actamase forte 2000mg/250mg powder for injection
What is actamase forte 2000mg/250mg powder for injection used for?
Actamase (Cefepime + Tazobactam) is used to treat ANTI INFECTIVES. It contains Cefepime (2000mg) + Tazobactum (250mg), which Cefepime inhibits bacterial cell wall synthesis by binding to penicillin-binding. Always consult your doctor before use. Take as prescribed.
- Generic Name: Cefepime + Tazobactam
- Manufacturer: AstraZeneca
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ actamase forte 2000mg/250mg powder for injection Uses & Benefits
Treatment of complicated urinary tract infections, intra-abdominal infections, pneumonia, skin and soft tissue infections, febrile neutropenia.
Off-label uses: Meningitis, osteomyelitis, septic arthritis (based on sensitivity).
๐ Drug Information
| Generic Name(s) | Cefepime + Tazobactam |
| Brand Name | Actamase |
| Manufacturer | AstraZeneca |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Antibiotic (Cephalosporin + Beta-lactamase inhibitor) |
| Route of Administration | Intravenous (IV) or Intramuscular (IM) |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light; reconstituted solution stable for 24 hours at room temperature or 7 days refrigerated. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Cefepime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs); Tazobactam inhibits beta-lactamases, preventing degradation of cefepime.
Mechanism Steps
๐ก How to Take actamase forte 2000mg/250mg powder for injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of actamase forte 2000mg/250mg powder for injection
โ Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Rash
- Injection site pain
- Headache
๐จ Serious Side Effects
- Severe allergic reactions (anaphylaxis)
- Clostridioides difficile colitis
- Seizures (especially with renal impairment)
- Acute kidney injury
- Bleeding (hypoprothrombinemia)
โ ๏ธ Rare Side Effects
- Hemolytic anemia
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- QT prolongation
- Pseudomembranous colitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased INR and bleeding risk |
| Probenecid | Major | Decreased renal excretion of cefepime, increased toxicity |
| Aminoglycosides | Major | Increased nephrotoxicity risk |
| Loop diuretics | Major | Increased nephrotoxicity risk |
| Oral contraceptives | Moderate | Reduced contraceptive efficacy |
| Live bacterial vaccines | Moderate | Reduced vaccine efficacy |
| Methotrexate | Moderate | Increased methotrexate toxicity |
| Antacids | Minor | No significant interaction |
| Iron supplements | Minor | No significant interaction |
๐จ Major Interactions
- Warfarin
- Probenecid
- Aminoglycosides
- Loop diuretics
โก Moderate Interactions
- Oral contraceptives
- Live bacterial vaccines
- Methotrexate
โน๏ธ Minor Interactions
- Antacids
- Iron supplements
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
No disulfiram-like reaction reported.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cefepime, tazobactam, or any cephalosporin; history of severe allergic reaction to penicillins or other beta-lactams.
๐ Monitoring Parameters
Renal function, CBC, signs of superinfection, bleeding, and allergic reactions.
๐คฑ Lactation Safety
Excreted in breast milk in low amounts; use with caution.
๐ Overdose Management
Supportive care; hemodialysis may enhance elimination.
โฐ Missed Dose
Administer as soon as remembered; if near next dose, skip missed dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Good quality medicine. Satisfied with the outcome.
Good quality medicine. Satisfied with the outcome.
Effective and reliable. Worked as expected.
Found this to be a helpful product. Good results.
Found this to be a helpful product. Good results.