention and follow your doctor's advice regarding discontinuation.
📅 Long-Term Use Effects
Long-term use of this medicine may require periodic monitoring of kidney function, vitamin B12 levels, and heart failure symptoms. Metformin can cause vitamin B12 deficiency over time. Saxagliptin may increase the risk of heart failure in some patients. Regular follow-up with your doctor is essential to monitor these parameters and adjust treatment as needed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are the cornerstone of diabetes management and can complement medicine.
Evidence: Well-establishedDepending on your condition, your doctor may consider other classes such as SGLT2 inhibitors, GLP-1 receptor agonists, or sulfonylureas.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, patients with diabetes should stay up to date with recommended vaccinations, including influenza and pneumococcal vaccines, as they are at higher risk of infections.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, consult your doctor about adjusting the timing of your dose. Keep enough supply for the entire trip and carry it in your hand luggage. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within the first week, but maximal effects may take 2 to 4 weeks. Regular monitoring is important.
A: Yes, but only under your doctor's supervision. Combining with insulin or sulfonylureas may increase the risk of hypoglycemia.
A: It depends on your kidney function. Your doctor will assess your eGFR and may adjust the dose or choose an alternative if your kidney function is severely impaired.
🤔 Common Patient Concerns
🔄 Substitutes for kombiglyze xr 5mg/1000mg tablet
View AllAlternative brands with exact same active ingredient:
-
riax-m xr 5mg/1000mg tabletDr Reddy's Laboratories Ltd ₹334.69 17.2% CHEAPER
-
zaxaglit m 5mg/1000mg tabletChemo Healthcare Pvt Ltd ₹478.13 18.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps manage blood sugar levels but does not cure diabetes. Lifestyle modifications and ongoing medical care are essential. - Myth: This medicine causes weight gain.
Fact: This medicine is generally weight neutral. Some patients may experience slight weight loss due to metformin. - Myth: You can stop taking this medicine once your sugar levels are normal.
Fact: Do not stop without consulting your doctor. Diabetes is a chronic condition and stopping medication can lead to uncontrolled blood sugar.