Aledime S 1000mg/500mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe or bloody diarrhea
- Seizures or confusion
- Decreased urine output or swelling
- Yellowing of skin or eyes
- Severe skin rash or blistering
- Persistent high fever
If experiencing severe symptoms, call emergency services immediately.
What is jedacef s 1000mg/500mg injection used for?
This medicine is a combination antibiotic injection containing ceftazidime and sulbactam, used to treat serious bacterial infections. It works by killing bacteria and is administered by a healthcare professional.
- Generic Name: Ceftazidime (1000mg) + Sulbactam (500mg)
- Manufacturer: Kritikos Care
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 jedacef s 1000mg/500mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा सेफ्टाज़िडाइम और सल्बैक्टम का संयोजन है, जिसका उपयोग गंभीर जीवाणु संक्रमणों के इलाज के लिए किया जाता है। यह मूत्र मार्ग, फेफड़ों, त्वचा, पेट और रक्त के संक्रमण में प्रभावी है। यह केवल अस्पताल में डॉक्टर द्वारा इंजेक्शन के रूप में दी जाती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, दस्त, मतली, सिरदर्द और दाने शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, दौरे और गंभीर दस्त हो सकते हैं। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल डॉक्टर की देखरेख में अस्पताल में दी जानी चाहिए। अपनी सभी एलर्जी और स्वास्थ्य समस्याओं के बारे में डॉक्टर को बताएं। निर्धारित खुराक पूरी करें। शराब से बचें। गंभीर दस्त या सांस लेने में कठिनाई हो तो तुरंत मदद लें।
💊 jedacef s 1000mg/500mg injection Uses & Benefits
[{"condition":"Complicated urinary tract infections","description":"Used to treat serious kidney and bladder infections caused by susceptible Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Lower respiratory tract infections","description":"Effective against hospital-acquired pneumonia and other severe lung infections.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats severe cellulitis, abscesses, and wound infections caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in combination with other antibiotics for complicated intra-abdominal infections.","evidence":"Well-established"},{"condition":"Bloodstream infections","description":"Treats sepsis and bacteremia caused by susceptible Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"May be used for osteomyelitis and septic arthritis caused by susceptible bacteria.","evidence":"Moderate"},{"condition":"Meningitis","description":"Used for bacterial meningitis caused by susceptible organisms, especially in patients with penicillin allergy.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Febrile neutropenia","description":"Sometimes used as empirical therapy in immunocompromised patients with fever and low white blood cell counts.","evidence":"Limited"},{"condition":"Peritonitis in dialysis patients","description":"Occasionally used intraperitoneally for peritoneal dialysis-associated peritonitis.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Urinary tract infections, Pneumonia, Skin infections, Intra-abdominal infections, Sepsis
📋 Drug Information
| Generic Name(s) | Ceftazidime (1000mg) + Sulbactam (500mg) |
| Brand Name | jedacef s 1000mg/500mg injection |
| Manufacturer | Kritikos Care |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Parenteral (intravenous or intramuscular injection) |
| Storage | Store below 25°C (77°F). Protect from light and moisture. Reconstituted solutions should be used within the time specified by the manufacturer. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Ceftazidime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to bacterial cell death. Sulbactam is a beta-lactamase inhibitor that protects ceftazidime from enzymatic degradation by certain beta-lactamase-producing bacteria, thereby extending its spectrum of activity.
Mechanism Steps
💡 How to Take jedacef s 1000mg/500mg injection
Strength: Injection: Ceftazidime 1000 mg + Sulbactam 500 mg
Dosage Information
| Adult Dosage | The usual adult dose is 1 g to 2 g of ceftazidime with 500 mg sulbactam every 8 to 12 hours, administered intravenously or intramuscularly. The exact dose and frequency depend on the type and severity of infection, renal function, and clinical response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function; dose should be adjusted based on creatinine clearance. Monitor renal function closely. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For creatinine clearance 31-50 mL/min, administer every 12 hours; for 16-30 mL/min, every 24 hours; for 6-15 mL/min, every 24 hours; for <5 mL/min, every 48 hours. Consult a clinician for precise dosing. |
| Hepatic Impairment | No specific dose adjustment is required for hepatic impairment alone, but monitor liver function. |
| Maximum Daily Dose | The maximum recommended daily dose is 6 g of ceftazidime (with corresponding sulbactam) in divided doses, but must be individualized. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of jedacef s 1000mg/500mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Gentamicin | Major | |
| Furosemide | Major | |
| Warfarin | Major | |
| Probenecid | Moderate | |
| Chloramphenicol | Moderate | |
| Oral contraceptives | Minor |
🚨 Major Interactions
- Aminoglycosides (e.g., gentamicin)
- Loop diuretics (e.g., furosemide)
- Warfarin
⚡ Moderate Interactions
- Probenecid
- Chloramphenicol
🍷 Alcohol Interaction
Avoid alcohol consumption during treatment as it may increase the risk of side effects such as nausea, vomiting, and headache.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to ceftazidime, sulbactam, or other cephalosporins","History of anaphylaxis to penicillins","Use in patients with known severe beta-lactam allergy"]
⚠️ Warnings & Precautions
["Use with caution in patients with renal impairment; dose adjustment may be required.","May cause Clostridioides difficile-associated diarrhea; monitor if diarrhea occurs.","Serious allergic reactions can occur; discontinue immediately if suspected.","May cause seizures, especially in patients with renal impairment.","Prolonged use may lead to superinfection with resistant organisms.","Monitor blood counts during prolonged therapy."]
🤱 Lactation Safety
Ceftazidime is excreted in human milk in low amounts. Sulbactam also passes into breast milk. Consult your doctor before breastfeeding while on this medicine.
💊 Overdose Management
Overdose may cause nausea, vomiting, and seizures. Treatment is supportive and symptomatic. Hemodialysis may be considered to remove ceftazidime in severe cases. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If a dose is missed, contact your healthcare provider for guidance. Do not attempt to self-administer.
Additional Safety Advice
This medicine must be administered only by a healthcare professional in a clinical setting. Inform your doctor about all allergies, especially to penicillins or cephalosporins, and about any kidney or liver problems. Do not self-administer or use leftover medicine. Complete the full course as prescribed, even if you feel better, to prevent resistance. Report severe diarrhea, rash, or breathing difficulty immediately. Avoid alcohol during treatment as it may worsen side effects. Keep all follow-up appointments for monitoring.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced renal function; dose adjustment is often needed. Monitor closely for side effects.
🤰 Pregnancy Planning (TTC)
Consult your doctor if you are planning pregnancy or are pregnant. Use only if clearly needed.
🏥 Post-Surgery Considerations
May be used to prevent or treat surgical site infections. Follow your surgeon's instructions.
🦷 Dental Procedures
Inform your dentist if you are on this medicine. It may be used for prophylaxis in certain dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise during acute infection. Gradually resume activity as you recover.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may need to take time off work during treatment, especially if hospitalized. Avoid driving if you feel dizzy or unwell.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full prescribed course even if you feel better.
📅 Long-Term Use Effects
Prolonged use may lead to antibiotic resistance and superinfections. Regular monitoring of renal and liver function is advised for long-term therapy. Discontinue if severe adverse effects occur.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on culture results, alternative antibiotics may be used.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions reported. Ensure routine vaccinations are up to date.
📦 Storage Guide
✅ DO
Store below 25°C
❌ DON'T
Do not freeze
✅ DO
Keep in original packaging
❌ DON'T
Do not use if solution is discolored or contains particles
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom
✈️ Traveling with This Medicine
This medicine is administered in a healthcare facility, so travel is not applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medicine as directed. Consult your doctor before travel if you have ongoing infection.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Improvement in symptoms may be seen within 24-48 hours, but the full course must be completed.
A: No, it must be administered by a healthcare professional in a clinical setting.
🤔 Common Patient Concerns
🔄 Substitutes for jedacef s 1000mg/500mg injection
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nexzone s 1000mg/500mg injectionNexocare Biotech Pvt Ltd ₹126.56 64.9% CHEAPER
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welcef sb 1000mg/500mg injectionWelbe Life Sciences ₹129.84 64% CHEAPER
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Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections.
Fact: This medicine is an antibiotic and is effective only against bacterial infections, not viruses. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course as prescribed to prevent resistance and relapse.
🔄 Alternative Options
Generic Alternatives
- Ceftazidime + Sulbactam injection
Brand Alternatives
- Aledime S 1000mg/500mg injection