actamase 1000 mg/125 mg injection - Uses, Price, Side Effects & Substitutes
What is actamase 1000 mg/125 mg injection used for?
Actamase (Cefepime + Tazobactam) is used to treat ANTI INFECTIVES. It contains Cefepime (1000mg) + Tazobactum (125mg), which Cefepime inhibits bacterial cell wall synthesis by binding to penicillin-binding. Always consult your doctor before use. Take as prescribed.
- Generic Name: Cefepime + Tazobactam
- Manufacturer: AstraZeneca
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ actamase 1000 mg/125 mg injection Uses & Benefits
Treatment of complicated urinary tract infections, intra-abdominal infections, pneumonia, skin and soft tissue infections, febrile neutropenia.
Off-label uses: Meningitis, osteomyelitis, septic arthritis (based on sensitivity).
๐ Drug Information
| Generic Name(s) | Cefepime + Tazobactam |
| Brand Name | Actamase |
| Manufacturer | AstraZeneca |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Antibiotic (Cephalosporin + Beta-lactamase inhibitor) |
| Route of Administration | Intravenous (IV) or Intramuscular (IM) |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light; reconstituted solution stable for 24 hours at room temperature or 7 days refrigerated. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Cefepime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs); Tazobactam inhibits beta-lactamases, preventing degradation of cefepime.
Mechanism Steps
๐ก How to Take actamase 1000 mg/125 mg injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of actamase 1000 mg/125 mg injection
โ Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Rash
- Injection site pain
- Headache
๐จ Serious Side Effects
- Severe allergic reactions (anaphylaxis)
- Clostridioides difficile colitis
- Seizures (especially with renal impairment)
- Acute kidney injury
- Bleeding (hypoprothrombinemia)
โ ๏ธ Rare Side Effects
- Hemolytic anemia
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- QT prolongation
- Pseudomembranous colitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased INR and bleeding risk |
| Probenecid | Major | Decreased renal excretion of cefepime, increased toxicity |
| Aminoglycosides | Major | Increased nephrotoxicity risk |
| Loop diuretics | Major | Increased nephrotoxicity risk |
| Oral contraceptives | Moderate | Reduced contraceptive efficacy |
| Live bacterial vaccines | Moderate | Reduced vaccine efficacy |
| Methotrexate | Moderate | Increased methotrexate toxicity |
| Antacids | Minor | No significant interaction |
| Iron supplements | Minor | No significant interaction |
๐จ Major Interactions
- Warfarin
- Probenecid
- Aminoglycosides
- Loop diuretics
โก Moderate Interactions
- Oral contraceptives
- Live bacterial vaccines
- Methotrexate
โน๏ธ Minor Interactions
- Antacids
- Iron supplements
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
No disulfiram-like reaction reported.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cefepime, tazobactam, or any cephalosporin; history of severe allergic reaction to penicillins or other beta-lactams.
๐ Monitoring Parameters
Renal function, CBC, signs of superinfection, bleeding, and allergic reactions.
๐คฑ Lactation Safety
Excreted in breast milk in low amounts; use with caution.
๐ Overdose Management
Supportive care; hemodialysis may enhance elimination.
โฐ Missed Dose
Administer as soon as remembered; if near next dose, skip missed dose; do not double dose.