Bupine 0.3mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Slow, shallow, or stopped breathing
- Extreme drowsiness or difficulty waking up
- Cold, clammy skin
- Pinpoint pupils
- Severe dizziness or fainting
- Chest pain or irregular heartbeat
- Signs of allergic reaction: rash, itching, swelling of face, lips, tongue, or throat
If experiencing severe symptoms, call emergency services immediately.
What is buprene 0.6mg injection used for?
This medicine is a prescription injectable opioid analgesic containing buprenorphine, used for moderate to severe pain and opioid dependence. It is administered by a healthcare professional and carries a risk of respiratory depression and dependence.
- Generic Name: Buprenorphine (0.3mg/ml)
- Manufacturer: Tribhawan Injectables
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 buprene 0.6mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा बुप्रेनोर्फिन का इंजेक्शन है, जिसका उपयोग मध्यम से गंभीर दर्द के इलाज के लिए किया जाता है। यह ओपिओइड दर्द निवारक दवाओं की श्रेणी में आती है और इसे केवल डॉक्टर या योग्य स्वास्थ्यकर्मी द्वारा ही दिया जाता है। यह दवा ओपिओइड निर्भरता के इलाज में भी सहायक हो सकती है, लेकिन इसका उपयोग कड़ी निगरानी में ही किया जाता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मतली, उल्टी, कब्ज, सिरदर्द और इंजेक्शन लगाने की जगह पर दर्द या सूजन शामिल हैं। गंभीर दुष्प्रभावों में सांस लेने में कठिनाई, निम्न रक्तचाप, धीमी हृदय गति और एलर्जी प्रतिक्रिया हो सकती है। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल अस्पताल या क्लिनिक में डॉक्टर की देखरेख में ही दी जानी चाहिए। इसे स्वयं न लगाएं। शराब और अन्य नींद लाने वाली दवाओं के साथ इसका सेवन न करें क्योंकि इससे सांस लेने में गंभीर समस्या हो सकती है। गाड़ी चलाने या मशीन चलाने से बचें जब तक कि आपको इस दवा का असर समझ न आ जाए। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 buprene 0.6mg injection Uses & Benefits
[{"condition":"Moderate to severe acute pain","description":"This medicine is used for the management of moderate to severe pain when other analgesics are insufficient.","evidence":"Well-established"},{"condition":"Opioid dependence","description":"Used as part of medication-assisted treatment for opioid use disorder under strict supervision.","evidence":"Well-established"},{"condition":"Chronic pain","description":"May be used for chronic pain management in some settings, though not first-line.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Neuropathic pain","description":"Sometimes prescribed off-label for neuropathic pain, but evidence is limited.","evidence":"Limited"},{"condition":"Restless legs syndrome","description":"Rarely used off-label for restless legs syndrome.","evidence":"Limited"}]
Primary treatment for: Moderate to severe pain
Also treats: Opioid dependence, Chronic pain
📋 Drug Information
| Generic Name(s) | Buprenorphine (0.3mg/ml) |
| Brand Name | buprene 0.6mg injection |
| Manufacturer | Tribhawan Injectables |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Opioids- Partial agonist |
| Route of Administration | Parenteral (intramuscular or intravenous injection) |
| Storage | Store at controlled room temperature 20°C to 25°C (68°F to 77°F). Protect from light. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Buprenorphine is a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor. It binds to these receptors in the central nervous system, producing analgesia and altering the response to pain. Its partial agonist activity at the mu receptor leads to a ceiling effect for respiratory depression, meaning that beyond a certain dose, further respiratory depression does not occur to the same extent as with full agonists. However, it can still cause respiratory depression, especially when combined with other depressants. Buprenorphine also has high affinity for the mu receptor, which allows it to displace other opioids and precipitate withdrawal in opioid-dependent individuals.
Mechanism Steps
💡 How to Take buprene 0.6mg injection
Strength: Injection: 0.3 mg/mL
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the indication, patient's age, weight, renal and hepatic function, and response to therapy. For acute pain, a typical adult dose is 0.3 mg administered intramuscularly or intravenously every 6 to 8 hours as needed. For opioid dependence, the dose is titrated under supervision. Do not self-administer. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of buprenorphine. Start with lower doses and monitor closely. |
| Renal Impairment | No specific dosage adjustment is established from available information. Use with caution in patients with renal impairment. |
| Hepatic Impairment | Buprenorphine is extensively metabolized in the liver. Use with caution in patients with hepatic impairment; dose reduction may be necessary. |
| Maximum Daily Dose | The maximum daily dose must be determined by a qualified clinician based on the patient's condition and response. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of buprene 0.6mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Benzodiazepines | Major | |
| Alcohol | Major | |
| MAO inhibitors | Major | |
| CYP3A4 inhibitors | Moderate | |
| CYP3A4 inducers | Moderate |
🚨 Major Interactions
- Benzodiazepines (e.g., diazepam, lorazepam)
- Other CNS depressants (e.g., alcohol, barbiturates, general anesthetics)
- MAO inhibitors
⚡ Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- CYP3A4 inducers (e.g., rifampin, carbamazepine)
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine because it can potentiate the sedative and respiratory depressant effects of buprenorphine, leading to severe respiratory depression, coma, and even death.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to buprenorphine or any component of the formulation","Acute or severe bronchial asthma","Known or suspected gastrointestinal obstruction","Severe respiratory depression","Acute alcoholism, delirium tremens","Concurrent use of MAO inhibitors"]
⚠️ Warnings & Precautions
["Risk of respiratory depression, especially with concomitant CNS depressants","Potential for abuse and dependence","Use with caution in elderly, debilitated, or patients with hepatic or renal impairment","May impair mental and physical abilities required for driving or operating machinery","Prolonged use may lead to physical dependence and withdrawal","Not recommended for use in children unless specifically indicated","Use with caution in patients with head injury or increased intracranial pressure"]
🤱 Lactation Safety
Buprenorphine is excreted in human milk. Caution should be exercised when administered to a nursing woman. Monitor infant for sedation and respiratory depression.
💊 Overdose Management
In case of overdose, prioritize airway management and ventilation. Naloxone may be used to reverse respiratory depression, but due to buprenorphine's high affinity for mu receptors, higher doses of naloxone may be required. Monitor vital signs and provide supportive care. Seek immediate medical attention.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If a dose is missed, consult your healthcare provider for guidance. Do not attempt to self-administer.
Additional Safety Advice
This medicine must only be administered by a healthcare professional in a setting equipped to monitor and manage respiratory depression. Do not use this medicine if you are allergic to buprenorphine or any of its ingredients. Inform your doctor if you have a history of substance abuse, lung disease, liver disease, kidney disease, or mental health conditions. Avoid alcohol and other central nervous system depressants while receiving this medicine, as they can increase the risk of severe respiratory depression. Do not drive or operate heavy machinery until you know how this medicine affects you. If you are pregnant or breastfeeding, discuss the risks and benefits with your doctor. Do not stop this medicine abruptly without medical advice, as withdrawal symptoms may occur. Keep this medicine out of the reach of children and pets. Store as directed by your healthcare provider.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially respiratory depression and sedation. Start with lower doses and monitor closely.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before using this medicine. It may not be safe during pregnancy.
🏥 Post-Surgery Considerations
This medicine may be used for postoperative pain management. It should be administered by a healthcare professional, and patients should be monitored for respiratory depression.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, as it may interact with anesthetics or other medications used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that require mental alertness until you know how this medicine affects you. Consult your doctor before resuming exercise routines.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause sedation and dizziness, which may impair your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. Inform your employer if your job requires such activities.
🛑 When to Stop This Medicine
Do not stop this medicine abruptly without consulting your doctor, as withdrawal symptoms may occur. Your doctor will gradually reduce the dose if discontinuation is necessary.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to physical dependence and addiction. Withdrawal symptoms may occur upon abrupt discontinuation. Regular monitoring of liver function, respiratory status, and pain control is recommended. Patients should be evaluated periodically to determine the need for continued therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For mild to moderate pain, non-opioid analgesics like acetaminophen or NSAIDs may be used.
Evidence: Well-establishedCan complement medicine for chronic pain management.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Consult your doctor regarding vaccinations while on this medicine.
📦 Storage Guide
✅ DO
Store at controlled room temperature 20°C to 25°C (68°F to 77°F).
❌ DON'T
Do not freeze.
✅ DO
Protect from light.
❌ DON'T
Do not use if solution is discolored or contains particles.
✅ DO
Keep out of reach of children.
❌ DON'T
Do not store in bathroom.
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging along with a copy of your prescription. Since it is an injectable controlled substance, check the laws of your destination country regarding opioid medications. Store it at room temperature and protect it from light. If traveling across time zones, consult your doctor about dose timing. Always declare it at customs if required.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 5-15 minutes after intravenous injection and within 15-30 minutes after intramuscular injection.
A: The analgesic effect typically lasts 6 to 8 hours, but this can vary.
A: Consult your doctor. The safety of this medicine during pregnancy is not fully established, and it should be used only if the potential benefit justifies the potential risk.
🤔 Common Patient Concerns
🔄 Substitutes for buprene 0.6mg injection
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Buprenorphine injection is safe for self-administration.
Fact: This medicine must only be administered by a healthcare professional due to the risk of respiratory depression and other serious side effects. - Myth: Buprenorphine is not addictive.
Fact: Buprenorphine has a high potential for abuse and dependence, similar to other opioids.
🔄 Alternative Options
Generic Alternatives
- Buprenorphine injection (generic)
Brand Alternatives
- Bupine 0.3mg injection