Lumerax 40mg/240mg Tablet: Complete Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction: swelling of face, lips, throat, difficulty breathing, or severe rash.
- Irregular or rapid heartbeat, palpitations, or fainting.
- Yellowing of skin or eyes, dark urine, or severe abdominal pain (signs of liver problems).
- Unusual bruising or bleeding, or signs of infection (fever, sore throat) due to blood disorders.
- Persistent vomiting, which may prevent absorption of the medicine.
- Seizures or convulsions.
- Severe headache with visual disturbances.
If experiencing severe symptoms, call emergency services immediately.
What is gnate l 40mg/240mg tablet used for?
This medicine is a combination antimalarial tablet containing Artemether 40 mg and Lumefantrine 240 mg. It is used to treat acute uncomplicated Plasmodium falciparum malaria. It works by killing the malaria parasites in the blood. It must be taken with food for proper absorption.
- Generic Name: Artemether (40mg) + Lumefantrine (240mg)
- Manufacturer: Greenray Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 gnate l 40mg/240mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा आर्टेमेथर और ल्यूमेफैंट्रिन का संयोजन है, जिसका उपयोग मलेरिया (प्लास्मोडियम फाल्सीपेरम) के इलाज के लिए किया जाता है। यह मलेरिया परजीवी को मारती है और बुखार, ठंड लगना और पसीना जैसे लक्षणों को कम करती है। यह दवा खाने के साथ लेनी चाहिए, खासकर वसायुक्त भोजन के साथ, ताकि यह अच्छी तरह से अवशोषित हो सके। इसे डॉक्टर के निर्देशानुसार पूरा कोर्स करना जरूरी है, भले ही आप बेहतर महसूस करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चक्कर आना, मतली, उल्टी, पेट दर्द, भूख न लगना और नींद में गड़बड़ी शामिल हैं। ये आमतौर पर हल्के होते हैं और इलाज जारी रखने पर ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन दिल की धड़कन अनियमित होना, गंभीर एलर्जी, या लीवर की समस्या हो सकती है। अगर आपको सीने में दर्द, सांस लेने में तकलीफ, चेहरे या गले में सूजन, या त्वचा का पीला पड़ना दिखे, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे हमेशा भोजन के साथ लें, खासकर वसायुक्त भोजन के साथ। इलाज के दौरान शराब और ग्रेपफ्रूट जूस से बचें। अगर आपको दिल, लीवर या किडनी की कोई बीमारी है, या आप कोई अन्य दवा ले रहे हैं, तो डॉक्टर को बताएं। इस दवा से चक्कर आ सकते हैं, इसलिए वाहन चलाने या मशीन चलाने से बचें। पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें। इसे बच्चों की पहुंच से दूर रखें।
💊 gnate l 40mg/240mg tablet Uses & Benefits
- [{"condition":"Acute uncomplicated Plasmodium falciparum malaria","description":"This medicine is the first-line treatment for acute uncomplicated P.
- falciparum malaria in adults and children weighing 5 kg or more.
- It rapidly clears parasites and prevents recrudescence.","evidence":"Well-established"},{"condition":"Mixed malaria infections","description":"It may be used for mixed infections with P.
- falciparum, but additional treatment for P.
- vivax may be required.","evidence":"Established"}]
Off-label uses: [{"condition":"Malaria chemoprophylaxis","description":"This medicine is not approved for prevention of malaria and should not be used for this purpose.","evidence":"Not recommended"}]
Primary treatment for: Acute uncomplicated Plasmodium falciparum malaria
Also treats: Mixed malaria infections
📋 Drug Information
| Generic Name(s) | Artemether (40mg) + Lumefantrine (240mg) |
| Brand Name | gnate l 40mg/240mg tablet |
| Manufacturer | Greenray Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI MALARIALS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in the original packaging. Protect from moisture and direct sunlight. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization recommends artemisinin-based combination therapies (ACTs) as the first-line treatment for uncomplicated P. falciparum malaria. Artemether-lumefantrine is one of the recommended ACTs. |
| ICMR Guideline | The Indian Council of Medical Research recommends artemether-lumefantrine as a first-line treatment for uncomplicated P. falciparum malaria in India, in accordance with national drug policy. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antimalarial agents with complementary mechanisms. Artemether is a derivative of artemisinin that is activated by heme iron within the malaria parasite, generating free radicals that damage parasite proteins and membranes, leading to rapid parasite death. Lumefantrine inhibits the formation of beta-hematin (hemozoin) in the parasite's food vacuole, preventing the detoxification of heme and causing accumulation of toxic heme that kills the parasite. The combination ensures rapid reduction of parasite biomass by artemether and prolonged action by lumefantrine to eliminate remaining parasites.
Mechanism Steps
💡 How to Take gnate l 40mg/240mg tablet
Strength: Tablet containing Artemether 40 mg and Lumefantrine 240 mg.
Dosage Information
| Adult Dosage | The standard adult dose of this medicine is 4 tablets (each containing Artemether 40 mg and Lumefantrine 240 mg) taken orally at 0, 8, 24, 36, 48, and 60 hours. This is a total of 24 tablets over 3 days. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Always take with food, especially fatty meals, to ensure adequate absorption. Do not exceed the recommended dose. |
| Pediatric Dosage | Pediatric dosing is weight-based and must be determined by a pediatrician. The number of tablets per dose varies with body weight. This medicine is not recommended for children weighing less than 5 kg. Consult a pediatrician for appropriate dosing. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially cardiac effects. Use with caution and monitor closely. Dose adjustment may be necessary based on renal and hepatic function. |
| Renal Impairment | No specific dose adjustment is recommended for mild to moderate renal impairment. Use with caution in severe renal impairment as data is limited. Consult your doctor. |
| Hepatic Impairment | No specific dose adjustment is recommended for mild to moderate hepatic impairment. Use with caution in severe hepatic impairment. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose is 4 tablets (Artemether 160 mg + Lumefantrine 960 mg) per day, taken as two divided doses on the first day, and then one dose on subsequent days as per the schedule. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of gnate l 40mg/240mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampicin | Major | |
| Amiodarone | Major | |
| Hormonal contraceptives | Moderate | |
| Warfarin | Moderate | |
| Antacids | Moderate | |
| Grapefruit juice | Minor | |
| Carbamazepine | Major | |
| Phenytoin | Major | |
| Clarithromycin | Major |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin)
- CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin)
- QT-prolonging drugs (e.g., amiodarone, sotalol, haloperidol, moxifloxacin)
⚡ Moderate Interactions
- Hormonal contraceptives
- Warfarin
- Antacids
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol may increase the risk of liver toxicity and can worsen side effects such as dizziness and drowsiness. It may also affect the metabolism of the medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to artemether, lumefantrine, or any component of the formulation","Severe malaria (requires parenteral therapy)","First trimester of pregnancy (unless no other options available)","Severe hepatic impairment","Severe renal impairment","Congenital QT prolongation or family history of sudden death","Concurrent use with strong CYP3A4 inhibitors or inducers","Concurrent use with QT-prolonging drugs"]
⚠️ Warnings & Precautions
["Take with food to ensure adequate absorption.","Avoid alcohol during treatment.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Inform your doctor if you have a history of heart, liver, or kidney disease.","Do not use for malaria prevention.","Complete the full course of treatment even if you feel better.","If vomiting occurs within 1 hour of taking the dose, consult your doctor as a repeat dose may be needed.","Use with caution in elderly patients.","Not recommended for children weighing less than 5 kg.","Inform your doctor if you are taking any other medications, especially those affecting heart rhythm."]
🤱 Lactation Safety
This medicine is excreted in breast milk in small amounts. It is generally considered safe during breastfeeding, but consult your doctor before use. Monitor the infant for any adverse effects.
💊 Overdose Management
Overdose may cause severe QT prolongation, cardiac arrhythmias, and bone marrow suppression. There is no specific antidote. Treatment is supportive and symptomatic. Monitor ECG and vital signs. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. If you vomit within 1 hour of taking the dose, consult your doctor as a repeat dose may be needed.
Additional Safety Advice
This medicine must be taken exactly as prescribed by your doctor. Do not alter the dose or duration of treatment on your own. Always take this medicine with food, preferably a meal containing some fat, to improve absorption. Avoid grapefruit juice and alcohol during treatment as they may increase the risk of side effects. Inform your doctor if you have a history of heart problems, liver or kidney disease, or if you are taking any other medications, especially those that affect heart rhythm. This medicine may cause dizziness; avoid driving or operating heavy machinery until you know how it affects you. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. Complete the full course even if you feel better, to prevent relapse and resistance. Store this medicine in its original packaging at room temperature, away from moisture and direct sunlight. Keep out of reach of children. If you are pregnant or breastfeeding, consult your doctor before taking this medicine. This medicine is not for prevention of malaria; use appropriate preventive measures if traveling to endemic areas.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the cardiac effects of this medicine, especially QT prolongation. Use with caution and monitor closely. Dose adjustment may be needed based on kidney and liver function.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. It is generally not recommended during the first trimester unless absolutely necessary. Use effective contraception during treatment and for at least 1 week after.
🏥 Post-Surgery Considerations
If you have recently undergone surgery, inform your surgeon and anesthesiologist about this medicine. It may interact with anesthetic agents and affect heart rhythm. Your doctor will decide the best timing for surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, especially before any dental procedure that may involve bleeding or sedation. It may interact with certain medications used in dentistry.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness and fatigue. Avoid strenuous exercise until you feel fully recovered. Light activities like walking are fine, but listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness and fatigue, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. Take rest as needed and stay hydrated. Inform your employer if you need time off to recover.
🛑 When to Stop This Medicine
Do not stop taking this medicine before completing the full course, even if you feel better. Stopping early can lead to relapse and resistance. If you experience severe side effects, consult your doctor before stopping. Your doctor may adjust the treatment if needed.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended as it is intended for short-course treatment of acute malaria. Prolonged use may increase the risk of cardiac toxicity, liver enzyme elevations, and bone marrow suppression. Regular monitoring of liver and cardiac function may be required if used for extended periods. Always consult your doctor before considering long-term use.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Alternatives like artesunate-amodiaquine or dihydroartemisinin-piperaquine can be used if this medicine is not suitable.
Evidence: Well-establishedRest, hydration, and fever management with paracetamol can complement antimalarial treatment.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, if you are due for any vaccinations, inform your doctor. Live vaccines should be avoided during acute illness.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from moisture and direct sunlight. If crossing time zones, adjust your dosing schedule accordingly, but maintain the 8-hour intervals for the first day. Consult your doctor before travel if you have any medical conditions. Keep it in your carry-on luggage to avoid loss. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts reducing parasites within hours, but you may feel better within 24-48 hours. Complete the full course to ensure cure.
A: No, this medicine must be taken with food, especially fatty meals, to ensure proper absorption. Taking it without food can lead to treatment failure.
A: It may be used during pregnancy if the benefits outweigh the risks, but only under medical supervision. Consult your doctor.
A: Alcohol should be avoided as it may increase the risk of liver toxicity and worsen side effects like dizziness.
A: If you miss a dose, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose. Do not double the dose.
A: No, this medicine is only for treating active malaria infection, not for prevention.
🤔 Common Patient Concerns
🔄 Substitutes for gnate l 40mg/240mg tablet
View AllAlternative brands with exact same active ingredient:
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Tartlum 40mg/240mg TabletTusker Pharma Pvt Ltd ₹50.34 41% CHEAPER
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RT L 40mg/240mg TabletRoseate Medicare ₹79.50 6.8% CHEAPER
-
artisafe l 40 mg/240 mg tablet dtAlkem Laboratories Ltd ₹80.35 5.8% CHEAPER
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vartem l dry syrupVarenyam Healthcare Pvt Ltd ₹84.38 1.1% CHEAPER
-
Felban AL 40 mg/240 mg TabletPfizer Ltd ₹86.25 1.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken without food.
Fact: This medicine must be taken with food, especially fatty meals, to ensure adequate absorption of lumefantrine. Taking it without food can lead to treatment failure. - Myth: This medicine can be used to prevent malaria.
Fact: This medicine is not approved for malaria prevention. It is only for treatment of active malaria infection. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course of treatment to ensure all parasites are killed and to prevent relapse and resistance. - Myth: This medicine is safe to take with any other medication.
Fact: This medicine can interact with many drugs, especially those affecting heart rhythm or liver enzymes. Always inform your doctor about all medications you are taking.
🔄 Alternative Options
Generic Alternatives
- Artemether + Lumefantrine 40 mg + 240 mg tablet
Brand Alternatives
- Lumerax 40mg/240mg tablet