Astobone Tablet: Complete Guide to Uses, Dosage, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain or persistent diarrhea
- Yellowing of skin or eyes (jaundice)
- Dark urine or pale stools
- Swelling of face, lips, or throat, or difficulty breathing
- Severe headache with visual changes
- Decreased urine output or swelling in legs
If experiencing severe symptoms, call emergency services immediately.
What is danfix tablet used for?
This medicine is a combination of Glucosamine (500mg) and Diacerein (50mg) used to treat osteoarthritis. It works by supporting cartilage health and reducing inflammation. It is taken orally with meals, usually once or twice daily, as prescribed by a doctor. It may take 4-8 weeks for full effect.
- Generic Name: Glucosamine (500mg) + Diacerein (50mg)
- Manufacturer: Daniel Pasteur
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 danfix tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ग्लूकोसामाइन (500mg) और डायसेरिन (50mg) का संयोजन है, जिसका उपयोग ऑस्टियोआर्थराइटिस (जोड़ों की गठिया) के इलाज में किया जाता है। यह जोड़ों के दर्द, अकड़न और सूजन को कम करने में मदद करती है। यह कार्टिलेज को स्वस्थ रखने और सूजन को कम करने में सहायक है। इसका असर धीरे-धीरे होता है, इसलिए इसे कम से कम 4-8 सप्ताह तक नियमित रूप से लेना चाहिए। इसे डॉक्टर की सलाह के अनुसार भोजन के साथ लें।
साइड इफेक्ट्स: आम दुष्प्रभावों में पेट खराब होना, दस्त, जी मिचलाना, पेट दर्द, और सिरदर्द शामिल हैं। डायसेरिन के कारण दस्त हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन लीवर की समस्या, एलर्जी, या गंभीर दस्त हो सकते हैं। अगर आपको पीलिया, गहरे रंग का पेशाब, या गंभीर पेट दर्द हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो। शराब का सेवन न करें। अगर आपको लीवर या किडनी की बीमारी है, तो डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान इसका सेवन न करें। बच्चों से दूर रखें। दवा को ठंडी और सूखी जगह पर रखें।
💊 danfix tablet Uses & Benefits
- [{"condition":"Knee osteoarthritis","description":"Reduces pain and improves joint mobility in knee osteoarthritis.
- Effects may take 4-8 weeks to become noticeable.","evidence":"Moderate"},{"condition":"Hip osteoarthritis","description":"May help alleviate pain and stiffness in hip osteoarthritis, though evidence is less robust than for knee osteoarthritis.","evidence":"Limited"},{"condition":"Hand osteoarthritis","description":"Sometimes used to relieve symptoms of hand osteoarthritis, but clinical evidence is limited.","evidence":"Limited"}]
Off-label uses: [{"condition":"Low back pain","description":"Occasionally prescribed off-label for chronic low back pain with degenerative changes, but evidence is insufficient.","evidence":"Insufficient"},{"condition":"Temporomandibular joint disorders","description":"Rarely used off-label for TMJ pain, but no robust clinical trials support this use.","evidence":"Insufficient"}]
Primary treatment for: Osteoarthritis
Also treats: Knee osteoarthritis, Hip osteoarthritis, Hand osteoarthritis
📋 Drug Information
| Generic Name(s) | Glucosamine (500mg) + Diacerein (50mg) |
| Brand Name | danfix tablet |
| Manufacturer | Daniel Pasteur |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Do not refrigerate unless specified by the manufacturer. |
| Shelf Life | 24 months from the date of manufacture, or as indicated on the packaging. |
| WHO Guideline | Not established from the available information. Guidelines vary; consult your local clinical guidelines for osteoarthritis management. |
| ICMR Guideline | Not established from the available information. ICMR guidelines for osteoarthritis may include symptomatic slow-acting drugs, but specific recommendations for this combination are not available. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Glucosamine provides building blocks for glycosaminoglycans and proteoglycans in cartilage, potentially stimulating chondrocyte synthesis and reducing cartilage breakdown. Diacerein is metabolized to rhein, which inhibits interleukin-1 beta (IL-1β) and other pro-inflammatory cytokines, thereby reducing cartilage degradation and joint inflammation. Together, they aim to slow structural damage and provide symptomatic relief in osteoarthritis.
Mechanism Steps
💡 How to Take danfix tablet
Strength: Tablet containing Glucosamine 500mg and Diacerein 50mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally once or twice daily, preferably with meals. The exact dose and frequency must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal and hepatic function, and response to therapy. Do not self-adjust the dose. Follow your doctor's prescription exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially gastrointestinal and renal effects. Dose adjustment may be necessary based on renal and hepatic function. Regular monitoring is advised. |
| Renal Impairment | In patients with mild to moderate renal impairment, no specific dose adjustment is established, but caution is advised. In severe renal impairment, use is not recommended due to risk of accumulation. Consult a nephrologist or your doctor for individualized dosing. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, no specific dose adjustment is established, but caution is advised. In severe hepatic impairment, use is contraindicated. Regular monitoring of liver function is recommended. |
| Maximum Daily Dose | The maximum recommended daily dose is typically 2 tablets (1000mg glucosamine + 100mg diacerein), but this must be confirmed by your prescribing doctor. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of danfix tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Ibuprofen | Moderate | |
| Diclofenac | Moderate | |
| Insulin | Moderate | |
| Metformin | Moderate | |
| Furosemide | Moderate | |
| Hydrochlorothiazide | Moderate | |
| Antacids | Minor | |
| Tetracycline | Minor |
🚨 Major Interactions
- Warfarin
- Hepatotoxic drugs (e.g., methotrexate, isoniazid)
⚡ Moderate Interactions
- NSAIDs (e.g., ibuprofen, diclofenac)
- Antidiabetic drugs
- Diuretics
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the risk of liver problems and may worsen gastrointestinal side effects such as stomach bleeding or ulcers.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to glucosamine, diacerein, or any component of the formulation.","Inflammatory bowel disease (e.g., ulcerative colitis, Crohn's disease).","Severe liver disease.","Severe kidney disease.","Pregnancy and breastfeeding.","Children under 18 years of age (safety and efficacy not established)."]
⚠️ Warnings & Precautions
["Take with food to minimize stomach upset.","Avoid alcohol consumption during treatment.","Inform your doctor if you have diabetes, as glucosamine may affect blood sugar levels.","Use with caution in patients with a history of liver or kidney disease.","Do not use for acute pain; this medicine is for chronic osteoarthritis management.","Do not exceed the recommended dose.","Keep out of reach of children.","Store in a cool, dry place away from direct sunlight."]
🤱 Lactation Safety
Not established from the available information. It is not known whether glucosamine and diacerein are excreted in human breast milk. Breastfeeding is not recommended while taking this medicine.
💊 Overdose Management
Overdose may cause severe diarrhea, nausea, abdominal pain, and dehydration. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Contact a poison control center or emergency room right away.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Swallow the tablet whole with a glass of water, preferably with meals to reduce stomach upset. Do not crush or chew the tablet. Avoid alcohol while taking this medicine as it may increase the risk of liver problems. Inform your doctor if you have a history of liver disease, kidney disease, inflammatory bowel disease, or diabetes. Do not take this medicine if you are pregnant, planning to become pregnant, or breastfeeding. Keep out of reach of children. Store at room temperature away from direct sunlight and moisture. Do not use after the expiry date. If you miss a dose, take it as soon as you remember unless it is almost time for the next dose; do not double the dose. Regular follow-up with your doctor is important to monitor your response and check for any side effects.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to gastrointestinal and renal side effects. Dose adjustment may be necessary based on kidney and liver function. Regular monitoring is advised. Falls risk may increase if dizziness occurs.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended for women planning pregnancy. If you are trying to conceive, consult your doctor for alternative treatments for osteoarthritis. Use effective contraception while on this medicine.
🏥 Post-Surgery Considerations
If you are undergoing surgery, inform your surgeon and anesthesiologist about this medicine. It may need to be stopped before surgery due to potential effects on bleeding and liver function. Follow your doctor's instructions.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, especially if you are undergoing dental surgery or procedures that may cause bleeding. No specific precautions are established, but your dentist may need to know your medication history.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you can exercise, but avoid high-impact activities that stress your joints. If you experience increased pain or swelling, stop and consult your doctor. Low-impact exercises are generally safe and beneficial.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. If affected, avoid driving or operating heavy machinery until you know how it affects you. Otherwise, it should not significantly impact your daily work or activities. Take it with food to minimize stomach upset.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects such as persistent diarrhea, jaundice, or allergic reactions, stop immediately and seek medical attention. Your doctor may adjust the dose or switch to an alternative treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may require periodic monitoring of liver and kidney function. Some patients may experience persistent gastrointestinal symptoms. There is no evidence of serious long-term toxicity when used as prescribed, but regular follow-up is essential. Do not use for longer than recommended without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve joint function.
Evidence: Well-establishedReduces load on weight-bearing joints and improves symptoms.
Evidence: Well-establishedMay provide pain relief for some patients with osteoarthritis.
Evidence: ModerateCan be used for localized pain relief with fewer systemic side effects.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medications you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or exposure to extreme temperatures. Store at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking your doses at the same intervals as prescribed; you may need to adjust timing gradually. Check local customs regulations for carrying prescription medicines. Always carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine is slow-acting. You may start noticing improvement in 2-4 weeks, but maximum benefits often require 4-8 weeks of continuous use.
A: Yes, it is best taken with meals to reduce stomach upset and diarrhea.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, this medicine is not recommended during pregnancy due to lack of safety data. Consult your doctor for alternative treatments.
A: Do not stop without consulting your doctor. Your doctor may advise gradual withdrawal or alternative therapy.
🤔 Common Patient Concerns
🔄 Substitutes for danfix tablet
View AllAlternative brands with exact same active ingredient:
-
jointguard d 50 mg/500 mg tabletPsychotropics India Ltd ₹36.62 70.7% CHEAPER
-
mobigold dgm tabletAlkem Laboratories Ltd ₹41.02 67.2% CHEAPER
-
glunova plus tabletOrganic Laboratories ₹99.00 20.8% CHEAPER
-
dia-g tabletRaffles Pharmaceuticals ₹119.06 4.8% CHEAPER
-
compensate tabletKamakshi Drugs & Pharmaceuticals ₹121.88 2.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine provides instant pain relief.
Fact: This medicine is a slow-acting drug; it may take several weeks to show noticeable improvement. - Myth: It can cure osteoarthritis completely.
Fact: It helps manage symptoms and may slow cartilage damage, but it does not cure osteoarthritis. - Myth: It is safe to take without a prescription.
Fact: This is a prescription medicine; it should only be taken under medical supervision. - Myth: It can be taken during pregnancy without risk.
Fact: It is not recommended during pregnancy due to lack of safety data.
🔄 Alternative Options
Generic Alternatives
- Glucosamine 500mg + Diacerein 50mg tablet (generic versions available from various manufacturers)
Brand Alternatives
- Astobone Tablet (Aden Healthcare)