Dia-G Tablet: Complete Guide to Uses, Dosage, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe or persistent diarrhoea with signs of dehydration such as dizziness or reduced urine output.
- Yellowing of the skin or eyes, dark urine, or severe fatigue (possible liver injury).
- Swelling of the face, lips, or throat, or difficulty breathing (allergic reaction).
- Blood in vomit or black, tarry stools (gastrointestinal bleeding).
- Severe abdominal pain that does not go away.
- Chest pain or irregular heartbeat.
- Sudden severe headache with vision changes.
If experiencing severe symptoms, call emergency services immediately.
What is jointguard d 50 mg/500 mg tablet used for?
This medicine is a combination of Diacerein 50 mg and Glucosamine 500 mg used to treat osteoarthritis. It works by reducing cartilage breakdown and supporting cartilage repair. It is a slow-acting drug, so benefits may take 2 to 4 weeks. Take it with food to reduce stomach upset and avoid alcohol.
- Generic Name: Diacerein (50mg) + Glucosamine (500mg)
- Manufacturer: Psychotropics India Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 jointguard d 50 mg/500 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डायसरिन 50 मिलीग्राम और ग्लूकोसामाइन 500 मिलीग्राम का संयोजन है, जिसका उपयोग ऑस्टियोआर्थराइटिस (जोड़ों की घिसाई) के इलाज में किया जाता है। यह जोड़ों के दर्द, अकड़न और सूजन को कम करने में मदद करती है। यह दवा कार्टिलेज को टूटने से बचाती है और उसकी मरम्मत में सहायता करती है। यह एक धीमी गति से काम करने वाली दवा है, इसलिए इसका असर दिखने में 2 से 4 सप्ताह लग सकते हैं। इसे भोजन के साथ लेना चाहिए ताकि पेट की परेशानी कम हो। शराब का सेवन न करें क्योंकि इससे लिवर की समस्या हो सकती है। गर्भवती या स्तनपान कराने वाली महिलाओं को डॉक्टर की सलाह के बिना यह दवा नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सबसे आम दुष्प्रभाव पेट और आंतों से जुड़े होते हैं। इसमें दस्त, पेट दर्द, जी मिचलाना, और एसिडिटी शामिल हो सकते हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। दवा को भोजन के साथ लेने से पेट की परेशानी कम हो सकती है। कभी-कभी सिरदर्द, त्वचा पर चकत्ते, या पेशाब का रंग गहरा हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें गंभीर दस्त, लिवर की क्षति (आंखों या त्वचा का पीला पड़ना), और एलर्जी प्रतिक्रिया शामिल हो सकती है। अगर आपको गंभीर दस्त, उल्टी, या पेट में तेज दर्द हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। गोली को पूरा निगलें, चबाएं नहीं। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो। शराब का सेवन बिल्कुल न करें क्योंकि इससे लिवर की समस्या और पेट में ब्लीडिंग का खतरा बढ़ सकता है। डायबिटीज के मरीजों को ब्लड शुगर की निगरानी करनी चाहिए क्योंकि ग्लूकोसामाइन शुगर के स्तर को प्रभावित कर सकता है। गर्भावस्था, स्तनपान, या गर्भधारण की योजना बनाते समय डॉक्टर को जरूर बताएं। लंबे समय तक इस दवा का सेवन करने पर लिवर और किडनी की जांच समय-समय पर कराते रहें। दवा को ठंडी और सूखी जगह पर रखें, धूप से बचाएं और बच्चों की पहुंच से दूर रखें।
💊 jointguard d 50 mg/500 mg tablet Uses & Benefits
- [{"condition":"Knee osteoarthritis","description":"Reduces pain and improves physical function in mild to moderate knee osteoarthritis.
- Benefits appear after 2 to 4 weeks of regular use.","evidence":"Moderate"},{"condition":"Hip osteoarthritis","description":"May help relieve pain and stiffness in hip osteoarthritis, though evidence is less robust than for knee osteoarthritis.","evidence":"Limited"},{"condition":"Hand osteoarthritis","description":"Sometimes used to improve hand joint pain and function, but clinical evidence is inconsistent.","evidence":"Limited"},{"condition":"General joint pain and stiffness","description":"Often prescribed for chronic joint discomfort associated with cartilage wear, though it is not a rapid pain reliever.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Low back pain","description":"Occasionally prescribed off-label for chronic low back pain with degenerative changes, but evidence is weak.","evidence":"Limited"},{"condition":"Temporomandibular joint disorders","description":"Rarely used off-label for jaw joint pain, based on small studies only.","evidence":"Limited"}]
Primary treatment for: Osteoarthritis
Also treats: Knee osteoarthritis, Hip osteoarthritis, Hand osteoarthritis, Chronic joint pain
📋 Drug Information
| Generic Name(s) | Diacerein (50mg) + Glucosamine (500mg) |
| Brand Name | jointguard d 50 mg/500 mg tablet |
| Manufacturer | Psychotropics India Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a cool, dry place. Protect from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. Guidelines vary by region and may recommend symptomatic slow-acting drugs for osteoarthritis based on individual assessment. |
| ICMR Guideline | Not established from the available information. Consult local guidelines and your doctor for appropriate use. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Diacerein is a slow-acting anti-osteoarthritic drug that inhibits the production and activity of interleukin-1 beta, a cytokine that promotes cartilage degradation and joint inflammation. By blocking this pathway, diacerein reduces the expression of matrix metalloproteinases and other enzymes that break down cartilage. Glucosamine is an amino sugar that serves as a substrate for the synthesis of glycosaminoglycans and proteoglycans, which are essential components of the cartilage extracellular matrix. It may also have mild anti-inflammatory effects by reducing oxidative stress and cytokine release. Together, these ingredients aim to relieve symptoms and potentially slow cartilage deterioration in osteoarthritis.
Mechanism Steps
💡 How to Take jointguard d 50 mg/500 mg tablet
Strength: Immediate-release oral tablet containing Diacerein 50 mg and Glucosamine 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once or twice daily with meals, as prescribed by your doctor. The exact dose and duration depend on the indication, severity of osteoarthritis, and your overall health. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. Take the tablet with a full glass of water and food to reduce stomach upset. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially gastrointestinal effects and dehydration. Dose adjustment may be needed based on kidney and liver function. Regular monitoring is advised. Consult your doctor for individualized dosing. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose adjustment may be necessary based on creatinine clearance. Monitor kidney function and hydration status. Consult your doctor for specific dosing recommendations. |
| Hepatic Impairment | This medicine is contraindicated in severe liver disease. In mild to moderate liver impairment, use with caution and monitor liver function closely. Dose adjustment may be required. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is generally 100 mg of diacerein and 1500 mg of glucosamine, but this must be confirmed by your prescribing doctor. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of jointguard d 50 mg/500 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Insulin | Moderate | |
| Metformin | Moderate | |
| Furosemide | Moderate | |
| Ibuprofen | Moderate | |
| Paracetamol | Minor | |
| Antacids | Minor | |
| Laxatives | Moderate | |
| Isoniazid | Major |
🚨 Major Interactions
- Warfarin
- Hepatotoxic drugs (e.g., methotrexate, isoniazid)
- Diuretics (e.g., furosemide)
⚡ Moderate Interactions
- Antidiabetic drugs (e.g., insulin, metformin)
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Laxatives
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the risk of liver injury from diacerein and worsen gastrointestinal side effects such as stomach pain and diarrhoea. It may also increase the risk of bleeding. If you consume alcohol regularly, discuss this with your doctor before starting this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy or hypersensitivity to diacerein, glucosamine, or any component of this medicine.","Severe liver disease or active liver disease.","Inflammatory bowel disease (e.g., ulcerative colitis, Crohn's disease).","Intestinal obstruction or severe gastrointestinal conditions.","Pregnancy and breastfeeding unless specifically advised by a specialist.","Children and adolescents under 18 years of age (safety and efficacy not established)."]
⚠️ Warnings & Precautions
["Take this medicine with food to reduce gastrointestinal side effects.","Avoid alcohol during treatment due to increased risk of liver problems.","Monitor liver function periodically, especially with long-term use.","Use with caution in patients with kidney disease or dehydration risk.","Diabetic patients should monitor blood glucose more closely as glucosamine may affect levels.","Do not use this medicine for acute pain relief; it is a slow-acting drug.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Stop the medicine and seek medical help if you develop severe diarrhoea, yellowing of eyes, or signs of allergic reaction."]
🤱 Lactation Safety
It is not known whether diacerein or glucosamine pass into breast milk in significant amounts. This medicine is not recommended during breastfeeding without specialist advice. Consult your doctor to weigh benefits and risks.
💊 Overdose Management
Overdose of this medicine may cause severe diarrhoea, nausea, vomiting, and dehydration. There is no specific antidote. Treatment is supportive and symptomatic, including fluid and electrolyte replacement. In case of suspected overdose, contact your doctor or a poison control centre immediately. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, provided it is not close to the time for your next dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Swallow the tablet whole with a full glass of water, preferably with a meal to reduce stomach upset. Do not crush, chew, or break the tablet unless your doctor advises otherwise. Avoid alcohol while taking this medicine because it can increase the risk of liver problems and stomach bleeding. Do not take other painkillers or supplements without consulting your doctor, as some may interact. If you have diabetes, monitor your blood sugar levels more closely because glucosamine may affect glucose control. If you are pregnant, planning pregnancy, or breastfeeding, inform your doctor before using this medicine. Keep all follow-up appointments so your doctor can check your liver and kidney function. Store this medicine in a cool, dry place away from direct sunlight and out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients above 65 years may be more susceptible to gastrointestinal side effects, dehydration, and liver or kidney problems. Regular monitoring of liver and kidney function is advised. Dose adjustment may be needed based on renal and hepatic function. Ensure adequate hydration, especially if diarrhoea occurs.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy unless specifically advised by a specialist. If you are trying to conceive, discuss with your doctor to explore safer alternatives for managing osteoarthritis. Do not start or stop this medicine without medical advice.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be stopped before surgery due to potential effects on bleeding and liver function. Follow your doctor's instructions regarding when to stop and when to resume.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. There is no specific contraindication, but if you have a history of bleeding or liver problems, your dentist may take extra precautions. Continue taking your medicine as prescribed unless your doctor advises otherwise.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you can continue gentle exercises as advised by your doctor or physiotherapist. Avoid high-impact activities that stress your joints, such as running or jumping, especially during flare-ups. If you experience increased pain or swelling after exercise, rest and consult your doctor. Stay hydrated, especially if you experience diarrhoea.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness or dehydration due to diarrhoea, avoid driving or operating heavy machinery until you feel better. You can continue your normal daily activities as tolerated. Inform your employer if you need frequent bathroom breaks due to loose stools.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects such as persistent diarrhoea, signs of liver injury, or allergic reactions, stop the medicine and seek medical advice immediately. Your doctor will decide whether to continue, adjust the dose, or switch to another treatment based on your response and any adverse effects.
📅 Long-Term Use Effects
Long-term use of this medicine may require periodic monitoring of liver and kidney function. Diacerein has been associated with rare liver injury, so regular liver function tests are advised. Gastrointestinal side effects such as diarrhoea may persist or recur. The medicine may continue to provide symptomatic benefit, but its effect on cartilage structure is not fully established. Regular follow-up with your doctor is important to assess ongoing benefit and safety.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve joint function.
Evidence: Well-establishedReduces joint load and improves symptoms in knee osteoarthritis.
Evidence: Well-establishedMay provide local pain relief with fewer systemic side effects.
Evidence: ModerateMay provide temporary relief in knee osteoarthritis.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive routine vaccinations while taking this medicine. However, inform your healthcare provider about all medicines you are taking before any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription or a letter from your doctor, especially for international travel. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking your doses at the same intervals as prescribed; no specific time zone adjustment is usually needed for this medicine. Keep enough supply for your entire trip and carry it in your hand luggage to avoid loss or temperature extremes.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine is slow-acting. You may start noticing improvement in pain and stiffness after 2 to 4 weeks of regular use. Maximum benefits may take 4 to 8 weeks.
A: You should consult your doctor before combining with other painkillers, especially NSAIDs, as they may increase the risk of stomach bleeding.
A: No, alcohol should be avoided as it increases the risk of liver problems and gastrointestinal side effects.
A: Glucosamine may increase blood glucose levels. If you have diabetes, monitor your blood sugar more frequently and inform your doctor.
A: Do not stop without consulting your doctor. Your doctor will advise you on the duration of treatment based on your condition.
🤔 Common Patient Concerns
🔄 Substitutes for jointguard d 50 mg/500 mg tablet
View AllAlternative brands with exact same active ingredient:
-
mobigold dgm tabletAlkem Laboratories Ltd ₹41.02 12% COSTLIER
-
glunova plus tabletOrganic Laboratories ₹99.00 170.3% COSTLIER
-
dia-g tabletRaffles Pharmaceuticals ₹119.06 225.1% COSTLIER
-
compensate tabletKamakshi Drugs & Pharmaceuticals ₹121.88 232.8% COSTLIER
-
danfix tabletDaniel Pasteur ₹125.00 241.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine provides immediate pain relief.
Fact: This medicine is a slow-acting drug and may take 2 to 4 weeks to show benefits. It is not a rapid painkiller. - Myth: This medicine can cure osteoarthritis completely.
Fact: This medicine helps manage symptoms and may slow cartilage breakdown, but it does not cure osteoarthritis. - Myth: It is safe to take this medicine with alcohol.
Fact: Alcohol should be avoided as it increases the risk of liver problems and gastrointestinal side effects. - Myth: This medicine is safe for everyone.
Fact: It is not recommended for people with severe liver disease, inflammatory bowel disease, or during pregnancy and breastfeeding without specialist advice.
🔄 Alternative Options
Generic Alternatives
- Diacerein 50 mg + Glucosamine 500 mg tablet (generic)
Brand Alternatives
- Not established from the available information.