What is kallistro 2million iu powder for injection used for?

This medicine is a polymyxin antibiotic injection containing colistin sulphate 2 million IU, used to treat serious multidrug-resistant Gram-negative bacterial infections in hospital settings. It works by disrupting the bacterial outer membrane and is given under medical supervision with close monitoring of kidney function.

Generic Name: Colistin Sulphate (2Million IU)
Manufacturer: Bharat Serums & Vaccines Ltd
Form: Allopathy
Pregnancy Category: Consult doctor
Prescription Required: Yes

🇮🇳 kallistro 2million iu powder for injection के बारे में (Hindi Summary)

उपयोग: यह दवा कोलिस्टिन सल्फेट का इंजेक्शन है, जिसका उपयोग अस्पताल में गंभीर और मल्टीड्रग-रेसिस्टेंट ग्राम-नेगेटिव बैक्टीरिया के संक्रमण के इलाज के लिए किया जाता है। यह उन संक्रमणों में दी जाती है जो सामान्य एंटीबायोटिक्स से ठीक नहीं होते, जैसे निमोनिया, खून का संक्रमण, पेशाब की नली का संक्रमण और पेट के अंदर का संक्रमण। यह दवा केवल डॉक्टर की देखरेख में अस्पताल में ही दी जाती है। इसे खुद से नहीं लगाना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में किडनी पर असर, पेशाब कम आना, हाथ-पैर में झनझनाहट, चक्कर आना और इंजेक्शन लगाने की जगह पर दर्द शामिल हैं। गंभीर दुष्प्रभावों में किडनी खराब होना, मांसपेशियों में कमजोरी, सांस लेने में तकलीफ और गंभीर एलर्जी हो सकती है। अगर पेशाब बहुत कम आए, सांस लेने में दिक्कत हो, या शरीर में सूजन आए तो तुरंत डॉक्टर को बताएं।

सुरक्षा सलाह: यह दवा सिर्फ डॉक्टर या नर्स द्वारा अस्पताल में ही दी जानी चाहिए। इसे घर पर खुद न लगाएं। इलाज के दौरान किडनी की जांच करवाते रहें। डॉक्टर को अपनी सभी दवाओं के बारे में बताएं, खासकर दूसरे एंटीबायोटिक्स और दर्द निवारक दवाओं के बारे में। शराब न पिएं। पानी खूब पिएं, जब तक डॉक्टर न मना करें। इलाज बीच में न रोकें, चाहे आराम महसूस हो।

💊 kallistro 2million iu powder for injection Uses & Benefits

[{"condition":"Multidrug-resistant Gram-negative infections","description":"Used for serious infections caused by carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae when other options are limited.","evidence":"Well-established in hospital settings"},{"condition":"Hospital-acquired pneumonia and ventilator-associated pneumonia","description":"Prescribed for resistant Gram-negative pneumonia in critically ill patients, often in combination with another antibiotic.","evidence":"Established"},{"condition":"Bloodstream infections (bacteremia)","description":"Used for resistant Gram-negative bloodstream infections under specialist care.","evidence":"Established"},{"condition":"Complicated urinary tract infections","description":"Used for resistant Gram-negative urinary infections when susceptible and when safer options are not available.","evidence":"Established"},{"condition":"Intra-abdominal infections","description":"Used as part of combination therapy for resistant Gram-negative intra-abdominal infections.","evidence":"Established"}]

Off-label uses: [{"condition":"Aerosolized or nebulized therapy for resistant respiratory infections","description":"Sometimes used off-label by inhalation for resistant lung infections, but this is not the standard injectable route and requires specialist decision.","evidence":"Limited"},{"condition":"Intrathecal or intraventricular therapy for central nervous system infections","description":"Rarely used off-label for resistant meningitis or ventriculitis when intravenous therapy alone is insufficient.","evidence":"Limited"}]

Primary treatment for: Multidrug-resistant Gram-negative bacterial infections

Also treats: Hospital-acquired pneumonia, Ventilator-associated pneumonia, Bloodstream infections, Complicated urinary tract infections, Intra-abdominal infections

📋 Drug Information

Generic Name(s)	Colistin Sulphate (2Million IU)
Brand Name	kallistro 2million iu powder for injection
Manufacturer	Bharat Serums & Vaccines Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	GASTRO INTESTINAL
Action Class	Cell membrane active agent
Route of Administration	Parenteral (intravenous or intramuscular injection, as directed by a healthcare professional)
Storage	Store the unopened vial at room temperature (15-30°C), protected from light and moisture. After reconstitution, use as directed by the healthcare provider, usually within a specified time if refrigerated. Do not freeze.
Shelf Life	Not established from the available information. Check the expiry date on the vial.
WHO Guideline	Not established from the available information. Colistin is listed as a reserve antibiotic by the World Health Organization for certain multidrug-resistant infections, but specific recommendations vary by infection and region.
ICMR Guideline	Not established from the available information. The Indian Council of Medical Research has published guidance on antimicrobial use, but specific recommendations for this medicine should be confirmed with local guidelines.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1

Always check kidney function before starting and during treatment with this medicine.

2

Adjust the dose carefully in patients with renal impairment to avoid toxicity.

3

Monitor for neuromuscular blockade, especially in patients receiving muscle relaxants.

4

Use this medicine only for confirmed or strongly suspected multidrug-resistant Gram-negative infections.

5

Consider combination therapy with another active antibiotic to reduce resistance.

6

Educate patients and families about reporting decreased urine output or new weakness immediately.

7

Avoid concurrent use of other nephrotoxic drugs whenever possible.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅

Fever with severe infection

This medicine may be used for serious resistant infections with fever.

Likely Use

❌

Mild cold or flu

This medicine is not for viral infections.

Not Primary

✅

Resistant hospital-acquired pneumonia

This medicine is used for resistant Gram-negative pneumonia.

Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNot established from the available information for the injectable route. This medicine is given parenterally and is not intended for oral absorption.

DistributionColistin distributes into extracellular fluid and various tissues, but penetration into lung tissue, cerebrospinal fluid, and bone may be limited. Protein binding is moderate and varies by formulation.

Protein BindingNot established from the available information.

MetabolismColistin is not significantly metabolized in the body. It is eliminated mainly unchanged by the kidneys.

Half-LifeNot established from the available information. Half-life is prolonged in patients with kidney impairment.

ExcretionPrimarily excreted unchanged by the kidneys. Renal impairment significantly reduces clearance and increases the risk of toxicity.

BioavailabilityNot applicable for the injectable route. This medicine is given parenterally for systemic effect.

Onset of ActionNot established from the available information. Antibacterial effect begins after adequate blood levels are achieved, usually within hours of administration.

Peak Plasma TimeNot established from the available information for the injectable route.

Duration of ActionNot established from the available information. Duration depends on dosing interval, kidney function, and the infection being treated.

How It Works

Colistin is a polymyxin antibiotic that binds to the lipid A portion of bacterial lipopolysaccharide in the outer membrane of Gram-negative bacteria. This binding displaces calcium and magnesium ions, destabilizes the membrane, and increases permeability, which leads to leakage of cell contents and rapid bacterial death. It also has a detergent-like effect on the bacterial membrane.

Mechanism Steps

1

Binding to lipopolysaccharide: Colistin binds to the lipid A component of lipopolysaccharide in the outer membrane of Gram-negative bacteria.

2

Displacement of divalent cations: This binding displaces calcium and magnesium ions that stabilize the membrane.

3

Membrane destabilization: The outer membrane becomes permeable and loses its barrier function.

4

Cell leakage and death: Cellular contents leak out, and the bacterium dies rapidly.

💡 How to Take kallistro 2million iu powder for injection

Strength: Injection: 2 million IU per vial.

1This medicine is given by a healthcare professional as an injection.

2It is usually administered in a hospital or clinic setting.

3The dose and frequency are determined by your doctor.

4Do not attempt to self-administer this medicine.

5Report any side effects to your healthcare provider immediately.

Dosage Information

Adult Dosage	The dose is individualized by a qualified clinician based on the type and severity of infection, body weight, and kidney function. It is usually given in divided doses by injection in a hospital setting. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-administer.
Pediatric Dosage	Pediatric dosing is not established from available information. Consult a pediatrician.
Elderly Dosage	Elderly patients are more sensitive to kidney and nerve side effects. Dose must be individualized by a qualified clinician based on kidney function and overall health.
Renal Impairment	Dose must be reduced in patients with kidney impairment. A qualified clinician will adjust the dose based on creatinine clearance or serum creatinine. Close monitoring is required.
Hepatic Impairment	Not established from the available information. No specific dose adjustment is typically required for liver impairment, but consult a clinician.
Maximum Daily Dose	Not established from the available information. The maximum dose is determined by a qualified clinician based on the patient's condition and kidney function.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

No specific food restrictions

Follow your doctor's advice

This medicine is given by injection and does not have specific food interactions.

Alcohol

Avoid

Alcohol may increase the risk of kidney and nerve side effects.

⏰ What to Do If You Miss a Dose

📌 You are in the hospital and miss a scheduled dose

→ Inform your nurse or doctor immediately.

💡 They will decide whether to give the dose late or adjust the schedule.

📌 You are receiving home infusion and miss a dose

→ Contact your healthcare provider right away.

💡 Do not double the dose or self-administer an extra dose.

⚠️ Side Effects of kallistro 2million iu powder for injection

✅ Common Side Effects

Kidney function impairment (raised creatinine, reduced urine output) (Common)

Your doctor will monitor kidney function with blood tests. Report decreased urine output immediately.

Tingling or numbness in hands and feet (Common)

Tell your doctor if this occurs. Dose adjustment may be needed.

Dizziness (Common)

Avoid driving or operating machinery until you know how this medicine affects you.

Injection site pain or irritation (Common)

Report severe pain or swelling at the injection site to your nurse or doctor.

🚨 Serious Side Effects

Acute kidney injury (Uncommon to common)

Seek immediate medical attention if you notice a marked decrease in urine output, swelling, or confusion.

Neuromuscular blockade with muscle weakness or breathing difficulty (Rare)

Seek emergency care immediately if you develop new weakness, difficulty breathing, or difficulty swallowing.

Severe allergic reaction (anaphylaxis) (Rare)

Seek emergency care immediately if you develop rash, swelling of face or throat, or difficulty breathing.

⚠️ Rare Side Effects

Severe skin reactions such as Stevens-Johnson syndrome

Seek immediate medical attention if you develop a painful rash, blisters, or peeling skin.

Blood disorders such as low platelet count

Report unusual bruising or bleeding to your doctor immediately.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug	Severity	Effect
Aminoglycosides	Major
Amphotericin B	Major
Vancomycin	Major
NSAIDs	Major
Neuromuscular blockers	Major
Loop diuretics	Moderate
Cephalosporins	Moderate
Baclofen	Minor

🚨 Major Interactions

Other nephrotoxic drugs (e.g., aminoglycosides, amphotericin B, vancomycin, NSAIDs)
Neuromuscular blocking agents (e.g., vecuronium, pancuronium)

⚡ Moderate Interactions

Loop diuretics (e.g., furosemide)
Cephalosporins

🍷 Alcohol Interaction

Alcohol may increase the risk of kidney and nerve side effects. Avoid alcohol during treatment with this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy or hypersensitivity to colistin or other polymyxin antibiotics","Severe kidney impairment without appropriate dose adjustment and monitoring","Myasthenia gravis or other neuromuscular disorders (relative contraindication)"]

⚠️ Warnings & Precautions

["This medicine can cause serious kidney damage. Kidney function must be checked before and during treatment.","It can cause nerve and muscle effects, including breathing difficulty. Use with caution in patients with neuromuscular disorders.","Do not use for viral infections or infections not caused by susceptible Gram-negative bacteria.","Use with caution in elderly patients and those with existing kidney disease.","Avoid combining with other kidney-damaging drugs unless absolutely necessary.","Tell your doctor if you are pregnant, planning pregnancy, or breastfeeding."]

🤱 Lactation Safety

Not established from the available information. Colistin may pass into breast milk in small amounts. Consult your doctor before breastfeeding while on this medicine.

💊 Overdose Management

Overdose can cause severe kidney damage and neuromuscular blockade. There is no specific antidote. Treatment is supportive, including close monitoring of kidney function, breathing, and electrolytes. Dialysis may be considered in severe cases. Seek emergency medical care immediately.

⏰ Missed Dose

This medicine is given by a healthcare professional in a hospital or clinic. If you miss a scheduled dose, contact your healthcare provider immediately. Do not attempt to self-administer an extra dose.

Additional Safety Advice

General Safety

This medicine must be given only by a healthcare professional. Do not self-administer. Tell your doctor about all medicines you take, especially other antibiotics, muscle relaxants, and kidney-affecting drugs. Blood tests for kidney function and sometimes nerve function are needed during treatment. Stay well hydrated unless your doctor restricts fluids. Avoid alcohol during treatment. Do not stop treatment early even if you feel better, because incomplete treatment can lead to resistance and relapse.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of kidney damage and nerve side effects from this medicine. Kidney function should be checked frequently, and doses adjusted accordingly. They may also be more sensitive to dizziness and weakness.

🤰 Pregnancy Planning (TTC)

Not established from the available information. If you are planning pregnancy, discuss with your doctor before starting this medicine. Use only if clearly needed and prescribed by a specialist.

🏥 Post-Surgery Considerations

This medicine may be used after surgery if a resistant Gram-negative infection is suspected or confirmed. It is given under medical supervision, and kidney function is monitored closely during the postoperative period.

🦷 Dental Procedures

Inform your dentist if you are receiving this medicine. There are no specific dental precautions, but your dentist should know about your infection and treatment. Maintain good oral hygiene.

💚 Lifestyle Tips for Better Results

🏃

Stay well hydrated unless your doctor restricts fluids.

🥗

Avoid alcohol during treatment.

😴

Get plenty of rest to help your body fight the infection.

💧

Follow infection control practices like hand hygiene to prevent new infections.

🧘

Attend all follow-up appointments for kidney function monitoring.

🌞

Report any new symptoms promptly to your healthcare team.

🏋️ Exercise Considerations

Avoid strenuous exercise during treatment, especially if you feel weak or dizzy. Gentle activity may be allowed if you are stable, but consult your doctor first. If you experience muscle weakness or breathing difficulty, stop exercising and seek medical help.

🥗 Diet Recommendations

Eat a balanced diet to support recovery.

Stay well hydrated with water unless fluid-restricted.

Limit high-salt and processed foods to reduce kidney stress.

Include fruits and vegetables as tolerated.

Avoid alcohol.

💼 Impact on Daily Work & Life

This medicine is usually given in a hospital, so you may need to take time off work during treatment. You may feel tired or dizzy, so avoid driving or operating heavy machinery until you know how the medicine affects you. Discuss return-to-work plans with your doctor.

🛑 When to Stop This Medicine

Do not stop this medicine on your own. Your doctor will decide when to stop based on your infection response, culture results, and kidney function. Stopping early can lead to treatment failure and resistance.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of kidney damage and nerve problems. Kidney function should be monitored regularly during and after treatment. Prolonged use can also lead to bacterial resistance. Use should be limited to the shortest effective duration under specialist supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Other antibiotics based on culture sensitivity

If the bacteria are susceptible to other antibiotics, those may be used instead to reduce toxicity.

Evidence: Well-established

Combination therapy

Combining this medicine with another active antibiotic may improve efficacy and reduce resistance.

Evidence: Established

Supportive care

Fluids, oxygen, and other supportive measures are important alongside antibiotics.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Not established from the available information. There are no known vaccine interactions with this medicine. However, patients with serious infections may need to delay vaccinations until they recover. Consult your doctor.

📦 Storage Guide

✅ DO

Store the unopened vial at room temperature (15-30°C)

❌ DON'T

Do not freeze the vial

✅ DO

Keep in the original container protected from light

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Use reconstituted solution as directed by healthcare provider

❌ DON'T

Do not use if the solution is cloudy or has particles

✈️ Traveling with This Medicine

This medicine is given in a hospital or clinic and is not for self-administration during travel. If you are discharged with a prescription for home infusion, carry it in its original packaging with a copy of your prescription. Keep it at the recommended temperature and protect it from light. Inform airport security about any medical injections and carry a doctor's letter. Check local regulations before traveling with this medicine.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 62-year-old man in the intensive care unit with ventilator-associated pneumonia caused by multidrug-resistant Acinetobacter.

He was started on this medicine by his doctors after culture results showed resistance to other antibiotics. His kidney function was monitored daily, and the dose was adjusted. Over several days, his fever reduced and his breathing improved. He completed the course under close supervision.

💡 Lesson: This medicine can be life-saving for resistant infections but requires hospital care and close kidney monitoring.

👤 A 45-year-old woman with a resistant urinary tract infection after surgery.

She received this medicine through an intravenous line in the hospital. Her urine output was monitored, and she was encouraged to drink fluids as allowed. She reported mild tingling in her hands, which improved after the dose was adjusted. The infection cleared after the full course.

💡 Lesson: Reporting side effects early helps doctors adjust treatment and prevent serious complications.

💬 Questions Patients Often Ask

Q: How does this medicine work?

A: This medicine works by binding to the outer membrane of Gram-negative bacteria and disrupting it, which kills the bacteria.

Q: How is this medicine given?

A: It is given as an injection by a healthcare professional, usually in a hospital or clinic.

Q: What are the most important side effects to watch for?

A: Watch for decreased urine output, new muscle weakness, difficulty breathing, or signs of allergic reaction. Report these immediately.

Q: Can I stop the injection if I feel better?

A: No. You must complete the full course as prescribed to prevent resistance and relapse.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

Can this medicine damage my kidneys?
How often will my kidney function be checked?
Can I take this medicine if I am pregnant?
What should I do if I feel tingling in my hands or feet?
Can I breastfeed while on this medicine?
How long will I need this injection?
Can this medicine be given at home?

🔄 Substitutes for kallistro 2million iu powder for injection

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

Myth: Colistin is a safe antibiotic for any infection.
Fact: Colistin is a reserve antibiotic for serious multidrug-resistant infections and can cause kidney damage. It is not for mild or routine infections.
Myth: You can take colistin at home by yourself.
Fact: Colistin injection must be given by a healthcare professional in a hospital or clinic setting with proper monitoring.
Myth: Colistin works against viruses and fungi.
Fact: Colistin only works against certain Gram-negative bacteria. It does not treat viral or fungal infections.

🔄 Alternative Options

Generic Alternatives

Colistin sulphate injection

Brand Alternatives

Hicoly 2million IU Injection

📊 Comparison with Similar Medicines

[{"medicine":"Colistin sulphate injection","class":"Polymyxin antibiotic","route":"Parenteral","main_use":"Multidrug-resistant Gram-negative infections","key_side_effect":"Kidney damage"},{"medicine":"Polymyxin B injection","class":"Polymyxin antibiotic","route":"Parenteral","main_use":"Multidrug-resistant Gram-negative infections","key_side_effect":"Kidney damage and nerve effects"},{"medicine":"Tigecycline injection","class":"Glycylcycline antibiotic","route":"Parenteral","main_use":"Complicated infections including resistant organisms","key_side_effect":"Nausea, vomiting, liver effects"}]

Hicoly 2million IU Injection (Colistin Sulphate): Complete Medicine Guide

When to Call Your Doctor IMMEDIATELY

What is kallistro 2million iu powder for injection used for?

🇮🇳 kallistro 2million iu powder for injection के बारे में (Hindi Summary)

💊 kallistro 2million iu powder for injection Uses & Benefits

📋 Drug Information

👨‍⚕️ Doctor's Practical Tips

🔍 Is This Medicine Right for Your Symptom?

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

How It Works

Mechanism Steps

💡 How to Take kallistro 2million iu powder for injection

Dosage Information

Dosage Timeline

🍽️ Food Timing Guide

⏰ What to Do If You Miss a Dose

⚠️ Side Effects of kallistro 2million iu powder for injection

✅ Common Side Effects

🚨 Serious Side Effects

⚠️ Rare Side Effects

🔬 Drug Interactions

🚨 Major Interactions

⚡ Moderate Interactions

🍷 Alcohol Interaction

🔎 Check Your Other Medicines

🛡️ Safety & Warnings

🚫 Contraindications

⚠️ Warnings & Precautions

🤱 Lactation Safety

💊 Overdose Management

⏰ Missed Dose

Additional Safety Advice

👴 Special Considerations for Elderly

💡 For Patients Above 65

🤰 Pregnancy Planning (TTC)

🏥 Post-Surgery Considerations

🦷 Dental Procedures

💚 Lifestyle Tips for Better Results

🏋️ Exercise Considerations

🥗 Diet Recommendations

💼 Impact on Daily Work & Life

🛑 When to Stop This Medicine

📅 Long-Term Use Effects

🌿 Non-Medicine Approaches

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

📦 Storage Guide

✅ DO

❌ DON'T

✅ DO

❌ DON'T

✅ DO

❌ DON'T

✈️ Traveling with This Medicine

💰 Cost Analysis & Savings

👥 Real Patient Stories

💬 Questions Patients Often Ask

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

🔄 Substitutes for kallistro 2million iu powder for injection

🛑 Myths vs. Facts

🔄 Alternative Options

Generic Alternatives

Brand Alternatives

📊 Comparison with Similar Medicines

😊 Was this information helpful?

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