histacron syrup - Chlorpheniramine Maleate (2.5mg) + Ammonium Chloride (125mg) medicine

Actirex Syrup: Complete Guide to Uses, Dosage, Side Effects, and Safety

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🏭 Acron Pharmaceuticals 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for chlorpheniramine in allergic conditions; limited for ammonium chloride as expectorant.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or swelling of face, lips, or throat
  • Severe drowsiness or unresponsiveness
  • Seizures or convulsions
  • Rapid or irregular heartbeat
  • Inability to urinate
  • Severe abdominal pain or vomiting
  • Yellowing of skin or eyes
  • Confusion or hallucinations

If experiencing severe symptoms, call emergency services immediately.

What is histacron syrup used for?

This medicine is a combination syrup containing Chlorpheniramine Maleate (an antihistamine) and Ammonium Chloride (an expectorant). It is used to relieve cough, nasal congestion, and allergic symptoms such as sneezing and runny nose. It works by blocking histamine and thinning mucus. It may cause drowsiness, so avoid driving. Do not use without medical advice in children under 2 years, during pregnancy, or if you have glaucoma, urinary retention, or severe heart disease.

  • Generic Name: Chlorpheniramine Maleate (2.5mg) + Ammonium Chloride (125mg)
  • Manufacturer: Acron Pharmaceuticals
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 histacron syrup के बारे में (Hindi Summary)

उपयोग: यह दवा क्लोरफेनिरामाइन मेलिएट और अमोनियम क्लोराइड का संयोजन है, जिसका उपयोग खांसी, नाक बंद होना, छींक आना, नाक बहना और एलर्जी के लक्षणों से राहत दिलाने के लिए किया जाता है। यह एलर्जी के कारण होने वाली खांसी और जुकाम में प्रभावी है। यह दवा नींद ला सकती है, इसलिए वाहन चलाने या मशीन चलाने से बचें। बच्चों में इसका उपयोग डॉक्टर की सलाह के बिना न करें। गर्भवती महिलाएं और स्तनपान कराने वाली महिलाएं डॉक्टर से परामर्श करें।

साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, धुंधली दृष्टि, जी मिचलाना, पेट खराब होना और सिरदर्द शामिल हैं। कभी-कभी कब्ज, पेशाब रुकना, धड़कन तेज होना और पसीना आना भी हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, सांस लेने में कठिनाई, चेहरे या गले में सूजन हो सकती है। अगर कोई भी दुष्प्रभाव गंभीर या लगातार बना रहे, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। निर्धारित मात्रा से अधिक न लें। इस दवा को लेने के बाद नींद आ सकती है, इसलिए वाहन चलाने या मशीन चलाने से बचें। शराब और अन्य नींद लाने वाली दवाओं के साथ इसका सेवन न करें। यदि आपको ग्लूकोमा, पेशाब रुकने की समस्या, अस्थमा, हृदय रोग, उच्च रक्तचाप, थायरॉइड, गुर्दे या यकृत की बीमारी है, तो डॉक्टर को बताएं। बच्चों की पहुंच से दूर रखें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 histacron syrup Uses & Benefits

[{"condition":"Allergic rhinitis","description":"Relieves sneezing, runny nose, itchy and watery eyes, and nasal itching associated with seasonal or perennial allergies.","evidence":"Well-established for chlorpheniramine component"},{"condition":"Common cold with cough","description":"Provides symptomatic relief of cough, nasal congestion, and postnasal drip; ammonium chloride helps loosen mucus.","evidence":"Commonly used, supportive evidence"},{"condition":"Urticaria","description":"Reduces itching and hives due to allergic skin reactions.","evidence":"Well-established for chlorpheniramine component"},{"condition":"Productive cough","description":"Ammonium chloride acts as an expectorant to thin bronchial secretions and facilitate coughing out mucus.","evidence":"Traditional use, limited clinical trials"}]

Off-label uses: [{"condition":"Insomnia","description":"Sometimes used off-label for short-term sleep aid due to sedative effects of chlorpheniramine.","evidence":"Limited"},{"condition":"Motion sickness","description":"Occasionally used off-label for prevention of motion sickness due to anticholinergic effects.","evidence":"Limited"}]

Primary treatment for: Allergic rhinitis and common cold with cough

Also treats: Urticaria, Productive cough, Postnasal drip

📋 Drug Information

Generic Name(s)Chlorpheniramine Maleate (2.5mg) + Ammonium Chloride (125mg)
Brand Namehistacron syrup
ManufacturerAcron Pharmaceuticals
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Do not refrigerate. Keep the bottle tightly closed.
Shelf Life24 months from the date of manufacture, or as printed on the packaging.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always use the measuring cup provided to ensure accurate dosing.
2
Take this medicine with food or milk if it upsets your stomach.
3
Avoid driving or operating heavy machinery until you know how this medicine affects you.
4
Do not use this medicine for more than 7 days without consulting your doctor.
5
Keep this medicine out of reach of children and do not share it with others.
6
If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before use.
7
Inform your doctor about all other medicines you are taking to avoid interactions.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Runny nose and sneezing
This medicine is commonly prescribed for allergic rhinitis.
Likely Use
✅
Productive cough
Ammonium chloride helps thin mucus.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
❌
Chronic cough
Requires medical evaluation; do not self-medicate.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionChlorpheniramine is well absorbed from the gastrointestinal tract after oral administration. Ammonium chloride is also readily absorbed from the gastrointestinal tract.
DistributionChlorpheniramine distributes widely into body tissues and crosses the blood-brain barrier, which explains its sedative effects. Ammonium chloride distributes into extracellular fluid.
Protein BindingChlorpheniramine is approximately 70% bound to plasma proteins. Ammonium chloride is not significantly protein bound.
MetabolismChlorpheniramine is metabolized in the liver primarily by cytochrome P450 enzymes, including CYP2D6, to inactive metabolites. Ammonium chloride is metabolized in the liver to urea and hydrochloric acid.
Half-LifeChlorpheniramine elimination half-life is approximately 12 to 43 hours in adults, and may be prolonged in elderly or hepatic impairment. Ammonium chloride half-life is not well established.
ExcretionChlorpheniramine and its metabolites are excreted primarily in urine. Ammonium chloride is excreted as urea and chloride in urine.
BioavailabilityChlorpheniramine oral bioavailability is approximately 25 to 50%. Ammonium chloride bioavailability is not well established.
Onset of ActionAntihistaminic effects of chlorpheniramine begin within 30 to 60 minutes after oral administration. Expectorant effect of ammonium chloride may take longer.
Peak Plasma TimeChlorpheniramine peak plasma concentration occurs approximately 2 to 6 hours after oral administration. Ammonium chloride peak is not well established.
Duration of ActionChlorpheniramine effects last approximately 4 to 6 hours, but sedative effects may persist longer. Ammonium chloride expectorant effect lasts several hours.

How It Works

Chlorpheniramine Maleate competitively blocks histamine H1 receptors on effector cells, reducing allergic symptoms such as sneezing, rhinorrhea, and itching. It also has anticholinergic properties that contribute to dry mouth, urinary retention, and drowsiness. Ammonium Chloride is an expectorant that irritates the gastric mucosa, reflexively increasing respiratory tract fluid secretion, which thins mucus and makes cough more productive. It also acts as a mild systemic acidifier, which may help in certain toxicities but is not the primary intended effect in this combination.

Mechanism Steps

1
Histamine H1 receptor blockade: Chlorpheniramine binds to H1 receptors on smooth muscle, endothelium, and nerve endings, preventing histamine from triggering allergic responses.
2
Anticholinergic action: Chlorpheniramine also blocks muscarinic receptors, reducing secretions and causing dry mouth, but also contributing to drowsiness.
3
Gastric irritation and reflex expectoration: Ammonium chloride irritates the stomach lining, which reflexively stimulates respiratory tract fluid secretion, thinning mucus.
4
Mild systemic acidification: Ammonium chloride is metabolized to hydrochloric acid and urea, mildly lowering blood pH, which can increase respiratory rate and fluid secretion.

💡 How to Take histacron syrup

Strength: Each 5 mL of syrup contains Chlorpheniramine Maleate 2.5 mg and Ammonium Chloride 125 mg.

1Shake the bottle well before each use.
2Use the measuring cup or spoon provided with the product to measure the dose accurately.
3Take the syrup orally, with or without food. If stomach upset occurs, take with food or milk.
4Do not exceed the recommended dose or frequency.
5After taking, close the bottle tightly and store as directed.
6If symptoms persist beyond 7 days, consult your clinician.

Dosage Information

Adult DosageThe usual adult dose is 5 to 10 mL (1 to 2 teaspoons) every 4 to 6 hours as needed, not to exceed 6 doses in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to therapy. Do not exceed the recommended dose. Use the measuring cup or spoon provided with the product.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing based on age and weight. Do not use in children under 2 years of age without medical advice.
Elderly DosageElderly patients are more sensitive to the sedative and anticholinergic effects of chlorpheniramine. Use with caution, starting at the lower end of the dose range. Dose must be individualized by a qualified clinician based on renal and hepatic function.
Renal ImpairmentUse with caution in renal impairment. Ammonium chloride may cause metabolic acidosis and electrolyte disturbances. Dose adjustment may be necessary. Consult a clinician.
Hepatic ImpairmentUse with caution in hepatic impairment. Chlorpheniramine is metabolized in the liver; ammonium chloride may worsen hepatic encephalopathy. Dose adjustment may be necessary. Consult a clinician.
Maximum Daily DoseThe maximum recommended daily dose for adults is 60 mL (12 teaspoons) in 24 hours, not to exceed 6 doses. Do not exceed the prescribed dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases sedation and drowsiness.
Grapefruit juice
Avoid or use caution
May increase drug levels.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of histacron syrup

✅ Common Side Effects

Drowsiness (Common (10-20%))
Avoid driving or operating machinery. If persistent, consult your clinician.
Dry mouth, nose, or throat (Common (5-15%))
Sip water frequently, use sugar-free lozenges or saliva substitutes. Consult if severe.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying position. Avoid alcohol.
Nausea or stomach upset (Common (5-10%))
Take with food or milk. If persistent, consult your clinician.
Headache (Common (5-10%))
Rest, stay hydrated. Consult if severe or persistent.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling of face, lips, or throat, difficulty breathing, or dizziness.
Metabolic acidosis (Rare (<0.1%))
Seek medical attention if you experience rapid breathing, confusion, fatigue, or nausea. This is more likely with high doses or kidney/liver disease.
Urinary retention (Rare (<0.1%))
Consult a clinician if you are unable to urinate or have difficulty passing urine.
Severe drowsiness or respiratory depression (Rare (<0.1%))
Seek immediate medical help if you experience extreme sleepiness, slow breathing, or unresponsiveness.

⚠️ Rare Side Effects

Blood dyscrasias (e.g., agranulocytosis, thrombocytopenia)
Report unusual bruising, bleeding, fever, or sore throat to your clinician immediately.
Seizures
Seek emergency medical attention if seizures occur.
Hepatotoxicity
Report yellowing of skin or eyes, dark urine, or abdominal pain to your clinician.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAOIs Major
CNS depressants Major
Anticholinergics Major
CYP2D6 inhibitors Moderate
CYP3A4 inhibitors Moderate
Antihypertensives Moderate
Corticosteroids Minor
Diuretics Minor

🚨 Major Interactions

  • Monoamine oxidase inhibitors (MAOIs)
  • Central nervous system depressants (e.g., alcohol, benzodiazepines, opioids, barbiturates)
  • Anticholinergic drugs (e.g., atropine, tricyclic antidepressants, antiparkinson agents)

⚡ Moderate Interactions

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
  • Antihypertensives

🍷 Alcohol Interaction

Alcohol increases the sedative and central nervous system depressant effects of chlorpheniramine, leading to excessive drowsiness, impaired coordination, and risk of respiratory depression. Avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to chlorpheniramine, ammonium chloride, or any component of the formulation","Severe hypertension or severe coronary artery disease","Narrow-angle glaucoma","Urinary retention or prostatic hypertrophy","Severe hepatic or renal impairment","Metabolic acidosis","MAOI therapy within 14 days","Children under 2 years of age (due to risk of severe respiratory depression)"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery until effects are known.","Avoid alcohol and other CNS depressants.","Use with caution in elderly due to increased risk of confusion, sedation, and anticholinergic effects.","Use with caution in patients with asthma, COPD, or sleep apnea.","Do not use for chronic cough without medical evaluation.","May cause paradoxical excitation in children.","Prolonged use may lead to tolerance or rebound congestion.","Consult clinician before use in pregnancy or breastfeeding.","Do not exceed recommended dose; overdose can cause serious toxicity.","Keep out of reach of children."]

🤱 Lactation Safety

Chlorpheniramine is excreted in breast milk and may cause drowsiness in the infant. Ammonium chloride is also excreted in breast milk. Use with caution; consult your clinician before breastfeeding.

💊 Overdose Management

Overdose may cause severe drowsiness, confusion, seizures, respiratory depression, metabolic acidosis, and cardiac arrhythmias. Seek emergency medical attention immediately. Treatment is supportive and symptomatic, including gastric lavage if within 1-2 hours, activated charcoal, intravenous fluids, and monitoring of vital signs and electrolytes. There is no specific antidote. Hemodialysis may be considered in severe cases.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your clinician. Do not exceed the recommended dose. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause drowsiness. Avoid alcohol and other central nervous system depressants while taking this medicine. Inform your clinician if you have glaucoma, enlarged prostate, urinary retention, asthma, heart disease, high blood pressure, thyroid problems, kidney or liver disease, or diabetes. Do not use this medicine for persistent or chronic cough unless advised by a clinician. Keep out of reach of children. Store at room temperature away from direct sunlight and moisture. Do not use if the seal is broken or the syrup is discolored. If you are pregnant, planning pregnancy, or breastfeeding, consult your clinician before use. Do not share this medicine with others, even if they have similar symptoms.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the sedative and anticholinergic effects of chlorpheniramine. They may experience increased drowsiness, confusion, dry mouth, urinary retention, and constipation. Use with caution and at lower doses. Monitor renal and hepatic function.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before taking this medicine. Chlorpheniramine is generally considered safe in pregnancy but should be used only if clearly needed. Ammonium chloride should be used with caution. Discuss risks and benefits with your clinician.

🏥 Post-Surgery Considerations

Consult your doctor before using this medicine after surgery, as it may interact with anesthetics and other medications. It may also increase the risk of urinary retention post-operatively.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may cause dry mouth and interact with medications used during dental procedures. It may also increase the risk of bleeding if combined with certain drugs.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help thin mucus and prevent dry mouth.
🥗
Use a humidifier to ease nasal congestion.
😴
Avoid allergens such as dust, pollen, and pet dander.
💧
Get plenty of rest to support recovery.
🧘
Practice good hand hygiene to prevent infections.
🌞
Avoid smoking and exposure to secondhand smoke.

🏋️ Exercise Considerations

This medicine may cause drowsiness and dizziness. Avoid strenuous exercise or activities requiring alertness until you know how it affects you. If you exercise, ensure you are well hydrated.

🥗 Diet Recommendations

Drink warm fluids like soups and herbal teas.
Include vitamin C-rich fruits and vegetables.
Avoid cold and sugary drinks that may irritate the throat.
Eat light, easily digestible meals.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness, which may affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. Avoid these activities until you know how the medicine affects you. It may also cause dry mouth and dizziness, which can impact your comfort at work.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects. Do not stop abruptly if you have been taking it for a long time without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to tolerance, rebound congestion, and increased risk of side effects such as drowsiness, dry mouth, and urinary retention. Prolonged use of ammonium chloride can cause metabolic acidosis and electrolyte imbalances. Regular monitoring of renal function, electrolytes, and blood pH may be required if used for extended periods. Consult your doctor for periodic review.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Saline nasal irrigation

Helps clear nasal passages and reduce congestion without medication.

Evidence: Well-established
Steam inhalation

Can help loosen mucus and ease breathing.

Evidence: Traditional use
Antihistamine nasal sprays

Alternative for allergic rhinitis with fewer systemic side effects.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are acutely ill with fever, consult your doctor before vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from light and moisture. If traveling across time zones, continue your regular dosing schedule as advised by your doctor. Check customs regulations for carrying medicines. Do not leave it in a hot car or checked luggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with seasonal allergies and cough
She was prescribed this medicine for her allergic cough and runny nose. She took it as directed and noticed relief within an hour. She experienced mild drowsiness, so she avoided driving. She was advised to take it with food to prevent stomach upset.
💡 Lesson: Taking this medicine with food and avoiding driving can improve tolerability and safety.
👤 A 60-year-old man with a cold and productive cough
He used this medicine for his cough and congestion. He found that his cough became more productive and his nasal symptoms improved. However, he experienced dry mouth and dizziness, which subsided after a few days. He was advised to stay hydrated.
💡 Lesson: Dry mouth and dizziness are common side effects that can be managed with hydration and caution.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Antihistaminic effects begin within 30 to 60 minutes after taking this medicine.

Q: Can I take this medicine with other cold medicines?

A: Consult your doctor before combining with other cold medicines to avoid duplicate ingredients and interactions.

Q: Is this medicine safe for children?

A: It should not be used in children under 2 years without medical advice. For older children, consult a pediatrician for appropriate dosing.

Q: What should I do if I miss a dose?

A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for histacron syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Actirex syrup is an antibiotic.
    Fact: This medicine is not an antibiotic. It is a combination of an antihistamine and an expectorant used for symptomatic relief of cough and allergy.
  • Myth: It is safe to take Actirex syrup for any type of cough.
    Fact: This medicine is not suitable for all coughs. It should be used only for cough associated with allergy or common cold, and not for chronic cough or cough due to serious conditions without medical evaluation.
  • Myth: Actirex syrup can be given to infants without a doctor's advice.
    Fact: This medicine should not be used in children under 2 years of age without medical advice due to risk of serious side effects.

🔄 Alternative Options

Generic Alternatives

  • Chlorpheniramine Maleate + Ammonium Chloride syrup (various manufacturers)

Brand Alternatives

  • Actirex syrup

📊 Comparison with Similar Medicines

[{"medicine":"Actirex syrup","composition":"Chlorpheniramine 2.5mg + Ammonium Chloride 125mg per 5mL","primary_use":"Allergic cough and cold","sedation":"Moderate to high"},{"medicine":"Chlorpheniramine syrup alone","composition":"Chlorpheniramine 2mg per 5mL","primary_use":"Allergy","sedation":"Moderate to high"},{"medicine":"Dextromethorphan + Chlorpheniramine syrup","composition":"Dextromethorphan 10mg + Chlorpheniramine 2mg per 5mL","primary_use":"Dry cough and allergy","sedation":"Moderate"}]

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