Ketoconazole 200mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Yellowing of the skin or eyes (jaundice)
- Dark urine or pale stools
- Severe abdominal pain or swelling
- Persistent nausea, vomiting, or loss of appetite
- Unusual tiredness or weakness
- Fast, irregular, or pounding heartbeat
- Fainting or dizziness
- Swelling of face, lips, tongue, or throat
- Difficulty breathing
- Severe skin rash or blistering
If experiencing severe symptoms, call emergency services immediately.
What is ketojet 200mg tablet used for?
This medicine is an oral antifungal containing ketoconazole 200 mg. It is used for serious systemic fungal infections when other treatments are not suitable. It works by damaging the fungal cell membrane. It requires a prescription and close monitoring of liver function.
- Generic Name: Ketoconazole (200mg)
- Manufacturer: Levent Biotech Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ketojet 200mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा कीटोकोनाज़ोल 200 मिलीग्राम युक्त एक मौखिक एंटीफंगल टैबलेट है। इसका उपयोग गंभीर प्रणालीगत फंगल संक्रमणों जैसे ब्लास्टोमाइकोसिस, कोक्सीडियोइडोमाइकोसिस, हिस्टोप्लाज्मोसिस, क्रोमोमाइकोसिस और पैराकोक्सीडियोइडोमाइकोसिस के इलाज के लिए किया जाता है, खासकर उन रोगियों में जो अन्य एंटीफंगल दवाओं को सहन नहीं कर सकते या जिनका इलाज विफल रहा है। यह कुछ गंभीर त्वचा और नाखून संक्रमणों में भी प्रभावी हो सकती है। यह दवा फंगल कोशिका झिल्ली को नष्ट करके काम करती है। यह लीवर को नुकसान पहुंचा सकती है, इसलिए इसका उपयोग केवल गंभीर संक्रमणों में और डॉक्टर की देखरेख में ही किया जाना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सिरदर्द, चक्कर आना और खुजली शामिल हैं। गंभीर दुष्प्रभावों में लीवर की क्षति (पीलिया, गहरे रंग का मूत्र, गंभीर थकान), अधिवृक्क अपर्याप्तता और गंभीर एलर्जी प्रतिक्रियाएं शामिल हैं। यदि आपको लीवर की समस्या के लक्षण दिखें तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक को कम या ज्यादा न करें। इस दवा के साथ शराब का सेवन न करें क्योंकि इससे लीवर को नुकसान का खतरा बढ़ सकता है। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं, विशेष रूप से एंटासिड, एसिड रिड्यूसर और कुछ हृदय या दौरे की दवाएं। इलाज से पहले और दौरान लीवर फंक्शन टेस्ट कराना जरूरी है। यदि आपको खुराक लेने का समय चूक जाए, तो याद आते ही ले लें, लेकिन अगली खुराक का समय नजदीक हो तो छोड़ दें। दोहरी खुराक न लें।
💊 ketojet 200mg tablet Uses & Benefits
[{"condition":"Blastomycosis","description":"Treatment of pulmonary and extrapulmonary blastomycosis in patients who cannot tolerate amphotericin B or itraconazole.","evidence":"Well-established"},{"condition":"Coccidioidomycosis","description":"Treatment of progressive or chronic coccidioidomycosis, including meningitis, in patients unresponsive to other antifungals.","evidence":"Well-established"},{"condition":"Histoplasmosis","description":"Treatment of chronic or disseminated histoplasmosis in immunocompromised patients or those intolerant to other therapies.","evidence":"Well-established"},{"condition":"Chromomycosis","description":"Treatment of chromoblastomycosis caused by various dematiaceous fungi.","evidence":"Moderate"},{"condition":"Paracoccidioidomycosis","description":"Treatment of paracoccidioidomycosis, a systemic fungal infection common in Latin America.","evidence":"Moderate"},{"condition":"Severe dermatophytosis","description":"Treatment of extensive or recalcitrant skin and nail infections caused by dermatophytes when topical therapy fails.","evidence":"Limited"}]
Off-label uses: [{"condition":"Cushing's syndrome","description":"High-dose ketoconazole has been used off-label to reduce cortisol production in patients with Cushing's syndrome due to its inhibitory effect on adrenal steroidogenesis.","evidence":"Limited"},{"condition":"Prostate cancer","description":"Used off-label in some cases of advanced prostate cancer to suppress androgen production, but this is not a standard first-line treatment.","evidence":"Limited"}]
Primary treatment for: Systemic fungal infections
Also treats: Blastomycosis, Coccidioidomycosis, Histoplasmosis, Chromomycosis, Paracoccidioidomycosis, Severe dermatophytosis
📋 Drug Information
| Generic Name(s) | Ketoconazole (200mg) |
| Brand Name | ketojet 200mg tablet |
| Manufacturer | Levent Biotech Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OPHTHAL OTOLOGICALS |
| Action Class | Fungal ergosterol synthesis inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in a tightly closed container, protected from light and moisture. |
| Shelf Life | Typically 2 to 3 years from the date of manufacture, depending on the manufacturer. Check the expiry date on the package. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Ketoconazole inhibits the fungal cytochrome P450 enzyme 14α-demethylase, which is responsible for converting lanosterol to ergosterol, a key component of the fungal cell membrane. This inhibition leads to increased permeability and leakage of cellular contents, ultimately causing fungal cell death. In humans, ketoconazole also inhibits several cytochrome P450 enzymes, which can lead to drug interactions and endocrine effects such as reduced testosterone and cortisol synthesis.
Mechanism Steps
💡 How to Take ketojet 200mg tablet
Strength: Tablet, 200 mg
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 200 mg to 400 mg once daily, taken with food. For serious systemic fungal infections, the dose may be 200 mg to 400 mg daily. For skin and nail infections, a dose of 200 mg once daily may be used. The duration of treatment depends on the infection and clinical response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially liver toxicity and cardiac effects. Use with caution and monitor closely. Dose adjustment may be necessary based on liver and kidney function. |
| Renal Impairment | No specific dose adjustment is provided in the manufacturer's labeling for renal impairment. However, use with caution in patients with severe renal impairment. Consult your doctor. |
| Hepatic Impairment | This medicine is contraindicated in patients with acute or chronic liver disease. Use with extreme caution in patients with a history of liver disease. Dose adjustment may be necessary. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is 400 mg for adults, but higher doses have been used off-label under close supervision. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ketojet 200mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Cisapride | Major | |
| Terfenadine | Major | |
| Warfarin | Major | |
| Simvastatin | Major | |
| Midazolam | Major | |
| Rifampin | Major | |
| Antacids | Moderate | |
| Omeprazole | Moderate | |
| Cyclosporine | Moderate | |
| Alcohol | Minor |
🚨 Major Interactions
- Cisapride
- Terfenadine
- Astemizole
- Triazolam
- Midazolam
- HMG-CoA reductase inhibitors (statins)
- Warfarin
- Rifampin
- Isoniazid
- Phenytoin
⚡ Moderate Interactions
- Antacids
- H2 receptor antagonists (e.g., ranitidine)
- Proton pump inhibitors (e.g., omeprazole)
- Corticosteroids (e.g., dexamethasone)
- Cyclosporine
- Oral hypoglycemics (e.g., sulfonylureas)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase the risk of liver damage and may cause a disulfiram-like reaction with symptoms such as flushing, nausea, and headache.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Acute or chronic liver disease","Concurrent use with cisapride, terfenadine, astemizole, or other QT-prolonging drugs","Known hypersensitivity to ketoconazole or other imidazole antifungals","Pregnancy (unless benefit outweighs risk)","Lactation (unless benefit outweighs risk)"]
⚠️ Warnings & Precautions
["Hepatotoxicity: Serious liver injury can occur. Monitor liver function before and during therapy. Discontinue if signs of liver toxicity develop.","Adrenal insufficiency: May occur, especially at higher doses or with prolonged use. Monitor for symptoms.","Drug interactions: Ketoconazole is a potent CYP3A4 inhibitor and can increase levels of many drugs. Review all concomitant medications.","Absorption: Requires acidic gastric environment. Avoid antacids, H2 blockers, and proton pump inhibitors.","QT prolongation: Use with caution in patients with cardiac disease or electrolyte abnormalities.","Endocrine effects: May cause gynecomastia, decreased libido, and impotence in men.","Use in children: Safety and efficacy not established in pediatric patients.","Use in elderly: Use with caution due to increased risk of liver and cardiac effects."]
🤱 Lactation Safety
Ketoconazole is excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
In case of overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor liver function and cardiac rhythm.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not increase or decrease the dose without medical advice. Avoid alcohol while taking this medicine as it may increase the risk of liver damage. Inform your doctor about all other medications you are taking, especially antacids, acid reducers, and certain heart or seizure medicines. Your doctor will likely monitor your liver function with blood tests before and during treatment. Do not use this medicine for minor fungal infections like athlete's foot or ringworm unless specifically instructed. If you miss a dose, take it as soon as you remember, but skip it if it is almost time for your next dose; never double the dose. Store this medicine at room temperature away from moisture and heat. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at increased risk of liver toxicity, adrenal insufficiency, and cardiac arrhythmias. Use with caution and monitor liver function and ECG closely. Dose adjustment may be necessary based on renal and hepatic function.
🤰 Pregnancy Planning (TTC)
This medicine should be avoided during pregnancy unless the potential benefit justifies the potential risk to the fetus. If you are planning pregnancy, consult your doctor to discuss alternative antifungal treatments. Use effective contraception while taking this medicine.
🏥 Post-Surgery Considerations
This medicine may interact with anesthetics and other medications used during surgery. Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be temporarily stopped before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may interact with certain antibiotics or antifungals used in dental procedures. No specific precautions are required for routine dental work, but maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness or fatigue. Avoid strenuous exercise or operating heavy machinery until you know how it affects you. Light to moderate activity is generally safe if you feel well.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, fatigue, or nausea, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. Inform your employer if your work involves operating heavy machinery.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as liver problems, severe allergic reactions, or cardiac symptoms, stop the medicine and seek immediate medical attention. Your doctor will decide if and when to discontinue treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of liver toxicity, adrenal insufficiency, and hormonal effects such as gynecomastia and decreased libido. Regular monitoring of liver function and clinical assessment is required. Prolonged use should be avoided unless clearly necessary and under close medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
An alternative oral antifungal with a better safety profile for many systemic fungal infections.
Evidence: Well-establishedAnother oral antifungal with broad-spectrum activity and fewer liver-related risks.
Evidence: Well-establishedAn intravenous antifungal used for severe systemic fungal infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions reported with this medicine. However, live vaccines should be avoided in immunocompromised patients. Consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, continue your regular dosing schedule; consult your doctor if adjustments are needed. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Clinical improvement may take several days to weeks, depending on the infection. Complete the full course as prescribed.
A: Yes, take it with food to improve absorption and reduce stomach upset.
A: Avoid alcohol, antacids, H2 blockers, and proton pump inhibitors. Also avoid grapefruit juice.
A: This medicine can cause liver damage. Your doctor will monitor your liver function regularly. Report any symptoms of liver problems immediately.
🤔 Common Patient Concerns
🔄 Substitutes for ketojet 200mg tablet
View AllAlternative brands with exact same active ingredient:
-
kinal 200mg tabletSAC Pharmaceuticals ₹16.88 90.3% CHEAPER
-
katcon 200mg tabletZeelab Pharmacy Pvt Ltd ₹33.00 81% CHEAPER
-
davaindia ketoconazole 200mg tabletDavaindia Generic Pharmacy ₹35.00 79.8% CHEAPER
-
stayhappi ketoconazole 200mg tabletSarvagunaushdhi Pvt Ltd ₹36.00 79.2% CHEAPER
-
ketazol 200mg tabletShalina Laboratories Pvt Ltd ₹52.50 69.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used for any fungal infection.
Fact: This medicine is reserved for serious systemic fungal infections and is not recommended for minor skin or nail infections unless specifically prescribed. - Myth: This medicine is safe to take without monitoring.
Fact: This medicine can cause serious liver damage and requires regular liver function monitoring. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed to prevent recurrence and resistance.
🔄 Alternative Options
Generic Alternatives
- Ketoconazole 200 mg tablet
Brand Alternatives
- Fungicide tablet