Kenadion 10mg Injection: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Sudden drop in blood pressure or fainting
- Chest pain or irregular heartbeat
- Severe pain, swelling, or redness at the injection site
- Yellowing of the skin or eyes (jaundice) in newborns
- Unusual bleeding or bruising that does not stop
- Signs of a blood clot such as swelling in one leg, sudden shortness of breath, or chest pain
If experiencing severe symptoms, call emergency services immediately.
What is klot 10mg injection used for?
This medicine is a vitamin K injection used to treat and prevent bleeding caused by vitamin K deficiency. It works by helping the liver produce clotting factors. It is given by a healthcare professional and is also used to reverse the effects of blood thinners like warfarin.
- Generic Name: Vitamin K (10mg)
- Manufacturer: Tribhawan Injectables
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 klot 10mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा विटामिन के की कमी से होने वाले रक्तस्राव के इलाज और रोकथाम के लिए दी जाती है। यह शरीर में रक्त का थक्का बनाने वाले कारकों को सक्रिय करने में मदद करती है। इसका उपयोग वारफारिन जैसी रक्त पतला करने वाली दवाओं के प्रभाव को उलटने के लिए भी किया जाता है। नवजात शिशुओं में रक्तस्राव की बीमारी को रोकने के लिए भी यह दवा दी जाती है। यह इंजेक्शन के रूप में डॉक्टर या नर्स द्वारा दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन लगाने की जगह पर दर्द, लालिमा या सूजन शामिल है। कुछ लोगों को हल्की खुजली या दाने हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी की प्रतिक्रिया, सांस लेने में कठिनाई, चेहरे या गले में सूजन हो सकती है। ऐसा होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। खुद से इंजेक्शन न लगाएं। अगर आपको विटामिन के से एलर्जी है, लीवर की बीमारी है, या आप खून पतला करने वाली दवाएं ले रहे हैं, तो डॉक्टर को बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। इंजेक्शन के बाद कुछ समय तक निगरानी में रहें।
💊 klot 10mg injection Uses & Benefits
[{"condition":"Vitamin K deficiency bleeding","description":"This medicine is used to treat or prevent bleeding due to low vitamin K levels, which may occur with poor diet, malabsorption, or liver disease.","evidence":"Well-established"},{"condition":"Warfarin overdose reversal","description":"It is used to rapidly reverse the anticoagulant effect of warfarin in patients with excessive bleeding or high INR.","evidence":"Well-established"},{"condition":"Hemorrhagic disease of the newborn","description":"This medicine is given to newborns to prevent or treat a serious bleeding disorder caused by vitamin K deficiency.","evidence":"Well-established"},{"condition":"Prevention of bleeding in malabsorption syndromes","description":"Patients with conditions like cystic fibrosis or biliary obstruction may receive this medicine to prevent bleeding due to poor vitamin K absorption.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Prevention of bleeding in patients on long-term antibiotics","description":"Sometimes prescribed off-label when broad-spectrum antibiotics disrupt gut bacteria that produce vitamin K.","evidence":"Limited"}]
Primary treatment for: Vitamin K deficiency bleeding
Also treats: Warfarin overdose, Hemorrhagic disease of the newborn, Malabsorption syndromes, Liver disease
📋 Drug Information
| Generic Name(s) | Vitamin K (10mg) |
| Brand Name | klot 10mg injection |
| Manufacturer | Tribhawan Injectables |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | Vitamins |
| Route of Administration | Parenteral (intravenous, intramuscular, or subcutaneous injection) |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light. Do not freeze. Keep in the original carton until use. |
| Shelf Life | Not established from the available information. Refer to the product packaging for the expiry date. |
| WHO Guideline | The World Health Organization recommends vitamin K prophylaxis for all newborns to prevent hemorrhagic disease of the newborn. The recommended dose is 1 mg intramuscularly at birth. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine provides vitamin K, which is essential for the synthesis of active clotting factors in the liver. It acts as a cofactor for the enzyme gamma-glutamyl carboxylase, which converts specific glutamate residues in clotting factors II, VII, IX, and X, as well as proteins C and S, into their active forms. These modified proteins can then bind calcium and participate in the coagulation cascade. Without vitamin K, these factors remain inactive, leading to prolonged clotting times and a bleeding tendency. By replenishing vitamin K, this medicine restores the liver's ability to produce functional clotting factors, thereby improving blood coagulation.
Mechanism Steps
💡 How to Take klot 10mg injection
Strength: 10 mg injection
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the indication, severity of deficiency, and patient's clinical condition. For warfarin reversal, typical doses range from 5 mg to 10 mg given by slow intravenous injection, but the exact dose depends on the INR and bleeding status. For vitamin K deficiency bleeding, doses may vary. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. For newborns, the dose is typically 0.5 mg to 1 mg intramuscularly, but this must be determined by a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Dose should be individualized by a clinician based on clinical condition and response. |
| Renal Impairment | No specific dose adjustment is recommended for renal impairment. However, consult your doctor for individualized dosing. |
| Hepatic Impairment | Patients with severe liver disease may have a reduced response to this medicine. Dose should be individualized by a clinician based on liver function. |
| Maximum Daily Dose | Not established from the available information. The maximum dose should be determined by a qualified clinician based on the indication and patient's condition. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of klot 10mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Cefoperazone | Major | |
| Cefotetan | Major | |
| Cholestyramine | Moderate | |
| Mineral oil | Minor |
🚨 Major Interactions
- Warfarin
- Cephalosporins with NMTT side chain (e.g., cefoperazone, cefotetan)
⚡ Moderate Interactions
- Broad-spectrum antibiotics
- Bile acid sequestrants (e.g., cholestyramine)
🍷 Alcohol Interaction
Alcohol consumption may affect liver function and vitamin K metabolism. Chronic alcohol use can impair the liver's ability to synthesize clotting factors, potentially reducing the effectiveness of this medicine. It is advisable to avoid alcohol while receiving treatment with this medicine, especially if you have liver disease.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to vitamin K or any component of the injection","Severe liver disease with impaired clotting factor synthesis (relative contraindication)","Patients with known thrombotic disorders unless specifically indicated"]
⚠️ Warnings & Precautions
["This medicine should be given only by a healthcare professional.","Use with caution in patients with liver disease, as the response may be reduced.","Use with caution in patients with a history of blood clots or thrombotic disorders.","In newborns, especially premature infants, high doses may increase the risk of kernicterus.","Inform your doctor if you are taking blood thinners such as warfarin.","Do not use if the solution is discolored or contains particles.","Keep out of reach of children."]
🤱 Lactation Safety
Vitamin K is safe to use during breastfeeding. It is commonly given to newborns and is not known to cause harm to breastfed infants. However, consult your doctor before receiving this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine is unlikely to cause serious harm because vitamin K has a wide safety margin. However, very high doses in newborns can cause kernicterus. If overdose is suspected, seek immediate medical attention. Treatment is supportive and symptomatic. In case of accidental overdose, contact a poison control center or emergency room right away.
⏰ Missed Dose
This medicine is usually given as a single dose or as directed by your doctor. If you miss a scheduled dose, contact your doctor or healthcare provider for instructions. Do not attempt to self-administer an extra dose.
Additional Safety Advice
This medicine must only be given by a healthcare professional. Do not attempt to self-administer this injection. Before receiving this medicine, tell your doctor if you are allergic to vitamin K or any other medicines, if you have liver disease, if you have a blood clotting disorder, or if you are taking blood thinners such as warfarin. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. This medicine can interact with certain antibiotics and anticoagulants, so always provide a complete list of your medications. After the injection, remain under observation for a short period as advised by your doctor. Do not drive or operate heavy machinery if you feel dizzy or unwell after the injection. Keep all follow-up appointments and blood tests as recommended by your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have an increased risk of bleeding and may respond differently to this medicine. Dose should be individualized, and monitoring should be more frequent.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor. Vitamin K is generally considered safe during pregnancy, but the need for this medicine should be evaluated by a healthcare provider.
🏥 Post-Surgery Considerations
This medicine may be used after surgery to correct vitamin K deficiency or reverse anticoagulation. Follow your surgeon's instructions regarding activity and follow-up.
🦷 Dental Procedures
Inform your dentist if you have received this medicine, especially if you are on blood thinners. Your dentist may need to take precautions to prevent bleeding during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
There are no specific exercise restrictions while receiving this medicine. However, if you have a bleeding disorder, avoid activities that may cause injury or bleeding. Consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a clinical setting and usually does not affect your ability to work or drive. However, if you experience dizziness or other side effects after the injection, avoid driving or operating machinery until you feel better.
🛑 When to Stop This Medicine
This medicine is given as a single dose or a short course. Do not stop or change the regimen without consulting your doctor. If you experience severe side effects, seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of this medicine is not typical, as it is usually given as a short course. In patients with chronic malabsorption, repeated doses may be needed. Prolonged use should be monitored by a doctor. There is no known risk of long-term toxicity with vitamin K injections when used appropriately. However, in patients on warfarin, frequent use can interfere with anticoagulation control.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May be used for mild deficiency but not for emergency reversal of warfarin.
Evidence: Well-establishedUsed for urgent reversal of anticoagulation when vitamin K alone is insufficient.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, inform your doctor if you are scheduled to receive any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in direct sunlight
✅ DO
Check for particles before use
❌ DON'T
Do not use if discolored or contains particles
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label. Keep a copy of your prescription and a letter from your doctor explaining the need for the injection. Store it at room temperature and protect it from light. If traveling by air, carry it in your hand luggage. Check customs regulations for injectable medicines in your destination country. For scheduled doses, adjust timing according to time zone changes in consultation with your doctor.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 6 to 12 hours after injection, with maximum effect seen in 12 to 24 hours.
A: No, this medicine must be given by a healthcare professional in a clinical setting.
A: Common side effects include pain, redness, or swelling at the injection site. These are usually mild and temporary.
A: Vitamin K is considered safe during pregnancy when used as directed by a doctor. It is routinely given to newborns.
A: Yes, it is commonly given to newborns to prevent hemorrhagic disease of the newborn.
🤔 Common Patient Concerns
🔄 Substitutes for klot 10mg injection
View AllAlternative brands with exact same active ingredient:
-
kapilin 10mg injectionGlaxo SmithKline Pharmaceuticals Ltd ₹9.47 55.5% COSTLIER
-
kenadion 10mg injectionSamarth Life Sciences Pvt Ltd ₹56.68 830.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally as a supplement.
Fact: This medicine is an injectable form and must be given by a healthcare professional. Oral vitamin K is a different product. - Myth: This medicine is a blood thinner.
Fact: This medicine actually helps blood clot by providing vitamin K, which is essential for clotting factor synthesis. It is the opposite of a blood thinner. - Myth: This medicine is only for newborns.
Fact: While it is commonly used in newborns, it is also used in adults to treat vitamin K deficiency and warfarin overdose.
🔄 Alternative Options
Generic Alternatives
- Vitamin K injection
Brand Alternatives
- Kenadion 10mg injection