bdbrut Capsule (Ibrutinib 140 mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool, vomit, or urine
- Severe headache with confusion, seizures, or vision changes
- Fever with chills or feeling very unwell
- Palpitations, chest pain, dizziness, or fainting
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes, dark urine, or severe abdominal pain
- Unusual bruising or bleeding that does not stop
- Decreased urine output or sudden weight gain with swelling
If experiencing severe symptoms, call emergency services immediately.
What is ib-tib capsule used for?
This medicine contains ibrutinib 140 mg, a targeted cancer medicine used to treat certain B-cell cancers such as mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenström's macroglobulinemia. It is taken by mouth once daily and works by blocking the BTK enzyme to slow the growth of abnormal B cells.
- Generic Name: Ibrutinib (140mg)
- Manufacturer: Cadila Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ib-tib capsule के बारे में (Hindi Summary)
उपयोग: यह दवा इब्रुटिनिब 140 मिलीग्राम कैप्सूल है, जिसका उपयोग कुछ प्रकार के बी-सेल कैंसर जैसे मैंटल सेल लिंफोमा, क्रोनिक लिम्फोसाइटिक ल्यूकेमिया, वाल्डेनस्ट्रॉम मैक्रोग्लोबुलिनेमिया और कुछ अन्य लिंफोमा के इलाज के लिए किया जाता है। यह दवा बीटीके एंजाइम को रोककर असामान्य बी-कोशिकाओं की वृद्धि को धीमा करती है। यह मुँह से रोज एक बार ली जाती है और इसका उपयोग केवल कैंसर रोग विशेषज्ञ की देखरेख में ही किया जाना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में प्लेटलेट्स कम होना, दस्त, थकान, मांसपेशियों और जोड़ों में दर्द, चकत्ते, आसानी से नील पड़ना, जी मिचलाना और संक्रमण शामिल हैं। गंभीर दुष्प्रभावों में अत्यधिक रक्तस्राव, गंभीर संक्रमण, अनियमित दिल की धड़कन, उच्च रक्तचाप और मस्तिष्क में सूजन जैसी दुर्लभ समस्या हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, रोज एक ही समय पर, खाने के साथ या बिना खाने के। कैप्सूल को पूरा निगलें, इसे तोड़ें या चबाएं नहीं। बिना डॉक्टर की सलाह के दवा बंद न करें। अन्य दवाओं, जड़ी-बूटियों और सप्लीमेंट्स के बारे में डॉक्टर को बताएं। ग्रेपफ्रूट और सेविले संतरे से बचें। चोट लगने वाली गतिविधियों से बचें और रक्तस्राव के संकेत दिखने पर तुरंत डॉक्टर को बताएं। नियमित जांच और फॉलो-अप जरूर कराएं।
💊 ib-tib capsule Uses & Benefits
[{"condition":"Mantle cell lymphoma","description":"Used in adults with mantle cell lymphoma who have received at least one prior therapy, and in some settings as first-line treatment when other options are not suitable.","evidence":"Well-established"},{"condition":"Chronic lymphocytic leukemia","description":"Used as a single agent or in combination for adults with chronic lymphocytic leukemia, including those with high-risk genetic features.","evidence":"Well-established"},{"condition":"Small lymphocytic lymphoma","description":"Used for adults with small lymphocytic lymphoma, a condition closely related to chronic lymphocytic leukemia.","evidence":"Well-established"},{"condition":"Waldenström's macroglobulinemia","description":"Used for adults with Waldenström's macroglobulinemia, a rare type of non-Hodgkin lymphoma.","evidence":"Well-established"},{"condition":"Marginal zone lymphoma","description":"Used in adults with marginal zone lymphoma who need systemic therapy and have received prior treatment.","evidence":"Well-established"},{"condition":"Chronic graft-versus-host disease","description":"Used in adults with chronic graft-versus-host disease after failure of one or more prior lines of therapy following stem cell transplant.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Primary central nervous system lymphoma","description":"Sometimes used off-label in selected patients with primary central nervous system lymphoma, often in combination with other agents.","evidence":"Limited"},{"condition":"Relapsed or refractory follicular lymphoma","description":"Occasionally used off-label in some patients with relapsed or refractory follicular lymphoma.","evidence":"Limited"},{"condition":"Multiple myeloma","description":"Has been studied off-label in some combinations for multiple myeloma, but is not a standard approved use.","evidence":"Limited"}]
Primary treatment for: B-cell cancers such as mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenström's macroglobulinemia
Also treats: Small lymphocytic lymphoma, Marginal zone lymphoma, Chronic graft-versus-host disease
📋 Drug Information
| Generic Name(s) | Ibrutinib (140mg) |
| Brand Name | ib-tib capsule |
| Manufacturer | Cadila Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Bruton's tyrosine kinase (BTK) inhibitors |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 20°C and 25°C. Keep it in the original container, tightly closed, and protect it from moisture and direct sunlight. Keep out of reach of children. |
| Shelf Life | The shelf life of this medicine is not established from the available information. Check the expiry date printed on the pack and do not use after that date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a small-molecule inhibitor of Bruton's tyrosine kinase, an enzyme that plays a central role in signaling pathways used by B cells. By binding covalently to the active site of BTK, this medicine blocks the signals that help malignant B cells grow, divide, and survive. This leads to reduced proliferation and increased death of the abnormal B cells. In chronic graft-versus-host disease, the same BTK inhibition helps reduce activation of immune cells that attack the patient's own tissues.
Mechanism Steps
💡 How to Take ib-tib capsule
Strength: Ibrutinib 140 mg immediate-release capsule
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 420 mg taken by mouth once daily for most approved indications, which equals three capsules of 140 mg each. For chronic graft-versus-host disease, the usual dose is 420 mg once daily. When taken with certain moderate CYP3A inhibitors, the dose may be reduced to 140 mg once daily, and with strong CYP3A inhibitors, the dose may be reduced to 140 mg every other day or as directed. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and other medicines being taken. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Older adults can take this medicine, but they may be more sensitive to side effects such as bleeding, infections, irregular heartbeat, and high blood pressure. Close monitoring is recommended, and the dose may need adjustment based on kidney and liver function and other medicines. |
| Renal Impairment | Mild or moderate kidney problems usually do not require a dose change. Severe kidney problems or dialysis may require closer monitoring, and the dose should be individualized by a qualified clinician. |
| Hepatic Impairment | Patients with mild liver impairment usually do not need a dose change. Patients with moderate liver impairment may need a lower dose, and this medicine is not recommended in severe liver impairment. Dose must be individualized by a qualified clinician based on liver function tests. |
| Maximum Daily Dose | The maximum recommended daily dose is 420 mg taken once daily, unless a lower dose is specified by the doctor because of interactions or side effects. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ib-tib capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampin | Major | |
| Warfarin | Major | |
| Clarithromycin | Major | |
| Itraconazole | Major | |
| Carbamazepine | Major | |
| St. John's wort | Major | |
| Fluconazole | Moderate | |
| Diltiazem | Moderate | |
| Omeprazole | Minor |
🚨 Major Interactions
- Strong CYP3A inhibitors such as ketoconazole, itraconazole, clarithromycin, and ritonavir
- Strong CYP3A inducers such as rifampin, carbamazepine, and St. John's wort
- Warfarin and other blood thinners
- Antiplatelet medicines such as aspirin and clopidogrel
⚡ Moderate Interactions
- Moderate CYP3A inhibitors such as fluconazole and diltiazem
- Proton pump inhibitors such as omeprazole
- Blood pressure medicines
🍷 Alcohol Interaction
Alcohol may increase the risk of liver problems and stomach upset while taking this medicine. It is best to avoid alcohol or limit it strictly, and to discuss any alcohol use with your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergic reaction to this medicine or any of its ingredients","Severe liver impairment","Active serious bleeding","Use with strong CYP3A inhibitors or inducers without dose adjustment","Pregnancy","Breastfeeding"]
⚠️ Warnings & Precautions
["This medicine can cause serious bleeding. Avoid activities that increase injury risk and report any unusual bleeding.","This medicine can increase the risk of serious infections. Report fever, chills, or feeling very unwell immediately.","This medicine can cause irregular heartbeat and high blood pressure. Regular monitoring is needed.","This medicine can cause a rare brain swelling called posterior reversible encephalopathy syndrome. Seek emergency care for severe headache, confusion, seizures, or vision changes.","This medicine can increase the risk of second cancers, including skin cancer. Use sun protection and keep regular skin checks.","This medicine can harm an unborn baby. Use effective contraception during treatment and for a period after stopping.","Do not donate blood or sperm while taking this medicine and for a period after stopping, as advised by your doctor.","Tell all your doctors and dentists that you are taking this medicine before any procedure or surgery."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Because of the potential for serious side effects in a breastfed baby, breastfeeding is not recommended during treatment and for a period after stopping, as advised by the doctor.
💊 Overdose Management
There is no specific antidote for an overdose of this medicine. If an overdose is suspected, contact your doctor or a poison control center immediately. Treatment is supportive, with close monitoring of blood counts, liver function, heart rhythm, and blood pressure. Go to the nearest emergency department if you feel unwell after taking too much.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your oncologist, at the same time each day, with or without food. Swallow the capsule whole with a glass of water; do not crush, chew, or open it. Do not stop or change the dose without talking to your doctor first. Tell your doctor about all other medicines, supplements, and herbal products you take, especially antifungals, antibiotics, and seizure medicines, because they can change how this medicine works. Avoid grapefruit, grapefruit juice, and Seville oranges while on treatment. Use a soft toothbrush and an electric razor to reduce bleeding risk. Wash your hands often and avoid people who are sick. Use sunscreen and protective clothing when outdoors. Report any unusual bleeding, bruising, fever, chest pain, or shortness of breath immediately. Keep all follow-up appointments and blood tests. Do not donate blood or sperm while taking this medicine and for a period after stopping, as advised by your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may be more sensitive to side effects such as bleeding, infections, irregular heartbeat, and high blood pressure. Close monitoring is recommended, and the dose may need adjustment based on kidney and liver function and other medicines. Falls should be avoided because of the increased bleeding risk.
🤰 Pregnancy Planning (TTC)
This medicine can harm an unborn baby. Women who can become pregnant should use effective contraception during treatment and for a period after stopping, as advised by the doctor. Men with female partners should also use effective contraception during treatment and for a period after stopping. Talk to your doctor before planning a pregnancy.
🏥 Post-Surgery Considerations
This medicine can increase bleeding risk during and after surgery. Tell your surgeon and anesthesiologist that you are taking this medicine. Your doctor may ask you to stop this medicine for a few days before surgery and restart after the risk of bleeding has decreased. Do not stop or restart on your own.
🦷 Dental Procedures
Tell your dentist that you are taking this medicine before any dental work. This medicine can increase bleeding during dental procedures. Your dentist and doctor may recommend precautions such as using extra care with cleaning, delaying certain procedures, or checking blood counts before dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Gentle exercise such as walking or stretching is usually fine, but avoid contact sports and activities that can cause injury or bleeding. If you feel tired, dizzy, or have palpitations, stop and rest. Talk to your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause tiredness, dizziness, and vision changes in some patients. Avoid driving or operating heavy machinery if you feel unwell or dizzy. Most patients can continue their daily activities with some adjustments. Talk to your doctor about your work and travel plans, and take precautions to reduce infection and bleeding risk.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your doctor may stop or pause treatment if you develop serious side effects, if the cancer stops responding, or if you need surgery. Always consult your doctor before stopping, and follow their instructions for monitoring after stopping.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of serious bleeding, infections, high blood pressure, irregular heartbeat, and second cancers. Regular blood tests, blood pressure checks, heart monitoring, and skin examinations are needed throughout treatment. Some patients may need dose reductions or treatment breaks if side effects occur. Your doctor will review the benefits and risks regularly and decide how long you should continue.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Medicines such as acalabrutinib or zanubrutinib may be options for some patients.
Evidence: Well-establishedStandard chemotherapy and monoclonal antibody treatments may be used alone or in combination.
Evidence: Well-establishedMay be considered for eligible patients with certain B-cell cancers.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Talk to your doctor before receiving any vaccine while taking this medicine. Live vaccines should generally be avoided because this medicine weakens the immune system. Inactivated vaccines may be given, but the response may be reduced. Household members should be up to date on their vaccines to reduce the risk of passing infections to you.
📦 Storage Guide
✅ DO
Store at room temperature between 20°C and 25°C
❌ DON'T
Do not store in extreme heat or cold
✅ DO
Keep in the original container, tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label visible. Bring a copy of your prescription and a letter from your doctor explaining that you need this medicine during travel. Keep enough supply for your entire trip plus extra in case of delays. Store it at room temperature and protect it from heat, moisture, and direct sunlight. If you cross time zones, ask your doctor how to adjust the timing of your once-daily dose. Declare the medicine at customs if required and keep it in your hand luggage, not in checked baggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Some patients notice improvement in symptoms and lymph node size within a few weeks, but the full benefit usually takes several weeks to months of continuous treatment.
A: Yes, this medicine can be taken with or without food. Avoid grapefruit, grapefruit juice, and Seville oranges.
A: Take the missed dose as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose and continue your regular schedule. Do not double dose.
A: No. Do not stop this medicine without talking to your doctor first. Stopping suddenly can allow the cancer to return or worsen.
A: This medicine can harm an unborn baby and is not recommended during pregnancy. Use effective contraception during treatment and for a period after stopping, as advised by your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for ib-tib capsule
View AllAlternative brands with exact same active ingredient:
-
bdbrut capsuleBDR Pharmaceuticals Internationals Pvt ₹7,200.00 2.8% CHEAPER
-
ibronza 140mg capsuleSun Pharmaceutical Industries Ltd ₹7,801.88 5.4% COSTLIER
-
ibrushil 140mg capsuleShilpa Medicare Ltd ₹8,429.06 13.8% COSTLIER
-
ibrunat capsuleNatco Pharma Ltd ₹8,906.25 20.3% COSTLIER
-
ibrukem capsuleAlkem Laboratories Ltd ₹9,000.00 21.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure cancer completely.
Fact: This medicine can control certain B-cell cancers and improve outcomes, but it is not a guaranteed cure. Response varies between patients. - Myth: This medicine can be stopped once you feel better.
Fact: Stopping this medicine without medical advice can allow the cancer to return or worsen. Always talk to your doctor before stopping. - Myth: This medicine has no serious side effects.
Fact: This medicine can cause serious bleeding, infections, heart rhythm problems, and other serious side effects that need monitoring. - Myth: You can take any other medicine along with this medicine.
Fact: Many medicines and herbal products can interact with this medicine. Always check with your doctor or pharmacist first.
🔄 Alternative Options
Generic Alternatives
- Ibrutinib 140 mg capsule
Brand Alternatives
- bdbrut capsule