Isifrane 250 Liquid for Inhalation: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- High fever with muscle rigidity during or after anesthesia
- Severe drop in blood pressure
- Irregular heartbeat or chest pain
- Difficulty breathing or shortness of breath
- Yellowing of skin or eyes
- Decreased urine output
- Confusion or seizures after waking up
If experiencing severe symptoms, call emergency services immediately.
What is isifrane 250 liquid for inhalation used for?
This medicine is a liquid anesthetic that is inhaled to put patients to sleep during surgery. It is given only by anesthesia professionals in a hospital setting.
- Generic Name: Isoflurane (250mg)
- Manufacturer: Abbott
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 isifrane 250 liquid for inhalation के बारे में (Hindi Summary)
उपयोग: यह दवा एक इनहेलेशन एनेस्थेटिक है जिसका उपयोग सर्जरी के दौरान मरीज को बेहोश करने और दर्द रहित रखने के लिए किया जाता है। इसे केवल अस्पताल में प्रशिक्षित एनेस्थीसिया विशेषज्ञ द्वारा ही दिया जाता है। यह दवा सर्जरी के दौरान मरीज को सोते रहने और दर्द महसूस न होने देने में मदद करती है। इसे घर पर या खुद से नहीं लिया जा सकता।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, कंपकंपी और रक्तचाप में कमी शामिल हैं। कुछ मरीजों को दिल की धड़कन में अनियमितता या सांस लेने में कठिनाई हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें मैलिग्नेंट हाइपरथर्मिया और लीवर की समस्या शामिल हो सकती है।
सुरक्षा सलाह: यह दवा केवल अस्पताल में विशेषज्ञ की देखरेख में दी जाती है। इसे खुद से न लें। इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं और दवाओं के बारे में बताएं। इस दवा के बाद कुछ समय तक नींद या भ्रम हो सकता है, इसलिए तब तक गाड़ी न चलाएं जब तक पूरी तरह सतर्क न हो जाएं।
💊 isifrane 250 liquid for inhalation Uses & Benefits
[{"condition":"General anesthesia for surgery","description":"This medicine is used to induce and maintain general anesthesia during surgical procedures in adults and children.","evidence":"Well-established"},{"condition":"Maintenance of anesthesia","description":"It is commonly used to keep patients asleep and pain-free during the entire operation.","evidence":"Well-established"},{"condition":"Sedation for intensive care","description":"In some settings, it may be used for prolonged sedation of critically ill patients on ventilators.","evidence":"Established"}]
Off-label uses: [{"condition":"Refractory status epilepticus","description":"Rarely used as a last-resort treatment for prolonged seizures that do not respond to standard medicines.","evidence":"Limited"}]
Primary treatment for: Surgical anesthesia
Also treats: Intensive care sedation
📋 Drug Information
| Generic Name(s) | Isoflurane (250mg) |
| Brand Name | isifrane 250 liquid for inhalation |
| Manufacturer | Abbott |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | General anaesthetic agents |
| Route of Administration | Inhalation |
| Storage | Store at room temperature (20-25°C). Keep away from heat, sparks, and open flames. Store in a tightly closed container. Do not refrigerate or freeze. |
| Shelf Life | Typically 3 years from the date of manufacture. Check the expiry date on the label. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by interfering with nerve signals in the brain and spinal cord. It enhances the effect of the inhibitory neurotransmitter GABA at GABA-A receptors, which slows down brain activity. It also affects other ion channels such as glycine receptors and glutamate receptors, contributing to unconsciousness, immobility, and amnesia. The exact way it produces anesthesia is not completely understood.
Mechanism Steps
💡 How to Take isifrane 250 liquid for inhalation
Strength: Liquid for inhalation, 250 mg per bottle (as isoflurane).
Dosage Information
| Adult Dosage | This medicine is given by inhalation using a calibrated vaporizer. The concentration is adjusted by the anesthesia provider to maintain surgical anesthesia. The usual concentration ranges from 1% to 2.5% in oxygen or a mixture of oxygen and nitrous oxide. The dose must be individualized by a qualified clinician based on the patient's age, weight, medical condition, and the type of surgery. It is not for self-administration. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric anesthesiologist. |
| Elderly Dosage | Elderly patients may require lower concentrations because they are more sensitive to the effects. The anesthesia provider will adjust the dose carefully. |
| Renal Impairment | No specific dose adjustment is established. Use with caution in patients with kidney disease and monitor kidney function. |
| Hepatic Impairment | No specific dose adjustment is established. Use with caution in patients with liver disease and monitor liver function. |
| Maximum Daily Dose | Not applicable. The dose is titrated to effect by the anesthesia provider. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of isifrane 250 liquid for inhalation
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Succinylcholine | Major | |
| Propranolol | Major | |
| Morphine | Moderate | |
| Verapamil | Moderate | |
| Gentamicin | Minor |
🚨 Major Interactions
- Other inhaled anesthetics (e.g., halothane, enflurane)
- Neuromuscular blocking agents (e.g., succinylcholine)
- Beta-blockers (e.g., propranolol)
⚡ Moderate Interactions
- Opioid painkillers (e.g., morphine)
- Calcium channel blockers (e.g., verapamil)
🍷 Alcohol Interaction
Alcohol should be avoided before and after receiving this medicine. Alcohol can increase the sedative effects and impair recovery. Do not drink alcohol for at least 24 hours after anesthesia unless your doctor approves.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to isoflurane or other halogenated anesthetics","History of malignant hyperthermia","Known or suspected genetic susceptibility to malignant hyperthermia","Porphyria"]
⚠️ Warnings & Precautions
["This medicine must be administered only by trained anesthesia professionals.","It can cause malignant hyperthermia, a life-threatening emergency. Dantrolene must be immediately available.","It can cause low blood pressure and respiratory depression. Monitor closely.","It may increase intracranial pressure; use with caution in patients with head injury.","It can trigger seizures in susceptible individuals.","Repeated exposure may cause liver injury.","It may interact with other medicines; review all medications before use."]
🤱 Lactation Safety
It is not known if this medicine passes into breast milk. Because it is given only in a hospital setting and is rapidly eliminated, it is unlikely to affect a nursing infant. However, you should discuss with your doctor before breastfeeding after receiving this medicine.
💊 Overdose Management
Overdose with this medicine can cause severe respiratory depression, low blood pressure, and cardiac arrest. Treatment is supportive and includes stopping the medicine, ensuring a clear airway, giving oxygen, and providing circulatory support. There is no specific antidote. The anesthesia team will manage complications as they arise.
⏰ Missed Dose
This medicine is given only by a healthcare professional in a controlled setting. Missed doses are not applicable.
Additional Safety Advice
This medicine is given only by an anesthesia provider in a properly equipped medical facility. You should not handle or use this medicine yourself. Before receiving it, tell your doctor about all your medical conditions, especially heart, lung, liver, or kidney problems, and any family history of malignant hyperthermia. Also inform them of all medicines you take, including herbs and supplements. After receiving this medicine, you may feel drowsy or confused for a short time; do not drive or operate machinery until you are fully alert. Do not drink alcohol or take sedatives for at least 24 hours after anesthesia unless your doctor says it is okay. Follow all instructions given by your surgical team.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine. Lower concentrations may be needed. They may also have a higher risk of confusion after surgery. Close monitoring is required.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor before receiving this medicine. It should be used during pregnancy only if clearly needed. It can cross the placenta and affect the fetus.
🏥 Post-Surgery Considerations
After surgery, you will be monitored in the recovery area until you are awake and stable. You may experience nausea, shivering, or confusion. Follow your doctor's instructions for pain relief and activity.
🦷 Dental Procedures
This medicine is not typically used for dental procedures. If you are scheduled for dental work and have recently received this medicine, inform your dentist.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise for at least 24-48 hours after receiving this medicine. Your body needs time to recover from anesthesia. Consult your doctor before resuming exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You should not drive or operate machinery for at least 24 hours after receiving this medicine. You may feel drowsy or confused for a short time. Arrange for someone to drive you home and stay with you for the first night.
🛑 When to Stop This Medicine
This medicine is stopped by the anesthesia provider when surgery is complete. You should not stop it yourself. If you experience any unusual symptoms after surgery, contact your doctor.
📅 Long-Term Use Effects
Long-term effects are not well established for single use. Repeated or prolonged exposure may lead to liver or kidney problems due to fluoride buildup. Monitoring may be needed if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can be used instead of general anesthesia for some surgeries.
Evidence: Well-establishedSevoflurane or desflurane may be used as alternatives.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, inform your doctor about recent vaccinations before surgery.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from heat and open flames
❌ DON'T
Do not store near sources of ignition
✈️ Traveling with This Medicine
This medicine is not for personal use and is administered only in medical facilities. If you are traveling after surgery, carry a copy of your discharge summary and inform your doctor about your recent anesthesia. Do not attempt to carry or use this medicine yourself. Follow your doctor's advice regarding activity and medication during travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Unconsciousness occurs within a few minutes of inhaling the vapor.
A: The duration depends on the surgery. The anesthesia provider will keep you asleep until the procedure is complete.
A: No, this medicine ensures you are unconscious and pain-free during the procedure.
A: Common side effects include nausea, vomiting, shivering, and low blood pressure.
A: You will be instructed to fast before surgery to prevent complications. Follow your doctor's instructions.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: Isoflurane is a painkiller that can be taken at home.
Fact: This medicine is a general anesthetic and is only given by trained professionals in a hospital. - Myth: Isoflurane is safe for anyone.
Fact: It is not safe for people with a history of malignant hyperthermia or porphyria.