apra 40mg tablet - Pantoprazole (40mg) medicine

Apra 40mg Tablet - Uses, Price, Side Effects

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๐Ÿญ Kritikos Care ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 27, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 27, 2026

What is apra 40mg tablet used for?

Apra 40mg Tablet contains Pantoprazole 40mg, a proton pump inhibitor that reduces stomach acid production. It is used to treat acid reflux, GERD, and stomach ulcers. It works by blocking the enzyme in the stomach wall that produces acid, providing relief from heartburn and promoting healing of the esophagus.

  • Generic Name: Pantoprazole
  • Manufacturer: Kritikos Care
  • Form: Allopathy
  • Pregnancy Category: B
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š apra 40mg tablet Uses & Benefits

Gastroesophageal reflux disease (GERD), erosive esophagitis, Zollinger-Ellison syndrome, Helicobacter pylori eradication (combination therapy), peptic ulcer disease.

Off-label uses: Stress ulcer prophylaxis in critically ill patients; prevention of NSAID-induced ulcers.

๐Ÿ“‹ Drug Information

Generic Name(s)Pantoprazole
Brand NameAciban 40 Tablet
ManufacturerKritikos Care
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassProton pump inhibitors
Route of AdministrationOral
StorageStore at 20-25ยฐC (68-77ยฐF); protect from moisture and light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed after oral administration; absorption is rapid and complete.
DistributionVolume of distribution about 0.15 L/kg; extensively distributed in tissues.
Protein BindingApproximately 98% bound to plasma proteins, mainly albumin.
MetabolismExtensively metabolized in the liver via CYP2C19 and CYP3A4 isoenzymes.
Half-LifeAbout 1 hour (range 0.5-1.5 hours) in healthy subjects; prolonged in hepatic impairment.
ExcretionPrimarily renal (about 80% as metabolites); remainder in feces.
BioavailabilityOral bioavailability about 77%.
Onset of ActionWithin 1 hour; maximal acid suppression occurs after 2-4 days of dosing.
Peak Plasma Time2-3 hours after oral administration.
Duration of ActionAcid suppression lasts up to 24 hours after a single dose.

How It Works

Proton pump inhibitor that irreversibly inhibits H+/K+ ATPase in gastric parietal cells.

Mechanism Steps

1Pantoprazole is a prodrug that accumulates in the acidic environment of gastric parietal cell canaliculi.
2It is protonated and converted to its active form, a sulfenamide.
3The active form binds covalently to cysteine residues of the H+/K+ ATPase enzyme.

๐Ÿ’ก How to Take apra 40mg tablet

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โŒ ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of apra 40mg tablet

โœ… Common Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Abdominal pain
  • Flatulence
  • Constipation

๐Ÿšจ Serious Side Effects

  • Clostridium difficile-associated diarrhea
  • Fractures (hip, wrist, spine) with long-term use
  • Hypomagnesemia
  • Vitamin B12 deficiency
  • Acute interstitial nephritis
  • Cutaneous lupus erythematosus

โš ๏ธ Rare Side Effects

  • Hepatotoxicity
  • Pancreatitis
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Agranulocytosis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Moderate May increase INR and bleeding risk
Methotrexate Moderate May increase methotrexate toxicity
Ketoconazole Moderate May decrease absorption of ketoconazole

๐Ÿšจ Major Interactions

  • Clopidogrel
  • Methotrexate
  • Atazanavir
  • Rilpivirine
  • Cilostazol

โšก Moderate Interactions

  • Warfarin
  • Phenytoin
  • Diazepam
  • Digoxin
  • Iron salts
  • Mycophenolate mofetil

โ„น๏ธ Minor Interactions

  • Ketoconazole
  • Itraconazole
  • Ampicillin esters
  • Sucralfate

๐Ÿฝ๏ธ Food Interactions

Food may delay absorption but does not affect extent; best taken before meals.

๐Ÿท Alcohol Interaction

No direct interaction; alcohol may aggravate gastric conditions.

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Low
Kidney
Low
Heart
Low
Pregnancy
Category B

๐Ÿšซ Contraindications

Hypersensitivity to pantoprazole or any component; co-administration with rilpivirine.

๐Ÿ“Š Monitoring Parameters

Symptoms of acid-related disorders; magnesium levels with prolonged use; bone density with long-term use.

๐Ÿคฑ Lactation Safety

Excreted in breast milk; use with caution.

๐Ÿ’Š Overdose Management

Supportive care; no specific antidote; hemodialysis not effective.

โฐ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 27, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for apra 40mg tablet

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Alternative brands with exact same active ingredient (Pantoprazole (40mg)):

Medical Note: Always consult your doctor before switching medications.

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