Brucet 400 mg/333 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is ibutal 400 mg/333 mg tablet used for?
This medicine is a combination of Ibuprofen 400 mg and Paracetamol 333 mg used for short-term relief of moderate to severe pain and inflammation. It is taken orally with food, usually two to three times daily. Do not exceed 3 tablets in 24 hours.
- Generic Name: Ibuprofen (400mg) + Paracetamol (333mg)
- Manufacturer: Talent Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ibutal 400 mg/333 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा इबुप्रोफेन 400 मिलीग्राम और पैरासिटामोल 333 मिलीग्राम का संयोजन है। इसका उपयोग मध्यम से गंभीर दर्द और सूजन के अल्पकालिक उपचार के लिए किया जाता है, जैसे कि मांसपेशियों और जोड़ों का दर्द, दांत दर्द, मासिक धर्म में ऐंठन, और सर्जरी के बाद का दर्द। यह दवा दर्द और बुखार को कम करने में मदद करती है। इसे भोजन के साथ लेना चाहिए। इसका सेवन डॉक्टर के परामर्श के अनुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सीने में जलन, दस्त, कब्ज, चक्कर आना, सिरदर्द और नींद आना शामिल हैं। गंभीर दुष्प्रभावों में पेट या आंतों में रक्तस्राव, अल्सर, गुर्दे की समस्या, यकृत की क्षति, गंभीर एलर्जी प्रतिक्रिया और हृदय संबंधी समस्याएं शामिल हो सकती हैं। यदि आपको कोई गंभीर लक्षण दिखाई दे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। अनुशंसित खुराक से अधिक न लें। इसे भोजन या दूध के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब का सेवन न करें। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं, तो डॉक्टर से परामर्श करें। यदि आपको चक्कर आते हैं तो वाहन चलाने या मशीनरी चलाने से बचें। इस दवा को बच्चों की पहुंच से दूर रखें।
💊 ibutal 400 mg/333 mg tablet Uses & Benefits
[{"condition":"Musculoskeletal pain","description":"Relieves pain and inflammation in muscles, joints, and bones, such as back pain, sprains, and strains.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides effective relief from toothache and pain following dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Manages moderate to severe pain after surgery.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"Reduces pain and improves joint mobility in osteoarthritis of the knee, hip, and hand.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Helps alleviate pain and stiffness associated with rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Well-established"},{"condition":"Fever","description":"Reduces fever due to the paracetamol component.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, though not first-line.","evidence":"Limited"},{"condition":"Soft tissue injuries","description":"Used off-label for pain and swelling in soft tissue injuries like tendonitis and bursitis.","evidence":"Limited"}]
Primary treatment for: Pain and inflammation
Also treats: Osteoarthritis, Rheumatoid arthritis, Dysmenorrhea, Dental pain, Post-operative pain
📋 Drug Information
| Generic Name(s) | Ibuprofen (400mg) + Paracetamol (333mg) |
| Brand Name | ibutal 400 mg/333 mg tablet |
| Manufacturer | Talent Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Ibuprofen is a non-selective cyclooxygenase (COX) inhibitor that reversibly blocks both COX-1 and COX-2 enzymes, leading to decreased synthesis of prostaglandins, prostacyclin, and thromboxane. This results in analgesic, anti-inflammatory, and antipyretic effects. Paracetamol, although its exact mechanism is not fully understood, primarily acts centrally by inhibiting prostaglandin synthesis in the brain and possibly activating descending serotonergic pathways. It provides analgesia and antipyresis with minimal anti-inflammatory action. The combination provides enhanced pain relief through additive or synergistic effects.
Mechanism Steps
💡 How to Take ibutal 400 mg/333 mg tablet
Strength: Ibuprofen 400 mg + Paracetamol 333 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times daily, with food or milk. The maximum daily dose should not exceed 3 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose or duration of treatment without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney impairment. Use the lowest effective dose for the shortest duration possible. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose reduction may be necessary. Avoid in severe kidney impairment (eGFR <30 mL/min). Consult a doctor for dose adjustment. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose reduction may be necessary. Avoid in severe liver impairment. Consult a doctor for dose adjustment. |
| Maximum Daily Dose | The maximum daily dose is 3 tablets in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ibutal 400 mg/333 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Major | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Diuretics | Moderate | |
| Beta-blockers | Moderate | |
| Cyclosporine | Moderate |
🚨 Major Interactions
- Warfarin
- Aspirin
- Methotrexate
- Lithium
- ACE inhibitors and ARBs
⚡ Moderate Interactions
- Corticosteroids
- SSRIs
- Diuretics
- Beta-blockers
- Cyclosporine
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulcers, and liver damage, especially with paracetamol. It can also worsen drowsiness and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to ibuprofen, paracetamol, or any component of the formulation","History of asthma, urticaria, or allergic reaction to aspirin or other NSAIDs","Active or history of peptic ulcer or gastrointestinal bleeding","Severe heart failure, ischemic heart disease, or peripheral arterial disease","Severe kidney impairment (eGFR
⚠️ Warnings & Precautions
["Take with food or milk to reduce gastrointestinal irritation.","Avoid alcohol while taking this medicine.","Do not exceed the recommended dose or duration of treatment.","Use with caution in elderly patients due to increased risk of side effects.","Consult your doctor before use if you have a history of kidney or liver disease.","May cause dizziness or drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not use for more than 10 days for pain or 3 days for fever without consulting a doctor.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding."]
🤱 Lactation Safety
Ibuprofen and paracetamol are excreted in breast milk in small amounts. Short-term use is generally considered compatible with breastfeeding, but consult your doctor before use.
💊 Overdose Management
Overdose can cause severe liver damage, gastrointestinal bleeding, and kidney failure. Seek immediate medical attention. Treatment includes activated charcoal, supportive care, and administration of acetylcysteine for paracetamol toxicity. Hemodialysis may be required in severe cases.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Always take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of gastrointestinal bleeding and liver damage. Do not use this medicine if you have a history of stomach ulcers, bleeding disorders, severe kidney or liver disease, or heart failure. Inform your doctor about all other medications you are taking, especially blood thinners, corticosteroids, and antidepressants. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Store this medicine at room temperature away from moisture and heat. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly.
🤰 Pregnancy Planning (TTC)
Consult your doctor before taking this medicine if you are planning to become pregnant. It is not recommended during the third trimester.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain as prescribed by your doctor. Inform your surgeon about all medications you are taking.
🦷 Dental Procedures
This medicine can be used for dental pain. Inform your dentist if you are taking this medicine before any dental procedure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may increase pain while taking this medicine. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects, if your pain persists beyond 10 days, or if your fever lasts more than 3 days. Do not stop abruptly if you have been taking it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, ulcers, kidney impairment, liver damage, and cardiovascular events. Regular monitoring of kidney and liver function is recommended. Use the lowest effective dose for the shortest duration possible.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedMay help reduce pain and inflammation.
Evidence: LimitedMay provide pain relief for some individuals.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it.
A: It is best to take this medicine with food or milk to reduce the risk of stomach upset.
A: Do not take this medicine for more than 10 days for pain or 3 days for fever without consulting your doctor.
A: Consult your doctor before taking this medicine during pregnancy. It should be avoided in the third trimester.
🤔 Common Patient Concerns
🔄 Substitutes for ibutal 400 mg/333 mg tablet
View AllAlternative brands with exact same active ingredient:
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regaflam 400 mg/333 mg tabletMicro Labs Ltd ₹5.86 75% CHEAPER
-
dt ibuflam 400 mg/333 mg tabletLaborate Pharmaceuticals India Ltd ₹7.56 67.7% CHEAPER
-
brucet 400 mg/333 mg tabletMicro Labs Ltd ₹8.20 65% CHEAPER
-
imol 400 mg/333 mg tabletZydus Cadila ₹8.65 63.1% CHEAPER
-
Fenlur P 400mg/333mg TabletAllure Remedies Pvt Ltd ₹11.25 52% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe to take on an empty stomach.
Fact: This medicine should be taken with food or milk to reduce the risk of stomach upset and gastrointestinal bleeding. - Myth: This medicine can be taken long-term without any risk.
Fact: Prolonged use of this medicine can increase the risk of gastrointestinal, kidney, liver, and cardiovascular side effects. Use only as prescribed and for the shortest duration necessary. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol should be avoided while taking this medicine as it increases the risk of gastrointestinal bleeding and liver damage.
🔄 Alternative Options
Generic Alternatives
- Ibuprofen 400 mg + Paracetamol 333 mg tablet
Brand Alternatives
- Brucet 400 mg/333 mg tablet