Avanxit-FN Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- High fever with muscle rigidity and confusion
- Irregular heartbeat or palpitations
- Severe dizziness or fainting
- Involuntary movements of face, tongue, or limbs
- Yellowing of skin or eyes
- Suicidal thoughts or behavior
- Severe allergic reaction with swelling or difficulty breathing
If experiencing severe symptoms, call emergency services immediately.
What is avanxit-fn tablet used for?
This medicine is a prescription combination of flupenthixol (an antipsychotic) and nortriptyline (a tricyclic antidepressant) used to treat depression with anxiety or agitation. It works by balancing dopamine, serotonin, and norepinephrine in the brain. It is taken orally, usually once daily at bedtime, and must be used under medical supervision.
- Generic Name: Flupenthixol + Nortriptyline
- Manufacturer: Avallac Pharmaceutical LLP
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 avanxit-fn tablet के बारे में (Hindi Summary)
उपयोग: यह दवा फ्लूपेंथिक्सोल और नॉर्ट्रिप्टिलाइन का संयोजन है, जिसका उपयोग अवसाद (डिप्रेशन) और चिंता (एंग्जायटी) के इलाज के लिए किया जाता है। यह मस्तिष्क में डोपामाइन, सेरोटोनिन और नॉरएपिनेफ्रिन के स्तर को संतुलित करके काम करती है। यह दवा केवल डॉक्टर के पर्चे पर मिलती है और इसे डॉक्टर की सलाह के अनुसार ही लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, नींद आना, चक्कर आना, धुंधली दृष्टि, कब्ज और पेशाब में कठिनाई शामिल हैं। गंभीर दुष्प्रभावों में अनियमित दिल की धड़कन, गंभीर चक्कर, भ्रम, और एलर्जी की प्रतिक्रिया शामिल हो सकती है। यदि आपको कोई भी असामान्य लक्षण महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। दवा की खुराक बदलें या अचानक बंद न करें। शराब न पिएं क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। गाड़ी चलाने या मशीन चलाने से बचें जब तक आपको पता न चल जाए कि यह दवा आप पर कैसे असर करती है। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 avanxit-fn tablet Uses & Benefits
[{"condition":"Depression with anxiety","description":"This combination is used to treat depressive states that are accompanied by anxiety or agitation, where the antidepressant effect of nortriptyline and the anxiolytic effect of flupenthixol are both needed.","evidence":"Moderate"},{"condition":"Depression with psychotic features","description":"In some cases, this combination may be prescribed for depression with psychotic symptoms, as flupenthixol can help with psychosis while nortriptyline addresses the mood component.","evidence":"Limited"}]
Off-label uses: [{"condition":"Neuropathic pain","description":"Nortriptyline, a component of this medicine, is sometimes used off-label for neuropathic pain, but the combination is not standard for this purpose.","evidence":"Limited"},{"condition":"Insomnia","description":"The sedative effects of nortriptyline and flupenthixol may lead to off-label use for sleep difficulties, but this is not a recommended primary use.","evidence":"Limited"}]
Primary treatment for: Depression with anxiety
Also treats: Depression with psychotic features, Agitated depression
📋 Drug Information
| Generic Name(s) | Flupenthixol + Nortriptyline |
| Brand Name | Avanxit-FN Tablet |
| Manufacturer | Avallac Pharmaceutical LLP |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Antidepressant + Antipsychotic |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from direct sunlight, moisture, and heat. Do not refrigerate unless specified. Keep in the original container, tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Flupenthixol is a typical antipsychotic that blocks dopamine D1 and D2 receptors in the brain, reducing dopaminergic neurotransmission, which helps to control agitation, anxiety, and psychotic symptoms. Nortriptyline is a tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine at presynaptic neurons, increasing their availability in the synaptic cleft, which helps to improve mood and reduce anxiety. Additionally, nortriptyline has anticholinergic and antihistaminic effects, which contribute to its sedative properties. Together, these actions target both the mood and anxiety components of depressive disorders.
Mechanism Steps
💡 How to Take avanxit-fn tablet
Strength: Each tablet contains flupenthixol 0.5 mg and nortriptyline 10 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once daily, preferably at bedtime to minimize daytime drowsiness. However, the exact dose and frequency must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal and hepatic function, and response to treatment. Do not adjust the dose without consulting your doctor. The maximum daily dose should not exceed what is prescribed. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the effects of this medicine, especially sedation, anticholinergic effects, and orthostatic hypotension. Start with a lower dose and titrate slowly. Regular monitoring for falls, confusion, and cardiac effects is recommended. |
| Renal Impairment | In patients with renal impairment, dose adjustment may be necessary. Monitor renal function and adjust dose based on clinical response and tolerability. Consult your doctor for specific dosing recommendations. |
| Hepatic Impairment | In patients with hepatic impairment, dose reduction is recommended due to reduced metabolism of both flupenthixol and nortriptyline. Monitor liver function tests regularly. Consult your doctor for specific dosing recommendations. |
| Maximum Daily Dose | The maximum daily dose should not exceed the dose prescribed by your doctor. Typically, the maximum daily dose of this combination is one tablet, but this may vary based on individual clinical circumstances. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of avanxit-fn tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| CNS depressants | Major | |
| QT-prolonging drugs | Major | |
| CYP2D6 inhibitors | Major | |
| Anticholinergics | Moderate | |
| Antihypertensives | Moderate | |
| Thyroid hormones | Moderate | |
| Cimetidine | Moderate | |
| Antacids | Minor | |
| Caffeine | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Other CNS depressants (e.g., alcohol, benzodiazepines, opioids)
- QT-prolonging drugs (e.g., certain antiarrhythmics, antibiotics, antipsychotics)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., benztropine, diphenhydramine)
- Antihypertensive drugs
- Thyroid hormones
- Cimetidine
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase the sedative effects of both flupenthixol and nortriptyline, leading to excessive drowsiness, dizziness, and impaired coordination. It can also worsen depression and increase the risk of suicidal thoughts. Additionally, alcohol may increase the risk of liver toxicity and cardiac arrhythmias.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to flupenthixol, nortriptyline, or any component of the formulation","Concurrent use with monoamine oxidase inhibitors (MAOIs)","Severe liver disease","Untreated narrow-angle glaucoma","Recent myocardial infarction","Severe cardiac arrhythmias","Pregnancy and lactation unless clearly needed","Children under 18 years of age"]
⚠️ Warnings & Precautions
["May cause drowsiness and impair ability to drive or operate machinery.","Avoid alcohol and other CNS depressants.","May cause orthostatic hypotension; rise slowly from sitting or lying positions.","May increase risk of suicidal thoughts and behaviors, especially in young adults.","May cause anticholinergic effects; use with caution in patients with glaucoma, urinary retention, or constipation.","May cause extrapyramidal symptoms; report any involuntary movements to your doctor.","May cause neuroleptic malignant syndrome; seek immediate medical attention if symptoms occur.","May prolong QT interval; use with caution in patients with cardiac disease.","May cause blood dyscrasias; monitor blood counts if symptoms occur.","Use with caution in elderly patients due to increased risk of falls and confusion."]
🤱 Lactation Safety
Not established from the available information. Both flupenthixol and nortriptyline are excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose of this medicine can be life-threatening. Symptoms may include severe drowsiness, confusion, agitation, hallucinations, irregular heartbeat, seizures, and coma. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic, including gastric lavage if within 1-2 hours of ingestion, activated charcoal, and monitoring of cardiac and respiratory function. There is no specific antidote. Hemodialysis is not effective for removing flupenthixol or nortriptyline.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your doctor, as sudden discontinuation can cause withdrawal symptoms or worsening of your condition. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it can cause drowsiness and dizziness. Do not drink alcohol while taking this medicine, as it can increase drowsiness and impair your ability to think clearly. Inform your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements, as this medicine can interact with many other medications. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor before taking this medicine. Keep this medicine out of the reach of children and store it in a cool, dry place away from direct sunlight. Do not use this medicine for any condition other than the one for which it was prescribed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative, anticholinergic, and cardiovascular effects of this medicine. They are at increased risk of falls, confusion, and orthostatic hypotension. Start with a lower dose and monitor closely. Regular assessment of renal and hepatic function is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Both flupenthixol and nortriptyline may pose risks to the fetus. Your doctor may consider alternative treatments or adjust the dose. Effective contraception should be used during treatment if pregnancy is not desired.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with anesthetic agents and other medications used during surgery. Your doctor may advise you to stop the medicine temporarily before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It can cause dry mouth, which may increase the risk of dental caries and oral infections. It may also interact with local anesthetics and other medications used in dentistry.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness, dizziness, and orthostatic hypotension, which may increase the risk of falls during exercise. Avoid activities that require mental alertness, such as driving or operating machinery, until you know how the medicine affects you. Start with light exercises and gradually increase intensity as tolerated. Stay hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and difficulty concentrating, which may affect your ability to work, drive, or operate machinery. It is advisable to avoid these activities until you know how the medicine affects you. You may need to adjust your work schedule or tasks temporarily. Discuss with your employer if you need accommodations.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Your doctor will determine when and how to stop based on your condition and response to treatment. Stopping abruptly can cause withdrawal symptoms such as nausea, headache, dizziness, and anxiety, and may lead to relapse of depression. If you experience severe side effects, contact your doctor immediately for guidance.
📅 Long-Term Use Effects
Long-term use of this medicine may require regular monitoring of liver function, kidney function, blood counts, and cardiac function. Prolonged use of flupenthixol can increase the risk of tardive dyskinesia, which may be irreversible. Nortriptyline can cause anticholinergic effects and cardiac arrhythmias. Regular follow-up with your doctor is essential to assess the continued need for this medicine and to monitor for side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Cognitive behavioral therapy (CBT) can be effective for depression and anxiety and may complement medicine.
Evidence: Well-establishedRegular exercise, healthy diet, and stress management can help improve mood and reduce anxiety.
Evidence: Well-establishedSSRIs, SNRIs, or other tricyclic antidepressants may be considered if this combination is not suitable.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, consult your doctor about adjusting the timing of your dose. Store it at room temperature and avoid exposing it to extreme heat or cold. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The full antidepressant effect may take 2 to 4 weeks. Some effects like improved sleep and reduced anxiety may be noticed earlier.
A: No, you should not stop this medicine abruptly. Always consult your doctor before stopping, as sudden discontinuation can cause withdrawal symptoms and relapse.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, alcohol should be avoided as it can increase sedation, dizziness, and worsen depression.
A: Consult your doctor. This medicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
🤔 Common Patient Concerns
🔄 Substitutes for avanxit-fn tablet
View AllAlternative brands with exact same active ingredient:
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fpx n 0.5mg/10mg tabletTripada Lifecare Pvt Ltd ₹56.25 57.1% CHEAPER
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Femxip N 0.5mg/10mg TabletFemgrace Formulations ₹60.94 53.6% CHEAPER
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fluxip n 0.5mg/10mg tabletMedico Healthcare ₹84.38 35.7% CHEAPER
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cilapam fn 0.5mg/10mg tabletAlteus Biogenics Pvt Ltd ₹109.81 16.3% CHEAPER
-
flunor tabletMeethi Pharmaceuticals ₹131.25 SAME PRICE
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is addictive.
Fact: This medicine is not considered addictive in the traditional sense, but it can cause dependence and withdrawal symptoms if stopped abruptly. It should be tapered under medical supervision. - Myth: You can stop taking this medicine once you feel better.
Fact: You should never stop this medicine abruptly, even if you feel better. Stopping suddenly can cause withdrawal symptoms and relapse of depression. Always consult your doctor before stopping. - Myth: This medicine works immediately.
Fact: The full antidepressant effect may take 2 to 4 weeks to develop. Some effects like improved sleep and reduced anxiety may be noticed earlier.
🔄 Alternative Options
Generic Alternatives
- Flupenthixol + Nortriptyline combination (generic)
Brand Alternatives
- Avanxit-FN Tablet