Ferri 100 Injection: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or wheezing
- Swelling of the face, lips, or throat
- Sudden drop in blood pressure or fainting
- Severe chest pain or palpitations
- Severe abdominal pain with nausea and vomiting
- Signs of iron overload such as joint pain, fatigue, or skin discoloration
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is kokino injection used for?
This medicine is an intravenous iron preparation used to treat iron deficiency anemia when oral iron is not effective or not tolerated. It is given by a healthcare professional and works by replenishing iron stores to help the body produce healthy red blood cells.
- Generic Name: Iron Sucrose (100mg/5ml)
- Manufacturer: Anthem Biopharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 kokino injection के बारे में (Hindi Summary)
उपयोग: यह दवा आयरन सुक्रोज का एक इंजेक्शन है जिसका उपयोग आयरन की कमी से होने वाले एनीमिया के इलाज के लिए किया जाता है। यह उन लोगों के लिए उपयोगी है जो मुंह से आयरन की गोलियां नहीं ले सकते या जिन्हें जल्दी आयरन की आवश्यकता होती है। यह दवा डॉक्टर या नर्स द्वारा नस के माध्यम से दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चक्कर आना, मतली, उल्टी, पेट दर्द, दस्त, कब्ज, मांसपेशियों में ऐंठन, और इंजेक्शन की जगह पर दर्द या सूजन शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी की प्रतिक्रिया, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या रक्तचाप में अचानक गिरावट हो सकती है। कोई भी गंभीर लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल प्रशिक्षित स्वास्थ्य पेशेवर द्वारा ही दी जानी चाहिए। इंजेक्शन के दौरान और बाद में आपकी निगरानी की जाएगी। अपने डॉक्टर को अपनी सभी दवाओं और एलर्जी के बारे में बताएं। इस दवा को लेने के 48 घंटे के भीतर मुंह से आयरन की गोलियां न लें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। इंजेक्शन के तुरंत बाद वाहन न चलाएं या मशीनरी न चलाएं।
💊 kokino injection Uses & Benefits
- [{"condition":"Iron deficiency anemia","description":"This medicine is used to treat iron deficiency anemia when oral iron is not effective, not tolerated, or not fast enough.
- It replenishes iron stores and helps the body produce healthy red blood cells.","evidence":"Well-established"},{"condition":"Anemia of chronic kidney disease","description":"Patients with chronic kidney disease often have iron deficiency anemia.
- This medicine provides iron directly into the bloodstream, which is especially useful for those on dialysis.","evidence":"Well-established"},{"condition":"Postpartum anemia","description":"After childbirth, some women develop iron deficiency anemia.
- This medicine can quickly restore iron levels when oral iron is insufficient.","evidence":"Well-established"},{"condition":"Preoperative anemia","description":"In patients scheduled for major surgery, this medicine may be used to correct iron deficiency anemia before the procedure to reduce the need for blood transfusions.","evidence":"Emerging"}]
Off-label uses: [{"condition":"Restless legs syndrome","description":"Some studies suggest intravenous iron may help restless legs syndrome in patients with iron deficiency, but this is not a standard approved use.","evidence":"Limited"},{"condition":"Inflammatory bowel disease with iron deficiency","description":"Used off-label when oral iron is poorly tolerated or ineffective in patients with inflammatory bowel disease.","evidence":"Limited"}]
Primary treatment for: Iron deficiency anemia
Also treats: Anemia of chronic kidney disease, Postpartum anemia, Preoperative anemia
📋 Drug Information
| Generic Name(s) | Iron Sucrose (100mg/5ml) |
| Brand Name | kokino injection |
| Manufacturer | Anthem Biopharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Haemopoetic agents |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store at room temperature (15-30°C). Do not freeze. Keep in the original container and protect from light. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture. Check the expiry date on the packaging. |
| WHO Guideline | The World Health Organization recommends intravenous iron for the treatment of iron deficiency anemia in adults and children when oral iron is not effective or not tolerated. However, specific recommendations for iron sucrose may vary by region and clinical setting. |
| ICMR Guideline | The Indian Council of Medical Research recommends intravenous iron for the management of iron deficiency anemia in specific situations, such as chronic kidney disease, inflammatory bowel disease, and when oral iron fails. Dosing should follow national guidelines. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by delivering iron directly into the bloodstream. The iron sucrose complex is taken up by cells of the reticuloendothelial system, especially in the liver, spleen, and bone marrow. Once inside these cells, the iron is released from the sucrose carrier and becomes available for incorporation into hemoglobin, the oxygen-carrying protein in red blood cells. This helps to correct iron deficiency and supports the production of new red blood cells. The sucrose component is safely metabolized and excreted by the body.
Mechanism Steps
💡 How to Take kokino injection
Strength: Iron Sucrose 100 mg per 5 mL in a single-use vial.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the patient's iron deficit, body weight, and clinical condition. A common regimen for iron deficiency anemia is 100 mg to 200 mg of iron sucrose given intravenously 1 to 3 times per week, up to a maximum cumulative dose calculated from the patient's hemoglobin and body weight. The infusion is given slowly over 15 to 30 minutes. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Doses should be individualized by a clinician, and monitoring for side effects is recommended. |
| Renal Impairment | No specific dose adjustment is required for patients with kidney disease, but caution is advised. Monitor kidney function and iron levels closely. |
| Hepatic Impairment | Use with caution in patients with liver disease. Dose adjustment may be necessary, and liver function should be monitored. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the patient's iron deficit. A single dose should not exceed 200 mg of iron sucrose per infusion, and the total cumulative dose should not exceed the calculated iron requirement. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of kokino injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Oral iron supplements | Major | |
| Dimercaprol | Major | |
| Chloramphenicol | Moderate |
🚨 Major Interactions
- Oral iron supplements
- Dimercaprol
⚡ Moderate Interactions
- Chloramphenicol
- Vitamin C (oral)
🍷 Alcohol Interaction
Alcohol may increase the risk of stomach bleeding and can worsen anemia. It is advisable to avoid alcohol while receiving treatment for iron deficiency anemia.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to iron sucrose or any component of the product","Iron overload or hemochromatosis","Anemia not caused by iron deficiency","Severe liver disease with iron overload","First trimester of pregnancy (unless clearly needed)"]
⚠️ Warnings & Precautions
["This medicine must be given by a healthcare professional in a setting with emergency equipment.","Patients should be monitored for at least 30 minutes after infusion for signs of allergic reactions.","Use with caution in patients with a history of allergies, asthma, or eczema.","Avoid in patients with active infections.","Do not use in patients with iron overload.","Use with caution in elderly patients and those with liver or kidney disease.","Do not mix with other medicines in the same infusion."]
🤱 Lactation Safety
It is not known whether iron sucrose passes into breast milk. However, iron is a normal component of breast milk, and this medicine is not expected to harm a nursing infant. Consult your doctor before receiving this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can lead to iron overload, which may cause nausea, vomiting, abdominal pain, and eventually organ damage. Treatment includes stopping the infusion, supportive care, and possibly chelation therapy with deferoxamine. Seek immediate medical attention if overdose is suspected.
⏰ Missed Dose
This medicine is given by a healthcare professional, so missed doses are unlikely. If you miss an appointment for your infusion, contact your doctor to reschedule as soon as possible. Do not try to self-administer.
Additional Safety Advice
This medicine must only be given by a trained healthcare professional in a setting where emergency equipment is available. You will be monitored during and after the infusion for any signs of an allergic reaction. Tell your doctor if you have ever had an allergic reaction to iron or any medicine. Inform your doctor about all other medicines you are taking, especially other iron products, vitamin supplements, or medicines that affect blood pressure. Do not take oral iron supplements within 48 hours of receiving this medicine unless your doctor tells you otherwise. If you are pregnant or breastfeeding, discuss the risks and benefits with your doctor. This medicine is not recommended for children under certain ages; your doctor will decide if it is appropriate. Keep all follow-up appointments to monitor your blood counts and iron levels. Do not drive or operate heavy machinery immediately after receiving this medicine, as you may feel dizzy or lightheaded.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the side effects of this medicine, especially dizziness and low blood pressure. Doses should be individualized, and monitoring is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy and have iron deficiency anemia, discuss treatment options with your doctor. This medicine may be used during pregnancy if needed, but it is important to plan ahead and monitor iron levels.
🏥 Post-Surgery Considerations
After surgery, this medicine may be used to treat anemia caused by blood loss. It is given in a hospital setting, and your doctor will monitor your recovery and iron levels.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. There are no specific precautions for dental procedures, but it is important for your dentist to know your medical history.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
You may feel dizzy or tired after receiving this medicine. Avoid strenuous exercise immediately after the infusion. Gradually resume your normal activities as you feel better.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may need to take time off work for your infusion appointments. After the infusion, you might feel dizzy or tired, so it is best to avoid driving or operating heavy machinery until you feel normal. Most people can resume their normal activities the next day.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will decide when to stop based on your hemoglobin and iron levels. If you experience serious side effects, seek immediate medical attention and follow your doctor's advice.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to iron overload if not monitored properly. Regular blood tests to check iron stores are essential. Iron overload can cause damage to the liver, heart, and other organs. With appropriate monitoring, long-term use can be safe and effective for managing chronic iron deficiency anemia.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
First-line treatment for iron deficiency anemia if tolerated and effective.
Evidence: Well-establishedIncreasing iron-rich foods can help, but may not be enough for severe deficiency.
Evidence: Well-establishedReserved for severe, life-threatening anemia when rapid correction is needed.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your doctor that you are receiving this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not freeze
✅ DO
Keep in the original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in direct sunlight
✈️ Traveling with This Medicine
This medicine is given in a healthcare setting, so travel advice is limited. If you are traveling and need to receive this medicine, carry a copy of your prescription and medical records. Ensure that the clinic or hospital where you plan to receive it has the necessary facilities for monitoring. Store the medicine at room temperature and protect it from light. Check customs regulations if carrying the medicine across borders.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Improvement in hemoglobin levels is usually seen within 1 to 2 weeks after the first infusion, but it may take longer depending on the severity of anemia.
A: It is given as an intravenous infusion by a healthcare professional in a clinic or hospital setting.
A: Common side effects include headache, dizziness, nausea, and injection site reactions. These are usually mild and temporary.
A: You should avoid oral iron supplements for at least 48 hours after receiving this medicine unless your doctor tells you otherwise.
A: It may be used in pregnancy when clearly needed. Discuss the risks and benefits with your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for kokino injection
View AllAlternative brands with exact same active ingredient:
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synhafm-l injectionSanify Healthcare Pvt Ltd ₹45.00 77% CHEAPER
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ferizest injectionDWD Pharmaceuticals Ltd ₹187.17 4.5% CHEAPER
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i-key 100 injectionSerum Institute Of India Ltd ₹190.13 2.9% CHEAPER
-
blisfer 100mg injectionBlismed Pharmaceuticals Pvt. Ltd ₹232.50 18.7% COSTLIER
-
ihi 100mg injectionNovogen Captab ₹243.75 24.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Iron injections are painful and dangerous.
Fact: When given by a trained professional, iron injections are safe and well-tolerated. Pain at the injection site is usually mild and temporary. - Myth: You can take iron injections at home.
Fact: This medicine must be given in a clinic or hospital where emergency equipment is available, as serious allergic reactions can occur. - Myth: Iron injections are only for severe anemia.
Fact: They are used whenever oral iron is not effective, not tolerated, or when a rapid increase in iron is needed.
🔄 Alternative Options
Generic Alternatives
- Iron sucrose injection
Brand Alternatives
- Ferri 100 injection