cmvigone 450 tablet - Uses, Price, Side Effects & Substitutes
What is cmvigone 450 tablet used for?
Cymgal (Valganciclovir) is used to treat ANTI INFECTIVES. It contains Valganciclovir (450mg), which Valganciclovir is a prodrug of ganciclovir; ganciclovir is phosphorylated to gan. Always consult your doctor before use. Take as prescribed.
- Generic Name: Valganciclovir
- Manufacturer: Anthem Biopharma
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ cmvigone 450 tablet Uses & Benefits
Treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients; prevention of CMV disease in solid organ transplant recipients.
Off-label uses: CMV prophylaxis in hematopoietic stem cell transplant recipients, Treatment of CMV infection in HIV patients
๐ Drug Information
| Generic Name(s) | Valganciclovir |
| Brand Name | Cymgal |
| Manufacturer | Anthem Biopharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Antiviral (Non-HIV) drugs |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Valganciclovir is a prodrug of ganciclovir; ganciclovir is phosphorylated to ganciclovir triphosphate, which competitively inhibits viral DNA polymerase and incorporates into viral DNA, causing chain termination.
Mechanism Steps
๐ก How to Take cmvigone 450 tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cmvigone 450 tablet
โ Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Neutropenia
- Anemia
- Headache
- Insomnia
๐จ Serious Side Effects
- Severe neutropenia
- Thrombocytopenia
- Pancreatitis
- Renal impairment
- Seizures
- Retinal detachment
โ ๏ธ Rare Side Effects
- Hepatic failure
- Stevens-Johnson syndrome
- Anaphylaxis
- Hemolytic uremic syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Mycophenolate mofetil | Major | Increased risk of hematologic toxicity (neutropenia, anemia) |
| Didanosine | Major | Increased didanosine exposure and toxicity |
| Zidovudine | Major | Increased risk of severe neutropenia and anemia |
| Probenecid | Major | Reduced renal clearance of ganciclovir, increased toxicity |
| Tenofovir | Moderate | Increased risk of nephrotoxicity |
| Cidofovir | Moderate | Additive nephrotoxicity |
| Acyclovir | Moderate | Additive nephrotoxicity |
| Foscarnet | Moderate | Additive nephrotoxicity |
| Trimethoprim-sulfamethoxazole | Minor | Possible additive bone marrow suppression |
| Cyclosporine | Minor | Possible additive nephrotoxicity |
๐จ Major Interactions
- Mycophenolate mofetil
- Didanosine
- Zidovudine
- Probenecid
โก Moderate Interactions
- Tenofovir
- Cidofovir
- Acyclovir
- Foscarnet
โน๏ธ Minor Interactions
- Trimethoprim-sulfamethoxazole
- Cyclosporine
๐ฝ๏ธ Food Interactions
Take with food to reduce gastrointestinal side effects and improve absorption.
๐ท Alcohol Interaction
No known interaction; but alcohol may worsen gastrointestinal side effects.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to valganciclovir, ganciclovir, or acyclovir; absolute neutrophil count <500 cells/ยตL; platelet count <25,000/ยตL; hemoglobin <8 g/dL.
๐ Monitoring Parameters
Complete blood count (CBC) with differential, renal function, liver function tests.
๐คฑ Lactation Safety
Not recommended; ganciclovir is excreted in breast milk.
๐ Overdose Management
Supportive care; hemodialysis may reduce ganciclovir levels.
โฐ Missed Dose
Take as soon as remembered; if close to next dose, skip missed dose. Do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for cmvigone 450 tablet
View AllAlternative brands with exact same active ingredient (Valganciclovir (450mg)):
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vagacyte 450mg tabletPanacea Biotec Ltd โน778.52 44.4% CHEAPER
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cytomega 450mg tabletBiokindle Lifesciences Pvt Ltd โน825.00 41.1% CHEAPER
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valstead tabletSteadfast Medishield Pvt Ltd โน844.00 39.7% CHEAPER
-
cmvir 450mg tabletRene Lifescience โน850.00 39.3% CHEAPER
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valniche 450 tabletAlniche Life Sciences Pvt Ltd โน850.00 39.3% CHEAPER
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cmvee 450mg tabletRPG Life Sciences Ltd โน856.09 38.9% CHEAPER
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valchek tabletLa Renon Healthcare Pvt Ltd โน857.00 38.8% CHEAPER
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vylster tabletAkognos Life Sciences โน860.00 38.6% CHEAPER
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valbade 450mg tabletAubade Healthcare Pvt Ltd โน860.00 38.6% CHEAPER
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valocon 450mg tabletConcord Biotech Ltd โน863.15 38.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.