Derma IT Cream: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction (swelling of face, lips, throat, difficulty breathing)
- Signs of severe skin reaction (painful blisters, peeling skin, sores in mouth)
- No improvement after several days of use
- Worsening of infection (increased redness, swelling, pain, pus)
- Development of new symptoms such as fever or chills
If experiencing severe symptoms, call emergency services immediately.
What is itrostred oc cream used for?
This medicine is a topical cream containing ofloxacin and ornidazole, used to treat bacterial and protozoal skin infections. Apply a thin layer to the affected area 2-3 times daily as prescribed.
- Generic Name: Ofloxacin (0.75% w/w) + Ornidazole (2% w/w)
- Manufacturer: Leeford Healthcare Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 itrostred oc cream के बारे में (Hindi Summary)
उपयोग: यह दवा एक टॉपिकल क्रीम है जिसमें ऑफ़लोक्सासिन और ओर्निडाज़ोल होते हैं। इसका उपयोग त्वचा के बैक्टीरियल और प्रोटोज़ोअल संक्रमणों के इलाज के लिए किया जाता है, जैसे कि संक्रमित घाव, जले हुए घाव, और त्वचा के अल्सर। यह क्रीम संक्रमण पैदा करने वाले सूक्ष्मजीवों को मारती है और घाव को भरने में मदद करती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में लगाने की जगह पर जलन, खुजली, लालिमा, या सूखापन शामिल हो सकते हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको चेहरे, होंठ, या गले में सूजन, सांस लेने में कठिनाई, या पूरे शरीर पर दाने दिखें, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा का उपयोग डॉक्टर के निर्देशानुसार ही करें। इसे प्रभावित हिस्से पर पतली परत में लगाएं और हल्के हाथ से रगड़ें। आंखों, नाक, मुंह, और अन्य श्लेष्मा झिल्लियों के संपर्क से बचें। उपयोग से पहले और बाद में हाथ धोएं। बिना डॉक्टर की सलाह के इसे लंबे समय तक न लगाएं। गर्भवती या स्तनपान कराने वाली महिलाएं उपयोग से पहले डॉक्टर से परामर्श करें। बच्चों की पहुंच से दूर रखें।
💊 itrostred oc cream Uses & Benefits
[{"condition":"Infected wounds","description":"Used to treat bacterial and protozoal infections in wounds, promoting healing and preventing spread.","evidence":"Well-established"},{"condition":"Infected burns","description":"Helps control infection in burn wounds caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Skin ulcers","description":"Applied to infected ulcers to reduce microbial load and support healing.","evidence":"Well-established"},{"condition":"Bacterial skin infections","description":"Effective against a range of gram-positive and gram-negative bacteria causing skin infections.","evidence":"Well-established"},{"condition":"Protozoal skin infections","description":"Ornidazole component targets protozoa such as Trichomonas and Entamoeba in cutaneous lesions.","evidence":"Limited"}]
Off-label uses: [{"condition":"Acne vulgaris","description":"Sometimes used off-label for inflammatory acne due to antibacterial effects, but not first-line.","evidence":"Limited"},{"condition":"Rosacea","description":"May be used off-label for rosacea with secondary bacterial infection, but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Bacterial and protozoal skin infections
Also treats: Infected wounds, Infected burns, Skin ulcers
📋 Drug Information
| Generic Name(s) | Ofloxacin (0.75% w/w) + Ornidazole (2% w/w) |
| Brand Name | itrostred oc cream |
| Manufacturer | Leeford Healthcare Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | DERMA |
| Action Class | |
| Route of Administration | Topical |
| Storage | Store below 30°C in a cool, dry place. Protect from direct sunlight. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Ofloxacin, a fluoroquinolone, inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication, transcription, repair, and recombination. This leads to bacterial cell death. Ornidazole, a nitroimidazole, enters susceptible anaerobic bacteria and protozoa, where its nitro group is reduced to reactive intermediates that damage DNA, causing strand breakage and inhibiting nucleic acid synthesis. The combination provides broad-spectrum antimicrobial activity.
Mechanism Steps
💡 How to Take itrostred oc cream
Strength: Cream containing Ofloxacin 0.75% w/w and Ornidazole 2% w/w.
Dosage Information
| Adult Dosage | Apply a thin layer of this medicine to the affected area 2 to 3 times daily, or as directed by your doctor. The duration of treatment depends on the type and severity of the infection. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended frequency or duration without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients when used topically. However, they may be more susceptible to skin irritation. Use with caution and monitor for adverse effects. |
| Renal Impairment | No dose adjustment is required for topical use in patients with renal impairment, as systemic absorption is minimal. |
| Hepatic Impairment | No dose adjustment is required for topical use in patients with hepatic impairment, as systemic absorption is minimal. |
| Maximum Daily Dose | Not established from the available information. Use as prescribed by your doctor. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of itrostred oc cream
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | |
| Other topical antibiotics | Minor |
🚨 Major Interactions
- Other topical agents (e.g., corticosteroids)
⚡ Moderate Interactions
- Oral anticoagulants (e.g., warfarin)
🍷 Alcohol Interaction
No known interaction with alcohol when used topically. However, alcohol consumption may worsen certain skin conditions; consult your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to ofloxacin, ornidazole, or any component of the formulation","Use in the eyes or on mucous membranes","Application to large areas of broken skin without medical supervision"]
⚠️ Warnings & Precautions
["For external use only. Do not ingest.","Avoid contact with eyes, nose, mouth, and other mucous membranes.","Do not use on large areas or for prolonged periods without medical advice.","Discontinue if severe irritation or allergic reaction occurs.","Pregnant and breastfeeding women should consult a doctor before use.","Keep out of reach of children.","Do not use if the tube is damaged or the cream has changed appearance."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Consult your doctor before use. Avoid applying to the breast area to prevent infant exposure.
💊 Overdose Management
Overdose with topical application is unlikely. If accidental ingestion occurs, seek immediate medical attention. Symptoms may include nausea, vomiting, and abdominal pain. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Additional Safety Advice
Use this medicine exactly as prescribed by your doctor. Apply a thin layer to the affected area and gently rub it in, unless directed otherwise. Wash your hands thoroughly before and after application. Avoid contact with the eyes, nose, mouth, and other mucous membranes. Do not cover the treated area with airtight dressings unless instructed. Do not use this medicine for longer than recommended without consulting your doctor. If you are pregnant, planning to become pregnant, or breastfeeding, inform your doctor before using this medicine. Keep this medicine out of reach of children. Do not share this medicine with others, even if they have similar symptoms. If your condition does not improve within a few days or worsens, contact your healthcare provider.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have thinner skin and be more prone to irritation. Use with caution and monitor for adverse effects. No dose adjustment is needed for topical use.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before using this medicine. Topical use is generally considered low risk, but systemic absorption may occur.
🏥 Post-Surgery Considerations
If you have recently had surgery, consult your doctor before using this cream on surgical wounds. It may be used if prescribed for infected surgical sites.
🦷 Dental Procedures
No specific considerations for dental procedures, as this medicine is for topical skin use only.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
No specific exercise restrictions are required while using this medicine. However, avoid activities that may irritate or contaminate the affected area. If the infection is on a limb, avoid strenuous exercise that may cause friction or sweating.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is applied topically and is unlikely to affect your ability to drive or operate machinery. However, if you experience any allergic reaction or severe irritation, avoid these activities until you feel better.
🛑 When to Stop This Medicine
Stop using this medicine if you experience a severe allergic reaction, severe skin irritation, or if your doctor advises discontinuation. Do not stop prematurely even if symptoms improve, as this may lead to recurrence of infection. Consult your doctor before stopping.
📅 Long-Term Use Effects
Prolonged use of this medicine may lead to overgrowth of non-susceptible organisms, including fungi, and may promote antibiotic resistance. It should only be used for the prescribed duration. If long-term use is required, your doctor will monitor for secondary infections and other adverse effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Keeping wounds clean and covered can prevent infection and promote healing.
Evidence: Well-establishedDepending on the causative organism, other antibiotics may be used.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. However, if you have an active infection, consult your doctor about timing of vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case of customs checks. Store it in a cool, dry place away from direct sunlight. If traveling to a hot climate, keep it in a cool bag. No time zone adjustments are needed for topical use. Ensure you have enough supply for your trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start seeing improvement within a few days, but complete healing may take 1-2 weeks depending on the infection.
A: Consult your doctor before using on the face, as the skin there is more sensitive.
A: Consult your doctor. Topical use is generally considered low risk, but systemic absorption may occur.
A: Apply it as soon as you remember, but if it's almost time for the next dose, skip the missed dose and continue with your regular schedule.
🤔 Common Patient Concerns
🔄 Substitutes for itrostred oc cream
View AllAlternative brands with exact same active ingredient:
-
ofloscan-o plus creamMedishri Healthcare ₹60.94 40.3% CHEAPER
-
Trobate Forte CreamEveson Pharma ₹61.88 39.3% CHEAPER
-
fungx creamLancer Therapeutics ₹64.08 37.2% CHEAPER
-
dermiwin oc max creamWindlas Biotech Ltd ₹65.00 36.3% CHEAPER
-
cutiwin-it creamProvectus Life Sciences ₹65.63 35.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This cream can be used for any skin problem.
Fact: It is specifically for bacterial and protozoal infections; using it for other conditions may be ineffective and promote resistance. - Myth: More cream means faster healing.
Fact: Applying more than prescribed does not speed healing and may increase side effects. - Myth: It is safe to use indefinitely.
Fact: Prolonged use can lead to resistance and secondary infections; use only as directed.
🔄 Alternative Options
Generic Alternatives
- Ofloxacin 0.75% w/w + Ornidazole 2% w/w cream