FPX N 0.5mg/10mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- High fever with muscle rigidity and confusion
- Irregular heartbeat or palpitations
- Severe dizziness or fainting
- Involuntary movements of face, tongue, or limbs
- Seizures
- Yellowing of skin or eyes
- Difficulty breathing or swallowing
- Suicidal thoughts or behavior
If experiencing severe symptoms, call emergency services immediately.
What is fpx n 0.5mg/10mg tablet used for?
This medicine is a combination of flupenthixol (an antipsychotic) and nortriptyline (a tricyclic antidepressant) used to treat depression with anxiety or psychotic features. It works by balancing chemicals in the brain to improve mood and reduce anxiety.
- Generic Name: Flupenthixol (0.5mg) + Nortriptyline (10mg)
- Manufacturer: Tripada Lifecare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 fpx n 0.5mg/10mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा फ्लूपेंथिक्सोल और नॉर्ट्रिप्टिलाइन का संयोजन है, जिसका उपयोग अवसाद (डिप्रेशन) के इलाज में किया जाता है, खासकर जब चिंता या मानसिक लक्षण भी मौजूद हों। यह मूड को बेहतर बनाने और चिंता को कम करने में मदद करती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, नींद आना, चक्कर आना, धुंधली दृष्टि, कब्ज और वजन बढ़ना शामिल हैं। गंभीर दुष्प्रभावों में अनियमित दिल की धड़कन, बेहोशी, दौरे और न्यूरोलेप्टिक मैलिग्नेंट सिंड्रोम शामिल हो सकते हैं। यदि आपको कोई गंभीर दुष्प्रभाव महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे अचानक बंद न करें, क्योंकि इससे withdrawal के लक्षण हो सकते हैं। इस दवा के साथ शराब न लें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन चलाने या मशीनरी चलाने से बचें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें।
💊 fpx n 0.5mg/10mg tablet Uses & Benefits
- [{"condition":"Depression with anxiety","description":"This medicine is used to treat depression accompanied by anxiety symptoms.
- The combination helps improve mood and reduce anxiety.","evidence":"Well-established"},{"condition":"Depression with psychotic features","description":"It may be used when depression is accompanied by psychotic symptoms such as hallucinations or delusions.","evidence":"Moderate"},{"condition":"Treatment-resistant depression","description":"Sometimes prescribed when other antidepressants have not been effective.","evidence":"Limited"}]
Off-label uses: [{"condition":"Chronic pain with depression","description":"Nortriptyline component may help with certain types of chronic pain, but this combination is not primarily indicated for pain.","evidence":"Limited"},{"condition":"Anxiety disorders","description":"May be used off-label for severe anxiety, but not first-line.","evidence":"Limited"}]
Primary treatment for: Depression
Also treats: Anxiety, Psychotic depression
📋 Drug Information
| Generic Name(s) | Flupenthixol (0.5mg) + Nortriptyline (10mg) |
| Brand Name | fpx n 0.5mg/10mg tablet |
| Manufacturer | Tripada Lifecare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Flupenthixol blocks dopamine D1 and D2 receptors in the brain, which helps reduce psychotic symptoms and agitation. Nortriptyline inhibits the reuptake of serotonin and norepinephrine, increasing their availability in the synaptic cleft, which improves mood. The combination aims to address both depressive and anxious/psychotic symptoms.
Mechanism Steps
💡 How to Take fpx n 0.5mg/10mg tablet
Strength: Tablet containing flupenthixol 0.5 mg and nortriptyline 10 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally once or twice daily, or as directed by your doctor. The dose may be adjusted based on your response and tolerance. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Start with a lower dose and titrate slowly. Monitor for falls, confusion, and cardiac effects. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be required. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose should not exceed what is prescribed by your doctor. Typically, flupenthixol 0.5 mg and nortriptyline 10 mg once or twice daily. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of fpx n 0.5mg/10mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| CYP2D6 inhibitors | Major | |
| QT-prolonging drugs | Major | |
| CNS depressants | Moderate | |
| Anticholinergics | Moderate | |
| Antihypertensives | Moderate | |
| Cimetidine | Minor | |
| Rifampicin | Minor | |
| Alcohol | Moderate | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- MAO inhibitors
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- QT-prolonging drugs (e.g., amiodarone, sotalol, haloperidol)
⚡ Moderate Interactions
- CNS depressants (e.g., benzodiazepines, opioids, alcohol)
- Anticholinergic drugs (e.g., benztropine, diphenhydramine)
- Antihypertensive drugs
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase drowsiness, dizziness, and impair judgment, and may worsen depression.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to flupenthixol, nortriptyline, or any component of the formulation","Concurrent use with monoamine oxidase inhibitors","Recent myocardial infarction","Severe liver disease","Untreated narrow-angle glaucoma","Urinary retention","Severe cardiovascular disorders","Children under 18 years of age"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until effects are known.","Avoid alcohol consumption.","Do not stop abruptly; taper gradually under medical supervision.","May increase risk of suicidal thoughts in young adults; monitor closely.","Use with caution in elderly patients due to increased risk of falls and confusion.","May cause anticholinergic effects; use with caution in patients with glaucoma or urinary retention.","May prolong QT interval; use with caution in patients with cardiac disease.","May cause neuroleptic malignant syndrome; monitor for symptoms.","May cause tardive dyskinesia with long-term use.","Use with caution in patients with a history of seizures."]
🤱 Lactation Safety
This medicine may pass into breast milk and could cause serious adverse effects in a nursing infant. Breastfeeding is not recommended while taking this medicine.
💊 Overdose Management
Overdose can cause severe symptoms such as irregular heartbeat, seizures, coma, and respiratory depression. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor ECG and vital signs closely.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not stop taking it suddenly, as this can cause withdrawal symptoms such as nausea, headache, and insomnia. Avoid alcohol while taking this medicine, as it can increase drowsiness and dizziness. Be cautious when driving or operating machinery until you know how this medicine affects you. Inform your doctor if you have a history of heart disease, liver disease, kidney disease, seizures, or glaucoma. Regular monitoring of blood pressure, heart rate, and liver function may be required. Do not take this medicine if you are pregnant or breastfeeding without consulting your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to side effects such as drowsiness, dizziness, and confusion. Start with a lower dose and monitor closely for falls and cardiac effects.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. It may not be safe during pregnancy. Your doctor may switch you to a safer alternative.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect recovery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth, increasing risk of dental problems. Maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise until you know how this medicine affects you, as it may cause drowsiness or dizziness. Light to moderate exercise is generally safe.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness and dizziness, affecting your ability to drive or operate machinery. It may also affect concentration. Discuss with your doctor before resuming such activities.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects or need to discontinue, your doctor will guide you on tapering the dose gradually.
📅 Long-Term Use Effects
Long-term use may increase the risk of tardive dyskinesia, metabolic changes, and cardiac effects. Regular monitoring of weight, blood sugar, lipids, and ECG is recommended. Periodic assessment of liver and kidney function may be needed. Do not stop without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Cognitive behavioral therapy can complement medicine for depression.
Evidence: Well-establishedRegular exercise, healthy diet, and stress management can help improve mood.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions reported. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage. Store at room temperature, away from direct sunlight. If crossing time zones, adjust dosing schedule gradually in consultation with your doctor. Check customs regulations for controlled substances before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Antidepressant effects may take 2-4 weeks to become noticeable. Anxiolytic and antipsychotic effects may occur within hours to days.
A: No, stopping suddenly can cause withdrawal symptoms. Always taper gradually under medical supervision.
A: Not established from the available information. Consult your doctor if you are pregnant or planning pregnancy.
A: Avoid alcohol, driving, and operating machinery until you know how it affects you.
🤔 Common Patient Concerns
🔄 Substitutes for fpx n 0.5mg/10mg tablet
View AllAlternative brands with exact same active ingredient:
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Femxip N 0.5mg/10mg TabletFemgrace Formulations ₹60.94 8.3% COSTLIER
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fluxip n 0.5mg/10mg tabletMedico Healthcare ₹84.38 50% COSTLIER
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cilapam fn 0.5mg/10mg tabletAlteus Biogenics Pvt Ltd ₹109.81 95.2% COSTLIER
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avanxit-fn tabletAvallac Pharmaceutical LLP ₹131.25 133.3% COSTLIER
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flunor tabletMeethi Pharmaceuticals ₹131.25 133.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is addictive.
Fact: This medicine is not addictive, but it can cause withdrawal symptoms if stopped suddenly. It should be tapered gradually under medical supervision. - Myth: I can stop taking this medicine once I feel better.
Fact: You should continue taking this medicine as prescribed, even if you feel better, to prevent relapse. Consult your doctor before stopping. - Myth: This medicine will change my personality.
Fact: This medicine is intended to treat your symptoms and help you feel more like yourself. It does not change your personality.
🔄 Alternative Options
Generic Alternatives
- Flupenthixol and nortriptyline combination is available as generic tablets.
Brand Alternatives
- FPX N 0.5mg/10mg Tablet